An iodine-promoted domino reaction of arylamines/benzylamines, dialkyl but-2-ynedioates and 3-hydroxy-3-(indol-3-yl)indolin-2-ones afforded different spirooxindole derivatives depending on the electronic effect and the position of the substituents.
AB2C type four component quadruple cascade reaction between MBH acetate, 1,3-indanedione and aldehydes via [1 + 1 + 1 + 3] annulation progressed through Knoevenagel/Michael/Michael/Michael sequence for the synthesis of bis-spirocyclohexane.
A facile synthesis of spirooxindoles bearing a 3-oxoisobenzofuran-1(3H)-ylidene motif was developed via a tandem Michael addition/cyclization reaction between 2-arylidene-1,3-indanediones and 2-(2-oxoindolin-3-yl)malononitriles catalyzed by K2CO3.
A new 2-(4-(phenanthren-9-yl)benzylidene)-1H-indene-1,3(2H)-dione (PBI) probe was synthesized, meticulously characterized and applied for selective sensing of CN− ion.
L-Proline is widely used in 1,3-dipolar cycloaddition reactions. Azomethine ylide derived from decarboxylative condensation of L-proline and 1,2-dicarbonyl compounds can directly react with various dipolarophiles through 1,3-dipolar cycloaddition.