A modular strategy is developed to construct diverse organelle-targeting fluorescent probes for selective imaging of formaldehyde in the nucleus, ER, mitochondria, and lysosomes of live cells.
A two-photon excited fluorescent probe CMB-1 has been rationally developed based on a new sensing mechanism for the detection and regeneration of formaldehyde in living cells with minimal influence on its native homeostasis and local concentration.
A reaction-based fluorescent probe enables rapid (<2 min), selective detection of formaldehyde in food samples and imaging in lysosomes of live cells.
Here, we report NucRFAP-2, a nuclear-targeted, activity-based sensing ratiometric probe for formaldehyde (FA) detection, and apply it to identify new, human disease-relevant epigenetic contributors to the nuclear FA pool.
This review provides an overview of the progress in the development of AIE-based organic small molecule probes for detecting biologically important molecules, drug molecules, volatile organic compounds, and explosives over the past five years.