Magnetic nanocatalysts (MNCs) represent sustainable platforms for synthesizing imidazo[1,2-a]pyridine derivatives, key nitrogen-fused heterocycles with wide applications in medicinal chemistry, materials science, and agrochemistry.
Herein we disclose the synthesis and an overview of all the functionalization reactions at each carbon atom, viz, C2, C3, C5, C6, C7 and C8 of imidazo[1,2-a]pyridine.
Reusable catalysts are attractive alternatives to the metal-free catalysts accelerating the Groebke–Blackburn–Bienayme reaction for the efficient synthesis of imidazo[1,2-α]pyridines.
Novel imidazo[1,2-a]pyridine-based covalent inhibitors were synthesized via the scaffold hopping strategy. In vitro bioactivity assessment concluded that I-11 is a potent and selective KRAS G12C inhibitor.
We have developed a novel electrophilic iodocyclization reaction leading to naphthalene-fused imidazo[1,2-a]pyridinium salts showing green luminescence with high quantum yields (up to 0.77) and mega-large Stokes shift (up to 135 nm).