Magnetic nanocatalysts (MNCs) represent sustainable platforms for synthesizing imidazo[1,2-a]pyridine derivatives, key nitrogen-fused heterocycles with wide applications in medicinal chemistry, materials science, and agrochemistry.
Herein we disclose the synthesis and an overview of all the functionalization reactions at each carbon atom, viz, C2, C3, C5, C6, C7 and C8 of imidazo[1,2-a]pyridine.
One-step synthesis of 3-oyl-imidazo[1,2-a]pyridines accomplished by the solid-state manual grinding of β-enaminones, 2-aminopyridines and molecular iodine. This is the first report on synthesis of title compounds through grindstone chemistry.
We developed a CBr4-mediated, sustainable, solvent-free method to synthesize 2-arylimidazo[1,2-a]pyridines from 2-aminopyridines and acetophenones, enabling one-pot, oxidant-free C3 amino-functionalization and C3 bromo-functionalization using K2S2O8.
We have developed a protocol for the regioselective synthesis of substituted imidazo[1,2-α]pyridines at room temperature using low-energy visible light, inexpensive CuCl as a catalyst, readily available starting materials, mild reaction conditions, and O2 as a green oxidant.