α-Chiral amines are key intermediates for scalable preparation of bioactive compounds; herein we present a novel palladium-based nanocatalyst capable of selectively catalyzing the reductive amination of carbonyl compounds, which enables the in situ regeneration of amino donors from wasteful co-products in a one-enzyme cascade using ω-transaminase, without the requirement of the expensive coenzyme NAD(P)H.
This review explores linear cascade reactions by combining chemo-, photo- and biocatalysts for organic synthesis and strategies to overcome incompatibility issues.
This tutorial review will give readers an insight into the landmark discoveries and milestones that have helped shape and grow the field of biocatalysis since the discovery of the first enzyme.
A novel dual-enzyme cascade process utilizing carbonyl reductase and ω-transaminase enzyme was developed to remove by-products via the asymmetric reduction and increase product formation, making it ideal for both industrial and academic applications.
Via multi-enzyme cascade approaches, ω-amino fatty acids are able to be sustainably produced as nylon monomers from vegetable-derived precursors.