Alessandra Piccirilli, Mariagrazia Perilli, Fabrizia Brisdelli, Dario Mastrippolito, Gianluca D'Olimpio, Soheil Ershadrad, Biplab Sanyal and Luca Ottaviano
RSC Adv., 2025,15, 21199-21211
Abstract
This paper proves that graphene oxide is a potent non-competitive inhibitor for both serine- and metallo-β-lactamases. Its inhibitory effect is significantly diminished when preincubated with a substrate, indicating an oxidation-mediated mechanism.
Tahlia Hatzisarantinos, Elissar Mansour, Jonathan J. Du, Mohamed Fares, David E. Hibbs and Paul W. Groundwater
RSC Med. Chem., 2025,16, 5770-5786
From themed collection:
Antimicrobial Resistance
Abstract
Active sites of the a serine- (OXA-23 [PDB 4JF6]) and b metallo- (NDM-1 [PDB 5YPL]) β-lactamases.
Hong-Xin Li, Han Fang, Yu-Feng Zhang, Zong-Hui Zhang and Dong-Xu Xue
Inorg. Chem. Front., 2023,10, 1795-1802
From themed collection:
2023 Inorganic Chemistry Frontiers HOT articles
Abstract
A series of rare-earth pillar-layered MOFs based on kgd supermolecular building layers have been successfully isolated for the first time, with ethane-selective properties benefiting ethylene purification in a one-step process.
Hazem Elkady, Ibtehal Nasser Salman and Mohamed M. Khalifa
RSC Adv., 2025,15, 24450-24474
Abstract
This review highlights small-molecule-based strategies to combat antibiotic resistance, including β-lactamase inhibitors, efflux pump blockers, drug repurposing, and structure-based optimization of known antibiotics.
Mbongeni Shungube, Ayanda K. Hlophe, Letisha Girdhari, Victor T. Sabe, Byron B. Peters, Nakita Reddy, Kehinde F. Omolabi, Lloyd Chetty, Thilona Arumugam, Anil Chuturgoon, Hendrik G. Kruger, Per I. Arvidsson, Hua-Li Qin, Tricia Naicker and Thavendran Govender
RSC Adv., 2023,13, 18991-19001
Abstract
β-lactamases are enzymes that deactivate β-lactam antibiotics through a hydrolysis mechanism.