The new classification of APAP combinations (prodrugs, codrugs, and hybrids) was proposed. It makes a better understanding of the SAR studies for new pain relievers research and the design development for the analgesic APAP-based compounds.
Cyn alleviates APAP-induced ALI by activating the Keap1/Nrf2-mediated lipid peroxidation defense, and these effects are partly mediated through the activation of the AMPK/SIRT3 signaling pathway.
A novel Zn-doped Fe3O4 nanoparticle@N, S and P doped Elaeagnus angustifolia gum derived carbon hybrid electrocatalyst was prepared, characterized and applied for electrochemical sensing of acetaminophen covering urinary physiological concentration.
Kaempferol binds to Keap1, leading to the release of Nrf2 and activation of the Nrf2 pathway, which enhance antioxidant and anti-inflammatory effects, inhibit hepatocyte ferroptosis, and alleviate APAP-induced liver injury.
Manganese Prussian blue nanoparticles (MPBZs), bioactive antidotes for APAP poisoning, efficacious against APAP-induced liver injury (AILI) by inhibiting oxidative stress, suppressing hepatocyte apoptosis, and reducing inflammation.