Rapid access to polysaccharides of biological relevance is important for determining the link between nutritional oligo- and polysaccharides and the immune response. We describe the automated glycan assembly of a hyper branched heptadecasaccharide repeating unit of HH1-1.
Sialyl Lewisa (sLea), also known as cancer antigen 19-9, is a tumor-associated carbohydrate antigen. In this paper, chemical and chemoenzymatic syntheses of sLea tetrasaccharide antigen are reported.
A highly efficient, one-step stereo- and regioselective conversion of 6-deoxy-β-D-galacto-heptopyranosides to 6-deoxy-β-D-ido-heptopyranosides is reported to obtain several oligosaccharides related to the capsular polysaccharides of C. jejuni HS:4.
The stereoselective synthesis of non-reducing disaccharides is achieved by tailoring the choice of protecting groups to adjust the nucleophilicity and anomeric configuration of the lactol acceptor and the reactivity of the matching glycosyl donor.
An efficient catalytic regioselective acyl migration makes possible the straightforward preparation of various partially protected saccharide derivatives.