Diagnosis and Therapeutic Strategies of Inorganic Nanomaterials in Lymphatic System Diseases

Abstract

Lymphatic system diseases encompass a variety of conditions, including lymphoma, lymphedema, lymphatic malformations, and lymphadenitis. Diagnosing these diseases poses challenges, and conventional treatment methods often have limitations. In recent years, inorganic nanomaterials (INMs) have shown great promise in the precise diagnosis and treatment of lymphatic system diseases. This review highlights the research progress of INMs in the area of diagnosis, treatment, and the nanoplatform integrated diagnostic and therapeutic capabilities, facilitating "visualized treatment." Overall, INMs provide a promising new avenue for advancing early detection and precision therapy of lymphatic diseases, potentially overcoming the challenges inherent in traditional diagnostic and therapeutic methods. In addition, this review also emphasizes the latest advancements in using metal nanoparticles, quantum dots, and silica-based carriers for lymphatic imaging, targeted drug delivery, and therapeutic interventions. Looking ahead, the integration of inorganic materials with advanced technologies such as microfluidics and nanomedicine holds great potential for developing personalized treatment strategies. However, challenges remain, including the need for comprehensive assessments of biocompatibility and the long-term effects of inorganic materials in vivo. Future research should focus on optimizing the design and functionalization of these materials to enhance their specificity and efficacy in lymphatic system applications. Overall, this review summarizes the innovative applications of inorganic materials in the diagnosis and treatment of lymphatic diseases and provides an outlook for future research, offering valuable reference for researchers.