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Chemical Communications

Consequences of Encapsulated vs Covalently Attached Pd-NHC Amphiphilic Polymeric Nanocatalysts in Bioorthogonal Catalysis

Lieke de Jonge,   Ibai Hazenberg,   Harshit Singh,   Tessa Loman,   A. P. Prakasham  and  Anja Palmans  

Abstract

A comparison between novel Pd-NHC (N-heterocyclic carbene) catalysts covalently and non-covalently attached to polymeric nanoparticles reveals that hydrophobic domains in the vicinity of the Pd catalysts aid catalytic activity, and covalent attachment reduces cytotoxicity, opening new avenues to tune bioorthogonal reactivity of TMC-based nanocarriers.

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Article information

DOI
https://doi.org/10.1039/D5CC06993A
Article type
Communication
Submitted
09 Dec 2025
Accepted
26 Jan 2026
First published
26 Jan 2026
This article is Open Access
Creative Commons BY license

Chem. Commun., 2026, Accepted Manuscript

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Consequences of Encapsulated vs Covalently Attached Pd-NHC Amphiphilic Polymeric Nanocatalysts in Bioorthogonal Catalysis

L. de Jonge, I. Hazenberg, H. Singh, T. Loman, A. P. Prakasham and A. Palmans, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D5CC06993A

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