Themed collection Journal of Materials Chemistry B Recent Review Articles
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Issues affecting nanomedicines on the way from the bench to the market
The development of innovative nanomedicine has raised the standards over the last few decades.
J. Mater. Chem. B, 2020,8, 10681-10685
https://doi.org/10.1039/D0TB02180F
Functional peptide-based drug delivery systems
Representative strategies for designing smart drug delivery systems by using functional peptides in the past few years are highlighted in this review.
J. Mater. Chem. B, 2020,8, 6517-6529
https://doi.org/10.1039/D0TB00713G
Bioinspired wettable–nonwettable micropatterns for emerging applications
Wettable–nonwettable micropatterns have received tremendous attention due to their unique functionalities. Their emerging applications have been highlighted in this review.
J. Mater. Chem. B, 2020,8, 8101-8115
https://doi.org/10.1039/D0TB01382J
Phospholipid-mimicking cell-penetrating polymers: principles and applications
Phospholipid-mimicking amphiphilic polymers show nonendocytic internalization by membrane fusion.
J. Mater. Chem. B, 2020,8, 7633-7641
https://doi.org/10.1039/D0TB01520B
Cleaving DNA by nanozymes
Various nanomaterials can mimic the activities of nucleases for hydrolytic and oxidative DNA cleavage on different sites allowing interesting biomedical and bioanalytical applications.
J. Mater. Chem. B, 2020,8, 7135-7142
https://doi.org/10.1039/D0TB01274B
Chemoreactive nanomedicine
Triggering specific chemical reactions in the disease microenvironment can produce species for disease treatment that have high theranostic performance and low side effects on healthy cells/tissues.
J. Mater. Chem. B, 2020,8, 6753-6764
https://doi.org/10.1039/D0TB00436G
A review of in vitro cell culture testing methods for bioactive glasses and other biomaterials for hard tissue regeneration
Bioactive glasses are used to regenerate bone, and when developing new compositions, in vitro cell culture studies are key. As test parameters vary widely, this review provides an overview, helping researchers to select the appropriate ones.
J. Mater. Chem. B, 2020,8, 10941-10953
https://doi.org/10.1039/D0TB01493A
Nanodiamonds for bioapplications, recent developments
This review describes the very recent bioapplications of nanodiamonds combining nanoparticles and diamond features, underlining their multiple roles in theranostics.
J. Mater. Chem. B, 2020,8, 10878-10896
https://doi.org/10.1039/D0TB02221G
Current advances in the nano-delivery of celastrol for treating inflammation-associated diseases
Inflammation is ubiquitous in the body, and uncontrolled inflammation often contributes to various diseases.
J. Mater. Chem. B, 2020,8, 10954-10965
https://doi.org/10.1039/D0TB01939A
Growing tool-kit of photosensitizers for clinical and non-clinical applications
Photosensitizers are photosensitive molecules utilized in clinical and non-clinical applications by taking advantage of light-mediated reactive oxygen generation, which triggers local and systemic cellular toxicity.
J. Mater. Chem. B, 2020,8, 10897-10940
https://doi.org/10.1039/D0TB02085K
Design of hydrogel-based scaffolds for the treatment of spinal cord injuries
Hydrogel-based scaffold design approaches for the treatment of spinal cord injuries.
J. Mater. Chem. B, 2020,8, 10712-10738
https://doi.org/10.1039/D0TB01842B
Recent advances in pH-responsive nanomaterials for anti-infective therapy
The design and synthesis of pH-responsive antibacterial nanomaterials and their applications in anti-infective therapy.
J. Mater. Chem. B, 2020,8, 10700-10711
https://doi.org/10.1039/D0TB02177F
Supramolecular ensembles modified by near-infrared dyes and their biological applications
This review presents recently developed supramolecular ensembles modified by near-infrared dyes. We discussed the construction of these near-infrared dyes-based ensembles and their biological application.
J. Mater. Chem. B, 2020,8, 10686-10699
https://doi.org/10.1039/D0TB01829E
Bioactive metal-containing nanomaterials for ferroptotic cancer therapy
The metal-containing nanomaterials with inherent physichemical properties are potential agents for ferroptotic cancer therapy.
J. Mater. Chem. B, 2020,8, 10461-10473
https://doi.org/10.1039/D0TB02138E
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Advanced biomedical applications based on emerging 3D cell culturing platforms
We discuss the recent progress in the development of scaffold-free techniques for the fabrication of cell spheroids and their biomedical applications.
J. Mater. Chem. B, 2020,8, 10487-10501
https://doi.org/10.1039/D0TB01658F
Cellulose-based dispersants and flocculants
Various cellulosic derivatives ranging from nanoparticles to macromolecular compounds were studied as biodegradable and renewable dispersants and flocculants.
J. Mater. Chem. B, 2020,8, 10502-10526
https://doi.org/10.1039/D0TB02021D
A mini-review of embedded 3D printing: supporting media and strategies
Embedded 3D printing is an additive manufacturing method based on a material extrusion strategy.
J. Mater. Chem. B, 2020,8, 10474-10486
https://doi.org/10.1039/D0TB01819H
Group IV nanodots: synthesis, surface engineering and application in bioimaging and biotherapy
A timeline for C, Si, Ge NDs, showing the development of synthesis, functionalization, bioimaging, and therapy.
J. Mater. Chem. B, 2020,8, 10290-10308
https://doi.org/10.1039/D0TB01881C
Lanthanide nanoparticles with efficient near-infrared-II emission for biological applications
We discuss designing efficient NIR-II-emitting lanthanide NPs and summarize their recent progress in bioimaging, therapy, and biosensing, as well as their limitations and future opportunities.
J. Mater. Chem. B, 2020,8, 10257-10270
https://doi.org/10.1039/D0TB01745K
Nanocomposites for the delivery of bioactive molecules in tissue repair: vital structural features, application mechanisms, updated progress and future perspectives
Nanocomposites have attracted great attention in tissue repair as carriers for bioactive molecule delivery due to their biochemical and nanostructural similarity to that of physiological tissues, and controlled delivery of bioactive molecules.
J. Mater. Chem. B, 2020,8, 10271-10289
https://doi.org/10.1039/D0TB01670E
Mimicking the electrophysiological microenvironment of bone tissue using electroactive materials to promote its regeneration
A timely and comprehensive account of electroactive biomaterials promoting bone regeneration is provided by reviewing their physicochemical and biological properties.
J. Mater. Chem. B, 2020,8, 10221-10256
https://doi.org/10.1039/D0TB01601B
Chemical and physical chitosan hydrogels as prospective carriers for drug delivery: a review
This review summarizes and discusses recent research progress in chemical and physical chitosan hydrogels for drug delivery.
J. Mater. Chem. B, 2020,8, 10050-10064
https://doi.org/10.1039/D0TB01869D
Bioreactivity of decellularized animal, plant, and fungal scaffolds: perspectives for medical applications
With the integrated evaluation of the scaffold profile in the living systems, the decellularized animal, plant, and fungal scaffolds will become essential instruments for safe and controllable biomedical applications.
J. Mater. Chem. B, 2020,8, 10010-10022
https://doi.org/10.1039/D0TB01751E
Applications of decellularized materials in tissue engineering: advantages, drawbacks and current improvements, and future perspectives
Decellularized materials (DMs) are attracting more and more attention in tissue engineering because of their many unique advantages, and they could be further improved in some aspects through various means.
J. Mater. Chem. B, 2020,8, 10023-10049
https://doi.org/10.1039/D0TB01534B
Biomimetic two-dimensional nanozymes: synthesis, hybridization, functional tailoring, and biosensor applications
2D material-based nanozymes exhibited high potential for applications in biosensors and immunoassays.
J. Mater. Chem. B, 2020,8, 10065-10086
https://doi.org/10.1039/D0TB02051F
An insight into cell-laden 3D-printed constructs for bone tissue engineering
In this review, we have spotlighted various combinations of bioinks to optimize the biofabrication of 3D bone constructs.
J. Mater. Chem. B, 2020,8, 9836-9862
https://doi.org/10.1039/D0TB02019B
Biomedical application of mesoporous silica nanoparticles as delivery systems: a biological safety perspective
A comprehensive review on the biosafety of mesoporous silica nanoparticles for biomedical applications.
J. Mater. Chem. B, 2020,8, 9863-9876
https://doi.org/10.1039/D0TB01868F
From bulk to nano-delivery of essential phytochemicals: recent progress and strategies for antibacterial resistance
Nano-delivery helps to improve the solubility, stability, and efficacy of essential phytochemicals for the inhibition of bacterial resistance.
J. Mater. Chem. B, 2020,8, 9825-9835
https://doi.org/10.1039/D0TB01671C
Natural polysaccharides with different conformations: extraction, structure and anti-tumor activity
Natural polysaccharides as sustainable polymers are rich sources with good biological safety and various biological functions, which are important research topics in the fields of food and medicine.
J. Mater. Chem. B, 2020,8, 9652-9667
https://doi.org/10.1039/D0TB01713B
A minireview of viscosity-sensitive fluorescent probes: design and biological applications
Microenvironment-related parameters like viscosity, polarity, and pH play important roles in controlling the physical or chemical behaviors of local molecules, which determine the physical or chemical behaviors of surrounding molecules.
J. Mater. Chem. B, 2020,8, 9642-9651
https://doi.org/10.1039/D0TB01146K
Biomass-derived nanocarbon materials for biological applications: challenges and prospects
This review discusses the current status and future potential of biomass-derived nanocarbons for a wide range of biomedical/environmental applications, including bioimaging, microbial inactivation, wound care, and microbial electrochemical systems.
J. Mater. Chem. B, 2020,8, 9668-9678
https://doi.org/10.1039/D0TB01027H
Polymeric nano-carriers for on-demand delivery of genes via specific responses to stimuli
Polymeric nano-carriers for on-demand delivery of genes via specific responses to stimuli.
J. Mater. Chem. B, 2020,8, 9621-9641
https://doi.org/10.1039/D0TB01675F
Development of coinage metal nanoclusters as antimicrobials to combat bacterial infections
Infections from antibiotic-resistant bacteria have caused huge economic loss and numerous deaths over the past decades.
J. Mater. Chem. B, 2020,8, 9466-9480
https://doi.org/10.1039/D0TB00549E
Cationic dynamic covalent polymers for gene transfection
Dynamic covalent polymers have revealed strong potential in gene delivery, thanks to their versatile self-assembly, adaptive and responsive behaviors.
J. Mater. Chem. B, 2020,8, 9385-9403
https://doi.org/10.1039/D0TB01836H
DNAzyme–gold nanoparticle-based probes for biosensing and bioimaging
The design and applications of DNAzyme–gold nanoparticle-based probes in biosensing and bioimaging are summarized here.
J. Mater. Chem. B, 2020,8, 9449-9465
https://doi.org/10.1039/D0TB01750G
Inflammation and biomaterials: role of the immune response in bone regeneration by inorganic scaffolds
The design of inorganic scaffolds able to instruct the immune system, eliciting adequate feedback by tuning specific material properties, has become an emerging field of research.
J. Mater. Chem. B, 2020,8, 9404-9427
https://doi.org/10.1039/D0TB01379J
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Promising nanomaterials in the fight against malaria
Nanomaterials can offer customized tools for prophylactic and therapeutic purposes that bring new solutions in different stages of malaria infection.
J. Mater. Chem. B, 2020,8, 9428-9448
https://doi.org/10.1039/D0TB01398F
Carbon nanotube-based biomaterials for orthopaedic applications
Carbon nanotubes can enhance the functionality of orthopedic applications.
J. Mater. Chem. B, 2020,8, 9227-9238
https://doi.org/10.1039/D0TB01440K
Temperature-responsive supramolecular hydrogels
A subclass of hydrogels which are prepared from supramolecular interactions can realized enhanced functionality, especially in the context of biomedical applications, upon the inclusion of temperature-responsive properties.
J. Mater. Chem. B, 2020,8, 9197-9211
https://doi.org/10.1039/D0TB01814G
Structural design and antimicrobial properties of polypeptides and saccharide–polypeptide conjugates
The development and progress of antimicrobial polypeptides and saccharide–polypeptide conjugates in regards to their structural design, biological functions and antimicrobial mechanism.
J. Mater. Chem. B, 2020,8, 9173-9196
https://doi.org/10.1039/D0TB01916J
Spatiotemporal regulation of dynamic cell microenvironment signals based on an azobenzene photoswitch
Photoisomerization and red-shifted photoswitching make azobenzene superior for exploring the cell-material interactions and designing tissue-engineering scaffolds.
J. Mater. Chem. B, 2020,8, 9212-9226
https://doi.org/10.1039/D0TB01737J
Advances in biomedical and pharmaceutical applications of protein-stabilized gold nanoclusters
The review provides an overview on protein-stabilized gold nanoclusters which offer intriguing applications for the use as theranostics, as diagnostics and as biosensors.
J. Mater. Chem. B, 2020,8, 8952-8971
https://doi.org/10.1039/D0TB01610A
Stimuli-responsive functional materials for soft robotics
This review provides an overview of stimuli-responsive functional materials and their applications in soft robotics.
J. Mater. Chem. B, 2020,8, 8972-8991
https://doi.org/10.1039/D0TB01585G
Biocompatible nitrogen-doped carbon dots: synthesis, characterization, and application
Nitrogen-doped carbon dots have emerged as a biocompatible functional carbon nanomaterial for a variety of biomedical applications such as optical imaging, photoacoustic imaging, drug delivery, photothermal therapy, and photodynamic therapy.
J. Mater. Chem. B, 2020,8, 8935-8951
https://doi.org/10.1039/D0TB01334J
Core–shell nanostructures: perspectives towards drug delivery applications
Nanosystems have shown encouraging outcomes and substantial progress in the areas of drug delivery and biomedical applications.
J. Mater. Chem. B, 2020,8, 8992-9027
https://doi.org/10.1039/D0TB01559H
Nanotechnology-based drug delivery systems for enhanced diagnosis and therapy of oral cancer
Oral cancer is a common malignant life-threatening tumor.
J. Mater. Chem. B, 2020,8, 8781-8793
https://doi.org/10.1039/D0TB00957A
Applications of nanomaterials for scavenging reactive oxygen species in the treatment of central nervous system diseases
Nanomaterials with excellent ROS-scavenging ability and biodistribution are considered as promising candidates in alleviating oxidative stress and restoring redox balance in CNS diseases, further facilitating the function recovery of the CNS.
J. Mater. Chem. B, 2020,8, 8748-8767
https://doi.org/10.1039/D0TB01380C
In situ formation of injectable hydrogels for chronic wound healing
Hydrogels have been widely used in wound healing treatment over the past decade.
J. Mater. Chem. B, 2020,8, 8768-8780
https://doi.org/10.1039/D0TB01074J
Harnessing biomolecules for bioinspired dental biomaterials
We review the range of biomolecules used across dental biomaterials to spur the design and implementation of bioinspired multifunctional materials.
J. Mater. Chem. B, 2020,8, 8713-8747
https://doi.org/10.1039/D0TB01456G
Liquid-phase electron microscopy imaging of cellular and biomolecular systems
Liquid-phase electron microscopy, a new method for real-time nanoscopic imaging in liquid, makes it possible to study cells or biomolecules with a singular combination of spatial and temporal resolution. We review the state of the art in biological research in this growing and promising field.
J. Mater. Chem. B, 2020,8, 8490-8506
https://doi.org/10.1039/D0TB01300E
Advances in local and systemic drug delivery systems for post-surgical cancer treatment
Graphical representation of local and systemic drug delivery systems.
J. Mater. Chem. B, 2020,8, 8507-8518
https://doi.org/10.1039/D0TB00987C
Functionalized graphene oxide as a vehicle for targeted drug delivery and bioimaging applications
Graphene oxide (GO) has emerged as a polynomially functional carbon nanomaterial with rational applications in diverse fields such as biomedical engineering, electrocatalysis, biosensing, energy conversion, and storage devices.
J. Mater. Chem. B, 2020,8, 8116-8148
https://doi.org/10.1039/D0TB01149E
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Multicomponent polysaccharide alginate-based bioinks
3D-Bioprinting has seen a rapid expansion in the last few years, with an increasing number of reported bioinks, amongst which, alginate is an ideal ingredient due to its biocompatibility and ease of gelation.
J. Mater. Chem. B, 2020,8, 8171-8188
https://doi.org/10.1039/D0TB01005G
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Advancements in the development on new liquid embolic agents for use in therapeutic embolisation
This review covers the current state-of-the-art in the development of liquid embolics for therapeutic embolisation.
J. Mater. Chem. B, 2020,8, 8207-8218
https://doi.org/10.1039/D0TB01576H
Recent advances in supramolecular block copolymers for biomedical applications
Supramolecular block copolymers with a dynamically reversible nature and hierarchical microphase-separated structures can greatly enrich the library of pharmaceutical carriers and outline future research directions for biological applications.
J. Mater. Chem. B, 2020,8, 8219-8231
https://doi.org/10.1039/D0TB01492C
Recent advances of polyoxometalates in multi-functional imaging and photothermal therapy
The recent advances of polyoxometalate clusters in terms of near infrared photothermal properties for targeted tumor therapy have been summarized while the combined applications with various bio-imaging techniques and chemotherapies are reviewed.
J. Mater. Chem. B, 2020,8, 8189-8206
https://doi.org/10.1039/D0TB01375G
Gradient scaffolds for osteochondral tissue engineering and regeneration
The tissue engineering approach for repairing osteochondral (OC) defects involves the fabrication of a biological tissue scaffold that mimics the physiological properties of natural OC tissue (e.g., the gradient transition between the cartilage surface and the subchondral bone).
J. Mater. Chem. B, 2020,8, 8149-8170
https://doi.org/10.1039/D0TB00688B
Recent advances of near infrared inorganic fluorescent probes for biomedical applications
Near infrared (NIR)-excitable and NIR-emitting probes have fuelled advances in biomedical applications owing to their power in enabling deep tissue imaging, offering high image contrast and reducing phototoxicity.
J. Mater. Chem. B, 2020,8, 7856-7879
https://doi.org/10.1039/D0TB01430C
Recent advances in bio-orthogonal and dynamic crosslinking of biomimetic hydrogels
This review highlights recent advances in bio-orthogonal and dynamic hydrogels crosslinked by irreversible click chemistry, enzymatic reactions, and covalent-adaptable network.
J. Mater. Chem. B, 2020,8, 7835-7855
https://doi.org/10.1039/D0TB01429J
Detection signal amplification strategies at nanomaterial-based photoelectrochemical biosensors
This review focusses on unique material modification and signal amplification strategies reported in developing photoelectrochemical biosensors with utmost sensitivity and selectivity.
J. Mater. Chem. B, 2020,8, 7880-7893
https://doi.org/10.1039/D0TB01191F
Vertical nanowire array-based biosensors: device design strategies and biomedical applications
We review the recent progress of vertical nanowire (VNW) array-based biosensors for the effective collection of biomedical information at the molecular level, extracellular level, and intracellular level.
J. Mater. Chem. B, 2020,8, 7609-7632
https://doi.org/10.1039/D0TB00990C
Three-dimensional scaffold-free microtissues engineered for cardiac repair
In this review article, we present the state-of-the-art approaches and recent advancements in the engineering of scaffold-free cardiac microtissues for myocardial repair.
J. Mater. Chem. B, 2020,8, 7571-7590
https://doi.org/10.1039/D0TB01528H
Exosome: a significant nano-scale drug delivery carrier
Exosomes have outstanding advantages as drug delivery carriers in the treatment of various diseases.
J. Mater. Chem. B, 2020,8, 7591-7608
https://doi.org/10.1039/D0TB01499K
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Enzyme catalysis powered micro/nanomotors for biomedical applications
This review provides insights on enzyme powered motors using fuels present in biological environments for biomedical applications.
J. Mater. Chem. B, 2020,8, 7319-7334
https://doi.org/10.1039/D0TB01245A
Flexible electrochemical biosensors for healthcare monitoring
Flexible electrochemical biosensors are studied hugely because of tremendous advantages including the fast response, high sensitivity, inherent miniaturization, convenient operation, and portability which are suitable for wearable biosensors.
J. Mater. Chem. B, 2020,8, 7303-7318
https://doi.org/10.1039/D0TB01325K
Nanoclay-based drug delivery systems and their therapeutic potentials
Natural and modified nanostructured clay minerals as drug carriers and support matrices for drug delivery, cancer therapy, gene therapy, and tissue engineering.
J. Mater. Chem. B, 2020,8, 7335-7351
https://doi.org/10.1039/D0TB01031F
Stimuli-responsive polymer-based systems for diagnostic applications
The unique properties of stimuli-responsive polymers make them valuable for myriad applications, their use for biosensing and molecular diagnostics is reviewed here.
J. Mater. Chem. B, 2020,8, 7042-7061
https://doi.org/10.1039/D0TB00570C
Microphysiological systems for the modeling of wound healing and evaluation of pro-healing therapies
Wound healing microphysiological systems have been engineered with synthetic and natural materials and techniques such as bioprinting or viscous finger patterning. Model designs focus on particular phases of wound healing or the recapitulation of micro-anatomies.
J. Mater. Chem. B, 2020,8, 7062-7075
https://doi.org/10.1039/D0TB00544D
Finely tuned Prussian blue-based nanoparticles and their application in disease treatment
The Prussian blue (PB) based nanostructure is a mixed-valence coordination network with excellent biosafety, remarkable photothermal effect and multiple enzyme-mimicking behaviours.
J. Mater. Chem. B, 2020,8, 7121-7134
https://doi.org/10.1039/D0TB01248C
Progress in the therapeutic applications of polymer-decorated black phosphorus and black phosphorus analog nanomaterials in biomedicine
Owing to fascinating properties and biodegradability, opportunities and challenges of emerging black phosphorus (BP) and BP analogs (BPAs) in biomedical applications have been coexisted to study.
J. Mater. Chem. B, 2020,8, 7076-7120
https://doi.org/10.1039/D0TB00824A
About this collection
This collection contains recent Review-type articles published by Journal of Materials Chemistry B, the home for high impact applications, properties and synthesis of exciting new materials for biology and medicine. New articles will be added to this collection as soon as possible after publication.