Themed collection Molecular Bioengineering.

16 items
Open Access Minireview

Engineering the interaction of short antimicrobial peptides with bacterial barriers

Designing short antimicrobial peptides and tuning their interaction with bacterial barriers.

Graphical abstract: Engineering the interaction of short antimicrobial peptides with bacterial barriers
From the themed collection: Emerging Investigator Series
Review Article

Recent advances in 3D bioprinting of polysaccharide-based bioinks for fabrication of bioengineered tissues

Complex multilayered tissues have been regenerated by extrusion-based 3D bioprinting with biocompatible polymers. Multilayer fabrications with tissue-specific bioinks are possible by controlling gel properties including interaction between layers.

Graphical abstract: Recent advances in 3D bioprinting of polysaccharide-based bioinks for fabrication of bioengineered tissues
From the themed collection: Molecular Bioengineering.
Review Article

Fabrication of a photothermal antibacterial platform for bacterial infectious skin wound healing: a review

Antibiotics are the main strategy to treat bacterial infections, but can cause bacterial resistance. We comprehensively summarize work on the fabrication of photothermal antibacterial platforms for bacterial infectious skin wound healing.

Graphical abstract: Fabrication of a photothermal antibacterial platform for bacterial infectious skin wound healing: a review
From the themed collection: Emerging Investigator Series
Open Access Review Article

Enhancing enzymatic activity with nanoparticle display – an updated compendium and engineering outlook

Schematic depicting enzyme kinetic enhancement when displayed on a nanoparticle surface. We provide a state of the art review of this phenomenon describing what is known about how it arises along with examples grouped by nanomaterials.

Graphical abstract: Enhancing enzymatic activity with nanoparticle display – an updated compendium and engineering outlook
From the themed collection: Molecular Bioengineering.
Open Access Paper

Enhanced glucose-responsivity of PBA–diol hydrogel networks by reducing crosslink affinity

New diol chemistries are explored for insulin delivery from glucose-responsive hydrogels comprised of dynamic-covalent crosslinking interactions between phenylboronic acids and diols.

Graphical abstract: Enhanced glucose-responsivity of PBA–diol hydrogel networks by reducing crosslink affinity
From the themed collection: Molecular Bioengineering.
Open Access Paper

Multi-site esterification: a tunable, reversible strategy to tailor therapeutic peptides for delivery

Peptides are naturally potent and selective therapeutics with massive potential; however, low cell membrane permeability limits their clinical implementation, particularly for hydrophilic, anionic peptides with intracellular targets.

Graphical abstract: Multi-site esterification: a tunable, reversible strategy to tailor therapeutic peptides for delivery
From the themed collection: Emerging Investigator Series
Paper

Supramolecular assembly of multifunctional protein gels via an N-glycosylation consensus sequence fusion domain

Stimuli-responsive polypeptide tags direct the assembly of active proteins into supramolecular assemblies. This allows for recombinant expression of soluble fusion protein and subsequent user-controlled formation of functional biomaterials.

Graphical abstract: Supramolecular assembly of multifunctional protein gels via an N-glycosylation consensus sequence fusion domain
From the themed collection: Molecular Bioengineering.
Paper

Liquid metal–polymer nano-microconjugations as an injectable and photo-activatable drug carrier

Nanoparticles of photoresponsive liquid–liquid phase-separation polymers complexed with liquid metals can concentrate drugs upon photoirradiation, opening up new DDS horizons.

Graphical abstract: Liquid metal–polymer nano-microconjugations as an injectable and photo-activatable drug carrier
From the themed collection: Molecular Bioengineering.
Paper

Design and engineering of an artificial disulfide bond in human cytochrome c to regulate the protein structure and function

An artificial disulfide bond was rationally constructed in human cytochrome c (hCyt c) via double mutations (A51C/G77C), which weakened the coordination of Met80 to the heme iron and enhanced the peroxidase activity of hCyt c.

Graphical abstract: Design and engineering of an artificial disulfide bond in human cytochrome c to regulate the protein structure and function
From the themed collection: Molecular Bioengineering.
Open Access Paper

Optimization of chondroitin production in E. coli using genome scale models

E. coli was used to produce chondroitin both in silico and in vivo, marking the first use of genome-scale metabolic models to predict its production. Identified targets can guide future works towards more efficient hosts for chondroitin production.

Graphical abstract: Optimization of chondroitin production in E. coli using genome scale models
From the themed collection: Molecular Bioengineering.
Paper

Formation mechanism of anisotropic gelatin hydrogel by self-assembly on oriented templates

The development of structurally controlled techniques inspired by the structural formation of living systems is of great importance for the fabrication of next-generation functional soft materials using environmentally friendly processes.

Graphical abstract: Formation mechanism of anisotropic gelatin hydrogel by self-assembly on oriented templates
From the themed collection: Emerging Investigator Series
Open Access Paper

A physics-inspired approach to the understanding of molecular representations and models

By drawing on similarities between energy landscapes and model response surfaces we gain new insight into model performance, even in the absence of data.

Graphical abstract: A physics-inspired approach to the understanding of molecular representations and models
From the themed collection: Molecular Bioengineering.
Open Access Paper

Cancer-targeting gold-decorated melanin nanoparticles for in vivo near-infrared photothermal therapy

Melanin-like nanoparticles decorated with gold nanoparticles are presented as cancer-targeting near-infrared (NIR) photothermal agents with excellent photothermal conversion and stability.

Graphical abstract: Cancer-targeting gold-decorated melanin nanoparticles for in vivo near-infrared photothermal therapy
From the themed collection: Molecular Bioengineering.
Open Access Paper

On the use of modelling antagonistic enzymes to aid in temporal programming of pH and PVA–borate gelation

A model was developed to help predict how enzymes can be used to temporally control the gelation of polyvinyl alcohol (PVA) with borate.

Graphical abstract: On the use of modelling antagonistic enzymes to aid in temporal programming of pH and PVA–borate gelation
From the themed collection: Molecular Bioengineering.
Paper

Light-activation of molecular motors in polymersomes

Light-activated molecular motors rotate at a similar frequency in polymersomes and in solution.

Graphical abstract: Light-activation of molecular motors in polymersomes
From the themed collection: Molecular Bioengineering.
Paper

In silico identification of novel PqsD inhibitors: promising molecules for quorum sensing interference in Pseudomonas aeruginosa

PqsD is an anthraniloyl-CoA anthraniloyltransferase involved in the synthesis of the secondary metabolites essential to the formation of Pseudomonas quinolone signal (PQS) inducer molecules.

Graphical abstract: In silico identification of novel PqsD inhibitors: promising molecules for quorum sensing interference in Pseudomonas aeruginosa
From the themed collection: Molecular Bioengineering.
16 items

About this collection

This special collection of MSDE, Guest Edited by Patrick Stayton (0000-0001-6939-6371) (University of Washington, USA) & José Rafael Bordin (0000-0002-8025-6529) (Federal University of Pelotas, Brazil) showcases the broad and diverse approaches to the cross-disciplinary field that is molecular bioengineering with a particular focus at the molecular level. We are particularly interested in receiving submissions at the interface of multiple disciplines and that showcase applied systems as well as novel design approaches. 

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