Issue 16, 2024

Near-infrared-driven upconversion nanoparticles with photocatalysts through water-splitting towards cancer treatment

Abstract

Water splitting is promising, especially for energy and environmental applications; however, there are limited studies on the link between water splitting and cancer treatment. Upconversion nanoparticles (UCNPs) can be used to convert near-infrared (NIR) light to ultraviolet (UV) or visible (Vis) light and have great potential for biomedical applications because of their profound penetration ability, theranostic approaches, low self-fluorescence background, reduced damage to biological tissue, and low toxicity. UCNPs with photocatalytic materials can enhance the photocatalytic activities that generate a shorter wavelength to increase the tissue penetration depth in the biological microenvironment under NIR light irradiation. Moreover, UCNPs with a photosensitizer can absorb NIR light and convert it into UV/vis light and emit upconverted photons, which excite the photoinitiator to create H2, O2, and/or OH˙ via water splitting processes when exposed to NIR irradiation. Therefore, combining UCNPs with intensified photocatalytic and photoinitiator materials may be a promising therapeutic approach for cancer treatment. This review provides a novel strategy for explaining the principles and mechanisms of UCNPs and NIR-driven UCNPs with photocatalytic materials through water splitting to achieve therapeutic outcomes for clinical applications. Moreover, the challenges and future perspectives of UCNP-based photocatalytic materials for water splitting for cancer treatment are discussed in this review.

Graphical abstract: Near-infrared-driven upconversion nanoparticles with photocatalysts through water-splitting towards cancer treatment

Article information

Article type
Review Article
Submitted
10 май 2023
Accepted
15 мар 2024
First published
19 мар 2024

J. Mater. Chem. B, 2024,12, 3881-3907

Near-infrared-driven upconversion nanoparticles with photocatalysts through water-splitting towards cancer treatment

P. Dash, P. K. Panda, C. Su, Y. Lin, R. Sakthivel, S. Chen and R. Chung, J. Mater. Chem. B, 2024, 12, 3881 DOI: 10.1039/D3TB01066J

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