Issue 14, 2023

Synthesis of atropisomeric phosphino-triazoles and their corresponding gold(i) complexes

Abstract

The synthesis of atropisomeric phoshino-triazoles is disclosed. It was found that the introduction of a phosphine functionality onto the 5-position of a 1,2,3-triazole ring could be highly restrictive towards the rotation around a triazole-aryl bond. VT NMR and chiral HPLC studies demonstrated that rotation was restricted even at high temperatures. Gold(I) chloride complexes of single-enantiomer phosphines were prepared and again demonstrated to be conformationally stable.

Graphical abstract: Synthesis of atropisomeric phosphino-triazoles and their corresponding gold(i) complexes

Supplementary files

Article information

Article type
Research Article
Submitted
01 мар 2023
Accepted
17 апр 2023
First published
18 апр 2023
This article is Open Access
Creative Commons BY license

Org. Chem. Front., 2023,10, 3460-3466

Synthesis of atropisomeric phosphino-triazoles and their corresponding gold(I) complexes

Y. Zhao, F. Meloni, L. Male, C. S. Le Duff, W. D. G. Brittain, B. R. Buckley and J. S. Fossey, Org. Chem. Front., 2023, 10, 3460 DOI: 10.1039/D3QO00322A

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