Issue 45, 2022

Antimicrobial potentials of natural products against multidrug resistance pathogens: a comprehensive review

Abstract

Antibiotic resistance is one of the critical issues, describing a significant social health complication globally. Hence, the discovery of novel antibiotics has acquired an increased attention particularly against drug-resistant pathogens. Natural products have served as potent therapeutics against pathogenic bacteria since the glorious age of antibiotics of the mid 20th century. This review outlines the various mechanistic candidates for dealing with multi-drug resistant pathogens and explores the terrestrial phytochemicals isolated from plants, lichens, insects, animals, fungi, bacteria, mushrooms, and minerals with reported antimicrobial activity, either alone or in combination with conventional antibiotics. Moreover, newly established tools are presented, including prebiotics, probiotics, synbiotics, bacteriophages, nanoparticles, and bacteriocins, supporting the progress of effective antibiotics to address the emergence of antibiotic-resistant infectious bacteria. Therefore, the current article may uncover promising drug candidates that can be used in drug discovery in the future.

Graphical abstract: Antimicrobial potentials of natural products against multidrug resistance pathogens: a comprehensive review

Article information

Article type
Review Article
Submitted
05 авг 2022
Accepted
03 окт 2022
First published
13 окт 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 29078-29102

Antimicrobial potentials of natural products against multidrug resistance pathogens: a comprehensive review

A. H. Elmaidomy, N. H. Shady, K. M. Abdeljawad, M. B. Elzamkan, H. H. Helmy, E. A. Tarshan, A. N. Adly, Y. H. Hussien, N. G. Sayed, A. Zayed and U. R. Abdelmohsen, RSC Adv., 2022, 12, 29078 DOI: 10.1039/D2RA04884A

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