Issue 7, 2017

Engineered doxorubicin-calcium@silica nanospheres with tunable degradability for controlled drug delivery

Abstract

Although silica materials have been widely used as drug delivery carriers, the intrinsic stability of inorganic –Si–O–Si– frameworks largely limits their applications. Herein, we develop a simple “one-step acid treatment” method to fabricate a series of inorganic nanomedicines, which are denoted as doxorubicin-calcium@silica (DOX-Ca@silica), with tunable degradability for controlling drug release on the basis of a degradable pure silica framework in a physiological environment. After the acid treatment, the interactions between calcium and the silica shell have been tuned according to the concentration of acid. Then in the following physiological environment, due to the calcium salt-assisted silica decomposition, the silica shells exhibit various degrees of degradability, which control the drug release behaviors for efficient cell-killing both in HeLa cells and in drug-resistant MCF-7 tumor cells. As an alternative to organic or organic–inorganic hybrid materials for precisely controlled drug release, these DOX-Ca@silica nanospheres demonstrate a novel design and application in the development of multifunctional materials for drug delivery.

Graphical abstract: Engineered doxorubicin-calcium@silica nanospheres with tunable degradability for controlled drug delivery

Supplementary files

Article information

Article type
Research Article
Submitted
28 мар 2017
Accepted
11 май 2017
First published
12 май 2017

Inorg. Chem. Front., 2017,4, 1135-1140

Engineered doxorubicin-calcium@silica nanospheres with tunable degradability for controlled drug delivery

W. Wang, Y. Zhao, S. Yang, Q. Wu, Y. Ju and S. Yu, Inorg. Chem. Front., 2017, 4, 1135 DOI: 10.1039/C7QI00169J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements