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A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) via a sequential C–H functionalisation strategy is reported. The route exploits direct functionalisation reactions around a simple arene core and comprises of two highly-selective copper-catalysed C–H arylations, a copper-catalysed C–H amination and a palladium-catalysed C–H carbonylation, which build up the structural complexity of the natural product framework.

Graphical abstract: The total synthesis of K-252c (staurosporinone) via a sequential C–H functionalisation strategy

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