Issue 13, 2016

Reduced graphene oxide-nickel nanoparticles/biopolymer composite films for the sub-millimolar detection of glucose

Abstract

Hybrid conjugates of graphene with metallic/semiconducting nanostructures can improve the sensitivity of electrochemical sensors due to their combination of well-balanced electrical/electrocatalytic properties and superior surface-to-volume ratio. In this study, the synthesis and physical characterization of a hybrid conjugate of reduced graphene oxide and nickel nanoparticles (rGO-Ni NPs) is presented. The conjugate was further deposited onto a glassy carbon electrode as a nanocomposite film of chitosan and glucose oxidase. The electrochemical response and morphology of the films were investigated using SEM, CV, and EIS, and their applications as a glucose biosensor explored for the first time in proof-of-concept tests. The low operating potential along with the good linearity and sensitivity (up to 129 μA cm−2 mM−1) found in the sub-millimolar range suggest potential applications in the self-management of hypoglycemia from blood samples or in the development of non-invasive assays for body fluids such as saliva, tears or breath.

Graphical abstract: Reduced graphene oxide-nickel nanoparticles/biopolymer composite films for the sub-millimolar detection of glucose

Supplementary files

Article information

Article type
Paper
Submitted
26 фев 2016
Accepted
05 май 2016
First published
06 май 2016

Analyst, 2016,141, 4151-4161

Author version available

Reduced graphene oxide-nickel nanoparticles/biopolymer composite films for the sub-millimolar detection of glucose

R. Krishna, J. M. Campiña, P. M. V. Fernandes, J. Ventura, E. Titus and A. F. Silva, Analyst, 2016, 141, 4151 DOI: 10.1039/C6AN00475J

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