Issue 58, 2015

Multi-functional fluorescent carbon dots with antibacterial and gene delivery properties

Abstract

Glucose is abundant in nature and can be found in various sources. In this study, we developed multifunctional carbon dots (CDs) with glucose and poly(ethyleneimine) (PEI), which were further quaternized using a facile approach. The CDs are designed to possess both anti-bacteria and gene delivery capabilities. The inherent property was characterized with TEM, NMR, FTIR and fluorescent spectroscopy. Antibacterial activity was evaluated with Broth minimum inhibitory concentration (MIC) assay on both Gram-positive and Gram-negative bacteria. The CDs showed excellent inhibitation to both bacteria. The expression of CDs condensed plasmid DNA in HEK 293T cells was investigated with luciferase expression assay. Gene transfection capability of the quaternized CDs was found to be up to 104 times efficient than naked DNA delivery.

Graphical abstract: Multi-functional fluorescent carbon dots with antibacterial and gene delivery properties

Supplementary files

Article information

Article type
Communication
Submitted
30 апр 2015
Accepted
13 май 2015
First published
13 май 2015

RSC Adv., 2015,5, 46817-46822

Multi-functional fluorescent carbon dots with antibacterial and gene delivery properties

Q. Dou, X. Fang, S. Jiang, P. L. Chee, T. Lee and X. J. Loh, RSC Adv., 2015, 5, 46817 DOI: 10.1039/C5RA07968C

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