Issue 31, 2024

Magneto-responsive biocomposites in wound healing: from characteristics to functions

Abstract

The number of patients with non-healing wounds continuously increases, and has become a prominent societal issue that imposes a heavy burden on both patients and the entire healthcare system. Although traditional dressings play an important role in wound healing, the complexity and diversity of the healing process pose serious challenges in this field. Magneto-responsive biocomposites, with their excellent biocompatibility, remote spatiotemporal controllability, and unique convenience, demonstrate enticing advantages in the field of wound dressings. However, current research on magneto-responsive biocomposites as wound dressings lacks comprehensive and in-depth reviews, which to some extent, restricts the deeper understanding and further development of this field. Based on this, this paper reviews the latest advances in magnetic responsive wound dressings for wound healing. First, we review the process of skin wound healing and parameters for assessing repair progress. Then, we systematically discuss the preparation strategies and unique characteristics of magneto-responsive biocomposites, focusing on magneto-induced orientation, magneto-induced mechanical stimulation, and magnetocaloric effect. Subsequently, this review elaborates the multiple mechanisms of magneto-responsive biocomposites in promoting wound healing, including regulating cell behavior, enhancing electrical signal, controlling drug release, and accelerating tissue reconstruction. Finally, we further propose the development direction and future challenges of magnetic responsive biomaterials as wound dressings in clinical application.

Graphical abstract: Magneto-responsive biocomposites in wound healing: from characteristics to functions

Article information

Article type
Review Article
Submitted
05 апр 2024
Accepted
30 июн 2024
First published
04 июл 2024

J. Mater. Chem. B, 2024,12, 7463-7479

Magneto-responsive biocomposites in wound healing: from characteristics to functions

H. Ding, L. Hao and H. Mao, J. Mater. Chem. B, 2024, 12, 7463 DOI: 10.1039/D4TB00743C

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