Issue 15, 2024

Ultrasound-augmented cancer immunotherapy

Abstract

Cancer is a growing worldwide health problem with the most broadly studied treatments, in which immunotherapy has made notable advancements in recent years. However, innumerable patients have presented a poor response to immunotherapy and simultaneously experienced immune-related adverse events, with failed therapeutic results and increased mortality rates. Consequently, it is crucial to develop alternate tactics to boost therapeutic effects without producing negative side effects. Ultrasound is considered to possess significant therapeutic potential in the antitumor field because of its inherent characteristics, including cavitation, pyrolysis, and sonoporation. Herein, this timely review presents the comprehensive and systematic research progress of ultrasound-enhanced cancer immunotherapy, focusing on the various ultrasound-related mechanisms and strategies. Moreover, this review summarizes the design and application of current sonosensitizers based on sonodynamic therapy, with an attempt to provide guidance on new directions for future cancer therapy.

Graphical abstract: Ultrasound-augmented cancer immunotherapy

Article information

Article type
Review Article
Submitted
14 ноя 2023
Accepted
23 фев 2024
First published
26 фев 2024

J. Mater. Chem. B, 2024,12, 3636-3658

Ultrasound-augmented cancer immunotherapy

B. Liu, F. Du, Z. Feng, X. Xiang, R. Guo, L. Ma, B. Zhu and L. Qiu, J. Mater. Chem. B, 2024, 12, 3636 DOI: 10.1039/D3TB02705H

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