Issue 17, 2024

Halogen atom regulation of acceptor–donor–acceptor type conjugated molecules for photothermal antibacterial and antibiofilm therapy

Abstract

Drug-resistant bacteria and biofilm have caused serious public health problems. It is necessary to develop a treatment that is highly effective against drug-resistant bacteria without inducing drug resistance. Herein, we prepare a series of nanoparticles based on three conjugated molecules (BTP-BrCl, BTP-ClBr, and BTP-ClmBr) with acceptor–donor–acceptor (A–D–A) structure. By adjusting the position of the halogen atoms, the photothermal properties can be effectively regulated. In particular, these three nanoparticles (BTP-BrCl, BTP-ClBr, and BTP-ClmBr NPs) exhibited photothermal conversion efficiencies (PCE) up to 57.4%, 60.3%, and 75.9%, respectively. Among these nanoparticles, BTP-ClmBr NPs with the chlorine atom close to the carbonyl and the bromine atom away from the carbonyl in the acceptor have the highest PCE. Due to their excellent photothermal properties, all the NPs achieved more than 99.9% antibacterial activity against AmprE. coli, S. aureus and MRSA. When S. aureus was treated with these three nanoparticles under light irradiation, little biofilm formation was observed. Moreover, they could kill more than 99.9% of the bacteria in the biofilm. In summary, this study provides a strategy for the preparation of high-performance nano-photothermal agents and their application in the field of anti-drug resistant bacteria and biofilm prevention and cure.

Graphical abstract: Halogen atom regulation of acceptor–donor–acceptor type conjugated molecules for photothermal antibacterial and antibiofilm therapy

Supplementary files

Article information

Article type
Paper
Submitted
30 апр 2024
Accepted
12 июл 2024
First published
17 июл 2024

Biomater. Sci., 2024,12, 4386-4392

Halogen atom regulation of acceptor–donor–acceptor type conjugated molecules for photothermal antibacterial and antibiofilm therapy

Y. Zhao, Y. Cui, S. Xie, R. Qi, L. Xu and H. Yuan, Biomater. Sci., 2024, 12, 4386 DOI: 10.1039/D4BM00605D

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