Introducing C2 asymmetry in chromans—a brief story†
Abstract
The Trost group made notable attempts in the 1990s to synthesize several natural products such as vitamin E and its analogs, clusifoliol, rhododaurichromanic acid A, siccanin, and calanolide A and B through the palladium-catalyzed asymmetric allylic alkylation (AAA) reaction. This review highlights Prof. Trost's contributions to chroman chemistry, and specifically to the most challenging C2 asymmetry.
- This article is part of the themed collection: 2022 Focus and Perspective articles