Issue 6, 2017

Understanding the choice of copper by heme-copper oxidase using biosynthetic models in myoglobin

Abstract

Heme-copper oxidases (HCOs) are key metalloenzymes in biosystems, responsible for the reduction of O2 to H2O using a heme-CuB dinuclear center. Meanwhile, the reason behind the choice of copper for the nonheme metal center remains unclear. This article highlights a recent report by Lu and co-workers, which provides strong evidence for the preference of copper over iron for the nonheme metal center, resolving a long-standing question that puzzled researchers for decades.

Graphical abstract: Understanding the choice of copper by heme-copper oxidase using biosynthetic models in myoglobin

Article information

Article type
Highlight
Submitted
22 дек 2016
Accepted
10 апр 2017
First published
12 апр 2017

Inorg. Chem. Front., 2017,4, 918-920

Understanding the choice of copper by heme-copper oxidase using biosynthetic models in myoglobin

Y. Lin, Inorg. Chem. Front., 2017, 4, 918 DOI: 10.1039/C6QI00603E

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