Interaction of SlyD with HypB of Helicobacter pylori facilitates nickel trafficking

Tianfan Cheng; Hongyan Li; Xinming Yang; Wei Xia; Hongzhe Sun

doi:10.1039/C3MT00014A

Interaction of SlyD with HypB of Helicobacter pylori facilitates nickel trafficking†

Tianfan Cheng,^a Hongyan Li,^a Xinming Yang,^a Wei Xia^ab and Hongzhe Sun*^a

* Corresponding authors

^a Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China
E-mail: hsun@hku.hk
Fax: +852 2857 1586
Tel: +852 2859 8974

^b Immune Disease Institute, Children's Hospital Boston, Harvard Medical School, 3 Blackfan Circle, Boston, USA

Abstract

SlyD from Helicobacter pylori interacts with the [NiFe] hydrogenase accessory protein HypB through its IF domain. HpSlyD delivers Ni²⁺ to HpHypB, leading to the enhancement of GTPase activity of HpHypB and implying the facilitation of Ni²⁺ delivery from HpHypB to [NiFe] hydrogenase.

This article is part of the themed collections: Nickel in biology and Metallomics in China

Metallomics

Interaction of SlyD with HypB of Helicobacter pylori facilitates nickel trafficking†

Abstract

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