Issue 30, 2012

Dipicolylamine as a unique structural switching element for helical peptides

Abstract

Developing novel methods for metal-induced switching of peptide structures expands the design principles of functional biomolecules and biomaterials. Here, a simple method for on-resin synthesis of dipicolylamine (Dpa)-containing peptides was developed. Whereas addition of divalent metal ions such as Fe(II) and Cu(II) to a peptide bearing a pair of Dpa moieties at the i and i + 4 positions led to the formation of a 1 : 1 complex of Dpa with metals, addition of Ni(II) yielded a cross-linked structure of Dpa–metal (2 : 1). This feature was utilized for the selective detection of Ni(II) using the peptide–Fe(II) complex. Repeated switching of the helical structure was also achieved by multiple additions of divalent metal ions to the peptide.

Graphical abstract: Dipicolylamine as a unique structural switching element for helical peptides

Supplementary files

Article information

Article type
Paper
Submitted
17 дек 2011
Accepted
24 апр 2012
First published
25 апр 2012

Org. Biomol. Chem., 2012,10, 6062-6068

Dipicolylamine as a unique structural switching element for helical peptides

Y. Azuma, H. Imai, T. Yoshimura, T. Kawabata, M. Imanishi and S. Futaki, Org. Biomol. Chem., 2012, 10, 6062 DOI: 10.1039/C2OB07118E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements