In this review, we summarize various strategies for constructing CF2H groups based on different approaches, resulting in a series of difluoromethyl derivatives.
The incorporation of a difluoromethyl group within an aromatic ring is highly desirable.
The intermediary-produced CF2H radical, produced by one-electron oxidation of difluoromethylborates [pinB(Aryl)CF2H][K(18-cr-6)] using photo-redox catalysts, is advantageous for synthesizing the difluoromethylated benzene-fused γ-sultams.
A general and efficient photochemical strategy for difluoromethylation/radical cascade cyclization of alkynes with sodium difluoromethylsulfinate (NaSO2CF2H) has been disclosed.
A simple and efficient method for the copper-catalyzed selective C5-H bromination and difluoromethylation of 8-aminoquinoline amides using ethyl bromodifluoroacetate as the bifunctional reagent.