The combining use of BnSCF2D, mCPBA and Tf2O serves as an efficient multi-component reagents system (MCRS) for the synthesis of 4-SCF2D-isocoumarins-1-imines/isocoumarins via intramolecular cyclization of 2-alkynylbenzamides/2-alkynylbenzoates.
This review article provides an intensive state-of-the-art over the period 2000–2022 centred around the discovery, classifications, biosynthetic pathways and therapeutic potentialities of 351 structurally diverse fungal containing-isocoumarins.
A simple and efficient method to access 4-selenyl-isocoumarin derivatives through visible-light-promoted selenylation/cyclization of o-(1-alkynyl) benzoates has been developed.
A novel Ru-catalyzed C–H activation/cyclization reaction is described for the efficient synthesis of 3-C-glycosyl isocoumarins and 2-glycosyl-4H-chromen-4-ones utilizing carbonyl sulfoxonium ylide glycogen as a key reagent.
The synthesis of chalcogenated pyrazole-fused isocoumarins and ninhydrin-based hydrazones was accomplished using the same starting materials by changing the solvent and temperature of the reactions.