A metal-free protocol utilizing DBU catalysis for post-Ugi amide-ester exchange and Conia-ene double cyclization has been successfully developed, allowing the synthesis of diverse highly functionalized benzo-fused spiroindolines with anti-cancer activities under mild conditions.
The review highlights the use of Ugi multicomponent reactions and subsequent transformation strategies to create diverse indole frameworks in enantioselective and diastereoselective manner, underscoring their vital importance in medicinal chemistry.
A two-step one-pot synthesis of 2,6-diarylmorpholin-3-ones involving Ugi reaction followed by a triflic acid-promoted intramolecular condensation accompanied by a loss of the isocyanide-originated amide moiety is described.
This review summarizes recent advances in the combination of Ugi-4CR and dearomatization for the synthesis of spirocycles.
A one-pot strategy to prepare pyrido[1,2,3-de]quinoxaline-2,5-diones from alkynamide-containing Ugi adducts through a sequential spirocyclization and rearrangement sequence in a highly regioselective manner is reported.