This review highlights the advances in Au(NHC)-catalyzed enyne cycloisomerization, including 1,n-enyne and oxidative pathways, emphasizing mechanistic insights and the role of NHC ligands in enhancing reactivity, selectivity, and stability.
A palladium-catalyzed dearomative 1,6-enyne cycloisomerization of C2- or C3-alkyne-tethered benzofurans and C2-alkyne-tethered indoles via a 6-endo-dig cyclization is described.
Rh2(II)-catalyzed regio- and stereoselective cycloisomerization of benzo-fused 1,6-enynes is describled, which enables rapid construction of 6,5,3-tricyclic skeletons with high efficiency and excellent enantioselectivity.
This review highlights a curated selection of publications utilizing homogeneous gold-catalyzed cycloaddition and cyclization reactions for the total synthesis of natural products reported from 2016 to mid-2023.
Dirhodium-catalyzed transformations, not limited to carbene and nitrene transfer reactions, are reviewed, including cycloisomerization, hetero-Diels–Alder (HDA) reactions, ene reactions, arylation, radical oxidation reactions and C–H activation, etc.