Grape seed extract supplementationat low doses (25 mg per kg BW per day) modulates the transcriptional programs that controls the hepatic lipid metabolism in lean normolipidemic Wistar rats through PPARβ/δ activation.
Canagliflozin, empagliflozin, lumacaftor, eprosartan, and dapagliflozin were identified as hit compounds against PPARβ/δ. Canagliflozin reduced lipid accumulation and oxidative stress in steatotic HepG2 cells, indicating potential anti-NAFLD effects.
A glutathione-derived chemical tool was developed to mimic glutathionylation in proteins, demonstrating that the glutathione modification of FABP5 cysteine 127 induces cancer cell migration.
Gut microbiota-derived PA, an odd-chain saturated fatty acid, can modulate several signaling pathways to hold great promise for the treatment of several diseases.
A catalytic convergent assembly of a 6–6 bis-heterocyclic ring in one-go from the gold-catalyzed cycloisomerization of o-azidoarylynones in the presence of an anthranil with sequential C–N and C–O bond formation has been developed.