Canagliflozin, empagliflozin, lumacaftor, eprosartan, and dapagliflozin were identified as hit compounds against PPARβ/δ. Canagliflozin reduced lipid accumulation and oxidative stress in steatotic HepG2 cells, indicating potential anti-NAFLD effects.
A glutathione-derived chemical tool was developed to mimic glutathionylation in proteins, demonstrating that the glutathione modification of FABP5 cysteine 127 induces cancer cell migration.
Gut microbiota-derived PA, an odd-chain saturated fatty acid, can modulate several signaling pathways to hold great promise for the treatment of several diseases.
A catalytic convergent assembly of a 6–6 bis-heterocyclic ring in one-go from the gold-catalyzed cycloisomerization of o-azidoarylynones in the presence of an anthranil with sequential C–N and C–O bond formation has been developed.
Flexible ambiphilic ligand scaffolds have garnered attention in catalysis due to their ability to adopt multiple binding orientations.