Competitive recognition strategy based on a gold nano-hexagons microarray chip for simultaneous high-sensitivity detection of diabetic retinopathy-associated miR-21 and miR-152

Jingwen Zhu, Xia Zong, Taijing Xu, Ying Chen, Xinjue Dai, Xiaowei Cao and Changhua Lu

New J. Chem., 2025, 49, 1908
DOI: 10.1039/D4NJ04608K

Biomineralized zeolitic imidazolate framework-8 nanoparticles enable polymerase/endonuclease synergetic amplification reaction in living cells for sensitive microRNA imaging

Ke Zhang, Xiayun Le, Qiaoqin Yu, Juan Zhang, Dandan Wang, Tingting Chen and Xia Chu

Chem. Commun., 2021, 57, 8472
DOI: 10.1039/D1CC02577E

A novel β-cyclodextrin-assisted enhancement strategy for portable and sensitive detection of miR-21 in human serum

Feng Yao, Longjie Wu, Yamin Xiong, Chaojie Su, Yujing Guo, Shajidan Bulale, Miaomiao Zhou, Yongmei Tian and Leiliang He

Anal. Methods, 2024, 16, 1639
DOI: 10.1039/D3AY02269B

Design and simulation of biomimetic microfluidic designs to achieve uniform flow and DNA capture for high-throughput multiplexing

Enas Osman, Jonathan L'Heureux-Hache, Phoebe Li and Leyla Soleymani

Lab Chip, 2025, 25, 1462
DOI: 10.1039/D4LC01023J

A dual-switch fluorescence biosensor with an entropy-driven and DNA walker cascade amplification circuit for sensitive microRNA detection

Zikang Xie, Zhaolong Tang, Xindie Zhuang, Xinhao Li, Baozheng Wang, Hong Wang and Yingwei Zhang

Nanoscale, 2025, 17, 8153
DOI: 10.1039/D5NR00159E

A simple, sensitive and label-free method for miRNA analysis in gastric cancer via catalytic hairpin assembly assisted programming of split-G-quadruplexes

Xiaoli Ma, Hongmei Liu and Siyu Tao

Anal. Methods, 2023, 15, 4236
DOI: 10.1039/D3AY00989K

Harnessing DNA computing and nanopore decoding for practical applications: from informatics to microRNA-targeting diagnostics

Sotaro Takiguchi, Nanami Takeuchi, Vasily Shenshin, Guillaume Gines, Anthony J. Genot, Jeff Nivala, Yannick Rondelez and Ryuji Kawano

Chem. Soc. Rev., 2025, 54, 8
DOI: 10.1039/D3CS00396E

Enabling spectral barcoding of SERS nanotags using gold nanostars

Nhung Thi Tuyet Nguyen, Mohammad Tavakkoli Yaraki and Yuling Wang

Mol. Syst. Des. Eng., 2023, 8, 251
DOI: 10.1039/D2ME00180B

Shielded loop-mediated catalytic hairpin assembly for the specific detection of microRNA

Jiani Wang, Fuxian Ge, Jing Wang, Di Zhang and Miran Tang

Analyst, 2026, 151, 2060
DOI: 10.1039/D5AN00955C

Nanomaterials promote the fast development of electrochemical MiRNA biosensors

Ruizhuo Ouyang, Ying Huang, Yuanhui Ma, Meina Feng, Xi Liu, Chongrui Geng, Yuefeng Zhao, Shuang Zhou, Baolin Liu and Yuqing Miao

RSC Adv., 2024, 14, 17929
DOI: 10.1039/D3RA08258J

MAGPIX and FLEXMAP 3D Luminex platforms for direct detection of miR-122-5p through dynamic chemical labelling

Antonio Marín-Romero, Valerie Regele, Dajana Kolanovic, Manuela Hofner, Juan José Díaz-Mochón, Christa Nöhammer and Salvatore Pernagallo

Analyst, 2023, 148, 5658
DOI: 10.1039/D3AN01250F

DNA-mediated precise regulation of SERS hotspots for biosensing and bioimaging

Jingjing Zhang, Chunyuan Song, Xiyu He, Jian Liu, Jie Chao and Lianhui Wang

Chem. Soc. Rev., 2025, 54, 5836
DOI: 10.1039/D5CS00124B

Quantitative detection of microRNA-21 in vivo using in situ assembled photoacoustic and SERS nanoprobes

Liting Zheng, Qingqing Li, Ying Wu, Lichao Su, Wei Du, Jibin Song, Lanlan Chen and Huanghao Yang

Chem. Sci., 2023, 14, 13860
DOI: 10.1039/D3SC04371A

Chitosan functionalized gold nanostars as a theranostic platform for intracellular microRNA detection and photothermal therapy

Xiaoxue Dong, Zongwei Zhu, Qian Sun, Hongqian Zhang and Chuanxu Yang

J. Mater. Chem. B, 2023, 11, 11082
DOI: 10.1039/D3TB02029K

Conformational change-based electrochemical biosensor for the simple and highly selective detection of miRNA in whole serum

Hedieh Haji-Hashemi, Kandeel Shafique and Beatriz Prieto-Simón

RSC Adv., 2025, 15, 40469
DOI: 10.1039/D5RA06247K

Integrating an entropy-driven DNA circuit with a tetrahedral scaffold as a generic in situ electrochemical biosensor for amplified detection of microRNAs

Xuyao Wang, Junlan Zhu, Peng Shu, Jiajing Wang, Maowen Huang, Hengchao Chen and Haifen Ma

Analyst, 2025, 150, 982
DOI: 10.1039/D4AN01528B

Cytidine-rich hydrogel as an electrochemical signal amplification strategy for microRNA detection

Xinying Zhang, Zhiwei Zhang, Chujing Yang, Ziheng Hu, Yingying Chen and Lingyan Feng

Analyst, 2022, 147, 2757
DOI: 10.1039/D2AN00667G

One-pot ligation-PCR for universal RNA biomarker detection

Jinding Liu, Zhixin Xie, Nini Li, Jiajia Li, Minghua Zhang, Yongqiang Cheng and Jiangyan Zhang

Analyst, 2026, 151, 1724
DOI: 10.1039/D5AN01203A

Integrated phase separation in microliter droplets for ultratrace-enriching biomarker analysis

Qihao Zha, Yong Luo, Conghui Liu and Tailin Xu

Lab Chip, 2024, 24, 1775
DOI: 10.1039/D3LC00953J

Orthometric multicolor encoded hybridization chain reaction amplifiers for multiplexed microRNA profiling in living cells

Wei Wei, Yiyi Zhang, Fan Yang, Liping Zhou, Yufan Zhang, Yeyu Wang, Shuangshuang Yang, Jinze Li and Haifeng Dong

Chem. Sci., 2023, 14, 5503
DOI: 10.1039/D3SC00563A

Microchip electrophoretic sensing of multiplex microRNAs based on dual nucleic acid amplification

Qihui Xie, Shuang Tang, Jianan Lv, Xing Geng, Fan Zhang and Qingjiang Wang

Analyst, 2026, 151, 1023
DOI: 10.1039/D5AN00625B

A universal orthogonal imaging platform for living-cell RNA detection using fluorogenic RNA aptamers

Peng Yin, Mingmin Ge, Shiyi Xie, Li Zhang, Shi Kuang and Zhou Nie

Chem. Sci., 2023, 14, 14131
DOI: 10.1039/D3SC04957D

Fluorescence intensity coded DNA frameworks based on the FRET effect enable multiplexed miRNA imaging in living cells

Xiaoshuang Zhao, Yi Xu and Xianqiang Mi

Anal. Methods, 2023, 15, 3051
DOI: 10.1039/D3AY00578J

A Bst-driven Cas12a cascade amplification strategy for microRNA detection

Quanzhong Xu and Mingfang Ji

Anal. Methods, 2026, 18, 899
DOI: 10.1039/D5AY01957E

cShot: spatial dynamic imaging of cell cycle-dependent miRNA heterogeneity using dynamic DNA patterns

Jie Zhou, Yuwei Sha, Ling'ou Qin, Fengying Yuan, Yu Ouyang, Yaqin Chai, Pu Zhang and Ruo Yuan

Chem. Sci., 2026, 17, 6524
DOI: 10.1039/D5SC09638C

Metal sulfide nanoparticle-based dual barcode-triggered DNAzyme cascade for multiplex miRNA detection in a single assay

Jiao Wang, Liyuan Wen, Ruyuan Cao, Xiaorong Gao, Xia Li, Ensheng Xu, Qi Zhang, Shuling Xu, Caifeng Dai and Qingwang Xue

Anal. Methods, 2022, 14, 4523
DOI: 10.1039/D2AY01367C

Dual-output entropy-driven catalytic amplification coupled with G-quadruplex dimers for ultrasensitive label-free detection of miRNA-21

Chuan Long, Yao Yao, Ziyi Gao, Qi Liu and Xiaoqing Chen

Anal. Methods, 2025, 17, 6998
DOI: 10.1039/D5AY01060H

Label-free microRNA detection using a locked-to-unlocked transforming system assembled by microfluidics

Xuting Liu, Yi Zhen, Nengsheng Ye and Lu Zhang

Lab Chip, 2022, 22, 4984
DOI: 10.1039/D2LC00911K

Rapid colorimetric analysis of multiple microRNAs using encoded hydrogel microparticles

Ju Yeon Kim, Seok Joon Mun, Yoon Ho Roh and Ki Wan Bong

Analyst, 2021, 146, 5508
DOI: 10.1039/D1AN00622C

Endogenous glutathione-activated DNA nanoprobes for spatially controllable imaging of microRNA in living cells

Yuyan Li, Fanghua Zhang, Wendong Liu, Mingzheng Shao, Zhe Hao, Hongyan Zhang, Ruizhong Zhang, Xiyan Li and Libing Zhang

Chem. Commun., 2023, 59, 5431
DOI: 10.1039/D3CC01155K

High-fidelity imaging of intracellular microRNA via a bioorthogonal nanoprobe

Hengyi Chen, Xiaohui Chen, Yi Chen, Chong Zhang, Zixin Sun, Jiaxi Mo, Yongzhong Wang, Jichun Yang, Dongsheng Zou and Yang Luo

Analyst, 2023, 148, 1682
DOI: 10.1039/D3AN00088E

Fluorescence coding techniques for RNA detection

Junren Wang, Qin Xiang, Haifeng Dong and Xueji Zhang

Sens. Diagn., 2024, 3, 914
DOI: 10.1039/D4SD00085D

Highly repeatable detection of miRNAs in complex biological mixtures mediated by magnetically separable spherical nucleic acids and homogeneous signal amplification

Kaifei Jin, Xiyue Xie, Jing Zhu, Zhenqiang Wang, Yuxin Xing, Lu Wang, Kaiyong Cai and Jixi Zhang

Sensors and Actuators B: Chemical, 2023, 393, 134191
DOI: 10.1016/j.snb.2023.134191

Advances in modelling the risk of benign and malignant lung nodules

Shang Du, Tangwei Wu, Hui Wang, Zheqiong Tan and Zhongxin Lu

Front. Oncol., 2025, 15
DOI: 10.3389/fonc.2025.1648548

A Simple and Robust Exponential Amplification Reaction (EXPAR)-Based Hairpin Template (exp-Hairpin) for Highly Specific, Sensitive, and Universal MicroRNA Detection

Haijing Guo, Jun Chen, Yaqiang Feng and Zong Dai

Anal. Chem., 2024, 96, 2643
DOI: 10.1021/acs.analchem.3c05323

Phosphorothioate and 2′-Fluoro Ribose Substitution-Mediated Hydrophobic Effect Empowers RNA Probes for Highly Sensitive and Subtype-Selective miRNA Imaging

Yingshun Zhou, Yuanyuan Fan, Hao Zhang, Qingqing Li, Haibin Si, Lu Li and Bo Tang

ACS Nano, 2026, 20, 1370
DOI: 10.1021/acsnano.5c17740

S9.6 Antibody-Mediated Wireless Portable Biosensor with Multiple Affinity Enhancements for Comprehensive Detection of Nucleic Acid in Serum

Yi Wang, Zeyu Ma, Yingjing Li, Hongyan Yang, Jia Jin, Yuxia Jin and Guobao Zhou

Anal. Chem., 2025, 97, 9386
DOI: 10.1021/acs.analchem.5c00566

Target-triggered assembly of functional G-quadruplex DNAzyme nanowires for sensitive detection of miRNA in lung tissues

Su Jiang, Qian Liu, Juan Hu, Dong Yuan, Yan Zhang and Chun-yang Zhang

Sensors and Actuators B: Chemical, 2022, 373, 132689
DOI: 10.1016/j.snb.2022.132689

Fluorescence-encoded barcodes for multiplexed detection and imaging: principles, strategies, and prospects

Wenhao Dai, Mengjie Zong, Tongtong Zhang, Fan Zhang, Haifeng Dong and Xueji Zhang

Coordination Chemistry Reviews, 2026, 554, 217603
DOI: 10.1016/j.ccr.2026.217603

Sensitive and reliable analysis of endometrial cancer related microRNA using ternary hybridization hairpin probe

Hongli Yan, Xiaohui Fan, Changmin Bai, Li Shan, Jing Chen and Ying Kang

Analytical Biochemistry, 2023, 670, 115134
DOI: 10.1016/j.ab.2023.115134

Endogenous enzyme-driven unarming of spherical nucleic acid in a divide-and-conquer pattern for amplified imaging of microRNA in tumor cells

Chao Long, Hong Huang, Xin-Ru Yu, Kai-Li Mao, Yu-xi Yang, Xiong Yang, Li-Jian Xu and Zai-Sheng Wu

Talanta, 2026, 305, 129602
DOI: 10.1016/j.talanta.2026.129602

An optimized microRNA detection platform based on PAM formation-regulated CRISPR/Cas12a activation

Dawei Li, Pengda Liang, Shen Ling, Yapeng Wu and Bei Lv

International Journal of Biological Macromolecules, 2024, 266, 130848
DOI: 10.1016/j.ijbiomac.2024.130848

Multiplexed and accurate quantification strategy for miRNA based on specific terminal-mediated PCR with equivalent amplification

Yunfei Guo, Jun Li, Hao Yang, Hongchen Gu, Gaolian Xu and Hong Xu

Talanta, 2023, 258, 124463
DOI: 10.1016/j.talanta.2023.124463

Circulating miRNA as diagnostic tools for gynecological diseases and their applications in biosensor development

Yu-Ling Wu, Hsu-Ching Yen, Yi-Hsuan Chen, Leo Yang, Pao-Ling Torng and Ja-an Annie Ho

Anal Bioanal Chem, 2026, 418, 533
DOI: 10.1007/s00216-025-06196-1

Patterned microarrays or nanoscale assemblies for optical sensing of biomarkers

Xiaohui Lu and Zheng Li

TrAC Trends in Analytical Chemistry, 2024, 179, 117873
DOI: 10.1016/j.trac.2024.117873

Hydrogel-Based In Situ DNA Extension Assay for Multiplexed and Rapid Detection of MicroRNA

Wookyoung Jang, Yu Jin Kim, Hyun Kyo Roh, E Loomee Song and Ki Wan Bong

Anal. Chem., 2025, 97, 7317
DOI: 10.1021/acs.analchem.4c06995

Exosomal miR‐26a‐5p From Urine‐Derived Stem Cells Mitigates Renal Fibrosis via Targeting NRAS

Wenhong Jiang, Rundong Guo, Shuyao Wang, Xiangqi Li, Zenan Zhang, Qijun Sun, Jiayong Piao, Zheng Zhao, Shulong Yang and Zhaozhu Li

The FASEB Journal, 2026, 40
DOI: 10.1096/fj.202504385RR

A Programmable DNAzyme for the Sensitive Detection of Nucleic Acids

Chenzhi Shi, Donglei Yang, Xiaowei Ma, Li Pan, Yuanchuan Shao, Gaurav Arya, Yonggang Ke, Chuan Zhang, Fuan Wang, Xiaolei Zuo, Min Li and Pengfei Wang

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202320179

A Cascaded DNA Circuit in Bead Arrays for Quantitative Single-Cell MicroRNA Analysis

Furui Jin and Danke Xu

Anal. Chem., 2021, 93, 11617
DOI: 10.1021/acs.analchem.1c02388

i-Motif DNA molecular beacon for microRNA detection

Tengshuo Luo, Ziyue Guan, Yunlong Liu, Jun Zhou, Jean-Louis Mergny and Mingpan Cheng

Nucleic Acids Research, 2025, 53
DOI: 10.1093/nar/gkaf556

Dual-channel fluorescence biosensor for simultaneous miR-133a and ATP detection in living muscle cells

Liandong Zhao, Mingzhu Zhao, Jing Wang, Shuqi Zhang, Rong-Mei Kong, Jianxin Yang, Yan Zhao and Weiheng Kong

Microchim Acta, 2025, 192
DOI: 10.1007/s00604-025-07364-x

Recent Advances in Hydrogel-Promoted Photoelectrochemical Sensors

Yali Cui, Yanyuan Zhang, Lin Wang and Yuanqiang Hao

Biosensors, 2025, 15, 524
DOI: 10.3390/bios15080524

Decomposition Mueller matrix polarimetry for enhanced miRNA detection with antimonene-based surface plasmon resonance sensor and DNA-linked gold nanoparticle signal amplification

Quoc-Hung Phan, Quoc-Thinh Dinh, Yi-Cheng Pan, Yi-Ting Huang, Zi-Hao Hong and Tzu-Shiang Lu

Talanta, 2024, 270, 125611
DOI: 10.1016/j.talanta.2023.125611

Label-Free miRNA-21 Analysis Based on Strand Displacement and Terminal Deoxynucleotidyl Transferase-Assisted Amplification Strategy

Ying Yan, Han Zhao, Yukang Fang, Changbei Ma and Junxiang Chen

Biosensors, 2022, 12, 328
DOI: 10.3390/bios12050328

Clinical impact of circulating tumor DNA to track minimal residual disease in colorectal cancer patients. Hopes and limitations

C. Soueidy, A. Zaanan, M. Gelli, E. Moati, C. Gallois, V. Taly, P. Laurent-Puig, L. Benhaim and J. Taieb

ESMO Gastrointestinal Oncology, 2024, 4, 100068
DOI: 10.1016/j.esmogo.2024.100068

SERS detection platform based on a nucleic acid aptamer-functionalized Au nano-dodecahedron array for efficient simultaneous testing of colorectal cancer-associated microRNAs

Shuofeng Zhang, Fengsong Chen, Yanqing Zhang, Yemin Xu, Lu Wang, Xiya Wang, Long Jia, Yong Chen, Yongcheng Xu, Zhengrong Zhang and Bin Deng

Biomed. Opt. Express, 2024, 15, 3366
DOI: 10.1364/BOE.520161

A Programmable Automatic Cascade Machinery for Single-Molecule Profiling of Multiple Noncoding RNAs in Breast Tissues

Wen Li, Wen-Jing Liu, Jun Lu, Fei Ma and Chun-Yang Zhang

Anal. Chem., 2025, 97, 4224
DOI: 10.1021/acs.analchem.4c07017

Split Probe-Induced Protein Translational Amplification for Nucleic Acid Detection

Yoo-Hong Min, Yoonseo Hong, Cheol-Hee Kim, Kyung-Ho Lee, Yong-Beom Shin and Ju-Young Byun

ACS Appl. Bio Mater., 2024, 7, 8389
DOI: 10.1021/acsabm.4c01187

Pitfalls and challenges of peptide nucleic acid immobilisation on carbon surfaces for sequence-specific capturing of nucleic acid biomarkers

Xiaotong Meng, Loukia Petrou, Ahmad Kenaan, Daanyaal Khan, Danny O'Hare and Sylvain Ladame

Biosensors and Bioelectronics, 2024, 264, 116634
DOI: 10.1016/j.bios.2024.116634

Bio-analysis of Saliva Using Paper Devices and Colorimetric Assays

Adhan Narasimhan, Harshil Jain, Kowshika Muniandy, Raja Chinnappan and Naresh Kumar Mani

J. Anal. Test., 2024, 8, 114
DOI: 10.1007/s41664-023-00282-y

Dual-Mode Self-Calibrated Strategy Based on Synergistic Amplification Effects of in Situ Rolling Circle Amplification and Hydrophobic inner Wall of the Nanopores for Highly Sensitive Detection of microRNA

Yilin Zhang, Jiangxue Dong, Yufan Zhang, Saimei Zhang, Yajie Fan, Yanlei Li, Qun Ma, Hongyuan Yan, Shigang Shen and Zhongfeng Gao

J. Anal. Test., 2026, 10, 284
DOI: 10.1007/s41664-025-00396-5

Simultaneous detection of miR-21 and miR-155 using a multiplexed silicon nanowire FET biosensor

Bharath Kumar Yadlapalli, Pei-Jun Wu, Yu-Hsiang Lee and Wen-Yih Chen

Microchemical Journal, 2026, 224, 117657
DOI: 10.1016/j.microc.2026.117657

Prognostic Implication of a Cuproptosis-Related miRNA Signature in Hepatocellular Carcinoma

Ze Jin, Mengmeng Wang, Yajun Meng, Di Chen, Yushuang Xu, Xin Jiang, Zhifan Xiong and Mihajlo Jakovljevic

Journal of Healthcare Engineering, 2022, 2022, 1
DOI: 10.1155/2022/4694323

Thermus thermophilus Argonaute-Mediated Single Particle Counting Platform for Multiplex Cancer-Related Biomarkers Detection

Min Jiang, Xin Zhao, Chengchao Zhang, Rui Liu, Jianyu Hu and Yi Lv

Anal. Chem., 2025, 97, 11907
DOI: 10.1021/acs.analchem.5c02118

Detection of Short DNA Sequences with DNA Nanopores**

Luyan Yang, Christophe Cullin and Juan Elezgaray

ChemPhysChem, 2022, 23
DOI: 10.1002/cphc.202200021

A dual amplification-based CRISPR/Cas12a biosensor for sensitive detection of miRNA in prostate cancer

Yuqing Zhu, Xiaohe Zheng, Shujun Zhou, Wenjing Xiao, Xiaorui Sun, Jianming Zhou, Feiyang Qian, Tenghua Zhang, Yan Sheng and Jiaming Hu

Analytica Chimica Acta, 2023, 1279, 341769
DOI: 10.1016/j.aca.2023.341769

Dual-Accelerated Signal Amplification in Biosensing via Spatial Confining Catalytic Hairpin Assembly-Activated Spherical CRISPR/Cas12a System for Trans-Cleavage of Hairpin DNA Reporters

Zhuqi Sui, Baoqiang Chen, Jia Zhao, Haidong Yang, Longhua Guo and Jianguo Xu

Anal. Chem., 2025, 97, 4668
DOI: 10.1021/acs.analchem.4c07111

Assembly of DNA triangular pyramid frustum for ultrasensitive quantification of exosomal miRNA

Renpeng Xia, Hua Chai, Jin Jiao and Peng Miao

Biosensors and Bioelectronics, 2023, 231, 115297
DOI: 10.1016/j.bios.2023.115297

Binding-driven forward tearing protospacer activated CRISPR-Cas12a system and applications for microRNA detection

Lina Zhao, Xiangyu Deng, Yuqing Li, Qing Zhao, Lizhu Xiao, Jianjiang Xue, Anyi Chen, Wei Cheng and Min Zhao

J Nanobiotechnol, 2024, 22
DOI: 10.1186/s12951-024-02915-5

Target-driven cascade amplified assembly of covalent organic frameworks on tetrahedral DNA nanostructure with multiplex recognition domains for ultrasensitive detection of microRNA

Hongying Yang, Yunxia Jin, Hui Qian, Yuqi Wang, Ting Bao, Zhen Wu, Wei Wen, Xiuhua Zhang and Shengfu Wang

Analytica Chimica Acta, 2024, 1311, 342743
DOI: 10.1016/j.aca.2024.342743

Microfluidic-Enabled Self-Directed Hydrogel Microspheres for Multiplexed MicroRNA Assays

Yongning Lin, Gaowa Xing, Zengnan Wu, Jin-Ming Lin, Jiaxu Lin, Ying Hou, Yajing Zheng, Yan Xu and Ling Lin

Anal. Chem., 2025, 97, 1972
DOI: 10.1021/acs.analchem.4c05349

DNA Logic Circuits for Multiple Tumor Cells Identification Using Intracellular MicroRNA Molecular Bispecific Recognition

Qiqi Yang, Fan Yang, Wenhao Dai, Xiangdan Meng, Wei Wei, Yaru Cheng, Jinhong Dong, Huiting Lu and Haifeng Dong

Adv Healthcare Materials, 2021, 10
DOI: 10.1002/adhm.202101130

miR-16-5p may modulate migration and proliferation through TP53 and LncRNA-NEAT1 in triple-negative breast cancer

Qingtao Ni, Yida Qian, Tongbo Yi, Jian Zhou, Kai Sang and Chi Pan

Gene Reports, 2024, 37, 102038
DOI: 10.1016/j.genrep.2024.102038

A facile optical fiber-embedded microfluidic biochip for rapid and sensitive detection of microRNA-let-7a in serum

Yongkai Lu, Jiaxin Xu, Siyan Liu, Baochun Tian and Feng Long

Microchim Acta, 2025, 192
DOI: 10.1007/s00604-024-06865-5

Enzyme-free catalyzed self-assembly of three-dimensional hyperbranched DNA structures for in situ SERS imaging and molecular logic operations

Shuzhen Yue, Zhenjie Qiao, Xiaofang Wang and Sai Bi

Chemical Engineering Journal, 2022, 446, 136838
DOI: 10.1016/j.cej.2022.136838

Photothermal effect-assisted reduced graphene oxide biosensor for amplification-free detection of miRNA

Wenrui Xu, Xiaoguang Gao, Yuyan Zhai, Xiaoliang Zhang, Yingqian Wang, Rong Deng and Xiaochun Li

Biosensors and Bioelectronics, 2025, 284, 117532
DOI: 10.1016/j.bios.2025.117532

Review: Comparison of traditional and modern diagnostic methods in breast cancer

Hussein Kareem Elaibi, Farah Fakhir Mutlag, Ebru Halvaci, Aysenur Aygun and Fatih Sen

Measurement, 2025, 242, 116258
DOI: 10.1016/j.measurement.2024.116258

Electrochemical Strategies for MicroRNA Quantification Leveraging Amplification and Nanomaterials: A Review

Alexander Hunt and Gymama Slaughter

Chemosensors, 2025, 13, 242
DOI: 10.3390/chemosensors13070242

Integration of catalytic hairpin assembly probes into microneedles for detection of MicroRNA in plants

Long Chen, Xiquan Ding, Yue Dong, Hongyan Chen, Fei Gao, Bo Cui, Xiang Zhao, Haixin Cui, Xiaofeng Gu and Zhanghua Zeng

Sensors and Actuators B: Chemical, 2024, 404, 135277
DOI: 10.1016/j.snb.2024.135277

Fluorescence Signal Amplification Based on Arginine-Glycine-Aspartate-Gold-Nanoparticle Conjugates for in Situ Monitoring of microRNAs

Zhaoyan Zhao, Li Sun, Zhongting Wang, Yuhui Liao and Changjun Gao

ACS Appl. Nano Mater., 2025, 8, 5862
DOI: 10.1021/acsanm.5c01054

A Programmable DNAzyme for the Sensitive Detection of Nucleic Acids

Chenzhi Shi, Donglei Yang, Xiaowei Ma, Li Pan, Yuanchuan Shao, Gaurav Arya, Yonggang Ke, Chuan Zhang, Fuan Wang, Xiaolei Zuo, Min Li and Pengfei Wang

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202320179

MicroRNA Sensors Based on CRISPR/Cas12a Technologies: Evolution From Indirect to Direct Detection

Songcheng Yu, Xueying Lei and Chenling Qu

Critical Reviews in Analytical Chemistry, 2025, 55, 968
DOI: 10.1080/10408347.2024.2329229

A Versatile Electrochemical Biosensor for the Detection of Circulating MicroRNA toward Non‐Small Cell Lung Cancer Diagnosis

Fanyu Meng, Wenjun Yu, Changqiang Chen, Susu Guo, Xiaoting Tian, Yayou Miao, Lifang Ma, Xiao Zhang, Yongchun Yu, Lin Huang, Kun Qian and Jiayi Wang

Small, 2022, 18
DOI: 10.1002/smll.202200784

MOF-Powered MicroRNA Catch for Ultrasensitive Breast-Cancer Screening

Qi Sun, Zhi-Chao Lu, Rui-Cheng Li, Zheng-Xian Zhang, Jing-Lian Su, Cheng Wang, Huai-Song Wang, Xing-Hua Xia and Ya Ding

Anal. Chem., 2026, 98, 3803
DOI: 10.1021/acs.analchem.5c05884

A one-pot isothermal Cas12-based assay for the sensitive detection of microRNAs

He Yan, Yunjie Wen, Zimu Tian, Nathan Hart, Song Han, Steven J. Hughes and Yong Zeng

Nat. Biomed. Eng, 2023, 7, 1583
DOI: 10.1038/s41551-023-01033-1

MicroRNAs as Biomarkers in Spinal Muscular Atrophy

Maruša Barbo, Damjan Glavač, Gregor Jezernik and Metka Ravnik-Glavač

Biomedicines, 2024, 12, 2428
DOI: 10.3390/biomedicines12112428

Multiplexed detection of single-point mutations in unprocessed human serum with SERS-integrated PCR

Joel Sanchez Barea, Ara Lee and Dong-Ku Kang

Sensors and Actuators B: Chemical, 2024, 401, 134954
DOI: 10.1016/j.snb.2023.134954

Co-reactant confined and vertically ordered silica nanochannel regulated electrochemiluminescence for homogeneous detection of miRNA

Jiajing Xu, Weiqiang Yang, Jiancong Ni, Qingxiang Wang and Zhenyu Lin

Sensors and Actuators B: Chemical, 2023, 397, 134694
DOI: 10.1016/j.snb.2023.134694

Molecular Recognition-Modulated Hetero-Assembly of Nanostructures for Visualizable and Portable Detection of Circulating miRNAs

Huadong Wang, Yali Sun, Zeying Zhang, Xu Yang, Bobing Ning, Pavel Senyushkin, Bogdan Bogdanov, Georgii Zmaga, Yonggan Xue, Jimei Chi, Hongfei Xie, Sisi Chen, Tingqing Wu, Zewei Lian, Qi Pan, Bingda Chen, Zhiyu Tan, Xiangyu Pan, Meng Su and Yanlin Song

Anal. Chem., 2023, 95, 11769
DOI: 10.1021/acs.analchem.3c01996

A Triple-Input AND-Logic System Employing an APE1-Propelled Bipedal DNA Walker for Highly Sensitive Detection of Dual miRNAs

Haoping Zhang, Min Pan, Xinyi Wang, Jingyu Tao, Zhaolong Tang, Hong Wang and Yingwei Zhang

ACS Sens., 2025, 10, 8801
DOI: 10.1021/acssensors.5c02731

Prediction of miRNA-disease associations using a dual-channel contrastive model based on multi-source information fusion

Wenhui Lian, Zhen Tang, Shiyin Li, Chunlin Chen and Zhixiang Yin

PeerJ Computer Science, 2025, 11, e3378
DOI: 10.7717/peerj-cs.3378

Flexible photoelectrochemical biosensor for ultrasensitive microRNA detection based on concatenated multiplex signal amplification

Yuecan Zhao, Junzhu Xiang, Hao Cheng, Xiaojuan Liu and Feng Li

Biosensors and Bioelectronics, 2021, 194, 113581
DOI: 10.1016/j.bios.2021.113581

Biomarkers of obesity-mediated insulin resistance: focus on microRNAs

Yichen Cai, Pan Liu, Yumei Xu, Yuguo Xia, Xiaowan Peng, Haiyan Zhao and Qiu Chen

Diabetol Metab Syndr, 2023, 15
DOI: 10.1186/s13098-023-01137-3

A Y-shape-structured photoelectrochemical biosensor based on Bi4NbO8Cl/TiO2 heterojunction and enzyme-mediated electrocatalysis for sensitive and selective determination of microRNA in serum

Yu Zhong, Zhi-Wei Xu, Zhang-Jian Cheng, Ai-Lin Liu and Yun Lei

Microchemical Journal, 2025, 214, 113954
DOI: 10.1016/j.microc.2025.113954

Monolithic Acoustic Droplet Centrifuge Array for Enhancing Point‐of‐Care Detection of Trace MicroRNAs

Jingui Qian, Chuanmin Liu, Jingjing He, Xiaojin Liu, Shaohui Zheng, Jing Liu, Minghui Chen, Yong‐Qing Fu and Longzhen Qiu

Small, 2026, 22
DOI: 10.1002/smll.202509713

Fusogenic Liposome-Mediated Extracellular Vesicles MicroRNA Profiling for Lung Cancer Diagnosis

Fanyu Meng, Ruimin Wang, Wenjun Yu, Wei Nie, Minjia Niu, Yujie Wang, Yuewei Zhao, Xvelian Li, Yan Zhou, Zhengying Gu, Chen Chi, Yuqing Lou, Hua Zhong, Lin Huang and Jiayi Wang

ACS Nano, 2026
DOI: 10.1021/acsnano.6c00879

Analytical techniques for nucleic acid and protein detection with single-molecule sensitivity

Soochul Shin, Juyoung Kim, Eunho Song, Sun Han and Sungchul Hohng

Exp Mol Med, 2025, 57, 938
DOI: 10.1038/s12276-025-01453-w

Iridium Complex with Specific Intercalation in the G-Quadruplex: A Phosphorescence and Electrochemiluminescence Dual-Mode Homogeneous Biosensor for Enzyme-Free and Label-Free Detection of MicroRNA

Haiyin Li, Qiaoting Yang, Zhixin Wang and Feng Li

ACS Sens., 2023, 8, 1529
DOI: 10.1021/acssensors.2c02575

Recent Progresses in Electrochemical DNA Biosensors for MicroRNA Detection

Lulu Zhang, Wenqiong Su, Shuopeng Liu, Chengjie Huang, Behafarid Ghalandari, Adeleh Divsalar and Xianting Ding

Phenomics, 2022, 2, 18
DOI: 10.1007/s43657-021-00032-z

Integrating synthetic biology and biosensing: Current trends and future prospects

Karuna Korgaonkar, Nagarjuna Prakash Dalbanjan, Maruti J. Gurav, Manjunath P. Eelager, Vishwanath B. Chachadi and S.K. Praveen Kumar

Next Research, 2025, 2, 100911
DOI: 10.1016/j.nexres.2025.100911

Sample‐to‐answer salivary miRNA testing: New frontiers in point‐of‐care diagnostic technologies

Zhikun Zhang, Tianyi Liu, Ming Dong, Md. Ahasan Ahamed and Weihua Guan

WIREs Nanomed Nanobiotechnol, 2024, 16
DOI: 10.1002/wnan.1969

Enzyme-Assisted Colorimetric Salivary miR-21 Detection by Functional Gold Nanoparticles

Shiyu Zhang, Shan Guan, Cuixia Hu, Yumin Liu, Zhikun Zhang and Jilong Han

NANO, 2024, 19
DOI: 10.1142/S1793292024500887

Detection of Hepatocellular Carcinoma Using Optimized miRNA Combinations and Interpretable Machine Learning Models

Zhengwu Long and Lisheng Zhang

IEEE Access, 2025, 13, 66078
DOI: 10.1109/ACCESS.2025.3559105

Ultramultiplex NaLnF4 Nanosatellites Combined with ICP-MS for Exosomal Multi-miRNA Analysis and Cancer Classification

Yun Wen, Xue-Wei Zhang, Yuan-Yuan Li, Shuai Chen, Yong-Liang Yu and Jian-Hua Wang

Anal. Chem., 2022, 94, 16196
DOI: 10.1021/acs.analchem.2c03727

Recent progress on nanozymes in electrochemical sensing

Wenting Wu and Jing Li

Journal of Electroanalytical Chemistry, 2023, 936, 117391
DOI: 10.1016/j.jelechem.2023.117391

Dielectric Nanocavity Enhanced Fluorescence Emission for Ultrasensitive Wavelength-Multiplexed Detection

Bowen Fu, Zhiyi Yuan, Guocheng Fang, Wen-jie Wang, Zhongshu Xiong and Yu-Cheng Chen

Nano Lett., 2025, 25, 8961
DOI: 10.1021/acs.nanolett.5c01087

A generic and non-enzymatic electrochemical biosensor integrated molecular beacon-like catalyzed hairpin assembly circuit with MOF@Au@G-triplex/hemin nanozyme for ultrasensitive detection of miR-721

Yuliang Li, Chengli Zhang, Yingjuan He, Jining Gao, Wei Li, Lin Cheng, Fengjun Sun, Peiyuan Xia and Qian Wang

Biosensors and Bioelectronics, 2022, 203, 114051
DOI: 10.1016/j.bios.2022.114051

Dual-Signal Cascaded Nucleic Acid Amplification Circuit-Loaded Metal-Organic Frameworks for Accurate and Robust Imaging of Intracellular MicroRNA

Sijia Liu, Benrui Weng, Yaqi Liu, Siyuan Wang, Nana Kang, Jiabing Ran, Hanghang Liu, Shuo Huang, Zhangshuang Deng, Changying Yang, Huimin Wang and Fuan Wang

Langmuir, 2023, 39, 10453
DOI: 10.1021/acs.langmuir.3c00897

Breaking Barcode Limits: Metal Nanoparticle Lego Brick Self-Assembly for High-Throughput Screening

Zili Huang, Xiaobo Xie, Yi Wu, Rui Liu and Yi Lv

J. Am. Chem. Soc., 2025, 147, 4904
DOI: 10.1021/jacs.4c13706

Enzyme‐Activated Programmable Theranostic Platform for Spatiotemporal Imaging of Intracellular MicroRNA and On‐Demand Manipulation‐Mediated Therapy

Xiangdan Meng, Xuejiao Pang, Sirong Sun, Heng An, Fan Yang, Xueji Zhang and Haifeng Dong

Small, 2026, 22
DOI: 10.1002/smll.202512828

Stimuli-Responsive Fusion of Binary-Star Intelligent DNA System for the Signal-On Amplification Detection of Cancer-Related miRNA

Liujing Pan, Yao Wu, Wenhao Pan and Zai-Sheng Wu

Anal. Chem., 2025, 97, 28384
DOI: 10.1021/acs.analchem.5c06801

Isolation strand displacement: Multi directional regulation and control strand displacement to enrich the DNA toolbox

Mengyang Hu, Yidan Sang, Xuemei Yan, Can Qiao, Zhenliang Zhang, Yafei Dong and Luhui Wang

Chemical Engineering Journal, 2025, 516, 164074
DOI: 10.1016/j.cej.2025.164074

Amplification-Free and Label-Free Multiplexed Profiling of Extracellular Vesicle-Derived MicroRNA via Micropore Sensing Based on PNA-Functionalized Hydrogel Barcodes

Wookyoung Jang, Chang-Woo Song, Jinhwa Hong, Soon Young Lim, Dong ge ra mi Moon, Hye Yeon Roh, Kyong Hwa Park, Chang-Soo Han and Ki Wan Bong

ACS Sens., 2026, 11, 1129
DOI: 10.1021/acssensors.5c03052

2’-O-Methyl-Modified Molecular Beacons for Highly Sensitive and Specific Exosomal Tumor microRNA Analysis Based on Nuclease-Assisted Signal Amplification

天鹏吕

AAC, 2024, 14, 95
DOI: 10.12677/aac.2024.142012

Multiplex detection of meningitis pathogens by a vertical flow paper microarray and signal enhancement suitable for low-resource settings: Proof of concept

Pedro Réu, Giulia Gaudenzi, Deborah Nanjebe, Gustav Svedberg, Dan Nyehangane, Miren Urrutia Iturritza, Phuthumani Mlotshwa, Chris Hadjineophytou, Jens Karlsson, Jesper Gantelius, Juliet Mwanga-Amumpaire, Edmund Loh, Helene Andersson Svahn, Elias Kumbakumba, Tobias Alfvén, Yap Boum II and Aman Russom

Talanta Open, 2024, 10, 100357
DOI: 10.1016/j.talo.2024.100357

Triple-Branch Catalytic Assembly DNAzyme Motivated DNA Tweezer for Sensitive and Reliable mecA Gene Detection in Staphylococcus aureus

Xiaoyang Li, Meiyan Xu, Fangmin Gan and Hui Zhao

J. Microbiol. Biotechnol., 2024, 34, 2450
DOI: 10.4014/jmb.2409.09008

Entropy-driven DNA circuit with two-stage strand displacement for elegant and robust detection of miRNA let-7a

Lanxin Nie, Xiaogang Zeng, Li Hongbo, Suqin Wang, Zhanghui Lu and Ruqin Yu

Analytica Chimica Acta, 2023, 1269, 341392
DOI: 10.1016/j.aca.2023.341392

Extracellular vesicle-based biosensors for Alzheimer’s disease: A new frontier in precision diagnostics

Jinjin Pei, Nishanthi Chella Perumal, Panpan Meng, Qianfa Long and Chella Perumal Palanisamy

Ageing Research Reviews, 2026, 113, 102904
DOI: 10.1016/j.arr.2025.102904

Circulating microRNAs as Potential Biomarkers in Pancreatic Cancer—Advances and Challenges

Attila A. Seyhan

IJMS, 2023, 24, 13340
DOI: 10.3390/ijms241713340

Construction of Multiplexed Assays on Single Anisotropic Particles Using Microfluidics

Zengnan Wu, Yajing Zheng, Ling Lin, Gaowa Xing, Tianze Xie, Jiaxu Lin, Xiaorui Wang and Jin-Ming Lin

ACS Cent. Sci., 2025, 11, 294
DOI: 10.1021/acscentsci.4c02009

One-pot room-temperature visualization platform combining strand displacement amplification and rolling circle amplification for the sensitive detection of microRNAs with a smartphone

Wenhao Dai, Fan Zhang, Meiqin Zhang, Xueji Zhang and Haifeng Dong

Sensors and Actuators B: Chemical, 2026, 458, 139771
DOI: 10.1016/j.snb.2026.139771

A DNA tetrahedron assisted SDA-cas12a strategy for highly sensitive detection of spinal cord injury biomarker miR-144-3p

Jianghu Huang, Xin Lin, Zhihua Zheng, Feiyue Lin and Weihua Liu

Microchemical Journal, 2026, 220, 116512
DOI: 10.1016/j.microc.2025.116512

New prospects of environmental RNA metabarcoding research in biological diversity, ecotoxicological monitoring, and detection of COVID-19: a critical review

Sakib Tahmid Rishan, Richard J. Kline and Md Saydur Rahman

Environ Sci Pollut Res, 2024, 31, 11406
DOI: 10.1007/s11356-023-31776-y

Assembling G-wire-induced pyrene excimer switching for microRNA amplified detection based on exonuclease III-assisted target recycling and Fe3O4@PDA nanoparticles

Mei Li, Qingyou Cai, Yue Meng, Weihong Zheng, Guojiang Mao and Hua Wang

Microchemical Journal, 2023, 191, 108753
DOI: 10.1016/j.microc.2023.108753

Nucleic acid amplification-free detection of DNA and RNA at ultralow concentration

Yan Cao, Zhenrong Zheng and Harold G Monbouquette

Current Opinion in Biotechnology, 2021, 71, 145
DOI: 10.1016/j.copbio.2021.07.022

DNA nanotechnology-based strategies for gastric cancer diagnosis and therapy

Congcong Li, Tongyang Xu, Guopeng Hou, Yin Wang and Qinrui Fu

Materials Today Bio, 2025, 30, 101459
DOI: 10.1016/j.mtbio.2025.101459

Mechanistic insights into exosomal miRNAs: Modulators of inflammation in cancer and cardiovascular disease: A review

Zhoulei Zhu, Yutong Yao, Yuquan He and Xin Hu

International Journal of Biological Macromolecules, 2025, 321, 146563
DOI: 10.1016/j.ijbiomac.2025.146563

Triple-signal miRNA detection: A universal biosensor platform based on element labeling and CHA amplification strategy

Xue-Wei Zhang, Yuan-Yuan Li, Zhi-Wei Wu, Jin-Hui Liu and Bo Lin

Talanta, 2026, 298, 128879
DOI: 10.1016/j.talanta.2025.128879

Aptamer‐Signatured Nanoparticle Protein Corona for Size‐Dependent Fluorescent Barcoding Diagnosis

Yue Sun, Jinlong Fan, Yunfeng Zong, Baichuan Jin, Weizhao Yao, Ze Wang, Ting Fu, Luo Fang, Yuan Liu and Weihong Tan

Small, 2025, 21
DOI: 10.1002/smll.202410434

Photothermal sensing via DNAzyme catalysis for MicroRNA detection at the point-of-care

Chenbiao Li, Xue Lin, Fengye Mo, Zhiqiao Zou, Jiayun Hu, Dedong Cao, Yushan Tian, Jinghong Li and Xiaoqing Liu

Biosensors and Bioelectronics, 2025, 288, 117832
DOI: 10.1016/j.bios.2025.117832

Deep Learning Promotes Profiling of Multiple miRNAs in Single Extracellular Vesicles for Cancer Diagnosis

Xue-Wei Zhang, Gong-Xiang Qi, Meng-Xian Liu, Yan-Fei Yang, Jian-Hua Wang, Yong-Liang Yu and Shuai Chen

ACS Sens., 2024, 9, 1555
DOI: 10.1021/acssensors.3c02789

Recent advances in suspension microarray-based multiplexed biosensing technologies integrated with fluorescence signal amplification

Wookyoung Jang, E Loomee Song and Ki Wan Bong

TrAC Trends in Analytical Chemistry, 2025, 192, 118397
DOI: 10.1016/j.trac.2025.118397

Fluorescence energy transfer biosensing platform based on hyperbranched rolling circle amplification and multi-site strand displacement for ultrasensitive detection of miRNA

Hongkun Li, Qianqian Cai, Di Wu, Guifen Jie and Hong Zhou

Analytica Chimica Acta, 2022, 1222, 340190
DOI: 10.1016/j.aca.2022.340190

Ultrasensitive detection of microRNA-21 in human serum based on the confinement effect enhanced chemical etching of gold nanorods

Min Huang, Ru Cheng, Shuai Wen, Liangtong Li, Jie Gao, Xiaohui Zhao, Chunmei Li, Hongyan Zou and Jian Wang

Chinese Chemical Letters, 2024, 35, 109379
DOI: 10.1016/j.cclet.2023.109379

Recent Advances in Single‐Atom Materials Prompted Photoelectrochemical Sensing

Yewen Yang, Xiuhua Wei, Shu Chen, Peisheng Zhang, Maotian Xu and Yuanqiang Hao

Electroanalysis, 2025, 37
DOI: 10.1002/elan.70000

Target recycle initiated entropy driven assembly strategy for sensitive, enzyme-free, and portable miRNA detection

Zhijun Jiang and Zhiyuan Liu

Analytical Biochemistry, 2024, 693, 115593
DOI: 10.1016/j.ab.2024.115593

Breaking through PCR multiplexing barriers: A shared-label-tagged primer design enables high-efficiency single-reaction booster PCR (SLP-bPCR)

Jun Zhao, Zhenyu Wang, Ke Yang, Guoqing Deng, Yong Liu and Ling Zhu

Analytica Chimica Acta, 2026, 1383, 344869
DOI: 10.1016/j.aca.2025.344869

Diagnostic use of circulating cells and sub-cellular bio-particles

Atakan Tevlek

Progress in Biophysics and Molecular Biology, 2024, 192, 19
DOI: 10.1016/j.pbiomolbio.2024.08.002

Forced-Convection Porous Hydrogel Platform for Rapid miRNA Detection

Chan Woo Park, Min Hyuk Park, Jun Hyun Park, Taehoon Kim and Jae Jung Kim

Anal. Chem., 2026
DOI: 10.1021/acs.analchem.5c08185

Ligation-recognition triggered RPA-Cas12a cis-cleavage fluorogenic RNA aptamer for one-pot and label-free detection of MicroRNA in breast cancer

Hao Liu, Meng-Mei Lv, Xiang Li, Mei Su, Yin-Gang Nie and Zhan-Ming Ying

Biosensors and Bioelectronics, 2025, 272, 117106
DOI: 10.1016/j.bios.2024.117106

An enzymatically activated AND-gate DNA logic circuit for tumor cells recognition via multi-microRNAs detection

Hanrong Yan, Guojun Cao, Jin Wang, Xu Zhu, Shuqing Dong, Yuqi Huang, Minghao Chao, Yuting Li, Fenglei Gao and Lei Hua

Biosensors and Bioelectronics, 2024, 256, 116278
DOI: 10.1016/j.bios.2024.116278

Establishment and application of a triplex RT qPCR assay system for the identification of forensic body fluids

Shuxiao Hu, Liping Chen, Jiayao Duan, Sheng Hu, Yixia Zhao, Yang Li, Ruiqin Yang, Anquan Ji, Jie Lian and Qifan Sun

Forensic Science International: Genetics, 2026, 81, 103337
DOI: 10.1016/j.fsigen.2025.103337

Color-Coded Traffic Signal Method Combined with Nanodiamond Quantum Sensing for Accurate miRNA Detection

Wei Wang, Youqiang Xing, Lei Liu, Min Wu, Peng Huang, Bingjue Li and Ze Wu

ACS Sens., 2025, 10, 310
DOI: 10.1021/acssensors.4c02511

Poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) modified metal-organic frameworks boosting carbon dots electrochemiluminescence emission for sensitive miRNA detection

Honghong Wang, Pengfei Liu, Jiaxin Peng, Haoming Yu and Li Wang

Biosensors and Bioelectronics, 2024, 249, 116015
DOI: 10.1016/j.bios.2024.116015

Non‐Invasive Diagnosis of Early Colorectal Cancerization via Amplified Sensing of MicroRNA‐21 in NIR‐II Window

Fuheng Zhai, Baofeng Yun, Jiang Ming, Tianyu Yu, Benhao Li, Xiao Liu, Xusheng Wang, Zi‐Han Chen, Changfeng Song, Mengyao Zhao, Wenlin Li, Zhebin Liu, Aibin Liang, Jiyu Li and Fan Zhang

Advanced Materials, 2025, 37
DOI: 10.1002/adma.202501378

CRISPR/Cas13a-triggered exonuclease III-propelled DNA amplifier for one-pot detection of microRNAs

Ziheng Zheng, Zhihan Li, Yaqing Liu, Yongfu Wang and Chunjin Xu

Microchemical Journal, 2025, 215, 114152
DOI: 10.1016/j.microc.2025.114152

DSN enzyme recognition initiated rolling circle amplification (DiRCA) for accurate miRNA detection in immune response and immune repair after trauma

Yi Mei, Jun Zhang, Li Zhu, Tianjiao Li, Hong Zhou, Mingjia Xie, Dongmei Zeng and Yajun Gou

J Anal Sci Technol, 2023, 14
DOI: 10.1186/s40543-023-00383-4

Bipedal DNAzyme walker triggered dual-amplification electrochemical platform for ultrasensitive ratiometric biosensing of microRNA-21

Liang Tian, Jiyuan Zhang, Yi Zhang, Olayinka Oderinde, Caiyun Li, Lili Duan, Yihong Wang and Jiansheng Cui

Biosensors and Bioelectronics, 2023, 220, 114879
DOI: 10.1016/j.bios.2022.114879

3D DNAzyme walker based electrochemical biosensor for attomolar level microRNA-155 detection

Jiaying Zhao, Congjuan He, Yanyi Long, Jincan Lei, Huan Liu, Jingzhou Hou, Changjun Hou and Danqun Huo

Analytica Chimica Acta, 2023, 1276, 341642
DOI: 10.1016/j.aca.2023.341642

A preamplification-free dual nuclease-assisted cascade platform for ultrasensitive and specific miRNA detection

Ziheng Zheng, Yaqing Liu, Chunjin Xu and Yonghui Cui

Microchemical Journal, 2026, 220, 116179
DOI: 10.1016/j.microc.2025.116179

Highly accurate multiplexed nanoplasmonic detection of microRNAs using splinted ligation

Yun Ju Sung, Sihwa Joo, Ui Jin Lee, Ki joong Lee, Jaejong Lee, Na rae Jo, Yong-Beom Shin and Mina Lee

Chemical Engineering Journal, 2025, 511, 162100
DOI: 10.1016/j.cej.2025.162100

A membrane biosensor based on colour differences encoded upconversion silica nanoparticles for multiplex nucleic acids detection

Tongxu Gu, Jiajun Zhong, Zhe Wang and Pengli Bai

Chemical Engineering Journal, 2023, 469, 144022
DOI: 10.1016/j.cej.2023.144022

Self-Generation of Distinguishable Fluorescent Probes via a One-Pot Process for Multiple MicroRNA Detection by Liquid Chromatography

Chang Song, Chang Liu, Jisen Chen, Ziyu Ma, Sheng Tang, Ruirong Pan, Xiaocen Suo, Zuowei Yan, Hian Kee Lee and Wei Shen

Anal. Chem., 2023, 95, 4113
DOI: 10.1021/acs.analchem.2c04941

Chain-based precision amplification biosensor for microRNA detection based on dCas13a system and iridium complex

Yiming Zhang, Zhi Chen, Songrui Wei, Yujun Zhang, Yingxia Liu, Hui Li, Jing Wang, Qi Gao, Defa Li, Han Zhang and Zhongjian Xie

Sensors and Actuators B: Chemical, 2026, 447, 138881
DOI: 10.1016/j.snb.2025.138881

Triple cycling integrating with primer exchange reaction (TCiPER) for ultra-sensitive and label-free detection of MicroRNA

Ye Tian, Tao Di, Chao Bai, Xinxi Li, Jun Luo, Zhenwei Yang, Lei Zhang and Wenbin Zhang

Microchemical Journal, 2024, 197, 109782
DOI: 10.1016/j.microc.2023.109782

Micro RNA in Colorectal Cancer—Potential Diagnostic and Prognostic Markers—An Updated Review

Weronika Pająk, Jakub Kleinrok, Joanna Pec, Karolina Michno, Jan Wojtas, Miłosz Badach, Barbara Teresińska and Jacek Baj

IJMS, 2025, 26, 8615
DOI: 10.3390/ijms26178615

Multiplexed and streamlined DNA methylation detection of colorectal cancer-related genes using graphically encoded hydrogel microparticles and rolling circle amplification

Wookyoung Jang, So Jung Oh, Eun Sun Kim and Ki Wan Bong

Biosensors and Bioelectronics, 2025, 287, 117725
DOI: 10.1016/j.bios.2025.117725

Coupling an anti-fouling recognition interface with dual biological signal amplifications for ultrasensitive and label-free electrochemical myocardial microRNA assay in complex sample matrix

Yihe Li, Lingrong Cui, Zhijiang Dai, Jin Zhang, Jianmei Yang, Yan Zhao, Yun Xiang and Ruo Yuan

Microchemical Journal, 2025, 218, 115544
DOI: 10.1016/j.microc.2025.115544

Study Progress of Circulating miRNA for Predicting Metastasis in Non-Small Cell Lung Cancer

靖靖丛

ACM, 2024, 14, 65
DOI: 10.12677/acm.2024.1471982

SPARC: A programmable molecular diagnostic platform based on a signal-triggered, self-supplied crRNA and tiered PER-transcription-CRISPR cascade for early detection of hepatocellular carcinoma

Xinying Chang, Cong Han, Haishuo Ji, Zhe Zeng, Jingyi Yang, Qirui Liu, Chao Jia, Lili Zhao, Chunlei Zhou, Shujia Chen, Wolfgang Knoll, Jia Li, Zhenglu Wang and Liyun Zhang

Analytica Chimica Acta, 2026, 1394, 345209
DOI: 10.1016/j.aca.2026.345209

Catalytic Amplification-Mediated Single-Nanotag Assembly for Sensitive Detection of Circulating microRNAs

Xiao Chen, Chengchao Zhang, Hui Yin, Min Jiang, Jianyu Hu, Rui Liu and Yi Lv

Anal. Chem., 2026, 98, 7273
DOI: 10.1021/acs.analchem.5c06208

A Photoacoustic Contrast Agent for miR-21 via NIR Fluorescent Hybridization Chain Reaction

Raina M. Borum, Colman Moore, Soo Khim Chan, Nicole F. Steinmetz and Jesse V. Jokerst

Bioconjugate Chem., 2022, 33, 1080
DOI: 10.1021/acs.bioconjchem.1c00375

A bead-based dendritic amplification system for multiplex miRNA detection

Feiyang Qian, Rui Zhu, Yao Lu, Tenghua Zhang, Yuqing Zhu, Yan Sheng and Jiaming Hu

Chemical Engineering Journal, 2026, 527, 171416
DOI: 10.1016/j.cej.2025.171416

CRISPR/Cas12a‐Enabled Multiplex Biosensing Strategy Via an Affordable and Visual Nylon Membrane Readout

Tao Hu, Xinxin Ke, Wei Li, Yu Lin, Ajuan Liang, Yangjing Ou and Chuanxia Chen

Advanced Science, 2023, 10
DOI: 10.1002/advs.202204689

(Eu-MOF)-derived Smart luminescent sensing for Ultrasensitive on-site detection of MiR-892b

Yuchi Zhang, Mengqin Shi, Yin Qian, Haiying Wang, Xinzhe Zhang, Jinpeng He, Binbin Jiang, Yanmei Chen and Xiaoxia Mao

Analytica Chimica Acta, 2023, 1284, 341990
DOI: 10.1016/j.aca.2023.341990

Urinary miRNAs: Technical Updates

Santhi Raveendran, Alia Al Massih, Muna Al Hashmi, Asma Saeed, Iman Al-Azwani, Rebecca Mathew and Sara Tomei

MIRNA, 2024, 13, 110
DOI: 10.2174/0122115366305985240502094814

Duplex-specific nuclease powered 3D DNA walker and quantum dots barcodes for homogeneous electrochemical detection of microRNAs

Jiaying Zhao, Congjuan He, Huisi Yang, Yanyi Long, Jiangbo Dong, Li Wen, Zhikun Hu, Xinxue Yin, Changjun Hou and Danqun Huo

Analytica Chimica Acta, 2023, 1262, 341246
DOI: 10.1016/j.aca.2023.341246

A CRISPR/Cas13a system based on a dumbbell-shaped hairpin combined with DNA-PAINT to establish the DCP-platform for highly sensitive detection of Hantaan virus RNA

Jiamei Zhong, Ziyue Xu, Jiawei Peng, Liwen Guan, Jianxiong Li, Zhuoxun Zhou, Yu Zhang, Jie Zhang, Shiwen Liu, Yifei Yang and Xian Hao

Talanta, 2025, 291, 127852
DOI: 10.1016/j.talanta.2025.127852

Extended Linear Confined Zipper Cascaded Reaction for Highly Efficient Intracellular Imaging and Assisting Diagnosis of Thyroid Cancer

Lu Liu, Pan Ju, Ketong Yang, Xiaoming Li, Kaili Duan, Jingling Xie, Min Liu, Junman Chen and Rong Luo

Small, 2025, 21
DOI: 10.1002/smll.202500202

Emerging Biosensing Methods to Monitor Lung Cancer Biomarkers in Biological Samples: A Comprehensive Review

Raja Chinnappan, Tanveer Ahmad Mir, Sulaiman Alsalameh, Tariq Makhzoum, Alaa Alzhrani, Khalid Alnajjar, Salma Adeeb, Noor Al Eman, Zara Ahmed, Ismail Shakir, Khaled Al-Kattan and Ahmed Yaqinuddin

Cancers, 2023, 15, 3414
DOI: 10.3390/cancers15133414

Advances in nanozyme-assisted CRISPR diagnostic technology

Lang Luo, Yeling Yang, Yubei Zhang and Guobin Mao

Front. Bioeng. Biotechnol., 2026, 14
DOI: 10.3389/fbioe.2026.1796403

Dual-mode biosensor based on cascade CHA-HCR amplification and multilayer core-satellite nanostructures for highly sensitive microRNA detection

Baozheng Wang, Zixuan Ding, Wen Li, Hong Wang and Yingwei Zhang

Sensors and Actuators B: Chemical, 2026, 448, 138939
DOI: 10.1016/j.snb.2025.138939

Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2025

Nicole Jaffrezic-Renault and Jin-Ming Lin

Chemosensors, 2026, 14, 83
DOI: 10.3390/chemosensors14040083

Multiplexed MicroRNA biomarker detection by bridging lifetime filtering imaging and dynamic chemical labeling

Maria Padial-Jaudenes, Mavys Tabraue-Chávez, Simone Detassis, Maria J. Ruedas-Rama, M. Carmen Gonzalez-Garcia, Mario Antonio Fara, F. Javier López-Delgado, Juan A. González-Vera, Juan J. Guardia-Monteagudo, Juan J. Diaz-Mochon, Emilio Garcia-Fernandez, Salvatore Pernagallo and Angel Orte

Sensors and Actuators B: Chemical, 2024, 417, 136136
DOI: 10.1016/j.snb.2024.136136

Single-molecule/particle counting for microRNA detection and imaging

Fei Ma and Xinyi Zhang

TrAC Trends in Analytical Chemistry, 2023, 164, 117085
DOI: 10.1016/j.trac.2023.117085

Self-assembled “feather-like” CuS@MIL-101 nanostructure for CL-FL-PT triple-modal signal amplification: PER-controlled AND logic gate detection of miR-21&miR-155

Junyuan Yang, Hao Jiang, Anyi Li, Yulin Deng and Xuefei Lv

Biosensors and Bioelectronics, 2026, 295, 118282
DOI: 10.1016/j.bios.2025.118282

Identification of biomarkers and analysis of infiltrated immune cells in stable and ruptured abdominal aortic aneurysms

Yubin Chen, Tianyu Ouyang, Cheng Fang, Can-e Tang, Kaibo Lei, Longtan Jiang and Fanyan Luo

Front. Cardiovasc. Med., 2022, 9
DOI: 10.3389/fcvm.2022.941185

A Cascade Signal Amplification Based on Dynamic DNA Nanodevices and CRISPR/Cas12a Trans-cleavage for Highly Sensitive MicroRNA Sensing

Xingrong Li, Decai Zhang, Xiufeng Gan, Ping Liu, Qingyuan Zheng, Tiantian Yang, Guozhen Tian, Shijia Ding and Yurong Yan

ACS Synth. Biol., 2021, 10, 1481
DOI: 10.1021/acssynbio.1c00064

Highly Sensitive Multiplexed Sensing of miRNAs in a Gastric Cancer Patient’s Liquid Biopsy

Liang Luan, Lin Yang, Yating Zhang, Jing Liu, Bingtao Hu, Lingzhi Ye, Wei Ye, Jienan Shen, Hong Chen, Xiangmeng Qu, Hui Yang and Yunhui Li

Anal. Chem., 2024, 96, 20015
DOI: 10.1021/acs.analchem.4c04639

Development of a multi-miRNA detection platform for enhanced diagnostics of colorectal cancer

Bo Zhou, Tingting Fan, Hui Chen, Yiming Huang, Xinjie Lai, Shanshan Feng, Zijian Ding, Yan Chen and Yuyang Jiang

Biosensors and Bioelectronics, 2025, 287, 117639
DOI: 10.1016/j.bios.2025.117639

Programmed Fluorescence-Encoding DNA Nanoflowers for Cell-Specific-Target Multiplexed MicroRNA Imaging

Fan Zhang, Wenhao Dai, Meiqin Zhang, Haifeng Dong and Xueji Zhang

Anal. Chem., 2025, 97, 10588
DOI: 10.1021/acs.analchem.4c06960

Exosomal Communication Between Cumulus–Oocyte Complexes and Granulosa Cells: A New Molecular Axis for Oocyte Competence in Human-Assisted Reproduction

Charalampos Voros, Diamantis Athanasiou, Despoina Mavrogianni, Antonia Varthaliti, Kyriakos Bananis, Antonia Athanasiou, Aikaterini Athanasiou, Georgios Papadimas, Athanasios Gkirgkinoudis, Ioannis Papapanagiotou, Kyriaki Migklis, Dimitrios Vaitsis, Aristotelis-Marios Koulakmanidis, Dimitris Mazis Kourakos, Sofia Ivanidou, Maria Anastasia Daskalaki, Marianna Theodora, Panagiotis Antsaklis, Dimitrios Loutradis and Georgios Daskalakis

IJMS, 2025, 26, 5363
DOI: 10.3390/ijms26115363

Cutting-edge RNA quantitative detection methods for rapid and on-site analysis

Tao Dong, Chenghui Yu, Feng Han, Qi Mao, Weixuan Jing, Zhaochu Yang, Nuno Miguel Matos Pires, José Higino Correia, Qijing Lin, Fei Hu, Honghong Yao, Kui Hu, Tao Xu and Zhuangde Jiang

TrAC Trends in Analytical Chemistry, 2025, 190, 118274
DOI: 10.1016/j.trac.2025.118274

A highly sensitive and robust one-pot assay for the detection of microRNAs

Nat. Biomed. Eng, 2023, 7, 1539
DOI: 10.1038/s41551-023-01043-z

Remotely Activated DNA Probe System for the Detection and Imaging of Dual miRNAs

Yan Zhong, Zhihao Li, Zheng Li, Bo Li, Hui Xin and Chunyan Wang

ACS Appl. Bio Mater., 2024, 7, 462
DOI: 10.1021/acsabm.3c01079

Multiplex digital PCR for the simultaneous quantification of a miRNA panel

Florence Busato, Sylvain Ursuegui, Jean-François Deleuze and Jorg Tost

Analytica Chimica Acta, 2025, 1335, 343440
DOI: 10.1016/j.aca.2024.343440

Synthetic Gene Circuit-Based Assay with Multilevel Switch Enables Background-Free and Absolute Quantification of Circulating Tumor DNA

Chao Zhang, Zedong Li, Jie Liu, Chang Liu, Haoqing Zhang, Won Gu Lee, Chunyan Yao, Hui Guo and Feng Xu

Research, 2023, 6
DOI: 10.34133/research.0217

Shedding Light on DNA‐Based Nanoprobes for Live‐Cell MicroRNA Imaging

Fan Yang, Huiting Lu, Xiangdan Meng, Haifeng Dong and Xueji Zhang

Small, 2022, 18
DOI: 10.1002/smll.202106281

Innovative Oral Nano/Gene Delivery System Based on Engineered Modified Saccharomyces cerevisiae for Colorectal Cancer Therapy

Tianli Shen, Xuejun Sun, Shuanying Yang, Wei Wang, Zilu Chen, Yuyao Lin, Sihua Li, Hang Peng, Lizhong Zeng, Gan Li, Xuqi Li, Bo Wang, Jingya Ning, Haimei Wen, Bo Lei and Long Zhang

ACS Nano, 2024, 18, 28212
DOI: 10.1021/acsnano.4c08044

Light-Triggered Signal Enhancement Strategy Integrated with a CRISPR/Cas13a-Based Assay for Ultrasensitive and Specific miRNA Detection

Tao Hu, Yingying Yu, Yu Lin and Chuanxia Chen

Anal. Chem., 2023, 95, 18587
DOI: 10.1021/acs.analchem.3c04487

Advances in Point-of-Care Testing of microRNAs Based on Portable Instruments and Visual Detection

Zhong-Yu Wang, Ming-Hui Sun, Qun Zhang, Pei-Feng Li, Kun Wang and Xin-Min Li

Biosensors, 2023, 13, 747
DOI: 10.3390/bios13070747

CRISPR/Cas‐Based MicroRNA Biosensors

Qian Zhang, Xinyi Zhang, Xiaoran Zou, Fei Ma and Chun‐Yang Zhang

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202203412

A machine-learning-integrated portable electrochemiluminescence sensing platform for the visualization and high-throughput immunoassays

Mengmeng Li, Zhongzeng Zhou, Guang Tian and Conghui Liu

Talanta, 2025, 287, 127639
DOI: 10.1016/j.talanta.2025.127639

Triple-hairpin mediated feedback system based on rolling circle amplification for enhanced imaging and detection of intracellular microRNA

Jing Zhang, Qi Xiang, Xuemei Hu, Guoqiao Huang, Quan Yuan, Qiufeng Song, Yinghao Cheng, Chan Li, Chang Xue and Zhifa Shen

Sensors and Actuators B: Chemical, 2023, 375, 132896
DOI: 10.1016/j.snb.2022.132896

Recent Advances in DNA‐Based Nanoprobes for In vivo MiRNA Imaging

Caixia Wang, Xuefang Song, Jieyu Shen, Yuxin Xie, Huangxian Ju and Ying Liu

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202402566

Effects of brain microRNAs in cognitive trajectory and Alzheimer’s disease

Selina M. Vattathil, Sarah Sze Min Tan, Paul J. Kim, David A. Bennett, Julie A. Schneider, Aliza P. Wingo and Thomas S. Wingo

Acta Neuropathol, 2024, 148
DOI: 10.1007/s00401-024-02818-7

A Single-Tube, Single-Enzyme Clustered Regularly Interspaced Short Palindromic Repeats System (UNISON) with Internal Controls for Accurate Nucleic Acid Detection

Jialing Zhong, Xiaolong Wu, Chuanghao Guo, Conghui Liu, Qianling Zhang, Yong Chen and Yizhen Liu

Anal. Chem., 2024, 96, 19348
DOI: 10.1021/acs.analchem.4c03403

Reconfigurable acoustic tweezer for precise tracking and in-situ sensing of trace miRNAs in tumor cells

Jingui Qian, Bowei Zhang, Chuanmin Liu, Yuhang Xue, Hong Zhou, Liang Huang, Shaohui Zheng, Minghui Chen and Yong-Qing Fu

Biosensors and Bioelectronics, 2025, 282, 117505
DOI: 10.1016/j.bios.2025.117505

Recent Strategies for MicroRNA Detection: A Comprehensive Review of SERS-Based Nanobiosensors

Sang Baek Sim, Izzati Haizan, Min Yu Choi, Yubeen Lee and Jin-Ha Choi

Chemosensors, 2024, 12, 154
DOI: 10.3390/chemosensors12080154

Molecular biosensors for detection of miRNA and its application in medical diagnosis

Mehdi Dadmehr, Mehrana Allahverdi, Noosha Khalighi Kalat, Bahar Sheikhnejad and Morteza Hosseini

TrAC Trends in Analytical Chemistry, 2026, 195, 118626
DOI: 10.1016/j.trac.2025.118626

Simultaneous Multi-miRNA Detection in Urinary Small Extracellular Vesicles Using Target-Triggered Locked Hairpin DNA-Functionalized Au Nanoprobes for Systemic Lupus Erythematosus Diagnosis

Xiaofei Chen, Qingyong Xiang, Shaohan Yan, Yingyu Wang, Ning Su, Xue Yang, Mingxia Gao and Xiangmin Zhang

Anal. Chem., 2024, 96, 16370
DOI: 10.1021/acs.analchem.4c03794

The role of MicroRNAs in the diagnosis and treatment of oral premalignant disorders

J. H. Shazia Fathima, Selvaraj Jayaraman, Ramya Sekar and Nazmul Huda Syed

Odontology, 2024, 112, 1023
DOI: 10.1007/s10266-024-00934-0

Structure-switching G-quadruplex: An efficient CRISPR/Cas12a signal reporter for label-free colorimetric biosensing

Yang Chen, Bei Lv, Wenzhu Wang, Yapeng Wu and Dawei Li

International Journal of Biological Macromolecules, 2025, 307, 142410
DOI: 10.1016/j.ijbiomac.2025.142410

Magnetic separation-integrated electrochemical biosensor with synergy of photo-electronic cascading for high-reproducibility detection of miRNA biomarker in tumor tissue

Zhenghe Shi, Wentao Liu, Xuzhou Liu, Kaixiu Fu, Yunyun Wu, Hongrui Zhu, Chunhui Zhai, Xiyue Xie and Jixi Zhang

Talanta, 2026, 297, 128675
DOI: 10.1016/j.talanta.2025.128675

Engineering Multipedal DNA Walker on Paper for Sensitive Electrochemical Detection of Plant MicroRNA

Xiaojuan Liu, Junzhu Xiang, Hao Cheng, Yuying Wang and Feng Li

Chin. J. Chem., 2022, 40, 2808
DOI: 10.1002/cjoc.202200368

miRNA-based electrochemical biosensors for ovarian cancer

Saber Rouhi, Hassan Ghasemi, Mehdi Alizadeh, Ahmad Movahedpour, Farzaneh Vahedi, Mehdi Fattahi, Saleh Aiiashi and Seyyed Hossein Khatami

Clinica Chimica Acta, 2025, 564, 119946
DOI: 10.1016/j.cca.2024.119946

A label-free cyclic amplification strategy for microRNA detection by coupling graphene oxide-controlled adsorption with superlong poly(thymine)-hosted fluorescent copper nanoparticles

Fengzhou Xu, Zhenzhen Qiao, Lan Luo, Xiaoxiao He, Yanli Lei, Jinlu Tang, Hui Shi and Kemin Wang

Talanta, 2022, 243, 123323
DOI: 10.1016/j.talanta.2022.123323

Excitation/emission-enhanced heterostructure photonic crystal array synergizing with "DD-A" FRET entropy-driven circuit for high-resolution and ultrasensitive analysis of ctDNA

Jie Luo, Chuyan Zhang, Mengfan Wu, Xiuyuan Yao, Yixiang Duan and Yongxin Li

Biosensors and Bioelectronics, 2024, 263, 116615
DOI: 10.1016/j.bios.2024.116615

Assessment of salivary microRNA by RT-qPCR: Facing challenges in data interpretation for clinical diagnosis

Marc Van Der Hofstadt, Anna Cardinal, Morgane Lepeltier, Jérémy Boulestreau, Alimata Ouedraogo, Malik Kahli, Pierre Champigneux, Laurence Molina, Franck Molina, Thi Nhu Ngoc Van and Guido Sebastiani

PLoS ONE, 2024, 19, e0314733
DOI: 10.1371/journal.pone.0314733

State-of-the-art signal amplification strategies for nucleic acid and non-nucleic acid biosensors

Ijaz Gul, Muhammad Akmal Raheem, Md. Reyad-ul-Ferdous, Xi Yuan, Zhenglin Chen, Chenying lv, Minjiang Chen, Jiansong Ji, Duanpo Wu, Qiang Zhao, Chenggang Yan and Dongmei Yu

Sensors and Actuators Reports, 2025, 9, 100268
DOI: 10.1016/j.snr.2024.100268

High Sensitivity and Specificity Platform to Validate MicroRNA Biomarkers in Cancer and Human Diseases

Anastassia Kanavarioti, M. Hassaan Rehman, Salma Qureshi, Aleena Rafiq and Madiha Sultan

ncRNA, 2024, 10, 42
DOI: 10.3390/ncrna10040042

Integration of CRISPR/Cas12a and Toehold‐Mediated Strand Displacement for Alternative Conventional miRNA Detection

David Septian Sumanto Marpaung, Ayu Oshin Yap Sinaga, Damayanti Damayanti, Ni Wayan Arya Utari, Harmiansyah, Arthur Karangan and Muh Kusmali

ChemBioChem, 2026, 27
DOI: 10.1002/cbic.202500932

Endogenous mRNA-Powered and Spatial Confinement-Derived DNA Nanomachines for Ultrarapid and Sensitive Imaging of Let-7a

Yinghui Feng, Shenghong Liu, Yao Yao, Miao Chen, Qi Liu and Xiaoqing Chen

Anal. Chem., 2024, 96, 564
DOI: 10.1021/acs.analchem.3c04837

microRNA Detection via Nanostructured Biochips for Early Cancer Diagnostics

Sara Martino, Chiara Tammaro, Gabriella Misso, Michela Falco, Marianna Scrima, Marco Bocchetti, Ilaria Rea, Luca De Stefano and Michele Caraglia

IJMS, 2023, 24, 7762
DOI: 10.3390/ijms24097762

Constraint Coupling of Redox Cascade and Electron Transfer Synchronization on Electrode‐Nanosensor Interface for Repeatable Detection of Tumor Biomarkers

Xiyue Xie, Kaifei Jin, Zhenqiang Wang, Shuai Wang, Jing Zhu, Jixi Huang, Shuqi Tang, Kaiyong Cai and Jixi Zhang

Small Methods, 2024, 8
DOI: 10.1002/smtd.202301330

A low-background autocatalytic DNA circuit for sensitive and multiplexed enzyme-free isothermal miRNA amplification

Junlan Liu, Linyi Deng and Yuan Gao

Chemical Engineering Journal, 2025, 519, 165098
DOI: 10.1016/j.cej.2025.165098

NiCl2@g-C3N4-based Label-free Dual-mode Sensing Platform for Highly Sensitive and Selective Detection of MicroRNA-183-5p in Serum

Jinxiong Xue, Jingping Huang, Xue Lin, Wuyuan Pan and Fang Ke

J Fluoresc, 2025, 36, 1619
DOI: 10.1007/s10895-025-04639-7

Refresh-In-Sensing Reusable Biosensor for Ultrasensitive Analysis of MicroRNA Based on Photoresponsive Plasmonic Nanoprobes

Yi Wang, Le Sun, Bo Kou, Ziwei Dong, Fengjv Shen, Yu Chen, Yang Zhou, Quli Fan, Jingjing Shen, Weibing Wu and Lei Zhang

ACS Sens., 2026, 11, 739
DOI: 10.1021/acssensors.5c04052

Signal-On Mass Spectrometric Biosensing of Multiplex Matrix Metalloproteinases with a Phospholipid-Structured Mass-Encoded Microplate

Junjie Hu, Fei Liu, Yunlong Chen, Jia Fu and Huangxian Ju

Anal. Chem., 2023, 95, 8974
DOI: 10.1021/acs.analchem.3c01039

Near‐Infrared Fluorescence Imaging of miRNA Using a Transmembrane Polypeptide‐Based Genetic Reporter

Wen‐Jie Shu, Zhe Ma, Xiaojie Tian and Fu Wang

Small Methods, 2024, 8
DOI: 10.1002/smtd.202300990

DNA tetrahedron-assisted catalytic hairpin assembly enables robust in situ miRNA detection and imaging in living cells and clinical samples

Zhengquan Yang, Bingyu Yang, Jingmei Wang, Qihui Yu, Wenxuan Du, Yaxin Meng, Qiulei Li, Huo Xu, Weizhong Wang and Jianxin Lyu

Sensors and Actuators B: Chemical, 2025, 444, 138453
DOI: 10.1016/j.snb.2025.138453

One-Pot Detection of miRNA by Dual Rolling Circle Amplification at Ambient Temperature with High Specificity and Sensitivity

Wenhua Sun, Kunling Hu, Ziting Song, Ran An and Xingguo Liang

Biosensors, 2025, 15, 317
DOI: 10.3390/bios15050317

DNA-Programmed Four-Bit Quaternary Fluorescence Encoding (FLUCO) Enables 51-Colored Bioimaging Analysis

Dongsheng Mao, Xiaochen Tang, Runchi Zhang, Tianshu Chen, Chenbin Liu, Hongquan Gou, Pei Sun, Yichun Mao, Jie Deng, Wenxing Li, Fenyong Sun and Xiaoli Zhu

J. Am. Chem. Soc., 2024, 146, 16428
DOI: 10.1021/jacs.4c00811

Simultaneous and rapid colorimetric detection of distinct miRNAs using Split-LAMP

Yi Jing Chua, Steven Poh Chuen Sim, Medha Shridharan and Yiqi Seow

Front. Bioeng. Biotechnol., 2023, 11
DOI: 10.3389/fbioe.2023.1271297

Elegant biosensor based on magnetic beads and target-directed enzyme-free dual-amplification for the detection of miRNA-let-7a

Qian Wang, Xiaogang Zeng, Weihua Zhao, Hongbo Li, Suqin Wang, Zhanghui Lu and Ruqin Yu

Sensors and Actuators B: Chemical, 2023, 390, 133980
DOI: 10.1016/j.snb.2023.133980

Comprehensive analysis of peripheral blood non-coding RNAs identifies a diagnostic panel for fungal infection after transplantation

Anli Yang, Huadi Chen, Jianwei Lin, Ming Han, Xiaopeng Yuan, Tao Zhang, Qingwei Nian, Mengran Peng, Dian Li, Chenglin Wu and Xiaoshun He

Bioengineered, 2022, 13, 4039
DOI: 10.1080/21655979.2022.2032963

Dumbbell probe initiated multi-rolling circle amplification assisted CRISPR/Cas12a for highly sensitive detection of clinical microRNA

Xudan Shen, Ziwei Lin, Xianfeng Jiang, Xinlan Zhu, Su Zeng, Sheng Cai and Hui Liu

Biosensors and Bioelectronics, 2024, 264, 116676
DOI: 10.1016/j.bios.2024.116676

A novel cysteine catalytic oxidation-based colorimetric approach for sensitive analysis of acute pancreatitis-related microRNA

Mingwei Gong, Guoyan Jiang, Yuan Rong, Zeping Yang, Dong She and Chunhong Sun

J Anal Sci Technol, 2023, 14
DOI: 10.1186/s40543-023-00390-5

Competitive magneto enzyme-linked miRNA assay for quantification of microRNAs in exosomes

Mireia Bernuz, Mercè Martí and María Isabel Pividori

Talanta, 2026, 302, 129431
DOI: 10.1016/j.talanta.2026.129431

A Novel Dual Signal Amplification Strategy Integrating APE1-Assisted DNA Walker with Rolling Circle Amplification for Highly Sensitive, Label-Free Exosomal microRNA Analysis

Huihui Yang, Ziyue Qiu, Shishi Huang, Jing peng, Ting Huang, Qixia Zou, Wanyi Yang, Jinxiang Chen, Minmin Li, Zong Dai, Wei Xu and Jun Chen

Anal. Chem., 2026, 98, 7541
DOI: 10.1021/acs.analchem.5c07308

Single tube cell-free transcription and autocatalytic signal amplification based fluorescent biosensor for microRNA detection

Qian Xie, Ming Chen and Zhenyu Lin

Biosensors and Bioelectronics, 2026, 304, 118626
DOI: 10.1016/j.bios.2026.118626

Machine Learning-Enhanced Analysis of miRNA Biomarkers for Accurate Breast Cancer Diagnosis Using DNA Seagrass

Xingyu Tao, Xinyu Li, Qikun Lv, Gang Tian, Hengke Jia, Yuanjie Liu, Bo Shen, Xuhuai Fu and Yurong Yan

Anal. Chem., 2025, 97, 22582
DOI: 10.1021/acs.analchem.5c03687

An unique DNA junction scaffold-based electrochemical sensing platform achieving multilevel signal responses for amplified multiplexed nucleic acid analysis and logic operation

Dengfeng Qu, Zongli Gu, Jialiang Wu, Li Wang and Shufeng Liu

Sensors and Actuators B: Chemical, 2023, 390, 133956
DOI: 10.1016/j.snb.2023.133956

Exponential rolling circle amplification coupled with palindrome-directed bidirectional strand displacement amplification activation of dimeric CRISPR/Cas12a in miR-155 signaling

Jianguo Xu, Zhuqi Sui, Jia Zhao, Baoqiang Chen, Xiao-ming Meng and Min Yang

Sensors and Actuators B: Chemical, 2026, 448, 139020
DOI: 10.1016/j.snb.2025.139020

An enzyme-free and label-free multiplex detection of miRNAs by entropy-driven circuit coupled with capillary electrophoresis

Yanyan Sun, Yufei Peng, Yunlong Sun and Danke Xu

Talanta, 2025, 281, 126850
DOI: 10.1016/j.talanta.2024.126850

Label-free multiplex detection of miRNA-assayed hydrogel barcode using a low-aspect-ratio micropore sensor

Chang-Woo Song, Su Hyeon Bae, Ki Wan Bong and Chang-Soo Han

Sensors and Actuators B: Chemical, 2023, 380, 133376
DOI: 10.1016/j.snb.2023.133376

Fluorescence-based simultaneous dual oligo sensing of HCV genotypes 1 and 3 using magnetite nanoparticles

Pranay Amruth Maroju, Ramakrishnan Ganesan and Jayati Ray Dutta

Journal of Photochemistry and Photobiology B: Biology, 2022, 232, 112463
DOI: 10.1016/j.jphotobiol.2022.112463

Role of probe design and bioassay configuration in surface enhanced Raman scattering based biosensors for miRNA detection

Chiara Novara, Daniel Montesi, Sofia Bertone, Niccolò Paccotti, Francesco Geobaldo, Marwan Channab, Angelo Angelini, Paola Rivolo, Fabrizio Giorgis and Alessandro Chiadò

Journal of Colloid and Interface Science, 2023, 649, 750
DOI: 10.1016/j.jcis.2023.06.090

An ultrasensitive and multiplexed miRNA one-step real time RT-qPCR detection system and its application in esophageal cancer serum

Ying Xue, Kai Wang, Yunli Jiang, Yanmiao Dai, Xiaoyu Liu, Bing Pei, Hui Li, Hongwei Xu and Guodong Zhao

Biosensors and Bioelectronics, 2024, 247, 115927
DOI: 10.1016/j.bios.2023.115927

An innovative “double-locked” CRISPR/Cas12a system based on DNAzyme for the precise imaging of microRNAs in living cells

Lu Lu, Shihua Gan, Shixiu Xiao, Xiaomei Mu, Shulin Zhao and Jianniao Tian

International Journal of Biological Macromolecules, 2025, 310, 143605
DOI: 10.1016/j.ijbiomac.2025.143605

Efficient isolation of encoded microparticles in a degassed micromold for highly sensitive and multiplex immunoassay with signal amplification

Wookyoung Jang, E Loomee Song, Seok Joon Mun and Ki Wan Bong

Biosensors and Bioelectronics, 2024, 261, 116465
DOI: 10.1016/j.bios.2024.116465

Dual-Site Chemically Engineered MNAzymes for One-Pot Isothermal Detection of MicroRNAs

Yuying Huang, Can Jia, Yajuan Tang, Jun Zhang, Ruolian Zhao, Jihong Zhang and Lin Chai

ACS Omega, 2025
DOI: 10.1021/acsomega.5c09119

ddPCR-based profiling of plasma EV-miRNA identifies a noninvasive biomarker panel for tuberculosis

Zhuhua Wu, Jing Liang, Yuchuan Zhao, Jianming Hong, Yongping Xie, Yongzhao Liu, Shende Huang, Jingwen Lai, Xiaoyu Lai, Ran Wei, Jiawen Wang, Weilong Liu and Xunxun Chen

Eur J Med Res, 2025, 30
DOI: 10.1186/s40001-025-03533-z

A review of sample preparation for purification of microRNAs and analysis by mass spectrometry methods

Hiba Salim, Roger Pero-Gascon, Laura Pont, Estela Giménez and Fernando Benavente

Microchemical Journal, 2022, 182, 107849
DOI: 10.1016/j.microc.2022.107849

Circulating miR-200 Family and CTCs in Metastatic Breast Cancer before, during, and after a New Line of Systemic Treatment

Chiara Fischer, Andrey Turchinovich, Manuel Feisst, Fabian Riedel, Kathrin Haßdenteufel, Philipp Scharli, Andreas D. Hartkopf, Sara Y. Brucker, Laura Michel, Barbara Burwinkel, Andreas Schneeweiss, Markus Wallwiener and Thomas M. Deutsch

IJMS, 2022, 23, 9535
DOI: 10.3390/ijms23179535

Prognosis and immune landscape of bladder cancer can be predicted using a novel miRNA signature associated with cuproptosis

Zhilei Zhang, Fang Liu, Yongbo Yu, Fei Xie and Tao Zhu

PeerJ, 2024, 12, e18530
DOI: 10.7717/peerj.18530

Water-stable perovskite-silica nanocomposites for encoded microbeads construction and multiplexed detection

Tongxu Gu, Jiajun Zhong, Minghao Ge, Ruiju Shi, Liang He and Pengli Bai

Journal of Colloid and Interface Science, 2024, 657, 580
DOI: 10.1016/j.jcis.2023.11.185

Sensing miRNAs for Disease Diagnostics

Linyi Deng, Pei Guo, Da Han and Weihong Tan

Analysis & Sensing, 2023, 3
DOI: 10.1002/anse.202200083

Recent advances in the construction strategy, functional properties, and biosensing application of self-assembled triangular unit-based DNA nanostructures

Mengxia Duan, Yuting Chang, Xiaowan Chen, Zhouping Wang, Shijia Wu and Nuo Duan

Biotechnology Advances, 2024, 76, 108436
DOI: 10.1016/j.biotechadv.2024.108436

In-situ thermal cycling amplification on the surface of upconversion nanoparticles and enabling multiplexed microRNA assay

Yuxin Wang, Le Mao, Junyue Sun, Chenghui Liu and Wei Ren

Sensors and Actuators B: Chemical, 2025, 445, 138562
DOI: 10.1016/j.snb.2025.138562

Sensitive fluorescence detection of miRNA-124 in cardiomyocytes under oxidative stress using a nucleic acid probe

Shuo Li, Xiang-Yu Pei, Xin-Yi Liu, Shu-Liang Wang, Wen Xu, Jing-Jing Wang, Zhen Feng, Han Ding, Yin-Feng Zhang and Rui Zhang

Heliyon, 2024, 10, e33588
DOI: 10.1016/j.heliyon.2024.e33588

A Unique Y-Shaped DNA Probe for MicroRNA-21 Detection and the Mechanism of Fluorescence Amplification

Longsheng Zhang, Pengfei Chen, Haonan Xu, Yanqin Huang, Pengfei Sun, Xingfen Liu and Quli Fan

IEEE Sensors J., 2026, 26, 9842
DOI: 10.1109/JSEN.2026.3660061

Simulation‐Guided Rational Design of DNA Walker‐Based Theranostic Platform

Jingyan Mou, Haoping Zhang, Linghao Zhang, Beibei Zhang, Jiajia Liu, Shasha Zheng, Qiaoni Kou, Hong Wang, Xin Su, Shaojun Guo, Yonggang Ke and Yingwei Zhang

Small, 2024, 20
DOI: 10.1002/smll.202400963

Application of electrochemical biosensors for the detection of microRNAs (miRNAs) related to cancer

Masoud Negahdary and Lúcio Angnes

Coordination Chemistry Reviews, 2022, 464, 214565
DOI: 10.1016/j.ccr.2022.214565

Signal-on/signal-off bead-based assays for the multiplexed monitoring of base excision repair activities by flow cytometry

Guillaume Gines, Charlotte Brusa, Christine Saint-Pierre and Didier Gasparutto

Anal Bioanal Chem, 2022, 414, 2029
DOI: 10.1007/s00216-021-03849-9

A two-dimensional nanosheet-enhanced fluorescent biosensor with nucleic acid amplification for breast cancer-related miRNA detection

Xinyi Xia, Yuanchao Qi, Qingshan Chen, Huan Gong, Meixiang Yu, Xuemei Di, Jie Fan, Ping Yu, Xia Cheng and Hai Zhang

Talanta, 2026, 306, 129716
DOI: 10.1016/j.talanta.2026.129716

Machine Learning-Aided Identification of Fecal Extracellular Vesicle microRNA Signatures for Noninvasive Detection of Colorectal Cancer

Zhaowei Zhang, Xuyang Liu, Chuanyue Peng, Rui Du, Xiaoqin Hong, Jia Xu, Jiaming Chen, Xiaomin Li, Yujing Tang, Yuwei Li, Yang Liu, Chen Xu and Dingbin Liu

ACS Nano, 2025, 19, 10013
DOI: 10.1021/acsnano.4c16698

The role of micro-ribonucleic acid and small interfering-ribonucleic acid in precision nutrition for obesity management

Wardina Humayrah, Nindy Sabrina, Megah Stefani, Nurpudji Astuti Taslim, Reggie Surya, Matthew Nathaniel Handoko, Vincent Lau, Hardinsyah Hardinsyah, Trina Ekawati Tallei, Rony Abdi Syahputra and Fahrul Nurkolis

Clinical Nutrition ESPEN, 2025, 67, 463
DOI: 10.1016/j.clnesp.2025.03.049

Direct and accurate miRNA detection based on CRISPR/Cas13a-triggered exonuclease-iii-assisted colorimetric assay

Yunxiao Li, Qiuxia Wang and Yali Wang

J Anal Sci Technol, 2024, 15
DOI: 10.1186/s40543-024-00434-4

Product-induced catalytic amplification strategy based on DNA tetrahedron for detection of miRNA-21 in colorectal cancer

Kaihang Yu, Zhiyi Wu and Lizhu Yang

Talanta, 2025, 285, 127354
DOI: 10.1016/j.talanta.2024.127354

ICPMS based multiplexed bioassay: Principles, approaches and progresses

Ziyan Li, Rui Liu and Yi Lv

Applied Spectroscopy Reviews, 2023, 58, 39
DOI: 10.1080/05704928.2021.1918703

A novel entropy-driven dual-output mode integrated with DNAzyme for enhanced microRNA detection

Jianhong Zhang, Dan Bai, Guoming Xie, Yaxing Xie, Yu Lin, Yulei Hou, Ying Yu, Yaoyi Zhang, Rong Zhao, Zhongzhong Wang, Luojia Wang and Hui Chen

Talanta, 2024, 275, 126123
DOI: 10.1016/j.talanta.2024.126123

Study of reaction-diffusion controlled mass transport in stopped-flow fluidics for spatiotemporal multiplexing

Marcel Tintelott, Pradnya Gharpure, Yannick Coffinier, Xuan Thang Vu, Alexis Vlandas, Sven Ingebrandt and Vivek Pachauri

Physics of Fluids, 2023, 35
DOI: 10.1063/5.0146585

Dual-colorimetric amplification biosensor based on GNPs and G-quadruplex/hemin DNAzyme for multiplexed microRNAs

Juan Su, Weimin Ge, Yan Su, Xuemei Chen, Xingqi Zhao, Rui Ding, Ke Shi and Zhengyuequan Liu

Talanta, 2026, 297, 128682
DOI: 10.1016/j.talanta.2025.128682

Y-shaped nanoprobe-based DNA microarray for rapid detection of multiplex miRNAs with single-nucleotide specificity

Yichen Du, Rui Sun, Shuang Hao, Fuwan Yang, Qifei Hu and Ruyan Xue

Microchemical Journal, 2026, 222, 117169
DOI: 10.1016/j.microc.2026.117169

Single-Molecule Sensor for High-Confidence Detection of miRNA

Kalani M. Wijesinghe, Mazhar A. Kanak, J. Chuck Harrell and Soma Dhakal

ACS Sens., 2022, 7, 1086
DOI: 10.1021/acssensors.1c02748

Lighting up plants with near-infrared fluorescence probes

Yida Pang, Mengjiao Lu, Hyeonji Rha, Wenchao Yang, Amit Sharma, Yao Sun and Jong Seung Kim

Sci. China Chem., 2024, 67, 774
DOI: 10.1007/s11426-023-1815-9

Molecular Encoded Beads for Multiplexed Nucleic Acid Quantitative Detection

Wen Cheng, Wanyan Zeng, Jiahao Fan, Jiacheng Li, Yixuan Wu, Xiaohai Yang, Kemin Wang and Jin Huang

Anal. Chem., 2025, 97, 18292
DOI: 10.1021/acs.analchem.5c03432

Quantitative and Multiplexing Analysis of MicroRNAs by Direct Full-Length Sequencing in Nanopores

Chenzhi Shi, Donglei Yang, Xiaowei Ma, Yun Chen, Pengfei Hou, Li Pan, Min Li and Pengfei Wang

J. Am. Chem. Soc., 2025, 147, 15614
DOI: 10.1021/jacs.5c02808

Plasmon‐Enhanced Ultrasensitive Digital Imaging Immunoassay for the Quantification of microRNAs Assisted by Convolutional Neural Network Analysis

Zhongwen Long, Xinyu Shen, Xiaobo Zhang, Hui Zhang, Qianwei Zhou, Cheng Yang, Yuzhang Liang and Ting Xu

Adv Funct Materials, 2023, 33
DOI: 10.1002/adfm.202210561

The clinical implications of circulating microRNAs as potential biomarkers in screening oral squamous cell carcinoma

Huan Gao, Yi Shen, Zhengyang Feng, Yuxing Cai, Jianxin Yang, Yaqun Zhu and Qiliang Peng

Front. Oncol., 2022, 12
DOI: 10.3389/fonc.2022.965357

Detection of Exosomal MicroRNA with Hybrid Plasmonic Nanoheater‐Driven PCR for Pulmonary Fibrosis Progression

Yu Zhang, Jin Li, Yixuan Wu, Yunqing Wang, Xiaoyan Wang, Changjun Lv and Lingxin Chen

Small, 2026, 22
DOI: 10.1002/smll.202510264

Start small, think big: MicroRNAs in diabetes mellitus and relevant cardiorenal-liver metabolic health spectrum

Junren Chen, Maozhu Luo, Ziwei Xing, Yu Chen, Cheng Peng and Dan Li

Metabolism, 2025, 165, 156153
DOI: 10.1016/j.metabol.2025.156153

A Universal Strategy for Enhancing the Circulating miRNAs’ Detection Performance of Rolling Circle Amplification by Using a Dual-Terminal Stem-Loop Padlock

Hanqing Xu, Xianlan Wu, Qian Liu, Cheng Yang, Man Shen, Yingran Wang, Shuai Liu, Shuang Zhao, Ting Xiao, Minghui Sun, Zishan Ding, Jing Bao, Ming Chen and Mingxuan Gao

ACS Nano, 2024, 18, 436
DOI: 10.1021/acsnano.3c07721

An ultrasensitive one-pot Cas13a-based microfluidic assay for rapid multiplexed detection of microRNAs

Ya Zhang, Rouyu Su, Zheng Zhang, Yiyue Jiang, Yejia Miao, Shiqi Zhou, Miaomiao Ji, Chih-Wen Hsu, Hongpan Xu, Zhiyang Li and Guanghui Wang

Biosensors and Bioelectronics, 2025, 274, 117212
DOI: 10.1016/j.bios.2025.117212

Biomolecule Detection Methods Based on Nanoparticle Approaches

Tiexin Li, Zane Datson, Nadim Darwish and Francisco J. Lopez-Ruiz

ACS Omega, 2026, 11, 20002
DOI: 10.1021/acsomega.6c00231

Advancements in nanobiosensor technologies for in-vitro diagnostics to point of care testing

Chuntae Kim, Moon Sung Kang, Iruthayapandi Selestin Raja, Yoon Ki Joung and Dong-Wook Han

Heliyon, 2024, 10, e40306
DOI: 10.1016/j.heliyon.2024.e40306

Rational engineering of nucleic acid probe system for enhanced intracellular MicroRNA detection

Fan Yang, Huiting Lu, Xiangdan Meng, Liping Li, Wenhao Dai, Lingzhi Yang, Ruiping Zhang, Haifeng Dong and Xueji Zhang

Coordination Chemistry Reviews, 2023, 487, 215157
DOI: 10.1016/j.ccr.2023.215157

Precise diagnostics of multidimensional disease biomarkers via programmable DNA logic nanodevice integrated with signal-amplified visual readout

Sihui Yang, Zhi-Hui Xiao, Miao Wang, Li-Li Wang and Yan-Hua Tang

Sensors and Actuators B: Chemical, 2026, 458, 139836
DOI: 10.1016/j.snb.2026.139836

A two-chip acoustofluidic microdroplet centrifugation platform for high-sensitivity detection of miRNA

Fahui Dong, Zhi Yu, Xiaoxia Yang, Jie Chen, Luoke Hu, Yong Wang and Jingang Han

Sensors and Actuators A: Physical, 2025, 392, 116718
DOI: 10.1016/j.sna.2025.116718

Ultrasensitive and highly selective detection of miRNA via one-pot ligation refractory mutation system-quantitative PCR (LRMS-qPCR)

Yuebiao Tang, Houqi Wang, Yangqing Zhong, Huimin Liao, Haoliang Yin, Huiyun Xie, Hai Yi, Huixian Sun, Weilong Zhang, Suhui He, Zhaoyang Xie, Luxin Yu and Zhangquan Chen

Microchemical Journal, 2025, 210, 113019
DOI: 10.1016/j.microc.2025.113019

An RNA-based catalytic hairpin assembly circuit coupled with CRISPR-Cas12a for one-step detection of microRNAs

Pinru Chen, Luying Wang, Peipei Qin, Bin-Cheng Yin and Bang-Ce Ye

Biosensors and Bioelectronics, 2022, 207, 114152
DOI: 10.1016/j.bios.2022.114152

基于表面等离激元共振的液体活检技术研究进展（特邀）

曹健荣 Cao Jianrong, 李法君 Li Fajun, 王秀琦 Wang Xiuqi, 朱锦锋 Zhu Jinfeng, 徐国兵 Xu Guobing and 潘思骏 Pan Sijun

Chin. J. Laser, 2025, 52, 0907401
DOI: 10.3788/CJL241350

High-throughput quantitative detection of triple-negative breast cancer-associated expressed miRNAs by rolling circle amplification on fluorescence-encoded microspheres

Jieyu Liu, Liming Zhang, Wentao Zeng, Lihua Zhang, Nongyue He and Zhuoxuan Lu

Chinese Chemical Letters, 2023, 34, 108141
DOI: 10.1016/j.cclet.2023.108141

Non-invasive colorectal cancer screening methods: focusing on diagnostic genetic and epigenetic markers

Ghazaleh Behrouzian Fard, Razieh Amirfakhrian, Mahdi Hosseini Bafghi and Mehran Gholamin

Cancer Cell Int, 2025, 26
DOI: 10.1186/s12935-025-04097-y

MicroRNAs in drug addiction: Current status and future perspectives

Yue Zhao, Feng Qin, Shuang Han, Shu Li, Ying Zhao, Hongbo Wang, Jingwei Tian and Xiaobo Cen

Pharmacology & Therapeutics, 2022, 236, 108215
DOI: 10.1016/j.pharmthera.2022.108215

A Comprehensive Review on Capillary Electrophoresis–Mass Spectrometry in Advancing Biomolecular Research

Laura Pont, María Vergara‐Barberán and Enrique Javier Carrasco‐Correa

Electrophoresis, 2025, 46, 1053
DOI: 10.1002/elps.202400122

Hydrogel-Based Microdroplet Ensembles Encapsulating Multiplexed EXPAR Assays for Trichromic Digital Profiling of MicroRNAs and in-Depth Classification of Primary Urethral Cancers

Chanyu Yao, Qiang Wang, Xiaohui Lu, Xiaofeng Chen and Zheng Li

Nano Lett., 2024, 24, 15861
DOI: 10.1021/acs.nanolett.4c04898

DNA Logical Computing on a Transistor for Cancer Molecular Diagnosis

Derong Kong, Shen Zhang, Xinye Ma, Yuetong Yang, Changhao Dai, Li Geng, Yunqi Liu and Dacheng Wei

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202407039

A novel magnetic fluorescent nanoprobe for simultaneous separation and identification of microRNA199a in breast cancer

Delaram Enteshari, Razieh Ghasemi and Flora Forouzesh

Biochemical Engineering Journal, 2025, 218, 109676
DOI: 10.1016/j.bej.2025.109676

Optically encoded microspheres in liquid-phase suspension array technology for immunoluminescence diagnostics: A review

Jiuchuan Guo, Yiming Zhang, Bianzheng Wang, Yuxing Shi, Jingshan Duan, Chunhui Ren, Fuli Chen, Xing Ma and Jinhong Guo

Biosensors and Bioelectronics, 2025, 290, 117963
DOI: 10.1016/j.bios.2025.117963

Towards clinical application: Emerging strategies for ultrasensitive and selective miRNA detection

Yuhan Wang, Zijian Liu, Hen-Wei Huang, Jung Seung Lee, Kexin Liu, Mengru Yu and Xiaoyue Qi

TrAC Trends in Analytical Chemistry, 2026, 195, 118593
DOI: 10.1016/j.trac.2025.118593

Bimetallic and dual-ligands MOFs modified electrochemical sensor for fast and highly sensitive miR-21 detection

Zhikun Zhang, Ying Shi, Zhengjie Li, Jilong Han, Zhiyan Chen, Fangfang Ma, Yanchao Qi and Yumin Liu

Electrochimica Acta, 2025, 540, 147229
DOI: 10.1016/j.electacta.2025.147229

Laser-induced graphene (LIG)-based electrochemical microfluidic chip for simultaneous analysis of multiplex microRNAs

Xiaojuan Liu, Yue Wang, Yunhong Du, Jing Zhang, Yuying Wang, Yang Xue, Jiahui Zhao, Lei Ge, Limin Yang and Feng Li

Chemical Engineering Journal, 2024, 486, 150233
DOI: 10.1016/j.cej.2024.150233

AND Logic-Gate-Based Dual-Locking Probe System for the Sensitive Detection of microRNA and APE1

Jiani Wang, Xiaole Han, Hongyan Yu and Guoming Xie

Anal. Chem., 2024, 96, 9570
DOI: 10.1021/acs.analchem.4c01080

Development of an electrochemical biosensor based on rGO/Ag₂S-Au nanocomposites and L-CHA dual signal amplification for miR-155 detection

Shan Ou, Rui Li, Yonghua Yuan, Yueyuan Li, Lijuan Bai and Yuhan Chen

Biomedical Analysis, 2025, 2, 131
DOI: 10.1016/j.bioana.2025.11.002

Ultrasensitive miRNA detection via magnetic bead-confined catalytic hairpin assembly enabling transcription-driven crRNA assembly and CRISPR/Cas12a activation

Ming-Xi Pan, Meng-Mei Lv, Yin-Gang Nie, Mei Su, Cheng-Jun Zha, Ru-Yu Mei and Zhan-Ming Ying

Biosensors and Bioelectronics, 2026, 302, 118559
DOI: 10.1016/j.bios.2026.118559

Logical Analysis of Multiple miRNAs with Isothermal Molecular Classifiers Based on LATE-RCA

Tong Feng, Li Zhang, Ding Wang, Chen Zuo, Yaoyi Zhang, Di Wu, Weitao Wang, Hongyan Yu, Dan Bai, Huaixin Zhao, Yongcan Guo and Guoming Xie

Nano Lett., 2025, 25, 2576
DOI: 10.1021/acs.nanolett.5c00089

Exonuclease-based aptasensors: Promising for food safety and diagnostic aims

Ghasem Anbiaee, Zahra Khoshbin, Hamed Zahraee, Mohammad Ramezani, Mona Alibolandi, Khalil Abnous and Seyed Mohammad Taghdisi

Talanta, 2023, 259, 124500
DOI: 10.1016/j.talanta.2023.124500

Advances and Prospects in Liquid Biopsy Techniques for Malignant Tumor Diagnosis and Surveillance

Chengzhi Zhang, Tenghui Li, Qian Zhao, Rui Ma, Zhengchao Hong, Xuanzhang Huang, Peng Gao, Jingjing Liu, Junhua Zhao and Zhenning Wang

Small, 2024, 20
DOI: 10.1002/smll.202404709

Single molecule measurements of microRNAs in the serum of patients with pulmonary tuberculosis

Zhuhua Wu, Qiuchan Tan, Xiaojuan Jia, Huizhong Wu, Jing Liang, Wenpei Wen, Xuezhi Wang, Chenchen Zhang, Yuchuan Zhao, Yuhui Chen, Tingrong Luo, Wenjun Liu and Xunxun Chen

Front. Immunol., 2024, 15
DOI: 10.3389/fimmu.2024.1418085

Multiplex microRNA detection for breast cancer precise diagnosis by constructing split crRNA-based amplification-free CRISPR/Cas12a biosensor

Yeling Yang, Yufei Yang, Xuhua Mao, Wenhua Zhou, Xue-Feng Yu, Guobin Mao and Yingxin Ma

Chemical Engineering Journal, 2025, 522, 167489
DOI: 10.1016/j.cej.2025.167489

Proximity ligation initiated DNAzyme-powered catalytic hairpin assembly for sensitive and accurate microRNA analysis

Jiaguang Su, Wenjun Zheng and Yanbin Pan

Analytical Biochemistry, 2023, 680, 115299
DOI: 10.1016/j.ab.2023.115299

Hybrid layer-by-layer assembly of AuNPs/NSF composite for electrochemical detection of miRNA-196a

Jun Ji, Gaofan Shi, Jiayi Jiang, Shu Wu, Haoyuan Su, Hongzhi Pan and Dongdong Zeng

Discover Nano, 2024, 19
DOI: 10.1186/s11671-024-04127-0

A tetrahedral DNA-functionalized field effect transistor biosensor enhances ultrasensitive detection of extracellular vesicle microRNAs

Jikun Liu, Wanzhou Xu, Jiacheng Liu, Manqi Yu, Jiayin Xu, Yutao Li, Baoping Luo, Shi-Bo Cheng and Guo-Jun Zhang

Sensors and Actuators B: Chemical, 2026, 452, 139455
DOI: 10.1016/j.snb.2026.139455

Ferromagnetic Resonance Multiplexing of Orthogonal Magnetic Nanoparticle Agglutination for Simultaneous Analysis of Nucleic Acid Mutations and Nonspecific Interactions

Xiaoyan Zhang, Yuan Fang, Zhenhua Chen, Yilong He, Qian Gao, Zhuxin Dong, Zhongchao Huang and Bo Tian

Small, 2025, 21
DOI: 10.1002/smll.202502062

Efficient Detection of Biomarker of Radiation-Resistant Nasopharyngeal Carcinoma by Anchor Nucleic Acid Structure and DNase I Amplification

Zhiheng Lu, Yiyang Wu, Qingxiao Wang, Sen Li, Yanfei Cai and Zhaoqi Yang

NANO, 2023, 18
DOI: 10.1142/S1793292023500133

Triple-Layer locked nanodevice synergizes with Pd@PdPtRh nanozyme and 3D conductive nanocomplex for ultrasensitive dual-miRNA electrochemical biosensing

Xi Zhou, Li Zhang, Gaoli Zhang, Guoming Xie and Weixian Chen

Chemical Engineering Journal, 2025, 515, 163661
DOI: 10.1016/j.cej.2025.163661

Multiplex Nucleic Acid Assay of SARS-CoV-2 via a Lanthanide Nanoparticle-Tagging Strategy

Ziyan Li, Xue Chen, Zili Huang, Jing Zhou, Rui Liu and Yi Lv

Anal. Chem., 2021, 93, 12714
DOI: 10.1021/acs.analchem.1c02657

Catalytic Assembly of DNAzyme Integrates with Primer Exchange Reaction (CDiPER) for Highly Sensitive Detection of MicroRNA

Kun Zhang, Yan Li, Shengjie Jiang and Shang Ju

ACS Omega, 2024, 9, 10897
DOI: 10.1021/acsomega.3c10003

Validation of a Bead-Based Multiplex Assay for miRNA Quantification in Rat Liver Inflammation

Eun Kyeong Lee, Eun-Jeong Jeon, So-Hyeon Han, Eun Young Jang and Kyung Jin Jung

ACS Omega, 2026
DOI: 10.1021/acsomega.5c09640

Transcriptomic and microRNA profiling of peripheral blood mononuclear cells: A hypothesis for detecting erythropoietin gene doping in athletes

Sushmita Kumari, Jayaseelan Murgaiyan and Ankur Sharma

Medical Hypotheses, 2026, 206, 111843
DOI: 10.1016/j.mehy.2025.111843

Label-free detection of let-7a using AuNPs-coated polystyrene microparticles

Bonghyeok Eom, Sunghyun Ki, Soongwon Cho and Dong-Ku Kang

Microchemical Journal, 2025, 216, 114590
DOI: 10.1016/j.microc.2025.114590

Flexible-Arranged Biomimetic Array Integrated with Parallel Entropy-Driven Circuits for Ultrasensitive, Multiple, and Reliable Detection of Cancer-Related MicroRNAs

Ziyi Tian, Chuyan Zhang, Mengfan Wu, Jie Luo, Huiling Zhou, Yixiang Duan and Yongxin Li

ACS Sens., 2024, 9, 1290
DOI: 10.1021/acssensors.3c02183

Simple Amplifier Coupled with a Lanthanide Labeling Strategy for Multiplexed and Specific Quantification of MicroRNAs

Qi Kang, Beibei Chen, Man He and Bin Hu

Anal. Chem., 2022, 94, 12934
DOI: 10.1021/acs.analchem.2c03234

A precision miRNA-21 detection method based on self-powered biosensors

Hui Li, Jing Xu, Guanghui Chen, Huiling Wang and Zongshan Zhang

Biochemical Engineering Journal, 2024, 205, 109259
DOI: 10.1016/j.bej.2024.109259

Highly sensitive and facile microRNA detection based on target triggered exponential rolling-circle amplification coupling with CRISPR/Cas12a

Shiying Zhou, Human Sun, Jiangbo Dong, Peng Lu, Liyuan Deng, Yin Liu, Mei Yang, Danqun Huo and Changjun Hou

Analytica Chimica Acta, 2023, 1265, 341278
DOI: 10.1016/j.aca.2023.341278

Programmable Dual-Phase Electrochemical Biosensor Combines Homogeneous CRISPR/Cas12a Activation with Interfacial Poly-G Signaling for miRNA-21 Detection

Jia Zhao, Zhuqi Sui, Yi Wang, Haiyan Dong, Baoqiang Chen and Jianguo Xu

Anal. Chem., 2025, 97, 20515
DOI: 10.1021/acs.analchem.5c04010

Hitchhiking Delivery Systems: Therapeutic Hydrogels as Advanced Tools for Immunomodulatory Applications

Yue Zhao, Shanliang Song, Junmin Zhang, Xiangzhong Ren and Yanli Zhao

Chem. Rev., 2025, 125, 8089
DOI: 10.1021/acs.chemrev.4c00923

Formation of miRNA Nanoprobes—Conjugation Approaches Leading to the Functionalization

Iveta Vilímová, Katel Hervé-Aubert and Igor Chourpa

Molecules, 2022, 27, 8428
DOI: 10.3390/molecules27238428

Amplification-Free Testing of microRNA Biomarkers in Cancer

Bahareh Soleimanpour, Juan Jose Diaz Mochon and Salvatore Pernagallo

Cancers, 2025, 17, 2715
DOI: 10.3390/cancers17162715

Amplification-free microRNA profiling with femtomolar sensitivity on a plasmonic enhanced fluorescence nano-chip

Ruibin Hu, Yiyi Liu, Guanghui Wang, Jiahui Lv, Jingkai Yang, Hongjun Xiao, Ying Liu and Bo Zhang

Analytica Chimica Acta, 2023, 1280, 341870
DOI: 10.1016/j.aca.2023.341870

Enhancing multiplex detection capabilities of the Cas12a/blocker DNA system

Junhyeong Kim, Gun Haeng Lee, Daehan Nam and Ki Soo Park

Talanta, 2025, 281, 126864
DOI: 10.1016/j.talanta.2024.126864

Exponential rolling circle amplification-hybridization chain reaction (EXRCA-HCR) for AgNPs@gel-enhanced fluorescence ultrasensitive detection of miRNA-21

Wenjiao Zhang, Yuchen Song, Dongmei Deng, Meiyin Liu, Huinan Chen, Wanyi Zhang, Hong Lei, Zhiguo Li and Liqiang Luo

Analytica Chimica Acta, 2025, 1358, 344095
DOI: 10.1016/j.aca.2025.344095

Programmable Analysis of MicroRNAs by Thermus thermophilus Argonaute-Assisted Exponential Isothermal Amplification for Multiplex Detection (TEAM)

Qiuyuan Lin, Guobin Han, Xueen Fang, Hui Chen, Wenhao Weng and Jilie Kong

Anal. Chem., 2022, 94, 11290
DOI: 10.1021/acs.analchem.2c01945

Electrochemiluminescence Cascade Amplification Platform for Detection of Dual-microRNA and Operation of Concatenated Logic Circuit

Liping Zhu, Linying Yu and Xiurong Yang

Anal. Chem., 2022, 94, 17279
DOI: 10.1021/acs.analchem.2c04242

Direct Fluorescence Anisotropy Detection of miRNA Based on Duplex-Specific Nuclease Signal Amplification

Huilan Wu, Xiaoting Ling, Shoulong Huang, Qiang Zhao, Dapeng Zhang and Hailin Wang

Anal. Chem., 2025, 97, 8574
DOI: 10.1021/acs.analchem.5c00723

Click chemical ligation-enabled digital particle counting for multiplexed microRNA analysis

Dailu Jia, Wenjiao Fan, Wei Ren and Chenghui Liu

Biosensors and Bioelectronics, 2024, 261, 116508
DOI: 10.1016/j.bios.2024.116508

Overview of MicroRNAs as Diagnostic and Prognostic Biomarkers for High-Incidence Cancers in 2021

Chunyan Zhang, Caifang Sun, Yabin Zhao, Qiwen Wang, Jianlin Guo, Bingyu Ye and Guoying Yu

IJMS, 2022, 23, 11389
DOI: 10.3390/ijms231911389

Construction of a light-up multicolor fluorescent aptasensor for simultaneous measurement of multiple miRNAs in breast cancer tissues

Zichen Jiao, Ning-ning Zhao, Shu-hua Wei, Dong-ling Li, Tao Wang and Chun-yang Zhang

Sensors and Actuators B: Chemical, 2025, 433, 137542
DOI: 10.1016/j.snb.2025.137542

A novel high-fidelity DNA polymerase-driven or Taq DNA polymerase-driven one-pot miRNA multiplex RT-qPCR method mediated by RT-HOS

Guodong Zhao, Yanmiao Dai, Chenjing Xia, Ying Xue and Hongwei Xu

Sensors and Actuators B: Chemical, 2025, 445, 138559
DOI: 10.1016/j.snb.2025.138559

Surface-enhanced Raman scattering biosensors for detection of oncomiRs in breast cancer

Prachi Chauhan, Arpit Bhargava, Roshani Kumari, Pooja Ratre, Rajnarayan Tiwari, Rupesh Kumar Srivastava, Irina Yu. Goryacheva and Pradyumna Kumar Mishra

Drug Discovery Today, 2022, 27, 2121
DOI: 10.1016/j.drudis.2022.04.016

Aptasensors in colorectal Cancer: Emerging tools for precision diagnostics

Qamar Abuhassan, Ali M. Atoom, R. Roopashree, Jaya Bhanu Kanwar, T. Sudhakar, Vipasha Sharma, Ashish Singh Chauhan and Oybek Ruziyev

Clinica Chimica Acta, 2026, 581, 120751
DOI: 10.1016/j.cca.2025.120751

Aptasensing Technology and Its Potential Applications: Where Do We Stand?

Jhilik Roy, Neelanjana Bag, Shubham Roy, Dhananjoy Mondal, Tingting Gong, Rajib Mondal, Bing Guo, Ruma Basu and Sukhen Das

Mol. Pharmaceutics, 2025, 22, 3578
DOI: 10.1021/acs.molpharmaceut.5c00352

Multiplexed Single-Molecule Detection of Nucleic Acid Biomarkers with a Distance-Tuned Single FRET Pair

Srishty Sethi, Kalani M. Wijesinghe, Md Monirul Islam, J. Chuck Harrell and Soma Dhakal

Anal. Chem., 2025, 97, 18918
DOI: 10.1021/acs.analchem.5c01039

Single Nanoparticle Counting-Based Liquid Biopsy for Cancer Diagnosis

Min Jiang, Jing Zhou, Xiaobo Xie, Zili Huang, Rui Liu and Yi Lv

Anal. Chem., 2022, 94, 15433
DOI: 10.1021/acs.analchem.2c03367

A ZIF-8@DNAzyme-based DNA walker nanosystem for microRNAs sensing in living cells with high accuracy

Birong Liu, Mengxu Sun, Tong Li, Pengying Liang, Qianying Zhou, Mingqi Guo, Chunrong Li, Wen-Jun Duan, Min-Min Li, Jin-Xiang Chen, Bao-Ping Xie, Zong Dai and Jun Chen

Sensors and Actuators B: Chemical, 2023, 387, 133812
DOI: 10.1016/j.snb.2023.133812

Ultrasensitive and multiplexed miRNA detection system with DNA-PAINT

Samet Kocabey, Germán Chiarelli, Guillermo P. Acuna and Curzio Ruegg

Biosensors and Bioelectronics, 2023, 224, 115053
DOI: 10.1016/j.bios.2022.115053

Compartmentalized Suspension Array for the Isothermal, Digital, and Multiplex Detection of microRNAs

Thomas Jet, Coline Kieffer, Yannick Rondelez, Valérie Taly and Guillaume Gines

J. Am. Chem. Soc., 2025, 147, 25705
DOI: 10.1021/jacs.5c07214

Highly Magnetized Encoded Hydrogel Microparticles with Enhanced Rinsing Capabilities for Efficient microRNA Detection

Wookyoung Jang, Jiwoo Kim, Seok Joon Mun, Sun Min Kim and Ki Wan Bong

Biomedicines, 2021, 9, 848
DOI: 10.3390/biomedicines9070848

Exonuclease-iii -propelled DNAzyme cascade for sensitive and reliable cervical cancer related miRNA analysis

Hongli Wang, Daoli Wang and Yehong Xu

Analytical Biochemistry, 2024, 691, 115547
DOI: 10.1016/j.ab.2024.115547

Circulating microRNAs: A remarkable opportunity as non-invasive biomarkers from adult to pediatric brain tumor patients

Federica D’Antonio, Zaira Spinello, Lavinia Bargiacchi, Elena Splendiani, Sabrina Rossi, Laura Masuelli, Angela Mastronuzzi, Franco Locatelli, Elisabetta Ferretti and Giuseppina Catanzaro

Critical Reviews in Oncology/Hematology, 2025, 208, 104650
DOI: 10.1016/j.critrevonc.2025.104650

CRISPR CLAMP: Attomolar level of multiple miRNAs

Yiming Zhang, Zhi Chen, Songrui Wei, Jing Wang, Yujun Zhang, Huiling Lin, Hai Fu, Yingxia Liu, Qi Gao, Han Zhang and Zhongjian Xie

Chemical Engineering Journal, 2025, 511, 161990
DOI: 10.1016/j.cej.2025.161990

Toehold Strand Displacement-Mediated Exponential HCR for Highly Sensitive and Specific Analysis of miRNA in Living Cells

Mengxu Sun, Qianying Zhou, Jing Peng, Simin Liu, Jiaxin Luo, Lingling Bai, Wen-Jun Duan, Jin-Xiang Chen, Zong Dai and Jun Chen

Anal. Chem., 2024, 96, 9078
DOI: 10.1021/acs.analchem.4c00594

Ultrasensitive miRNA-21 detection via catalytic hairpin assembly-enhanced light-initiated chemiluminescence for early cancer diagnosis

Suzhen Zhang, Rongzhi Liu, Ruikang Liu, Xueqin Zhao, Hongming Fang, Yaping Zhang, Yuan Qin and Biao Huang

Talanta, 2026, 298, 128913
DOI: 10.1016/j.talanta.2025.128913

BSA‐Gold Nanoclusters Enhanced Clusterization‐Triggered–Emission of Nonconventional Luminophores‐Hydrogels in Dilute Aqueous Solution

Fengjiao Chen, Hao Dang, Hanlin Li, Hongbin Su, Liuxian Chen, Yao Gong, Lanxin Jiang, Hua Tang, Rui Chen and Wei Cheng

Adv Funct Materials, 2024, 34
DOI: 10.1002/adfm.202313098

Sensing multiplex microRNAs using dual-functional fork-type-track DNA nanomachine on optical fiber

Siqi Zhao, Yaxue Jia, Anping Wang, Shuai Yang, Jiahui Fu, Jinlan Yang and Li Yang

Sensors and Actuators B: Chemical, 2024, 413, 135873
DOI: 10.1016/j.snb.2024.135873

Sample-to-answer detection of miRNA from whole blood using thermally responsive alkane partitions

Evan H. Benke, David J. Boegner, Alejandra M. Bogusch and Ian M. White

Biosensors and Bioelectronics, 2025, 271, 117052
DOI: 10.1016/j.bios.2024.117052

Emerging Nanotechnological Strategies in Salivary and Blood Biomarker Detection for Oral Cancer

Ehsan Khaksar, Razieh Amiri, Fatemeh Zarei, Melika Rezaei, Milad Saeedzadeh and Yasamin Ghahramani

Adv. Appl. NanoBio. Technol., 2025, 6, 23
DOI: 10.18502/aanbt.v6i3.18619

Short prokaryotic Argonaute systems trigger cell death upon detection of invading DNA

Balwina Koopal, Ana Potocnik, Sumanth K. Mutte, Cristian Aparicio-Maldonado, Simon Lindhoud, Jacques J.M. Vervoort, Stan J.J. Brouns and Daan C. Swarts

Cell, 2022, 185, 1471
DOI: 10.1016/j.cell.2022.03.012

Integrated triple signal amplification strategy for ultrasensitive electrochemical detection of gastric cancer-related microRNA utilizing MoS2-based nanozyme, hybridization chain reaction, and horseradish peroxidase

Jianfeng Ma, Qunyan Yao, Suo Lv, Jiasheng Yi, Dan Zhu, Changfeng Zhu, Lianhui Wang and Shao Su

J Nanobiotechnol, 2024, 22
DOI: 10.1186/s12951-024-02848-z

Size-Coded Hydrogel Microbeads for Extraction-Free Serum Multi-miRNAs Quantifications with Machine-Learning-Aided Lung Cancer Subtypes Classification

Dayu Chen, Yingfei Wang, Ying Wei, Zhenda Lu, Huangxian Ju, Feng Yan and Ying Liu

Nano Lett., 2025, 25, 453
DOI: 10.1021/acs.nanolett.4c05233

Polyethylene Glycol Nanofiller for Robust Lyophilization of Graphically Encoded Hydrogel Microparticles

Wookyoung Jang, Ji Won Byun, Jun Hee Choi, Bolam Kim and Ki Wan Bong

Small, 2025, 21
DOI: 10.1002/smll.202503007

Advances in MoS2‐Au Nanostructured Platforms for Cancer‐Derived miRNA Detection

Faith Mokobi Zablon, Kristen Dellinger and Shyam Aravamudhan

Adv Materials Inter, 2026
DOI: 10.1002/admi.202500997

Design of portable electrochemiluminescence sensing systems for point-of-care-testing applications

Shuqi Xia, Jiangfei Pan, Deshen Dai, Zong Dai, Mengsu Yang and Changqing Yi

Chinese Chemical Letters, 2023, 34, 107799
DOI: 10.1016/j.cclet.2022.107799

Single particle mediated CRISPR/Cas13a ultrasensitive direct detection of miRNA-21 at femtomolar levels without nucleic acid amplification

Nandi Chen, Xiao Sun, Shaoxia Liang, Chong Cao, Xuandi Lai, Chunyan Song, Zhigang Yan and Chenchen Ge

Microchim Acta, 2026, 193
DOI: 10.1007/s00604-026-07861-7

Embarking on a journey through Micro-RNA and Circular-RNA detection methods

Zhaleh Asadi Fakhr, Xinlan Zhu, Hechen Wang, Ruiyang Ma, Ziwei Lin, Xudan Shen, Jiatong Liu, Su Zeng and Sheng Cai

TrAC Trends in Analytical Chemistry, 2024, 181, 118035
DOI: 10.1016/j.trac.2024.118035

Catapult-like DNA actuator for highly stable and ultrasensitive detection of urinary miRNA

Jae Chul Park, Sungwook Park, Seunghwan Bang, Hyunro Kim, Yongjin Lee, Min Gu Park, Sung Goo Yoon, Youngdo Jeong, Hojun Kim, Seok Ho Kang and Kwan Hyi Lee

Chemical Engineering Journal, 2025, 506, 159806
DOI: 10.1016/j.cej.2025.159806

DNA Logical Computing on a Transistor for Cancer Molecular Diagnosis

Derong Kong, Shen Zhang, Xinye Ma, Yuetong Yang, Changhao Dai, Li Geng, Yunqi Liu and Dacheng Wei

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202407039

Molybdenum disulfide based nanohybrids: insights into their role in electrochemical cancer biomarker detection

Naveen Thanjavur and Young-Joon Kim

Biomed. Eng. Lett., 2026
DOI: 10.1007/s13534-026-00562-3

Fluidic Spatial-Confinement Scaffold Affords a Multicomponent DNA Reaction with Improved Efficiency and Accelerated Kinetics

Qiming Rong, Huijun Hu, Mei Zhang, Lu Liu, Guoliang Ke and Xiao-Bing Zhang

Anal. Chem., 2023, 95, 8105
DOI: 10.1021/acs.analchem.3c01127

Aptamers and New Bioreceptors for the Electrochemical Detection of Biomarkers Expressed in Hepatocellular Carcinoma

Alexandra Pusta, Mihaela Tertis, Florin Graur, Cecilia Cristea and Nadim Al Hajjar

CMC, 2022, 29, 4363
DOI: 10.2174/0929867329666220222113707

miRquad: first-in-class dPCR multiplex TaqMan™ Advanced clinical research assay for microRNA detection in head and neck cancer

Matteo Allegretti, David J. Joun, Giulia Urbani, Valentina De Pascale, Federica Ganci, Raul Pellini, Giada Anna Beltramini, Stefano Ferrero, Stefano Fiori, Tania Moccia, Chiara Ciardiello, Elena Di Gennaro, Alfredo Budillon, Luca Sigalotti, Roberta Maestro, Mario Urtis, Eloisa Arbustini, Simona De Summa, Amalia Azzariti, Stella Gagliardi, Antonio Pisani, Gennaro Ciliberto, Paola Cornelia Maria Muti, Junko F. Stevens and Giovanni Blandino

J Exp Clin Cancer Res, 2025, 45
DOI: 10.1186/s13046-025-03590-6

Framework Nucleic Acid-Based Spatial-Confinement Amplifier for miRNA Imaging in Living Cells

Yinghui Feng, Qi Liu, Xinyi Zhao, Miao Chen, Xiaotong Sun, Hexiang Li and Xiaoqing Chen

Anal. Chem., 2022, 94, 2934
DOI: 10.1021/acs.analchem.1c04866

G-wire-based self-quenched fluorescence probe combining with target-activated isothermal cascade amplification for ultrasensitive microRNA detection

Qingyou Cai, Fanfan Wang, Jingying Ge, Zhiguo Xu, Mei Li, Hui Xu and Hua Wang

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022, 281, 121605
DOI: 10.1016/j.saa.2022.121605

Sequence Requirements for miR-424-5p Regulating and Function in Cancers

Jiangying Xuan, Yingxia Liu, Xiaoping Zeng and Hongmei Wang

IJMS, 2022, 23, 4037
DOI: 10.3390/ijms23074037

Emerging electrochemiluminescence biosensing and visual technique for potential applications in point-of-care testing of microRNAs

Yuyi Zhou, Yu Lin, Rongxian Ma, Xuecai Tan, Hu Luo and Kejing Huang

Sensors and Actuators B: Chemical, 2023, 392, 134073
DOI: 10.1016/j.snb.2023.134073

Engineered RNA Devices for In Vivo Targeted Therapeutics via Advanced Delivery Systems

Wei Luo, Xia Liu, Ying Han, Yijing Duan, Chuao Yu, Na Kong and Tian Xie

Aggregate, 2025, 6
DOI: 10.1002/agt2.70191

MicroRNAs in disease States

Mehdi Alizadeh, Hassan Ghasemi, Donya Bazhan, Neshat Mohammadi Bolbanabad, Fereshteh Rahdan, Narges Arianfar, Farzaneh Vahedi, Seyyed Hossein Khatami, Mortaza Taheri-Anganeh, Saleh Aiiashi and Nezam Armand

Clinica Chimica Acta, 2025, 569, 120187
DOI: 10.1016/j.cca.2025.120187

Multiplexed Salivary miRNA Quantification for Predicting Severe COVID-19 Symptoms in Children Using Ligation-RPA Amplification Assay

Md. Ahasan Ahamed, Zhikun Zhang, Aneesh Kshirsagar, Anthony J. Politza, Usha Sethuraman, Srinivasan Suresh, Steven Hicks, Feng Guo and Weihua Guan

ACS Sens., 2025, 10, 5150
DOI: 10.1021/acssensors.5c01275

PCR‐ and wash‐free detection of serum miRNA via signaling probe hybridization

Haruka Uno, Hiyori Takeuchi, Ishin Abe, Tomoko Yoshino, Tomoyuki Taguchi, Yuko Hirakawa, Tadashi Matsunaga and Tsuyoshi Tanaka

Biotech & Bioengineering, 2025, 122, 159
DOI: 10.1002/bit.28859

Nicked RCA-assisted self-assembling MNAzyme coupled with fluorogenic aptamer for label-free detection of miRNA

Xiang Li, Meng-mei Lv, Hao Liu, Yin-Gang Nie and Zhan-Ming Ying

Sensors and Actuators B: Chemical, 2025, 429, 137278
DOI: 10.1016/j.snb.2025.137278

A novel hybrid biosensor for miRNA detection based on peptide nucleic acids and molecularly imprinted polymers

Muhammed Abdel-Hamied, Min Guo, Yiming Wei, Joachim Bansmann, Rasha M. El Nashar, Franz Oswald, Boris Mizaikoff and Christine Kranz

Bioelectrochemistry, 2025, 165, 108964
DOI: 10.1016/j.bioelechem.2025.108964

Femtomolar miRNA-21 detection in serum via a Y-shaped DNA assembly amplified catalytic hairpin assembly and Bi@PtAg nanocatalyst-driven electrochemical biosensor

Yuanhui Ma, Xi Liu, Minjie Yang, Ling Zha, Ying Huang, Dong Sun, Ruizhuo Ouyang, Yuqin Jiang, Yuqing Miao and Baolin Liu

Sensors and Actuators B: Chemical, 2026, 457, 139728
DOI: 10.1016/j.snb.2026.139728

Ultrasensitive, rapid, and highly specific detection of microRNAs based on PER-CRISPR/CAS

Ze Wang, Hongguo Wei, Shengjun Bu, Xue Li, Hongyu Zhou, Wenhui Zhang and Jiayu Wan

Bioorganic & Medicinal Chemistry Letters, 2022, 74, 128949
DOI: 10.1016/j.bmcl.2022.128949

Programmable Microparticle Array for In Situ Modification and Multiple miRNA Detection

Qinglin Zhu, Tingxiu Yan, Yuemeng Yang, Yongchao Song, Jingwei Lu, Yong Luo, Li-Ping Xu and Tailin Xu

ACS Sens., 2022, 7, 3654
DOI: 10.1021/acssensors.2c02158

Nanomaterial-driven hypersensitive microRNA detection for clinical precision medicine

Haoyi Su, Xuyao Liu, Yuting Zhu, Tieshi Luowu, Huaiyuan Sun, Tongyue Zhang, Qi Shi, Shaoxiong Lu, Ben Zhang, Meilin Yang, Junchen Guo, Boya Shi, Zhaopei Guo, Xianying Meng, Jie Chen and Qiang Zhang

Chemical Engineering Journal, 2025, 524, 169354
DOI: 10.1016/j.cej.2025.169354