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Front. Bioeng. Biotechnol., 2023, 11
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Advancements in Microphysiological systems: Exploring organoids and organ-on-a-chip technologies in drug development -focus on pharmacokinetics related organs-
Hiroshi Kimura, Masaki Nishikawa, Naokata Kutsuzawa, Fumiya Tokito, Takuma Kobayashi, Dhimas Agung Kurniawan, Hiroki Shioda, Wenxin Cao, Kenta Shinha, Hiroko Nakamura, Kotaro Doi and Yasuyuki Sakai
Drug Metabolism and Pharmacokinetics, 2025, 60, 101046
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A New Role for Extracellular Vesicles in Cardiac Tissue Engineering and Regenerative Medicine
Karl T. Wagner and Milica Radisic
Advanced NanoBiomed Research, 2021, 1
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Revolutionizing Epithelial Differentiability Analysis in Small Airway-on-a-Chip Models Using Label-Free Imaging and Computational Techniques
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Biosensors, 2024, 14, 581
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Simple design for membrane-free microphysiological systems to model the blood-tissue barriers
By Ashlyn T. Young, Halston Deal, Gabrielle Rusch, Vladimir A. Pozdin, Ashley C. Brown and Michael Daniele
Organs-on-a-Chip, 2023, 5, 100032
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Ecotoxicology Goes on a Chip: Embracing Miniaturized Bioanalysis in Aquatic Risk Assessment
Olivia Campana and Donald Wlodkowic
Environ. Sci. Technol., 2018, 52, 932
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Microfluidic platform accelerates tissue processing into single cells for molecular analysis and primary culture models
Jeremy A. Lombardo, Marzieh Aliaghaei, Quy H. Nguyen, Kai Kessenbrock and Jered B. Haun
Nat Commun, 2021, 12
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Integrating Biophysics in Toxicology
Giorgia Del Favero and Annette Kraegeloh
Cells, 2020, 9, 1282
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Microphysiological Systems: Stakeholder Challenges to Adoption in Drug Development
Passley Hargrove-Grimes, Lucie A. Low and Danilo A. Tagle
Cells Tissues Organs, 2022, 211, 269
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Intestinal organ chips for disease modelling and personalized medicine
Alican Özkan, Nina Teresa LoGrande, Jessica F. Feitor, Girija Goyal and Donald E. Ingber
Nat Rev Gastroenterol Hepatol, 2024, 21, 751
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Evaluation of integrative AQbD, advanced environmentally benign assessment tools for estimation of Polymyxin B in kidney-on-Chip (RPTEC) media using ESI-LC-MS/MS
Ankush Parmar, Saransh Chaudhary and Amarsinh Dattatray Deshmukh
Microchemical Journal, 2025, 218, 115071
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Engineered models for studying blood-brain-barrier-associated brain physiology and pathology
Hong Nam Kim
Organoid, 2021, 1, e10
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Engineers in Medicine: Foster Innovation by Traversing Boundaries
Monikka Mann, Imtiaz Qavi, Nan Zhang and George Tan
Crit Rev Biomed Eng, 2023, 51, 19
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Organ-On-A-Chip: An Emerging Research Platform
Nithin R, Ayushi Aggarwal, Anne Boyina Sravani, Pooja Mallya and Shaila Lewis
Organogenesis, 2023, 19
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Recent Advances in Integrated Organ‐Chip Sensing Toward Robust and User‐Friendly Systems
Bryan G. Schellberg, Ryan A. Koppes and Abigail N. Koppes
J Biomedical Materials Res, 2025, 113
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A high-throughput microfluidic bilayer co-culture platform to study endothelial-pericyte interactions
Miles T. Rogers, Ashley L. Gard, Robert Gaibler, Thomas J. Mulhern, Rivka Strelnikov, Hesham Azizgolshani, Brian P. Cain, Brett C. Isenberg, Nerses J. Haroutunian, Nicole E. Raustad, Philip M. Keegan, Matthew P. Lech, Lindsay Tomlinson, Jeffrey T. Borenstein, Joseph L. Charest and Corin Williams
Sci Rep, 2021, 11
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State of the Art in 3D Culture Models Applied to Thyroid Cancer
Alessandro Prete, Antonio Matrone and Roberto Plebani
Medicina, 2024, 60, 520
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3D cell culture models and organ‐on‐a‐chip: Meet separation science and mass spectrometry
Ann Lin, Frøydis Sved Skottvoll, Simon Rayner, Stig Pedersen‐Bjergaard, Gareth Sullivan, Stefan Krauss, Steven Ray Wilson and Sean Harrison
Electrophoresis, 2020, 41, 56
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Advances in biofabrication techniques towards functional bioprinted heterogeneous engineered tissues: A comprehensive review
William S. Harley, Chi Chung Li, Joseph Toombs, Cathal D. O'Connell, Hayden K. Taylor, Daniel E. Heath and David J. Collins
Bioprinting, 2021, 23, e00147
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Instrumented Microphysiological Systems for Real-Time Measurement and Manipulation of Cellular Electrochemical Processes
Jonathan R. Soucy, Adam J. Bindas, Abigail N. Koppes and Ryan A. Koppes
iScience, 2019, 21, 521
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The Fluidic Shear Stress Loading Method Enables Mechanobiological Stimulation in an On-Chip Pump-Integrated Microphysiological System
Jin Hong Yap, Satoshi Ishizaki, Hiroko Nakamura, Kenta Shinha and Hiroshi Kimura
Micromachines, 2025, 16, 1051
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Challenges and Future Prospects on 3D in-vitro Modeling of the Neuromuscular Circuit
Maider Badiola-Mateos, Arnau Hervera, José Antonio del Río and Josep Samitier
Front. Bioeng. Biotechnol., 2018, 6
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Cell-printed 3D liver-on-a-chip possessing a liver microenvironment and biliary system
Hyungseok Lee, Suhun Chae, Jae Yun Kim, Wonil Han, Jongmin Kim, Yeongjin Choi and Dong-Woo Cho
Biofabrication, 2019, 11, 025001
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Organs-on-chips: a decade of innovation
Carly Strelez, Hannah Y. Jiang and Shannon M. Mumenthaler
Trends in Biotechnology, 2023, 41, 278
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Pharmaceutical technologies with potential application to insecticide discovery†
Keith D Wing
Pest Management Science, 2021, 77, 3617
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On-chip modeling of tumor evolution: Advances, challenges and opportunities
Chengpan Li, Joseph Benjamin Holman, Zhengdi Shi, Bensheng Qiu and Weiping Ding
Materials Today Bio, 2023, 21, 100724
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State-of-the-art in high throughput organ-on-chip for biotechnology and pharmaceuticals
Suk-Heung Song and Sehoon Jeong
Clin Exp Reprod Med, 2025, 52, 114
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Integrating three-dimensional printing and bioprinting technologies to develop a stretchable in vitro model of the human airway
Junned Chan, Julian Gonzalez Rubio, Oscar O’Dwyer Lancaster-Jones, Yashasvi Verma, Charlotte Büchter, Stefan Jockenhoevel, Laura De Laporte, Mirko Trilling, Anja Lena Thiebes and Daniela Duarte Campos
Bio-des. Manuf., 2025, 8, 595
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Materials for blood brain barrier modeling in vitro
Magali P. Ferro, Sarah C. Heilshorn and Roisin M. Owens
Materials Science and Engineering: R: Reports, 2020, 140, 100522
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Differentiation of Bioengineered Skeletal Muscle within a 3D Printed Perfusion Bioreactor Reduces Atrophic and Inflammatory Gene Expression
Rowan P. Rimington, Andrew J. Capel, Kerry F. Chaplin, Jacob W. Fleming, H. C. Hemaka Bandulasena, Richard J. Bibb, Steven D. R. Christie and Mark P. Lewis
ACS Biomater. Sci. Eng., 2019, 5, 5525
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From Engineered Tissues and Microfludics to Human Eyes-On-A-Chip
Milica Radisic
Journal of Ocular Pharmacology and Therapeutics, 2020, 36, 4
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Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption
Vanessa Allwardt, Alexander J. Ainscough, Priyalakshmi Viswanathan, Stacy D. Sherrod, John A. McLean, Malcolm Haddrick and Virginia Pensabene
Bioengineering, 2020, 7, 112
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Magnetically Actuated Soft Electrodes for Multisite Bioelectrical Monitoring of Ex Vivo Tissues
Qianbi Peng, Jianping Huang, Chenyang Li, Mingguo Jiang, Chenyang Huang, Jinxin Luo, Hanfei Li, Ting Yin, Mingxue Cai, Shixiong Fu, Guoyao Ma, Zhiyuan Liu and Tiantian Xu
Cyborg Bionic Syst, 2025, 6
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Microfluidic organ-on-chip systems for periodontal research: advances and future directions
Gopu Sriram and Hardik Makkar
Front. Bioeng. Biotechnol., 2025, 12
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Recent progress in lab-on-a-chip for pharmaceutical analysis and pharmacological/toxicological test
Yongjian Ai, Feng Zhang, Chenlong Wang, Ruoxiao Xie and Qionglin Liang
TrAC Trends in Analytical Chemistry, 2019, 117, 215
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Drug discovery strategies for acute radiation syndrome
Vijay K. Singh, Thomas M. Seed and Ayodele O. Olabisi
Expert Opinion on Drug Discovery, 2019, 14, 701
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3D printing for chemical, pharmaceutical and biological applications
Andrew J. Capel, Rowan P. Rimington, Mark P. Lewis and Steven D. R. Christie
Nat Rev Chem, 2018, 2, 422
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Microfluidic Organ-on-A-chip: A Guide to Biomaterial Choice and Fabrication
Uyen M. N. Cao, Yuli Zhang, Julie Chen, Darren Sayson, Sangeeth Pillai and Simon D. Tran
IJMS, 2023, 24, 3232
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Integrating Biosensors in Organs-on-Chip Devices: A Perspective on Current Strategies to Monitor Microphysiological Systems
Erika Ferrari, Cecilia Palma, Simone Vesentini, Paola Occhetta and Marco Rasponi
Biosensors, 2020, 10, 110
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Microphysiological systems: What it takes for community adoption
Passley Hargrove-Grimes, Lucie A Low and Danilo A Tagle
Exp Biol Med (Maywood), 2021, 246, 1435
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Bioprinting of Organ-on-Chip Systems: A Literature Review from a Manufacturing Perspective
Ketan Thakare, Laura Jerpseth, Zhijian Pei, Alaa Elwany, Francis Quek and Hongmin Qin
JMMP, 2021, 5, 91
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Bone‐on‐a‐Chip: Microfluidic Technologies and Microphysiologic Models of Bone Tissue
Amin Mansoorifar, Ryan Gordon, Raymond C. Bergan and Luiz E. Bertassoni
Adv Funct Materials, 2021, 31
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The translational roadmap of the gut models, focusing on gut-on-chip
Giulia Malaguarnera, Miriam Graute and Antoni Homs Corbera
Open Res Europe, 2023, 1, 62
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Ion-Depleting Action of Perm-Selective Membranes for Enhancing Electrical Communication and Gated Ion Channel Activity in Cell Cultures
Vivek Yadav, Satyajyoti Senapati and Hsueh-Chia Chang
ACS Biomater. Sci. Eng., 2022, 8, 4618
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Numerical models for organ-on-a-chip: A systematic review and analyses
Weiguang Su, Yang Zhao, Siegfried Yeboah, Xinyu Li and Li Wang
Biomicrofluidics, 2025, 19
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The ethical aspects of human organ-on-chip models: A mapping review
Jesse Weidema, Martine de Vries, Christine Mummery and Nienke de Graeff
Stem Cell Reports, 2025, 20, 102686
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In Vitro Strategies to Vascularize 3D Physiologically Relevant Models
Alessandra Dellaquila, Chau Le Bao, Didier Letourneur and Teresa Simon‐Yarza
Advanced Science, 2021, 8
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Organ-On-A-Chip: A Survey of Technical Results and Problems
Alex Ede Danku, Eva-H Dulf, Cornelia Braicu, Ancuta Jurj and Ioana Berindan-Neagoe
Front. Bioeng. Biotechnol., 2022, 10
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The never‐ending search of an ideal culture system for domestic cat oocytes and embryos
Gaia Cecilia Luvoni, Martina Colombo and Maria Giorgia Morselli
Reprod Domestic Animals, 2018, 53, 110
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The 3C (Cell Culture, Computer Simulation, Clinical Trial) Solution for Optimizing the 3R (Replace, Reduction, Refine) Framework during Preclinical Research Involving Laboratory Animals
Susmita Roy, Mehnaz Parveen, Asis Bala and Debjeet Sur
ACS Pharmacol. Transl. Sci., 2025, 8, 1188
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Application of New Cellular and Microphysiological Systems to Drug Metabolism Optimization and Their Positioning Respective to In Silico Tools
Luca Docci, Neil Parrott, Stephan Krähenbühl and Stephen Fowler
SLAS Discovery, 2019, 24, 523
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Organoid: a promising solution to current challenges in cancer immunotherapy
Xiaowo Kang, Sriya K. Cheemalamarri and Qian Yin
npj Biomed. Innov., 2025, 2
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Bioengineered in vitro models of leukocyte–vascular interactions
Jaehyun Lee, Cort B. Breuer and Esak Lee
Biochemical Society Transactions, 2021, 49, 693
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Organ-on-a-Chip: Ubi sumus? Fundamentals and Design Aspects
Ana Sofia Morais, Maria Mendes, Marta Agostinho Cordeiro, João J. Sousa, Alberto Canelas Pais, Silvia M. Mihăilă and Carla Vitorino
Pharmaceutics, 2024, 16, 615
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Organ‐on‐a‐Chip: A Preclinical Microfluidic Platform for the Progress of Nanomedicine
Raquel O. Rodrigues, Patrícia C. Sousa, João Gaspar, Manuel Bañobre‐López, Rui Lima and Graça Minas
Small, 2020, 16
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Polylactic is a Sustainable, Low Absorption, Low Autofluorescence Alternative to Other Plastics for Microfluidic and Organ-on-Chip Applications
Alfredo E. Ongaro, Davide Di Giuseppe, Ali Kermanizadeh, Allende Miguelez Crespo, Arianna Mencattini, Lina Ghibelli, Vanessa Mancini, Krystian L. Wlodarczyk, Duncan P. Hand, Eugenio Martinelli, Vicki Stone, Nicola Howarth, Vincenzo La Carrubba, Virginia Pensabene and Maïwenn Kersaudy-Kerhoas
Anal. Chem., 2020, 92, 6693
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Methods for fabrication and evaluation of a 3D microengineered model of myelinated peripheral nerve
Parastoo Khoshakhlagh, Ashwin Sivakumar, Lauren A Pace, Daniel W Sazer and Michael J Moore
J. Neural Eng., 2018, 15, 064001
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Fabrication and Characterization of 3D Printed, 3D Microelectrode Arrays for Interfacing with a Peripheral Nerve-on-a-Chip
Avra Kundu, Laurie McCoy, Nilab Azim, Hieu Nguyen, Charles M. Didier, Tariq Ausaf, Anup D. Sharma, J. Lowry Curley, Michael J. Moore and Swaminathan Rajaraman
ACS Biomater. Sci. Eng., 2021, 7, 3018
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ABSTRACTS (BY NUMBER)

Tissue Engineering Part A, 2022, 28, S-1
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Advances in dynamic microphysiological organ-on-a-chip: Design principle and its biomedical application
Sang Hun Lee and Bong-Hyun Jun
Journal of Industrial and Engineering Chemistry, 2019, 71, 65
DOI: 10.1016/j.jiec.2018.11.041

The Promise and Challenges of Bioprinting in Tissue Engineering
Ryan Martin and Daeha Joung
Micromachines, 2024, 15, 1529
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A guide to the organ-on-a-chip
Chak Ming Leung, Pim de Haan, Kacey Ronaldson-Bouchard, Ge-Ah Kim, Jihoon Ko, Hoon Suk Rho, Zhu Chen, Pamela Habibovic, Noo Li Jeon, Shuichi Takayama, Michael L. Shuler, Gordana Vunjak-Novakovic, Olivier Frey, Elisabeth Verpoorte and Yi-Chin Toh
Nat Rev Methods Primers, 2022, 2
DOI: 10.1038/s43586-022-00118-6

A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems
Luana A. Osório, Elisabete Silva and Ruth E. Mackay
Bioengineering, 2021, 8, 113
DOI: 10.3390/bioengineering8080113

Organ-Specific Strategies in Bioprinting: Addressing Translational Challenges in the Heart, Liver, Kidney, and Pancreas
Mohamad Al Qassab, Moustafa Merheb, Safaa Sayadi, Pia Salloum, Zeina Dabbousi, Anthony Bayeh, Frederic Harb, Sami Azar and Hilda E. Ghadieh
JFB, 2025, 16, 356
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Facilitating implementation of organs-on-chips by open platform technology
Anke R. Vollertsen, Aisen Vivas, Berend van Meer, Albert van den Berg, Mathieu Odijk and Andries D. van der Meer
Biomicrofluidics, 2021, 15
DOI: 10.1063/5.0063428

Pharmacokinetic Analysis of Epithelial/Endothelial Cell Barriers in Microfluidic Bilayer Devices with an Air–Liquid Interface
Timothy S. Frost, Linan Jiang and Yitshak Zohar
Micromachines, 2020, 11, 536
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Development of a robotic-assisted handling and manipulation system for the high-scale bioproduction of 3D-bioprinted organ-on-a-chip devices
Nils Lindner, Andres Mejia-Wille, Anna Fritschen and Andreas Blaeser
HardwareX, 2024, 19, e00572
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Lane and band formation of oppositely driven colloidal particles in two-dimensional ring geometries
Tobias Vater, Marc Isele, Ullrich Siems and Peter Nielaba
Phys. Rev. E, 2022, 106
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A public-private partnership for the express development of antiviral leads: a perspective view
Anatoly Mayburd
Expert Opinion on Drug Discovery, 2021, 16, 23
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Construction, Features and Regulatory Aspects of Organ-chip for Drug Delivery Applications: Advances and Prospective
Babita Gupta, Rishabha Malviya, Saurabh Srivastava, Irfan Ahmad, Safia Obaidur Rab and Prerna Uniyal
CPD, 2024, 30, 1952
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The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors
Grissel Trujillo-de Santiago, Brenda Giselle Flores-Garza, Jorge Alfonso Tavares-Negrete, Itzel Montserrat Lara-Mayorga, Ivonne González-Gamboa, Yu Shrike Zhang, Augusto Rojas-Martínez, Rocío Ortiz-López and Mario Moisés Álvarez
Materials, 2019, 12, 2945
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Three-Dimensional in Vitro Models: A Promising Tool To Scale-Up Breast Cancer Research
Vajihe Azimian Zavareh, Laleh Rafiee, Mohammadali Sheikholeslam, Laleh Shariati, Golnaz Vaseghi, Houman Savoji and Shaghayegh Haghjooy Javanmard
ACS Biomater. Sci. Eng., 2022, 8, 4648
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Biomimetic Designer Scaffolds Made of D,L -Lactide- ɛ -Caprolactone Polymers by 2-Photon Polymerization
Nicole Hauptmann, Qilin Lian, Johanna Ludolph, Holger Rothe, Gerhard Hildebrand and Klaus Liefeith
Tissue Engineering Part B: Reviews, 2019, 25, 167
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Microfluidic Devices and 3D Printing for Synthesis and Screening of Drugs and Tissue Engineering
Harrson S. Santana, Mauri S. A. Palma, Mariana G. M. Lopes, Johmar Souza, Giovanni A. S. Lima, Osvaldir P. Taranto and João Lameu Silva
Ind. Eng. Chem. Res., 2020, 59, 3794
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Patient‐Specific Organoid and Organ‐on‐a‐Chip: 3D Cell‐Culture Meets 3D Printing and Numerical Simulation
Fuyin Zheng, Yuminghao Xiao, Hui Liu, Yubo Fan and Ming Dao
Advanced Biology, 2021, 5
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Bioreactor Technologies for Enhanced Organoid Culture
Joseph P. Licata, Kyle H. Schwab, Yah-el Har-el, Jonathan A. Gerstenhaber and Peter I. Lelkes
IJMS, 2023, 24, 11427
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Advances in Engineering Human Tissue Models
Chrysanthi-Maria Moysidou, Chiara Barberio and Róisín Meabh Owens
Front. Bioeng. Biotechnol., 2021, 8
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A Microfluidic Multisize Spheroid Array for Multiparametric Screening of Anticancer Drugs and Blood–Brain Barrier Transport Properties
Christoph Eilenberger, Mario Rothbauer, Florian Selinger, Anna Gerhartl, Christian Jordan, Michael Harasek, Barbara Schädl, Johannes Grillari, Julian Weghuber, Winfried Neuhaus, Seta Küpcü and Peter Ertl
Advanced Science, 2021, 8
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Vascularized microfluidic platforms to mimic the tumor microenvironment
Rhys Michna, Manasa Gadde, Alican Ozkan, Matthew DeWitt and Marissa Rylander
Biotech & Bioengineering, 2018, 115, 2793
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Advances in lung-on-a-chip platforms for nanotherapeutic evaluation and screening
Kimia Abedi, Jacqueline L. Pavelick, Claudia C. dos Santos and Edmond W.K. Young
Advanced Drug Delivery Reviews, 2026, 234, 115873
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Human organs-on-chips for disease modelling, drug development and personalized medicine
Donald E. Ingber
Nat Rev Genet, 2022, 23, 467
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Developing a Drug Screening Platform: MALDI-Mass Spectrometry Imaging of Paper-Based Cultures
Fernando Tobias, Julie C. McIntosh, Gabriel J. LaBonia, Matthew W. Boyce, Matthew R. Lockett and Amanda B. Hummon
Anal. Chem., 2019, 91, 15370
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Extracellular Vesicles in Cardiac Regeneration: Potential Applications for Tissues-on-a-Chip
Karl T. Wagner, Trevor R. Nash, Bohao Liu, Gordana Vunjak-Novakovic and Milica Radisic
Trends in Biotechnology, 2021, 39, 755
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Next generation of heart regenerative therapies: progress and promise of cardiac tissue engineering
Miguel F. Tenreiro, Ana F. Louro, Paula M. Alves and Margarida Serra
npj Regen Med, 2021, 6
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Microfluidics geometries involved in effective blood plasma separation
Anamika Maurya, Janani Srree Murallidharan, Atul Sharma and Amit Agarwal
Microfluid Nanofluid, 2022, 26
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Considering future qualification for regulatory science in the early development of microphysiological systems: a case study of microthrombosis in a Vessel-on-Chip
Huub J. Weener, Heleen H. T. Middelkamp and Andries D. Van der Meer
Front. Toxicol., 2024, 6
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Engineering Shelf-Stable Coating for Microfluidic Organ-on-a-Chip Using Bioinspired Catecholamine Polymers
Sultan Khetani, Kar Wey Yong, Vinayaraj Ozhukil Kollath, Erin Eastick, Milad Azarmanesh, Kunal Karan, Arindom Sen and Amir Sanati-Nezhad
ACS Appl. Mater. Interfaces, 2020, 12, 6910
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Convection–diffusion molecular transport in a microfluidic bilayer device with a porous membrane
Timothy S. Frost, Victor Estrada, Linan Jiang and Yitshak Zohar
Microfluid Nanofluid, 2019, 23
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Organ-On-A-Chip (OOAC) Technology: Impact on Drug Screening and Personalized Medicine
Subhashinee Singh, Nabanita Das, Manisha Rathore, Ambresh Nishad, Nisha Kumari and Rajdeep Guha
Regen. Eng. Transl. Med., 2025
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Technical aspects of microphysiological systems (MPS) as a promising wet human-in-vivo simulator
Toshiyuki Kanamori, Shinji Sugiura and Yasuyuki Sakai
Drug Metabolism and Pharmacokinetics, 2018, 33, 40
DOI: 10.1016/j.dmpk.2017.11.006

Human organotypic bioconstructs from organ-on-chip devices for human-predictive biological insights on drug candidates
Icilio Cavero, Jean-Michel Guillon and Henry H Holzgrefe
Expert Opinion on Drug Safety, 2019, 18, 651
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Optimization of Application-Driven Development of In Vitro Neuromuscular Junction Models
Julie B. Strickland, Katie Davis-Anderson, Sofiya Micheva-Viteva, Scott Twary, Rashi Iyer, Jennifer Foster Harris and Emilia A. Solomon
Tissue Engineering Part B: Reviews, 2022, 28, 1180
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