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A novel human arterial wall-on-a-chip to study endothelial inflammation and vascular smooth muscle cell migration in early atherosclerosis
Chengxun Su, Nishanth Venugopal Menon, Xiaohan Xu, Yu Rong Teo, Huan Cao, Rinkoo Dalan, Chor Yong Tay and Han Wei Hou
Lab Chip, 2021, 21, 2359
DOI: 10.1039/D1LC00131K

From cells-on-a-chip to organs-on-a-chip: scaffolding materials for 3D cell culture in microfluidics
John A. Terrell, Curtis G. Jones, Giraso Keza Monia Kabandana and Chengpeng Chen
J. Mater. Chem. B, 2020, 8, 6667
DOI: 10.1039/D0TB00718H

Multiplexed fluidic circuit board for controlled perfusion of 3D blood vessels-on-a-chip
Mees N. S. de Graaf, Aisen Vivas, Dhanesh G. Kasi, Francijna E. van den Hil, Albert van den Berg, Andries D. van der Meer, Christine L. Mummery and Valeria V. Orlova
Lab Chip, 2023, 23, 168
DOI: 10.1039/D2LC00686C

Understanding drug nanocarrier and blood–brain barrier interaction based on a microfluidic microphysiological model
Yuanyuan Fan, Chang Xu, Ning Deng, Ze Gao, Zhongyao Jiang, Xiaoxiao Li, Yingshun Zhou, Haimeng Pei, Lu Li and Bo Tang
Lab Chip, 2023, 23, 1935
DOI: 10.1039/D2LC01077A

On-chip perivascularnichesupporting stemness of patient-derived glioma cells in a serum-free, flowable culture
Magda Gerigk, Harry Bulstrode, HaoTian Harvey Shi, Felix Tönisen, Camilla Cerutti, Gillian Morrison, David Rowitch and Yan Yan Shery Huang
Lab Chip, 2021, 21, 2343
DOI: 10.1039/D1LC00271F

A photonic biosensor-integrated tissue chip platform for real-time sensing of lung epithelial inflammatory markers
John S. Cognetti, Maya T. Moen, Matthew G. Brewer, Michael R. Bryan, Joshua D. Tice, James L. McGrath and Benjamin L. Miller
Lab Chip, 2023, 23, 239
DOI: 10.1039/D2LC00864E

Organ-on-a-chip devices advance to market
Boyang Zhang and Milica Radisic
Lab Chip, 2017, 17, 2395
DOI: 10.1039/C6LC01554A

Spatial trans-epithelial electrical resistance (S-TEER) integrated in organs-on-chips
Noa Renous, Mark D. Kiri, Ronny A. Barnea, Rossana Rauti, Yael Leichtmann-Bardoogo and Ben M. Maoz
Lab Chip, 2022, 22, 71
DOI: 10.1039/D1LC00789K

From ex ovo to in vitro: xenotransplantation and vascularization of mouse embryonic kidneys in a microfluidic chip
Micaela Oliveira, Partha Protim Sarker, Ilya Skovorodkin, Ali Kalantarifard, Tugce Haskavuk, Jonatan Mac Intyre, Elizabath Nallukunnel Raju, Samin Nooranian, Hiroki Shioda, Masaki Nishikawa, Yasuyuki Sakai, Seppo J. Vainio, Caglar Elbuken and Irina Raykhel
Lab Chip, 2024, 24, 4816
DOI: 10.1039/D4LC00547C

Multiplexed blood–brain barrier organ-on-chip
M. Zakharova, M. A. Palma do Carmo, M. W. van der Helm, H. Le-The, M. N. S. de Graaf, V. Orlova, A. van den Berg, A. D. van der Meer, K. Broersen and L. I. Segerink
Lab Chip, 2020, 20, 3132
DOI: 10.1039/D0LC00399A

Engineering perfusion to meet tumor biology: are vascularized tumor-on-a-chip models ready to drive therapy innovation?
Ines Poljak, Ciro Chiappini and Giulia Adriani
Lab Chip, 2026, 26, 1162
DOI: 10.1039/D5LC01060H

Recent advances in 3D models for multiparametric blood–brain barrier detection in microfluidic systems
Chiara Boncristiani, Alessia Di Gilio, Federica De Castro, Alessandra Nardini, Jolanda Palmisani, Rebeca Martínez Vázquez, Gianluigi de Gennaro, Francesco Paolo Fanizzi, Giuseppe Ciccarella and Viviana Vergaro
J. Mater. Chem. B, 2025, 13, 6597
DOI: 10.1039/D4TB02499K

Bio-inspired engineering of a perfusion culture platform for guided three-dimensional nerve cell growth and differentiation
Zihou Wei, Tao Sun, Shingo Shimoda, Zhe Chen, Xie Chen, Huaping Wang, Qiang Huang, Toshio Fukuda and Qing Shi
Lab Chip, 2022, 22, 1006
DOI: 10.1039/D1LC01149A

Blood–brain barrier (BBB)-on-a-chip: a promising breakthrough in brain disease research
Bo Peng, Shiping Hao, Ziqiu Tong, Hua Bai, Sijun Pan, Kah-Leong Lim, Lin Li, Nicolas H. Voelcker and Wei Huang
Lab Chip, 2022, 22, 3579
DOI: 10.1039/D2LC00305H

Bridging barriers: advances and challenges in modeling biological barriers and measuring barrier integrity in organ-on-chip systems
Alisa Ugodnikov, Henrik Persson and Craig A. Simmons
Lab Chip, 2024, 24, 3199
DOI: 10.1039/D3LC01027A

Establishment of an ultrasound-responsive microfluidic chip BBB-glioblastoma model for studying sonodynamic therapy-enhanced nanodrug delivery
Liyang Wu, Bingcheng Lin, Huadong Fan and Yihong Li
Lab Chip, 2025, 25, 6673
DOI: 10.1039/D5LC00799B

Solute transport in the brain tissue: what are the key biophysical parameters tying in vivo and in vitro studies together?
Daniel Alcaide, Jean Cacheux, Aurélien Bancaud, Rieko Muramatsu and Yukiko T. Matsunaga
Biomater. Sci., 2023, 11, 3450
DOI: 10.1039/D3BM00027C

Microfluidic approach for the fabrication of cell-laden hollow fibers for endothelial barrier research
Thi Phuong Thuy Nguyen, Buu Minh Tran and Nae Yoon Lee
J. Mater. Chem. B, 2018, 6, 6057
DOI: 10.1039/C8TB02031K

The vascular niche in next generation microphysiological systems
Makena L. Ewald, Yu-Hsi Chen, Abraham P. Lee and Christopher C. W. Hughes
Lab Chip, 2021, 21, 3244
DOI: 10.1039/D1LC00530H

Microphysiological systems for ADME-related applications: current status and recommendations for system development and characterization
Stephen Fowler, Wen Li Kelly Chen, David B. Duignan, Anshul Gupta, Niresh Hariparsad, Jane R. Kenny, W. George Lai, Jennifer Liras, Jonathan A. Phillips and Jinping Gan
Lab Chip, 2020, 20, 446
DOI: 10.1039/C9LC00857H

Microfluidic-based vascularized microphysiological systems
Somin Lee, Jihoon Ko, Dohyun Park, Seung-Ryeol Lee, Minhwan Chung, Younggyun Lee and Noo Li Jeon
Lab Chip, 2018, 18, 2686
DOI: 10.1039/C8LC00285A

Electro-responsive hydrogel-based microfluidic actuator platform for photothermal therapy
Jang Ho Ha, Ha Hee Shin, Hyung Woo Choi, Jae Hyun Lim, Sung Joon Mo, Christian D. Ahrberg, Jong Min Lee and Bong Geun Chung
Lab Chip, 2020, 20, 3354
DOI: 10.1039/D0LC00458H

A microphysiological system for parallelized morphological and electrophysiological read-out of 3D neuronal cell culture
Peter D. Jones, Beatriz Molina-Martínez, Anita Niedworok and Paolo Cesare
Lab Chip, 2024, 24, 1750
DOI: 10.1039/D3LC00963G

Organ-On-A-Chip in vitro Models of the Brain and the Blood-Brain Barrier and Their Value to Study the Microbiota-Gut-Brain Axis in Neurodegeneration
Ilaria Raimondi, Luca Izzo, Marta Tunesi, Manola Comar, Diego Albani and Carmen Giordano
Front. Bioeng. Biotechnol., 2020, 7
DOI: 10.3389/fbioe.2019.00435

Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood–brain barrier
Jin Kim, Kyung-Tae Lee, Jong Seung Lee, Jisoo Shin, Baofang Cui, Kisuk Yang, Yi Sun Choi, Nakwon Choi, Soo Hyun Lee, Jae-Hyun Lee, Yong-Sun Bahn and Seung-Woo Cho
Nat Biomed Eng, 2021, 5, 830
DOI: 10.1038/s41551-021-00743-8

Microphysiological Systems in Cancer Research: Advancing Immunotherapy through Tumor Microenvironment‐Integrated Organ‐On‐Chip Models
Fabiana Moresi, Francesco Noto, Jyothsna Vasudevan, Xavier Bisteau, Giulia Adriani and Andrea Pavesi
Advanced Therapeutics, 2025, 8
DOI: 10.1002/adtp.202500098

Generation of a 3D Outer Blood–Retinal Barrier with Advanced Choriocapillaris and Its Application in Diabetic Retinopathy in a Microphysiological System
Ungsig Nam, Seokhun Lee and Jessie S. Jeon
ACS Biomater. Sci. Eng., 2023, 9, 4929
DOI: 10.1021/acsbiomaterials.3c00326

Studying Human Neurological Disorders Using Induced Pluripotent Stem Cells: From 2D Monolayer to 3D Organoid and Blood Brain Barrier Models
Sarah Logan, Thiago Arzua, Scott G. Canfield, Emily R. Seminary, Samantha L. Sison, Allison D. Ebert and Xiaowen Bai
Comprehensive Physiology, 2019, 9, 565
DOI: 10.1002/j.2040-4603.2019.tb00076.x

Recent advances in microfluidic platforms for single particle analysis
Kuangjun Li and Jing Wu
TrAC Trends in Analytical Chemistry, 2023, 165, 117139
DOI: 10.1016/j.trac.2023.117139

Three-Dimensional in vitro Models of Healthy and Tumor Brain Microvasculature for Drug and Toxicity Screening
Marie Piantino, Agathe Figarol and Michiya Matsusaki
Front. Toxicol., 2021, 3
DOI: 10.3389/ftox.2021.656254

Cholic Acid Protects In Vitro Neurovascular Units against Oxygen and Glucose Deprivation-Induced Injury through the BDNF-TrkB Signaling Pathway
Changxiang Li, Xueqian Wang, Juntang Yan, Fafeng Cheng, Xiaona Ma, Congai Chen, Wei Wang, Qingguo Wang and Robert Ostrowski
Oxidative Medicine and Cellular Longevity, 2020, 2020, 1
DOI: 10.1155/2020/1201624

A human-derived neurovascular unit in vitro model to study the effects of cellular cross-talk and soluble factors on barrier integrity
Chiara Barberio, Aimee Withers, Yash Mishra, Pierre-Olivier Couraud, Ignacio A. Romero, Babette Weksler and Róisín M. Owens
Front. Cell. Neurosci., 2022, 16
DOI: 10.3389/fncel.2022.1065193

Understanding parasite–brain microvascular interactions with engineered 3D blood–brain barrier models
Rory K. M. Long, Livia Piatti, François Korbmacher and Maria Bernabeu
Molecular Microbiology, 2022, 117, 693
DOI: 10.1111/mmi.14852

Motor neuron-derived induced pluripotent stem cells as a drug screening platform for amyotrophic lateral sclerosis
Mariana A. Amorós, Esther S. Choi, Axel R. Cofré, Nikolay V. Dokholyan and Marcelo Duzzioni
Front. Cell Dev. Biol., 2022, 10
DOI: 10.3389/fcell.2022.962881

Microphysiological systems for recapitulating physiology and function of blood-brain barrier
Suyeong Seo, Hwieun Kim, Jong Hwan Sung, Nakwon Choi, Kangwon Lee and Hong Nam Kim
Biomaterials, 2020, 232, 119732
DOI: 10.1016/j.biomaterials.2019.119732

Advances in Microfluidic Blood–Brain Barrier (BBB) Models
Arianna Oddo, Bo Peng, Ziqiu Tong, Yingkai Wei, Wing Yin Tong, Helmut Thissen and Nicolas Hans Voelcker
Trends in Biotechnology, 2019, 37, 1295
DOI: 10.1016/j.tibtech.2019.04.006

Refined Qingkailing protects the in vitro neurovascular unit against oxygen–glucose deprivation and re-oxygenation-induced injury
Zilin Ren, Congai Chen, Yuxiao Zheng, Shuang Zhang, Juntang Yan, Fafeng Cheng, Xueqian Wang, Qingguo Wang and Changxiang Li
Biomedicine & Pharmacotherapy, 2023, 167, 115580
DOI: 10.1016/j.biopha.2023.115580

Tissue Response to Neural Implants: The Use of Model Systems Toward New Design Solutions of Implantable Microelectrodes
Maurizio Gulino, Donghoon Kim, Salvador Pané, Sofia Duque Santos and Ana Paula Pêgo
Front. Neurosci., 2019, 13
DOI: 10.3389/fnins.2019.00689

Luminal flow actuation generates coupled shear and strain in a microvessel-on-chip
Claire A Dessalles, Clara Ramón-Lozano, Avin Babataheri and Abdul I Barakat
Biofabrication, 2022, 14, 015003
DOI: 10.1088/1758-5090/ac2baa

Modeling organ-specific vasculature with organ-on-a-chip devices
Dawn S Y Lin, Feng Guo and Boyang Zhang
Nanotechnology, 2019, 30, 024002
DOI: 10.1088/1361-6528/aae7de

Blood brain barrier: A tissue engineered microfluidic chip
Sikkandhar Musafargani, Sachin Mishra, Miklós Gulyás, P. Mahalakshmi, Govindaraju Archunan, Parasuraman Padmanabhan and Balázs Gulyás
Journal of Neuroscience Methods, 2020, 331, 108525
DOI: 10.1016/j.jneumeth.2019.108525

Modelling Human Physiology on-Chip: Historical Perspectives and Future Directions
Sirjana Pun, Li Cai Haney and Riccardo Barrile
Micromachines, 2021, 12, 1250
DOI: 10.3390/mi12101250

Electrophysiology Read-Out Tools for Brain-on-Chip Biotechnology
Csaba Forro, Davide Caron, Gian Angotzi, Vincenzo Gallo, Luca Berdondini, Francesca Santoro, Gemma Palazzolo and Gabriella Panuccio
Micromachines, 2021, 12, 124
DOI: 10.3390/mi12020124

Getting closer to modeling the gut-brain axis using induced pluripotent stem cells
Vanessa Hall and Katja Maria Sahlgren Bendtsen
Front. Cell Dev. Biol., 2023, 11
DOI: 10.3389/fcell.2023.1146062

Modeling ischemic stroke in a triculture neurovascular unit on-a-chip
Nienke R. Wevers, Arya Lekshmi Nair, Tania M. Fowke, Maria Pontier, Dhanesh G. Kasi, Xandor M. Spijkers, Charlie Hallard, Gwenaëlle Rabussier, Remko van Vught, Paul Vulto, Helga E. de Vries and Henriëtte L. Lanz
Fluids Barriers CNS, 2021, 18
DOI: 10.1186/s12987-021-00294-9

Microfluidic Platforms toward Rational Material Fabrication for Biomedical Applications
Qilong Zhao, Huanqing Cui, Yunlong Wang and Xuemin Du
Small, 2020, 16
DOI: 10.1002/smll.201903798

Integrated brain on a chip and automated organ‐on‐chips systems
Zhe Li, Yimeng Zhao, Xuefei Lv and Yulin Deng
Interdisciplinary Medicine, 2023, 1
DOI: 10.1002/INMD.20220002

3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip
Wenxiu Li, Zhihang Zhou, Xiaoyu Zhou, Bee Luan Khoo, Renardi Gunawan, Y. Rebecca Chin, Liang Zhang, Changqing Yi, Xinyuan Guan and Mengsu Yang
Adv Healthcare Materials, 2023, 12
DOI: 10.1002/adhm.202202609

Transwell‐Integrated 2 µm Thick Transparent Polydimethylsiloxane Membranes with Controlled Pore Sizes and Distribution to Model the Blood‐Brain Barrier
Mariia Zakharova, Martijn P. Tibbe, Lena S. Koch, Hai Le‐The, Anne M. Leferink, Albert van den Berg, Andries D. van der Meer, Kerensa Broersen and Loes I. Segerink
Adv Materials Technologies, 2021, 6
DOI: 10.1002/admt.202100138

3D biomaterial models of human brain disease
Janko Kajtez, Fredrik Nilsson, Alessandro Fiorenzano, Malin Parmar and Jenny Emnéus
Neurochemistry International, 2021, 147, 105043
DOI: 10.1016/j.neuint.2021.105043

Recent advancements in microphysiological systems for neural development and disease
Kyla Nichols, Ryan Koppes and Abigail Koppes
Current Opinion in Biomedical Engineering, 2020, 14, 42
DOI: 10.1016/j.cobme.2020.05.003

Best Practices for Translational Disease Modeling Using Human iPSC-Derived Neurons
Sandra J. Engle, Laura Blaha and Robin J. Kleiman
Neuron, 2018, 100, 783
DOI: 10.1016/j.neuron.2018.10.033

Emerging biomimetic biopolymer-based composites: advancing accessible and sustainable neural disease models and therapeutics
Daniela Duc, Jacob Pattem, Benjamin Gambrill, Polina Prokopovich, Aybike Kocatürkmen, Matthew Church, Amber Mays, Akash Bedi, Emmanuel Brousseau and Oommen P. Oommen
Front. Bioeng. Biotechnol., 2026, 13
DOI: 10.3389/fbioe.2025.1720254

Low-Cost, Rapid Fabrication of Customizable Polyethylene Glycol-Based Cell Culture Devices
Emily L. Pallack, Maxwell W. Oulundsen, Yan Kolpakov, Hannah R. Goldberg, Aneth J. Fernandez, Noah D. Teaney, Faith E.Y. Moran and Nisha R. Iyer
Tissue Engineering Part C: Methods, 2026, 32, 80
DOI: 10.1177/19373384261427525

Reconstituting neurovascular unit based on the close relations between neural stem cells and endothelial cells: an effective method to explore neurogenesis and angiogenesis
Wang Hongjin, Chen Han, Jiang Baoxiang, Yu Shiqi and Xu Xiaoyu
Reviews in the Neurosciences, 2020, 31, 143
DOI: 10.1515/revneuro-2019-0023

Study of the neurotoxicity of indoor airborne nanoparticles based on a 3D human blood-brain barrier chip
Yan Li, Yan Liu, Chuanlin Hu, Qing Chang, Qihong Deng, Xu Yang and Yang Wu
Environment International, 2020, 143, 105598
DOI: 10.1016/j.envint.2020.105598

Promising Strategies for the Development of Advanced In Vitro Models with High Predictive Power in Ischaemic Stroke Research
Elise Van Breedam and Peter Ponsaerts
IJMS, 2022, 23, 7140
DOI: 10.3390/ijms23137140

A Cost-Effective and Easy to Assemble 3D Human Microchannel Blood–Brain Barrier Model and Its Application in Tumor Cell Adhesion Under Flow
Yunfei Li and Bingmei M. Fu
Cells, 2025, 14, 456
DOI: 10.3390/cells14060456

Neurovascular models for organ-on-a-chips
Eunkyung Ko and Roger D. Kamm
In vitro models, 2022, 1, 125
DOI: 10.1007/s44164-022-00015-y

The neurotoxicity of Nε-(carboxymethyl)lysine in food processing by a study based on animal and organotypic cell culture
Yang Wu, Yan Li, Liangqing Zheng, Pengcheng Wang, Yan liu, Yongning Wu and ZhiYong Gong
Ecotoxicology and Environmental Safety, 2020, 190, 110077
DOI: 10.1016/j.ecoenv.2019.110077

Cerebral small vessel disease alters neurovascular unit regulation of microcirculation integrity involved in vascular cognitive impairment
Qin Yang, Xiaobo Wei, Bin Deng, Zihan Chang, Dana Jin, Yonghua Huang, John H. Zhang, Midori A. Yenari, Kunlin Jin and Qing Wang
Neurobiology of Disease, 2022, 170, 105750
DOI: 10.1016/j.nbd.2022.105750

Development of Microplatforms to Mimic the In Vivo Architecture of CNS and PNS Physiology and Their Diseases
John Saliba, Arij Daou, Samar Damiati, Jessica Saliba, Marwan El-Sabban and Rami Mhanna
Genes, 2018, 9, 285
DOI: 10.3390/genes9060285

Integrated in silico and 3D in vitro model of macrophage migration in response to physical and chemical factors in the tumor microenvironment
Sharon Wei Ling Lee, R J Seager, Felix Litvak, Fabian Spill, Je Lin Sieow, Penny Hweixian Leong, Dillip Kumar, Alrina Shin Min Tan, Siew Cheng Wong, Giulia Adriani, Muhammad Hamid Zaman and and Roger D Kamm
Integrative Biology, 2020, 12, 90
DOI: 10.1093/intbio/zyaa007

Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior
Raleigh M. Linville, Jackson G. DeStefano, Matt B. Sklar, Zinnia Xu, Alanna M. Farrell, Max I. Bogorad, Chengyan Chu, Piotr Walczak, Linzhao Cheng, Vasiliki Mahairaki, Katharine A. Whartenby, Peter A. Calabresi and Peter C. Searson
Biomaterials, 2019, 190-191, 24
DOI: 10.1016/j.biomaterials.2018.10.023

Advances in Non-Animal Testing Approaches towards Accelerated Clinical Translation of Novel Nanotheranostic Therapeutics for Central Nervous System Disorders
Mark J. Lynch and Oliviero L. Gobbo
Nanomaterials, 2021, 11, 2632
DOI: 10.3390/nano11102632

Advances in 3D neural, vascular and neurovascular models for drug testing and regenerative medicine
Diogo C. Fernandes, Rui L. Reis and J. Miguel Oliveira
Drug Discovery Today, 2021, 26, 754
DOI: 10.1016/j.drudis.2020.11.009

Unveiling the Influence of Tumor Microenvironment and Spatial Heterogeneity on Temozolomide Resistance in Glioblastoma Using an Advanced Human In Vitro Model of the Blood‐Brain Barrier and Glioblastoma
Maxine SY Lam, Joey JY Aw, Damien Tan, Ragavi Vijayakumar, Hui Yi Grace Lim, Swathi Yada, Qing You Pang, Nick Barker, Carol Tang, Beng Ti Ang, Radoslaw M. Sobota and Andrea Pavesi
Small, 2023, 19
DOI: 10.1002/smll.202302280

Aging on Chip: Harnessing the Potential of Microfluidic Technologies in Aging and Rejuvenation Research
Limor Zwi‐Dantsis, Vignesh Jayarajan, George M. Church, Roger D. Kamm, João Pedro de Magalhães and Emad Moeendarbary
Adv Healthcare Materials, 2025, 14
DOI: 10.1002/adhm.202500217

Wound-on-a-chip: High-throughput 3D wound healing assay with a novel SU-8 mesh chip
Yachao Wang, Jinchi Zhu, Peng Chen, Yiwei Li, Shuangqian Yan, Jie Wang, Wei Du and Bi-Feng Liu
Sensors and Actuators B: Chemical, 2019, 280, 86
DOI: 10.1016/j.snb.2018.10.050

Drug Delivery Across The Blood–Brain Barrier: Recent Advances in The Use of Nanocarriers
John JE Mulvihill, Eoghan M Cunnane, Aisling M Ross, Jason T Duskey, Giovanni Tosi and Andreas M Grabrucker
Nanomedicine (Lond.), 2020, 15, 205
DOI: 10.2217/nnm-2019-0367

Opportunities and challenges in delivering biologics for Alzheimer’s disease by low-intensity ultrasound
Liyu Chen, Esteban Cruz, Lotta E. Oikari, Pranesh Padmanabhan, Jae Song and Jürgen Götz
Advanced Drug Delivery Reviews, 2022, 189, 114517
DOI: 10.1016/j.addr.2022.114517

Polymer-based nanocarriers to transport therapeutic biomacromolecules across the blood-brain barrier
Elena Romero-Ben, Upashi Goswami, Jackeline Soto-Cruz, Amirreza Mansoori-Kermani, Dhiraj Mishra, Sergio Martin-Saldaña, Jone Muñoz-Ugartemendia, Alejandro Sosnik, Marcelo Calderón, Ana Beloqui and Aitor Larrañaga
Acta Biomaterialia, 2025, 196, 17
DOI: 10.1016/j.actbio.2025.02.065

A review on in vitro model of the blood-brain barrier (BBB) based on hCMEC/D3 cells
Dake Qi, Haiyang Lin, Bingying Hu and Yang Wei
Journal of Controlled Release, 2023, 358, 78
DOI: 10.1016/j.jconrel.2023.04.020

An Animal‐Free Patient‐Derived Tissue‐Mimetic Biochip Model of the Human Synovial Membrane for Human‐Relevant Osteoarthritis Research
Eva I. Reihs, Alexander Stoegner, Mateo G. Vasconez Martínez, Markus M. Schreiner, Melanie Cezanne, Ruth Gruebl‐Barabas, Bettina Rodriguez‐Molina, Juergen Alphonsus, Silvia Hayer, Richard Lass, Iris Gerner, Florien Jenner, Wolfgang Holnthoner, Stefan Toegel, Peter Ertl, Hans P. Kiener, Reinhard Windhager and Mario Rothbauer
Adv Healthcare Materials, 2025, 14
DOI: 10.1002/adhm.202404799

Stem Cells for Next Level Toxicity Testing in the 21st Century
Ellen Fritsche, Thomas Haarmann‐Stemmann, Julia Kapr, Saskia Galanjuk, Julia Hartmann, Peter R. Mertens, Angela A. M. Kämpfer, Roel P. F. Schins, Julia Tigges and Katharina Koch
Small, 2021, 17
DOI: 10.1002/smll.202006252

A Decade of Organs-on-a-Chip Emulating Human Physiology at the Microscale: A Critical Status Report on Progress in Toxicology and Pharmacology
Mario Rothbauer, Barbara E.M. Bachmann, Christoph Eilenberger, Sebastian R.A. Kratz, Sarah Spitz, Gregor Höll and Peter Ertl
Micromachines, 2021, 12, 470
DOI: 10.3390/mi12050470

Biomaterials for neuroengineering: applications and challenges
Huanghui Wu, Enduo Feng, Huanxin Yin, Yuxin Zhang, Guozhong Chen, Beier Zhu, Xuezheng Yue, Haiguang Zhang, Qiong Liu and Lize Xiong
Regenerative Biomaterials, 2025, 12
DOI: 10.1093/rb/rbae137

How Organ-on-a-Chip Technology Can Assist in Studying the Role of the Glymphatic System in Neurodegenerative Diseases
Sarah Spitz, Eunkyung Ko, Peter Ertl and Roger D. Kamm
IJMS, 2023, 24, 2171
DOI: 10.3390/ijms24032171

Organ-On-A-Chip: An Emerging Research Platform
Nithin R, Ayushi Aggarwal, Anne Boyina Sravani, Pooja Mallya and Shaila Lewis
Organogenesis, 2023, 19
DOI: 10.1080/15476278.2023.2278236

A guide for blood–brain barrier models
Yomna Soliman, Jana Al‐khodor, Gülnaz Yildirim Köken and Nur Mustafaoglu
FEBS Letters, 2025, 599, 599
DOI: 10.1002/1873-3468.15053

Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model
Sharon Wei Ling Lee, Giulia Adriani, Erica Ceccarello, Andrea Pavesi, Anthony Tanoto Tan, Antonio Bertoletti, Roger Dale Kamm and Siew Cheng Wong
Front. Immunol., 2018, 9
DOI: 10.3389/fimmu.2018.00416

Natural product-based bioactive agents in combination attenuate neuroinflammation in a tri-culture model
Yang Liu, Dennis Chang, Tianqing Liu and Xian Zhou
Front. Pharmacol., 2023, 14
DOI: 10.3389/fphar.2023.1135934

Mimicking the Articular Joint with In Vitro Models
Susanna Piluso, Yang Li, Florencia Abinzano, Riccardo Levato, Liliana Moreira Teixeira, Marcel Karperien, Jeroen Leijten, René van Weeren and Jos Malda
Trends in Biotechnology, 2019, 37, 1063
DOI: 10.1016/j.tibtech.2019.03.003

Comprehending the Membrane Properties for Emulation in Organs‐on‐a‐Chip
Tanmayee Makarand Sathe and Dhananjay Shrikrishna Bodas
Advanced NanoBiomed Research, 2026, 6
DOI: 10.1002/anbr.202500078

Micro/nanosystems for controllable drug delivery to the brain
Mingzhen Tian, Zhichao Ma and Guang-Zhong Yang
The Innovation, 2024, 5, 100548
DOI: 10.1016/j.xinn.2023.100548

Electrically controlled cellular migration on a periodically micropatterned PEDOT:PSS conducting polymer platform
M. ElMahmoudy, V. F. Curto, M. Ferro, A. Hama, G. G. Malliaras, R. P. O'Connor and S. Sanaur
J of Applied Polymer Sci, 2019, 136
DOI: 10.1002/app.47029

From cells to organoids: The evolution of blood-brain barrier technology for modelling drug delivery in brain cancer
Estrella Gonzales-Aloy, Aria Ahmed-Cox, Maria Tsoli, David S. Ziegler and Maria Kavallaris
Advanced Drug Delivery Reviews, 2023, 196, 114777
DOI: 10.1016/j.addr.2023.114777

A biomimetic chip to assess subcutaneous bioavailability of monoclonal antibodies in humans
Vineeth Chandran Suja, Qin M Qi, Kevin Halloran, Jifeng Zhang, Suyog Shaha, Supriya Prakash, Ninad Kumbhojkar, Antoine Deslandes, Sylvain Huille, Yatin R Gokarn, Samir Mitragotri and Rui Reis
PNAS Nexus, 2023, 2
DOI: 10.1093/pnasnexus/pgad317

Innovations in 3D Tissue Models of Human Brain Physiology and Diseases
Michael L. Lovett, Thomas J. F. Nieland, Yu‐Ting L. Dingle and David L. Kaplan
Adv Funct Materials, 2020, 30
DOI: 10.1002/adfm.201909146

Advances in modelling the human microbiome–gut–brain axis in vitro
Chrysanthi-Maria Moysidou and Róisín M. Owens
Biochemical Society Transactions, 2021, 49, 187
DOI: 10.1042/BST20200338

Recent progress in translational engineeredin vitromodels of the central nervous system
Polyxeni Nikolakopoulou, Rossana Rauti, Dimitrios Voulgaris, Iftach Shlomy, Ben M Maoz and Anna Herland
Brain, 2020, 143, 3181
DOI: 10.1093/brain/awaa268

Erythrocytes, a New Contributor to Age‐Associated Loss of Blood–Brain Barrier Integrity
Payam Amiri, Jonalyn DeCastro, Joshua Littig, Hsiang‐Wei Lu, Chao Liu, Irina Conboy and Kiana Aran
Advanced Science, 2021, 8
DOI: 10.1002/advs.202101912

Neurological diseases at the blood-brain barrier: Stemming new scientific paradigms using patient-derived induced pluripotent cells
Shyanne Page, Ronak Patel, Snehal Raut and Abraham Al-Ahmad
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2020, 1866, 165358
DOI: 10.1016/j.bbadis.2018.12.009

Three-dimensional co-culture of blood-brain barrier-composing cells in a culture insert with a collagen vitrigel membrane
Ai Shima, Shogo Nagata and Shoji Takeuchi
In Vitro Cell.Dev.Biol.-Animal, 2020, 56, 500
DOI: 10.1007/s11626-020-00486-x

Engineered human blood–brain barrier microfluidic model for vascular permeability analyses
Cynthia Hajal, Giovanni S. Offeddu, Yoojin Shin, Shun Zhang, Olga Morozova, Dean Hickman, Charles G. Knutson and Roger D. Kamm
Nat Protoc, 2022, 17, 95
DOI: 10.1038/s41596-021-00635-w

Innovative microfluidic technologies in precision research and therapy development in diabetic neuropathy: a narrative review
Donghee Lee, Kai Yang and Jingwei Xie
Advanced Technology in Neuroscience, 2024, 1, 123
DOI: 10.4103/ATN.ATN-D-24-00007

3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment
Aida Rodriguez-Garcia, Jacqueline Oliva-Ramirez, Claudia Bautista-Flores and Samira Hosseini
Advances in Polymer Technology, 2020, 2020, 1
DOI: 10.1155/2020/6187048

On-chip modeling of physiological and pathological blood-brain barrier microenvironment for studying glial responses to neuroinflammation
Yu-Lian Zeng, Yang Du, Xin-Xin Xu, Ya-Jun Wang, Sai-Xi Yu, Ting Liu, Shiyuan Luo, Xiao-Wei Xiang, Wei Liu, Yu-Chen Chen, Hongjun Huang, Hai Gao, Yuhui Shen, Yan Luo, Chengrong Bao and Yan-Jun Liu
Nano Today, 2023, 52, 101947
DOI: 10.1016/j.nantod.2023.101947

In Vitro Tumor Models on Chip and Integrated Microphysiological Analysis Platform (MAP) for Life Sciences and High-Throughput Drug Screening
Huyen Ngo, Sarnai Amartumur, Van Thi Ai Tran, Minh Tran, Yen N. Diep, Hansang Cho and Luke P. Lee
Biosensors, 2023, 13, 231
DOI: 10.3390/bios13020231

Recent Progress in the Development of Microfluidic Vascular Models
Kae Sato and Kiichi Sato
ANAL. SCI., 2018, 34, 755
DOI: 10.2116/analsci.17R006

Hybrid elastomer–plastic microfluidic device as a convenient model for mimicking the blood–brain barrier in vitro
Phuoc Quang Huy Nguyen, Duong Duy Duong, Jun Dae Kwun and Nae Yoon Lee
Biomed Microdevices, 2019, 21
DOI: 10.1007/s10544-019-0446-1

Evaluation of Cell‐Penetrating Peptides Using Microfluidic In Vitro 3D Brain Endothelial Barrier
Bohye Chung, Jaehoon Kim, Jiyoung Nam, Hyunho Kim, Yeju Jeong, Hui‐wen Liu, Youngkyu Cho, Yong Ho Kim, Hyun Jeong Oh and Seok Chung
Macromolecular Bioscience, 2020, 20
DOI: 10.1002/mabi.201900425

Cerebral Small Vessel Disease: Therapeutic Approaches Targeting Neuroinflammation, Oxidative Stress, and Endothelial Dysfunction
Habibe Yılmaz and Ulvi Bayraktutan
CIMB, 2025, 47, 232
DOI: 10.3390/cimb47040232

Short chain fatty acids: key regulators of the local and systemic immune response in inflammatory diseases and infections
Lisa-Marie Ney, Maximilian Wipplinger, Martha Grossmann, Nicole Engert, Valentin D. Wegner and Alexander S. Mosig
Open Biol., 2023, 13
DOI: 10.1098/rsob.230014

3D vascularized microphysiological system for investigation of tumor-endothelial crosstalk in anti-cancer drug resistance
Seunggyu Kim, Joonha Park, Jin-Nyoung Ho, Danhyo Kim, Sangchul Lee and Jessie S Jeon
Biofabrication, 2023, 15, 045016
DOI: 10.1088/1758-5090/acef99

Methodological innovations in perfusable vascular networks: Advancing high-density tissue models
Rinki Singh, Nobuhito Mori and Yasuyuki S. Kida
Regenerative Therapy, 2026, 32, 101109
DOI: 10.1016/j.reth.2026.101109

A 3D Real‐Scale, Biomimetic, and Biohybrid Model of the Blood‐Brain Barrier Fabricated through Two‐Photon Lithography
Attilio Marino, Omar Tricinci, Matteo Battaglini, Carlo Filippeschi, Virgilio Mattoli, Edoardo Sinibaldi and Gianni Ciofani
Small, 2018, 14
DOI: 10.1002/smll.201702959

Pericyte loss: a key factor inducing brain Aβ40 accumulation and neuronal degeneration in cerebral amyloid angiopathy
Tao Liu, Weihong Guo, Ming Gong, Linyuan Zhu, Tingting Cao, Yilong Huang, Yunzhu Yang, Jiayi Chen, Canhong Yang, Shufen Zhang, Jiafa Zhang and Tianming Lü
Exp Brain Res, 2025, 243
DOI: 10.1007/s00221-025-07134-4

Biofabrication for neural tissue engineering applications
L. Papadimitriou, P. Manganas, A. Ranella and E. Stratakis
Materials Today Bio, 2020, 6, 100043
DOI: 10.1016/j.mtbio.2020.100043

Brain-on-a-chip: Recent advances in design and techniques for microfluidic models of the brain in health and disease
Leyla Amirifar, Amir Shamloo, Rohollah Nasiri, Natan Roberto de Barros, Ze Zhong Wang, Bige Deniz Unluturk, Alberto Libanori, Oleksandr Ievglevskyi, Sibel Emir Diltemiz, Samuel Sances, Ilangko Balasingham, Stephanie K. Seidlits and Nureddin Ashammakhi
Biomaterials, 2022, 285, 121531
DOI: 10.1016/j.biomaterials.2022.121531

Engineering and monitoring cellular barrier models
Jose Yeste, Xavi Illa, Mar Alvarez and Rosa Villa
J Biol Eng, 2018, 12
DOI: 10.1186/s13036-018-0108-5

Lab-on-a-Chip Platforms as Tools for Drug Screening in Neuropathologies Associated with Blood–Brain Barrier Alterations
Cristina Elena Staicu, Florin Jipa, Emanuel Axente, Mihai Radu, Beatrice Mihaela Radu and Felix Sima
Biomolecules, 2021, 11, 916
DOI: 10.3390/biom11060916

Advances in Hydrogel-Based Microfluidic Blood–Brain-Barrier Models in Oncology Research
Ankur Sood, Anuj Kumar, Atul Dev, Vijai Kumar Gupta and Sung Soo Han
Pharmaceutics, 2022, 14, 993
DOI: 10.3390/pharmaceutics14050993

An isogenic hiPSC-derived BBB-on-a-chip
Pedram Motallebnejad, Andrew Thomas, Sarah L. Swisher and Samira M. Azarin
Biomicrofluidics, 2019, 13
DOI: 10.1063/1.5123476

A novel tri‐culture model for neuroinflammation
Yan‐Fang Zheng, Xian Zhou, Dennis Chang, Deep Jyoti Bhuyan, Jie Ping Zhang, Wen‐Zhen Yu, Xia‐Sen Jiang, Sai Wang Seto, Seung Yeon Yeon, Jia Li and Chun Guang Li
Journal of Neurochemistry, 2021, 156, 249
DOI: 10.1111/jnc.15171

Interactions of Neuronally Induced Stem Cells from Apical Papilla Spheres, Stems Cells from Apical Papilla, and Human Umbilical Vascular Endothelial Cells on Vasculogenesis and Neurogenesis
Mohammed S. Basabrain, Jialin Zhong, Junqing Liu, Yuchen Zhang, Mohamed Mahmoud Abdalla and Chengfei Zhang
Journal of Endodontics, 2024, 50, 64
DOI: 10.1016/j.joen.2023.10.006

A Minimized Valveless Electromagnetic Micropump for Microfluidic Actuation on Organ Chips
Shengli Mi, Haitao Pu, Shengyue Xia and Wei Sun
Sensors and Actuators A: Physical, 2020, 301, 111704
DOI: 10.1016/j.sna.2019.111704

Microneedle array facilitates hepatic sinusoid construction in a large-scale liver-acinus-chip microsystem
Shibo Li, Chengpan Li, Muhammad Imran Khan, Jing Liu, Zhengdi Shi, Dayong Gao, Bensheng Qiu and Weiping Ding
Microsyst Nanoeng, 2023, 9
DOI: 10.1038/s41378-023-00544-w

Advanced Materials and Sensors for Microphysiological Systems: Focus on Electronic and Electrooptical Interfaces
Hanie Kavand, Rohollah Nasiri and Anna Herland
Advanced Materials, 2022, 34
DOI: 10.1002/adma.202107876

Engineered 3D immuno-glial-neurovascular human miBrain model
Alice E. Stanton, Adele Bubnys, Emre Agbas, Benjamin James, Dong Shin Park, Alan Jiang, Rebecca L. Pinals, Liwang Liu, Nhat Truong, Anjanet Loon, Colin Staab, Oyku Cerit, Hsin-Lan Wen, David Mankus, Margaret E. Bisher, Abigail K. R. Lytton-Jean, Manolis Kellis, Joel W. Blanchard, Robert Langer and Li-Huei Tsai
Proc. Natl. Acad. Sci. U.S.A., 2025, 122
DOI: 10.1073/pnas.2511596122

Human Umbilical Vein Endothelial Cells (HUVECs) Co-Culture with Osteogenic Cells: From Molecular Communication to Engineering Prevascularised Bone Grafts
Ievgeniia Kocherova, Artur Bryja, Paul Mozdziak, Ana Angelova Volponi, Marta Dyszkiewicz-Konwińska, Hanna Piotrowska-Kempisty, Paweł Antosik, Dorota Bukowska, Małgorzata Bruska, Dariusz Iżycki, Maciej Zabel, Michał Nowicki and Bartosz Kempisty
JCM, 2019, 8, 1602
DOI: 10.3390/jcm8101602

Vascularizing the brain in vitro
Abdellah Aazmi, Hongzhao Zhou, Weikang Lv, Mengfei Yu, Xiaobin Xu, Huayong Yang, Yu Shrike Zhang and Liang Ma
iScience, 2022, 25, 104110
DOI: 10.1016/j.isci.2022.104110

In Vitro Microfluidic Models for Neurodegenerative Disorders
Tatsuya Osaki, Yoojin Shin, Vivek Sivathanu, Marco Campisi and Roger D. Kamm
Adv Healthcare Materials, 2018, 7
DOI: 10.1002/adhm.201700489

Barriers-on-chips: Measurement of barrier function of tissues in organs-on-chips
Yusuf B. Arık, Marinke W. van der Helm, Mathieu Odijk, Loes I. Segerink, Robert Passier, Albert van den Berg and Andries D. van der Meer
Biomicrofluidics, 2018, 12
DOI: 10.1063/1.5023041

Review of functional in vitro models of the blood-cerebrospinal fluid barrier in leukaemia research
Ulrike Erb, Christian Schwerk, Horst Schroten and Michael Karremann
Journal of Neuroscience Methods, 2020, 329, 108478
DOI: 10.1016/j.jneumeth.2019.108478

Neuromodulation of Cerebral Blood Flow: A Physiological Mechanism and Methodological Review of Neurovascular Coupling
Jiawen Zhong, Gen Li, Zexiang Lv, Jingbo Chen, Chunyan Wang, Ansheng Shao, Zhiwei Gong, Junjie Wang, Siqiao Liu, Jun Luo, Shuping Yang, Sibei Wu, Lin Ning, Zhinong Wang, Jiahao Li and Yu Wu
Bioengineering, 2025, 12, 442
DOI: 10.3390/bioengineering12050442

Organ‐on‐a‐Chip Systems for Women's Health Applications
Janna Nawroth, Julia Rogal, Martin Weiss, Sara Y. Brucker and Peter Loskill
Adv Healthcare Materials, 2018, 7
DOI: 10.1002/adhm.201700550

Modelling cancer in microfluidic human organs-on-chips
Alexandra Sontheimer-Phelps, Bryan A. Hassell and Donald E. Ingber
Nat Rev Cancer, 2019, 19, 65
DOI: 10.1038/s41568-018-0104-6

High-Throughput Methods in the Discovery and Study of Biomaterials and Materiobiology
Liangliang Yang, Sara Pijuan-Galito, Hoon Suk Rho, Aliaksei S. Vasilevich, Aysegul Dede Eren, Lu Ge, Pamela Habibović, Morgan R. Alexander, Jan de Boer, Aurélie Carlier, Patrick van Rijn and Qihui Zhou
Chem. Rev., 2021, 121, 4561
DOI: 10.1021/acs.chemrev.0c00752

Advances in current in vitro models on neurodegenerative diseases
Inês Pereira, Maria J. Lopez-Martinez and Josep Samitier
Front. Bioeng. Biotechnol., 2023, 11
DOI: 10.3389/fbioe.2023.1260397

HDL from an Alzheimer's disease perspective
Emily B. Button, Jérôme Robert, Tara M. Caffrey, Jianjia Fan, Wenchen Zhao and Cheryl L. Wellington
Current Opinion in Lipidology, 2019, 30, 224
DOI: 10.1097/MOL.0000000000000604

Development of nanomedicines for the treatment of Alzheimer’s disease: Raison d’être, strategies, challenges and regulatory aspects
Farhan Mazahir, Md Imtiyaz Alam and Awesh Kumar Yadav
Ageing Research Reviews, 2024, 98, 102318
DOI: 10.1016/j.arr.2024.102318

Hemorrhagic Transformation After Tissue Plasminogen Activator Treatment in Acute Ischemic Stroke
Chengli Liu, Jie Xie, Shanshan Sun, Hui Li, Tianyu Li, Chao Jiang, Xuemei Chen, Junmin Wang, Anh Le, Jiarui Wang, Zhanfei Li, Jian Wang and Wei Wang
Cell Mol Neurobiol, 2022, 42, 621
DOI: 10.1007/s10571-020-00985-1

Blood‐brain barrier development: Systems modeling and predictive toxicology
Katerine S. Saili, Todd J. Zurlinden, Andrew J. Schwab, Aymeric Silvin, Nancy C. Baker, E. Sidney Hunter, Florent Ginhoux and Thomas B. Knudsen
Birth Defects Research, 2017, 109, 1680
DOI: 10.1002/bdr2.1180

Harnessing cerebral organoids for Alzheimer's disease research
Adele Bubnys and Li-Huei Tsai
Current Opinion in Neurobiology, 2022, 72, 120
DOI: 10.1016/j.conb.2021.10.003

Benchmarking in vitro tissue-engineered blood–brain barrier models
Jackson G. DeStefano, John J. Jamieson, Raleigh M. Linville and Peter C. Searson
Fluids Barriers CNS, 2018, 15
DOI: 10.1186/s12987-018-0117-2

Microfluidic chip and its application in autophagy detection
Xiaobo Wang, Zixuan Liu, Fangfang Fan, Ya Hou, Hailing Yang, Xianli Meng, Yi Zhang and Fugang Ren
TrAC Trends in Analytical Chemistry, 2019, 117, 300
DOI: 10.1016/j.trac.2019.05.043

Brain-on-a-chip: A history of development and future perspective
Seokyoung Bang, Sohyeon Jeong, Nakwon Choi and Hong Nam Kim
Biomicrofluidics, 2019, 13
DOI: 10.1063/1.5120555

Real time monitoring of oxygen uptake of hepatocytes in a microreactor using optical microsensors
Christian Gehre, Marie Flechner, Sarah Kammerer, Jan-Heiner Küpper, Charles Dominic Coleman, Gerhard Paul Püschel, Katja Uhlig and Claus Duschl
Sci Rep, 2020, 10
DOI: 10.1038/s41598-020-70785-6

Design and validation of a microfluidic device for blood–brain barrier monitoring and transport studies
Giovanni Stefano Ugolini, Paola Occhetta, Alessandra Saccani, Francesca Re, Silke Krol, Marco Rasponi and Alberto Redaelli
J. Micromech. Microeng., 2018, 28, 044001
DOI: 10.1088/1361-6439/aaa816

A Reconfigurable In Vitro Model for Studying the Blood–Brain Barrier
Monica L. Moya, Michael Triplett, Melinda Simon, Javier Alvarado, Ross Booth, Joanne Osburn, David Soscia, Fang Qian, Nicholas O. Fischer, Kristen Kulp and Elizabeth K. Wheeler
Ann Biomed Eng, 2020, 48, 780
DOI: 10.1007/s10439-019-02405-y

Basement membrane properties and their recapitulation in organ-on-chip applications
Golestan Salimbeigi, Nihal E. Vrana, Amir M. Ghaemmaghami, Pinar Y. Huri and Garrett B. McGuinness
Materials Today Bio, 2022, 15, 100301
DOI: 10.1016/j.mtbio.2022.100301

Modular tissue-in-a-CUBE platform to model blood-brain barrier (BBB) and brain interaction
Isabel Koh and Masaya Hagiwara
Commun Biol, 2024, 7
DOI: 10.1038/s42003-024-05857-8

Hyperglycemic Neurovasculature‐On‐A‐Chip to Study the Effect of SIRT1‐Targeted Therapy for the Type 3 Diabetes “Alzheimer's Disease”
Minjeong Jang, Nakwon Choi and Hong Nam Kim
Advanced Science, 2022, 9
DOI: 10.1002/advs.202201882

Microphysiological Systems as Organ-Specific In Vitro Vascular Models for Disease Modeling
Ungsig Nam, Seokhun Lee, Ashfaq Ahmad, Hee-gyeong Yi and Jessie S. Jeon
BioChip J, 2024, 18, 345
DOI: 10.1007/s13206-024-00152-4

A Hybrid Nanofiber/Paper Cell Culture Platform for Building a 3D Blood–Brain Barrier Model
Kaixiang Huang, Andre D. Castiaux, Ram Podicheti, Douglas B. Rusch, R. Scott Martin and Lane A. Baker
Small Methods, 2021, 5
DOI: 10.1002/smtd.202100592

Development of an In Vitro Biomimetic Peripheral Neurovascular Platform
Afonso Malheiro, Adrián Seijas-Gamardo, Abhishek Harichandan, Carlos Mota, Paul Wieringa and Lorenzo Moroni
ACS Appl. Mater. Interfaces, 2022, 14, 31567
DOI: 10.1021/acsami.2c03861

Brain barriers and brain fluid research in 2016: advances, challenges and controversies
Richard F. Keep, Hazel C. Jones and Lester R. Drewes
Fluids Barriers CNS, 2017, 14
DOI: 10.1186/s12987-017-0052-7

Simple design for membrane-free microphysiological systems to model the blood-tissue barriers
By Ashlyn T. Young, Halston Deal, Gabrielle Rusch, Vladimir A. Pozdin, Ashley C. Brown and Michael Daniele
Organs-on-a-Chip, 2023, 5, 100032
DOI: 10.1016/j.ooc.2023.100032

Recent Progress in Microfluidic Models of the Blood-Brain Barrier
Lili Jiang, Shu Li, Junsong Zheng, Yan Li and Hui Huang
Micromachines, 2019, 10, 375
DOI: 10.3390/mi10060375

Practical guide for preparation, computational reconstruction and analysis of 3D human neuronal networks in control and ischaemic conditions
Noora Räsänen, Venla Harju, Tiina Joki and Susanna Narkilahti
Development, 2022, 149
DOI: 10.1242/dev.200012

Vascularized neural constructs for ex-vivo reconstitution of blood-brain barrier function
Haibing Yue, Kai Xie, Xianglin Ji, Bingzhe Xu, Chong Wang and Peng Shi
Biomaterials, 2020, 245, 119980
DOI: 10.1016/j.biomaterials.2020.119980

Selenium at the Neural Barriers: AReview
Nikolay Solovyev, Evgenii Drobyshev, Bastian Blume and Bernhard Michalke
Front. Neurosci., 2021, 15
DOI: 10.3389/fnins.2021.630016

Construction and Functional Evaluation of a Three-Dimensional Blood–Brain Barrier Model Equipped With Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells
Toshiki Kurosawa, Daiki Sako, Yuma Tega, Yasuyuki Debori, Yumi Tomihara, Kazunobu Aoyama, Yoshiyuki Kubo, Nobuyuki Amano and Yoshiharu Deguchi
Pharm Res, 2022, 39, 1535
DOI: 10.1007/s11095-022-03249-3

Microphysiological Neurovascular Barriers to Model the Inner Retinal Microvasculature
Thomas L. Maurissen, Georgios Pavlou, Colette Bichsel, Roberto Villaseñor, Roger D. Kamm and Héloïse Ragelle
JPM, 2022, 12, 148
DOI: 10.3390/jpm12020148

Modulation of Paracellular Permeability in SARS-CoV-2 Blood-to-Brain Transcytosis
Taylor E. Martinez, Karthick Mayilsamy, Shyam S. Mohapatra and Subhra Mohapatra
Viruses, 2024, 16, 785
DOI: 10.3390/v16050785

Advances in Hydrogels in Organoids and Organs‐on‐a‐Chip
Haitao Liu, Yaqing Wang, Kangli Cui, Yaqiong Guo, Xu Zhang and Jianhua Qin
Advanced Materials, 2019, 31
DOI: 10.1002/adma.201902042

Recent Developments in Microfluidic Technologies for Central Nervous System Targeted Studies
Maria Inês Teixeira, Maria Helena Amaral, Paulo C. Costa, Carla M. Lopes and Dimitrios A. Lamprou
Pharmaceutics, 2020, 12, 542
DOI: 10.3390/pharmaceutics12060542

Advances in BBB on Chip and Application for Studying Reversible Opening of Blood–Brain Barrier by Sonoporation
Yicong Cai, Kexin Fan, Jiawei Lin, Lin Ma and Fenfang Li
Micromachines, 2022, 14, 112
DOI: 10.3390/mi14010112

Porous Membrane Electrical Cell–Substrate Impedance Spectroscopy for Versatile Assessment of Biological Barriers In Vitro
Oleg Chebotarev, Alisa Ugodnikov and Craig A. Simmons
ACS Appl. Bio Mater., 2024, 7, 2000
DOI: 10.1021/acsabm.4c00114

Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms
Song Ih Ahn, Yoshitaka J. Sei, Hyun-Ji Park, Jinhwan Kim, Yujung Ryu, Jeongmoon J. Choi, Hak-Joon Sung, Tobey J. MacDonald, Allan I. Levey and YongTae Kim
Nat Commun, 2020, 11
DOI: 10.1038/s41467-019-13896-7

Mimicking the Human Physiology with Microphysiological Systems (MPS)
Jong Hwan Sung, Jamin Koo and Michael L. Shuler
BioChip J, 2019, 13, 115
DOI: 10.1007/s13206-019-3201-z

From 2D to 3D Co-Culture Systems: A Review of Co-Culture Models to Study the Neural Cells Interaction
Rongrong Liu, Xiaoting Meng, Xiyao Yu, Guoqiang Wang, Zhiyong Dong, Zhengjie Zhou, Mingran Qi, Xiao Yu, Tong Ji and Fang Wang
IJMS, 2022, 23, 13116
DOI: 10.3390/ijms232113116

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
Costantino Iadecola
Neuron, 2017, 96, 17
DOI: 10.1016/j.neuron.2017.07.030

From Petri Dishes to Organ on Chip Platform: The Increasing Importance of Machine Learning and Image Analysis
Arianna Mencattini, Fabrizio Mattei, Giovanna Schiavoni, Annamaria Gerardino, Luca Businaro, Corrado Di Natale and Eugenio Martinelli
Front. Pharmacol., 2019, 10
DOI: 10.3389/fphar.2019.00100

Dynamic 3D On-Chip BBB Model Design, Development, and Applications in Neurological Diseases
Xingchi Chen, Chang Liu, Laureana Muok, Changchun Zeng and Yan Li
Cells, 2021, 10, 3183
DOI: 10.3390/cells10113183

Biofabrication of vasculature in microphysiological models of bone
Ian T Whelan, E Moeendarbary, David A Hoey and Daniel J Kelly
Biofabrication, 2021, 13, 032004
DOI: 10.1088/1758-5090/ac04f7

In vitro modeling of the neurovascular unit: advances in the field
Aditya Bhalerao, Farzane Sivandzade, Sabrina Rahman Archie, Ekram Ahmed Chowdhury, Behnam Noorani and Luca Cucullo
Fluids Barriers CNS, 2020, 17
DOI: 10.1186/s12987-020-00183-7

Recent advancements on in vitro blood-brain barrier model: A reliable and efficient screening approach for preclinical and clinical investigation
Snigdha Singh, Mukta Agrawal, Rajat Vashist, Rohit K Patel, Sanchita Dhanchandra Sangave and Amit Alexander
Expert Opinion on Drug Delivery, 2023, 20, 1839
DOI: 10.1080/17425247.2023.2295940

Advances in modeling permeability and selectivity of the blood-brain barrier using microfluidics
Jindi Sun and Shang Song
Microfluid Nanofluid, 2024, 28
DOI: 10.1007/s10404-024-02741-z

Microfluidic models of the neurovascular unit: a translational view
Nienke R. Wevers and Helga E. De Vries
Fluids Barriers CNS, 2023, 20
DOI: 10.1186/s12987-023-00490-9

Tumor Targeted Delivery of an Anti‐Cancer Therapeutic: An In Vitro and In Vivo Evaluation
You Jung Kang, Claire K. Holley, Mohammad Reza Abidian, Achuthamangalam B. Madhankumar, James Connor and Sheereen Majd
Adv Healthcare Materials, 2021, 10
DOI: 10.1002/adhm.202001261

Biology and Models of the Blood–Brain Barrier
Cynthia Hajal, Baptiste Le Roi, Roger D. Kamm and Ben M. Maoz
Annu. Rev. Biomed. Eng., 2021, 23, 359
DOI: 10.1146/annurev-bioeng-082120-042814

The effect of serum starvation on tight junctional proteins and barrier formation in Caco-2 cells
Aisling M. Ross, Darragh R. Walsh, Rachel M. Cahalane, Lynnette Marcar and John J.E. Mulvihill
Biochemistry and Biophysics Reports, 2021, 27, 101096
DOI: 10.1016/j.bbrep.2021.101096

New tools for immunologists: models of lymph node function from cells to tissues
Tochukwu Ozulumba, Alyssa N. Montalbine, Jennifer E. Ortiz-Cárdenas and Rebecca R. Pompano
Front. Immunol., 2023, 14
DOI: 10.3389/fimmu.2023.1183286

Brain-on-a-Chip: Characterizing the next generation of advanced in vitro platforms for modeling the central nervous system
Ben M. Maoz
APL Bioengineering, 2021, 5
DOI: 10.1063/5.0055812

In vitro models of molecular and nano-particle transport across the blood-brain barrier
Cynthia Hajal, Marco Campisi, Clara Mattu, Valeria Chiono and Roger D. Kamm
Biomicrofluidics, 2018, 12
DOI: 10.1063/1.5027118

Total Saponins of Panax Notoginseng Modulate the Astrocyte Inflammatory Signaling Pathway and Attenuate Inflammatory Injury Induced by Oxygen- Glucose Deprivation/Reperfusion Injury in Rat Brain Microvascular Endothelial Cells
Xiaobing Wei, Yiqi Wen, Yongzhen Hu and Xuli Guo
CSCR, 2024, 19, 267
DOI: 10.2174/1574888X18666230509113912

Development of Microvascular Network in Microfluidic Brain‐on‐a‐Chip Models In Vitro: A Multidisciplinary Review
Alla B. Salmina, Mikis R. Saridis, Vitaly V. Ryzhkov, Sofia A. Korsakova, Anton S. Averchuk, Daniil A. Bystrov, Anastasiia A. Barbasheva, Pavel A. Libet, Alexei K. Kuguk, Leonid Y. Polynkin, Lyubov N. Muravyova, Kirill A. Mamaev, Ruslan Sh. Alibekov, Ivan A. Kushnir, Egor V. Yakovlev, Ilya A. Rodionov and Stanislav O. Yurchenko
Biotechnology Journal, 2025, 20
DOI: 10.1002/biot.70126

Cancer metastasis in vitro models – can 3D biofabrication and microfluidics sow the seeds in the right soil
Yordan Sbirkov, Ilian Koev, Azad Ozanian, Meri Hristamyan, Judith Hagenbuchner, Michael Ausserlechner and Victoria Sarafian
Front. Bioeng. Biotechnol., 2026, 14
DOI: 10.3389/fbioe.2026.1794850

Printing Cell Embedded Sacrificial Strategy for Microvasculature using Degradable DNA Biolubricant
Jiezhong Shi, Yifei Wan, Haoyang Jia, Gregor Skeldon, Dirk Jan Cornelissen, Katrina Wesencraft, Junxi Wu, Gail McConnell, Quan Chen, Dongsheng Liu and Wenmiao Shu
Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202417510

Understanding the brain uptake and permeability of small molecules through the BBB: A technical overview
Ekram Ahmed Chowdhury, Behnam Noorani, Faleh Alqahtani, Aditya Bhalerao, Snehal Raut, Farzane Sivandzade and Luca Cucullo
J Cereb Blood Flow Metab, 2021, 41, 1797
DOI: 10.1177/0271678X20985946

In Situ Formation of Microgel Array Via Patterned Electrospun Nanofibers Promotes 3D Cell Culture and Drug Testing in a Microphysiological System
Minhua Liang, Fan Lei, Yang Liu, Dongxu Lan, Hanhao Huang, Guoliang Zhang, Qi Feng, Xiaodong Cao and Hua Dong
ACS Appl. Bio Mater., 2021, 4, 6209
DOI: 10.1021/acsabm.1c00534

Parallelizable Microfluidic Platform to Model and Assess In Vitro Cellular Barriers: Technology and Application to Study the Interaction of 3D Tumor Spheroids with Cellular Barriers
Arya Lekshmi Nair, Lena Mesch, Ingo Schulz, Holger Becker, Julia Raible, Heiko Kiessling, Simon Werner, Ulrich Rothbauer, Christian Schmees, Marius Busche, Sebastian Trennheuser, Gert Fricker and Martin Stelzle
Biosensors, 2021, 11, 314
DOI: 10.3390/bios11090314

A perforated microhole-based microfluidic device for improving sprouting angiogenesis in vitro
Sijia Chen, Liguang Zhang, Yi Zhao, Ming Ke, Bo Li, Longcong Chen and Shaoxi Cai
Biomicrofluidics, 2017, 11
DOI: 10.1063/1.4994599

Establishment of highly metastatic sublines and insights into telomerase expression during tumor metastasis using a microfluidic system
Jie Wang, Jiali Xu, Xiaopeng Liu, Yuxiao Tong and Zhangrun Xu
Talanta, 2024, 280, 126690
DOI: 10.1016/j.talanta.2024.126690

Biosensor integrated brain-on-a-chip platforms: Progress and prospects in clinical translation
Berivan Cecen, Ecem Saygili, Iman Zare, Omid Nejati, Danial Khorsandi, Atefeh Zarepour, Emine Alarcin, Ali Zarrabi, Seda Nur Topkaya, Ozlem Yesil-Celiktas, Ebrahim Mostafavi and Ayça Bal-Öztürk
Biosensors and Bioelectronics, 2023, 225, 115100
DOI: 10.1016/j.bios.2023.115100

The emergence of 3D bioprinting in organ-on-chip systems
Kirsten Fetah, Peyton Tebon, Marcus J Goudie, James Eichenbaum, Li Ren, Natan Barros, Rohollah Nasiri, Samad Ahadian, Nureddin Ashammakhi, Mehmet R Dokmeci and Ali Khademhosseini
Prog. Biomed. Eng., 2019, 1, 012001
DOI: 10.1088/2516-1091/ab23df

3D in vitro blood–brain barrier models: recent advances and their role in brain disease research and therapy
Laura O’Halloran, Olutoyosi Akinsete, A. Leah Kogan, Michelle Wrona and Amira F. Mahdi
Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1637602

A 3D Biohybrid Real‐Scale Model of the Brain Cancer Microenvironment for Advanced In Vitro Testing
Omar Tricinci, Daniele De Pasquale, Attilio Marino, Matteo Battaglini, Carlotta Pucci and Gianni Ciofani
Adv Materials Technologies, 2020, 5
DOI: 10.1002/admt.202000540

Three-dimensional bioprinting of aneurysm-bearing tissue structure for endovascular deployment of embolization coils
Lindy K Jang, Javier A Alvarado, Marianna Pepona, Elisa M Wasson, Landon D Nash, Jason M Ortega, Amanda Randles, Duncan J Maitland, Monica L Moya and William F Hynes
Biofabrication, 2021, 13, 015006
DOI: 10.1088/1758-5090/abbb9b

Engineering “endothelialized” microfluidics for investigating vascular and hematologic processes using non-traditional fabrication techniques
Robert G. Mannino, Navaneeth K.R. Pandian, Abhishek Jain and Wilbur A. Lam
Current Opinion in Biomedical Engineering, 2018, 5, 13
DOI: 10.1016/j.cobme.2017.11.006

Perspective: The promise of multi-cellular engineered living systems
Roger D. Kamm, Rashid Bashir, Natasha Arora, Roy D. Dar, Martha U. Gillette, Linda G. Griffith, Melissa L. Kemp, Kathy Kinlaw, Michael Levin, Adam C. Martin, Todd C. McDevitt, Robert M. Nerem, Mark J. Powers, Taher A. Saif, James Sharpe, Shuichi Takayama, Shoji Takeuchi, Ron Weiss, Kaiming Ye, Hannah G. Yevick and Muhammad H. Zaman
APL Bioengineering, 2018, 2
DOI: 10.1063/1.5038337

Integrating Biosensors in Organs-on-Chip Devices: A Perspective on Current Strategies to Monitor Microphysiological Systems
Erika Ferrari, Cecilia Palma, Simone Vesentini, Paola Occhetta and Marco Rasponi
Biosensors, 2020, 10, 110
DOI: 10.3390/bios10090110

Tomorrow today: organ-on-a-chip advances towards clinically relevant pharmaceutical and medical in vitro models
Mario Rothbauer, Julie M Rosser, Helene Zirath and Peter Ertl
Current Opinion in Biotechnology, 2019, 55, 81
DOI: 10.1016/j.copbio.2018.08.009

3D hydrogel models of the neurovascular unit to investigate blood–brain barrier dysfunction
Geoffrey Potjewyd, Katherine A.B. Kellett and Nigel M. Hooper
Neuronal Signaling, 2021, 5
DOI: 10.1042/NS20210027

Recent Developments in Glioblastoma‐On‐A‐Chip for Advanced Drug Screening Applications
Surjendu Maity, Tamanna Bhuyan, Christopher Jewell, Satoru Kawakita, Saurabh Sharma, Huu Tuan Nguyen, Alireza Hassani Najafabadi, Menekse Ermis, Natashya Falcone, Junjie Chen, Kalpana Mandal, Danial Khorsandi, Can Yilgor, Auveen Choroomi, Emily Torres, Marvin Mecwan, Johnson V. John, Mohsen Akbari, Zhaohui Wang, Diogo Moniz‐Garcia, Alfredo Quiñones‐Hinojosa, Vadim Jucaud, Mehmet Remzi Dokmeci and Ali Khademhosseini
Small, 2025, 21
DOI: 10.1002/smll.202405511

Microfluidic strategies for the blood-brain barrier construction and assessment
Fangchao Yin, Wentao Su, Li Wang and Qiongzheng Hu
TrAC Trends in Analytical Chemistry, 2022, 155, 116689
DOI: 10.1016/j.trac.2022.116689

Aberrant blood-brain barrier dynamics in cerebral small vessel disease - a review of associations, pathomechanisms and therapeutic potentials
Sayyidah Maryamul Azra’ Zul Ramli, Hafizah Abdul Hamid, Che Mohd Nasril Che Mohd Nassir, Siti Nurulnabila A Rahaman, Muhammad Zulfadli Mehat, Jaya Kumar, Si-Yuen Lee and Muzaimi Mustapha
Vessel Plus, 2024
DOI: 10.20517/2574-1209.2024.22

Salidroside as a potential neuroprotective agent for ischemic stroke: a review of sources, pharmacokinetics, mechanism and safety
Fangfang Fan, Lu Yang, Rui Li, Xuemei Zou, Ning Li, Xianli Meng, Yi Zhang and Xiaobo Wang
Biomedicine & Pharmacotherapy, 2020, 129, 110458
DOI: 10.1016/j.biopha.2020.110458

Advances and Challenges of Bioassembly Strategies in Neurovascular In Vitro Modeling: An Overview of Current Technologies with a Focus on Three-Dimensional Bioprinting
Salvatore Mancuso, Aditya Bhalerao and Luca Cucullo
IJMS, 2024, 25, 11000
DOI: 10.3390/ijms252011000

Generation of a perfusable three-dimensional human neurovascular chip to model brain drug delivery and immune cell extravasation
Boning Qiu, Sara Pompe, Katerina T. Xenaki, Alessia di Maggio, Paul M.P. van Bergen en Henegouwen, Sabrina Oliveira, Enrico Mastrobattista and Massimiliano Caiazzo
Journal of Controlled Release, 2025, 387, 114257
DOI: 10.1016/j.jconrel.2025.114257

In vitro human brain barrier models for studying thyroid hormone transport
Kim Heikamp, Timo Hamers and Ellen V. S. Hessel
Critical Reviews in Toxicology, 2025, 55, 645
DOI: 10.1080/10408444.2025.2540446

Real-Time Ratiometric Imaging of Micelles Assembly State in a Microfluidic Cancer-on-a-Chip
Natalia Feiner-Gracia, Adrianna Glinkowska Mares, Marina Buzhor, Romen Rodriguez-Trujillo, Josep Samitier Marti, Roey J. Amir, Silvia Pujals and Lorenzo Albertazzi
ACS Appl. Bio Mater., 2021, 4, 669
DOI: 10.1021/acsabm.0c01209

Current Status of In vitro Models of the Blood-brain Barrier
Brijesh Shah and Xiaowei Dong
CDD, 2022, 19, 1034
DOI: 10.2174/1567201819666220303102614

Microfluidics for Neuronal Cell and Circuit Engineering
Rouhollah Habibey, Jesús Eduardo Rojo Arias, Johannes Striebel and Volker Busskamp
Chem. Rev., 2022, 122, 14842
DOI: 10.1021/acs.chemrev.2c00212

Effects of vascular endothelial cells on the neurite outgrowth of nerve cells
Tomoki Asaba, Tatsuya Osaki, Koki Murayama, Sayuri Hamano, Tatsuto Kageyama and Junji Fukuda
Journal of Bioscience and Bioengineering, 2025, 140, 168
DOI: 10.1016/j.jbiosc.2025.05.010

2D versus 3D human induced pluripotent stem cell-derived cultures for neurodegenerative disease modelling
Eduarda G Z Centeno, Helena Cimarosti and Angela Bithell
Mol Neurodegeneration, 2018, 13
DOI: 10.1186/s13024-018-0258-4

From microfluidics to microphysiological systems: Past, present, and future
María Virumbrales-Muñoz and Jose M. Ayuso
Organs-on-a-Chip, 2022, 4, 100015
DOI: 10.1016/j.ooc.2022.100015

In situ sensors for blood-brain barrier (BBB) on a chip
Yan Liang and Jeong-Yeol Yoon
Sensors and Actuators Reports, 2021, 3, 100031
DOI: 10.1016/j.snr.2021.100031

Human in vitro models of neurovasculature and the application to pre-clinical intracerebral haemorrhage research
Siobhan Crilly and Mihai Lomora
Bioactive Materials, 2026, 56, 294
DOI: 10.1016/j.bioactmat.2025.10.018

Biofabrication Strategies and Engineered In Vitro Systems for Vascular Mechanobiology
Shantanu Pradhan, Omar A. Banda, Cindy J. Farino, John L. Sperduto, Keely A. Keller, Ryan Taitano and John H. Slater
Adv Healthcare Materials, 2020, 9
DOI: 10.1002/adhm.201901255

Advanced materials and biofabrication technologies to design in vitro functional central nervous system models
Cecilia Traldi, Vanessa Chiappini, Giovanna Menduti, Chiara Tonda-Turo and Marina Boido
Front. Med. Eng., 2023, 1
DOI: 10.3389/fmede.2023.1270943

Engineering Tissue Barrier Models on Hydrogel Microfluidic Platforms
Daniel Vera, María García-Díaz, Núria Torras, Mar Álvarez, Rosa Villa and Elena Martinez
ACS Appl. Mater. Interfaces, 2021, 13, 13920
DOI: 10.1021/acsami.0c21573

Printing Cell Embedded Sacrificial Strategy for Microvasculature using Degradable DNA Biolubricant
Jiezhong Shi, Yifei Wan, Haoyang Jia, Gregor Skeldon, Dirk Jan Cornelissen, Katrina Wesencraft, Junxi Wu, Gail McConnell, Quan Chen, Dongsheng Liu and Wenmiao Shu
Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202417510

Advances in ex vivo models and lab-on-a-chip devices for neural tissue engineering
Sahba Mobini, Young Hye Song, Michaela W. McCrary and Christine E. Schmidt
Biomaterials, 2019, 198, 146
DOI: 10.1016/j.biomaterials.2018.05.012

Revolutionizing neurotherapeutics: blood-brain barrier-on-a-chip technologies for precise drug delivery
Burhan Kantawala, Sanobar Shariff, Nagham Ramadan, Violette Fawaz, Youmna Hassan, Nadine Mugisha, Konstantin Yenkoyan, Abubakar Nazir and Olivier Uwishema
Annals of Medicine & Surgery, 2024, 86, 2794
DOI: 10.1097/MS9.0000000000001887

Micropatterned Neurovascular Interface to Mimic the Blood–Brain Barrier’s Neurophysiology and Micromechanical Function: A BBB-on-CHIP Model
Ajay Vikram Singh, Vaisali Chandrasekar, Peter Laux, Andreas Luch, Sarada Prasad Dakua, Paolo Zamboni, Amruta Shelar, Yin Yang, Vaibhav Pandit, Veronica Tisato and Donato Gemmati
Cells, 2022, 11, 2801
DOI: 10.3390/cells11182801

Inhibition of the α7 nicotinic acetylcholine receptor alleviates pyroptosis in blood-brain barrier induced by Cryptococcus neoformans
Jingyu Chen, Bingliang Zhou, Jinhu Zou, Penghui Wang, Xiangshun Meng, Pengwei Huang, Jie Chen and Hong Cao
Microbial Pathogenesis, 2026, 213, 108377
DOI: 10.1016/j.micpath.2026.108377

A filter-free blood-brain barrier model to quantitatively study transendothelial delivery of nanoparticles by fluorescence spectroscopy
Edwin De Jong, David S. Williams, Loai K.E.A. Abdelmohsen, Jan C.M. Van Hest and Inge S. Zuhorn
Journal of Controlled Release, 2018, 289, 14
DOI: 10.1016/j.jconrel.2018.09.015

In Vitro Models of the Blood–Cerebrospinal Fluid Barrier and Their Applications in the Development and Research of (Neuro)Pharmaceuticals
Fatemeh Dabbagh, Horst Schroten and Christian Schwerk
Pharmaceutics, 2022, 14, 1729
DOI: 10.3390/pharmaceutics14081729

Recent advances in blood-brain barrier-on-a-chip models
Johanna Vetter, Ilaria Palagi, Ari Waisman and Andreas Blaeser
Acta Biomaterialia, 2025, 197, 1
DOI: 10.1016/j.actbio.2025.03.041

Microfluidic devices for the detection of disease-specific proteins and other macromolecules, disease modelling and drug development: A review
S. Amir, A. Arathi, S. Reshma and P.V. Mohanan
International Journal of Biological Macromolecules, 2023, 235, 123784
DOI: 10.1016/j.ijbiomac.2023.123784

Standardization of research methods employed in assessing the interaction between metallic-based nanoparticles and the blood-brain barrier: Present and future perspectives
Aisling M. Ross, David Mc Nulty, Colm O'Dwyer, Andreas M. Grabrucker, Patrick Cronin and John J.E. Mulvihill
Journal of Controlled Release, 2019, 296, 202
DOI: 10.1016/j.jconrel.2019.01.022

Tissue-engineered blood-brain barrier models via directed differentiation of human induced pluripotent stem cells
Gabrielle N. Grifno, Alanna M. Farrell, Raleigh M. Linville, Diego Arevalo, Joo Ho Kim, Luo Gu and Peter C. Searson
Sci Rep, 2019, 9
DOI: 10.1038/s41598-019-50193-1

Cell type-specific changes in transcriptomic profiles of endothelial cells, iPSC-derived neurons and astrocytes cultured on microfluidic chips
H. H. T. Middelkamp, A. H. A. Verboven, A. G. De Sá Vivas, C. Schoenmaker, T. M. Klein Gunnewiek, R. Passier, C. A. Albers, P. A. C. ‘t Hoen, N. Nadif Kasri and A. D. van der Meer
Sci Rep, 2021, 11
DOI: 10.1038/s41598-021-81933-x

Modeling the blood-brain barrier for treatment of central nervous system (CNS) diseases
Olivia Rice, Allison Surian and Yupeng Chen
J Tissue Eng, 2022, 13
DOI: 10.1177/20417314221095997

What human blood-brain barrier models can tell us about BBB function and drug discovery?
Lino Ferreira
Expert Opinion on Drug Discovery, 2019, 14, 1113
DOI: 10.1080/17460441.2019.1646722

Lab-on-a-Chip Technologies for the Single Cell Level: Separation, Analysis, and Diagnostics
Axel Hochstetter
Micromachines, 2020, 11, 468
DOI: 10.3390/mi11050468

Cryptotanshinone Attenuates Oxygen-Glucose Deprivation/ Recovery-Induced Injury in an in vitro Model of Neurovascular Unit
Hongye Zhao, Tiezheng Zheng, Xiaohan Yang, Ming Fan, Lingling Zhu, Shuhong Liu, Liying Wu and Changkai Sun
Front. Neurol., 2019, 10
DOI: 10.3389/fneur.2019.00381

Organ-on-a-Chip: The Future of Therapeutic Aptamer Research?
Thoa Thi Thanh Tran, Antonio Delgado and Sehoon Jeong
BioChip J, 2021, 15, 109
DOI: 10.1007/s13206-021-00016-1

Recent Advances in Microfluidic-Based Microphysiological Systems
Sung-Min Kang
BioChip J, 2022, 16, 13
DOI: 10.1007/s13206-021-00043-y

Biosynthetic, biomimetic, and self-assembled vascularized Organ-on-a-Chip systems
Anna Fritschen and Andreas Blaeser
Biomaterials, 2021, 268, 120556
DOI: 10.1016/j.biomaterials.2020.120556

Biomedical Application of Functional Materials in Organ-on-a-Chip
Chizhu Ding, Xiang Chen, Qinshu Kang and Xianghua Yan
Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.00823

Blood–Brain Barrier Dynamic Device with Uniform Shear Stress Distribution for Microscopy and Permeability Measurements
Nina Choublier, Yoann Müller, Loris Gomez Baisac, Jeremy Laedermann, Casimir de Rham, Xavier Declèves and Adrien Roux
Applied Sciences, 2021, 11, 5584
DOI: 10.3390/app11125584

Artificial intelligence and machine learning driven nanorobotics for targeted brain delivery: Redefining blood-brain barrier navigation
Suraj Kumar, Rishabha Malviya, Sathvik Belagodu Sridhar, Tarun Wadhwa and Javedh Shareef
Journal of Neuroscience Methods, 2026, 429, 110695
DOI: 10.1016/j.jneumeth.2026.110695

Modeling the blood–brain barrier: Beyond the endothelial cells
Benjamin D. Gastfriend, Sean P. Palecek and Eric V. Shusta
Current Opinion in Biomedical Engineering, 2018, 5, 6
DOI: 10.1016/j.cobme.2017.11.002

Neuron(s)-on-a-Chip: A Review of the Design and Use of Microfluidic Systems for Neural Tissue Culture
David Choy Buentello, Mariana García-Corral, Grissel Trujillo-de Santiago and Mario Moisés Alvarez
IEEE Rev. Biomed. Eng., 2024, 17, 243
DOI: 10.1109/RBME.2022.3217486

Emerging Three‐Dimensional Integrated Systems for Biomimetic Neural In Vitro Cultures
Miriam Seiti, Paola Serena Ginestra, Elisabetta Ceretti, Eleonora Ferraris and Adrian Ranga
Adv Materials Inter, 2022, 9
DOI: 10.1002/admi.202101297

3D brain angiogenesis model to reconstitute functional human blood–brain barrier in vitro
Somin Lee, Minhwan Chung, Seung‐Ryeol Lee and Noo Li Jeon
Biotech & Bioengineering, 2020, 117, 748
DOI: 10.1002/bit.27224

Current progress and challenges in the development of brain tissue models: How to grow up the changeable brain in vitro?
Alla B Salmina, Olga P Alexandrova, Anton S Averchuk, Sofia A Korsakova, Mikis R Saridis, Sergey N Illarioshkin and Stanislav O Yurchenko
J Tissue Eng, 2024, 15
DOI: 10.1177/20417314241235527

An engineered neurovascular unit for modeling neuroinflammation
Suyeong Seo, Chi-Hoon Choi, Kyung Sik Yi, Seung U Kim, Kangwon Lee, Nakwon Choi, Hong Jun Lee, Sang-Hoon Cha and Hong Nam Kim
Biofabrication, 2021, 13, 035039
DOI: 10.1088/1758-5090/abf741

Review Article: Capturing the physiological complexity of the brain's neuro-vascular unit in vitro
Hossein Heidari and Hayden Taylor
Biomicrofluidics, 2018, 12
DOI: 10.1063/1.5045126

Modeling neural circuit, blood–brain barrier, and myelination on a microfluidic 96 well plate
Seung-Ryeol Lee, Sujin Hyung, Seokyoung Bang, Younggyun Lee, Jihoon Ko, Somin Lee, Hyung Joon Kim and Noo Li Jeon
Biofabrication, 2019, 11, 035013
DOI: 10.1088/1758-5090/ab1402

Cerebrovascular development: mechanisms and experimental approaches
Timothy J. A. Chico and Elisabeth C. Kugler
Cell. Mol. Life Sci., 2021, 78, 4377
DOI: 10.1007/s00018-021-03790-1

Implementation of blood-brain barrier on microfluidic chip: Recent advance and future prospects
Wangyu Bi, Shanglin Cai, Tong Lei and Lei Wang
Ageing Research Reviews, 2023, 87, 101921
DOI: 10.1016/j.arr.2023.101921

Translational Nanomedicines Across Human Reproductive Organs Modeling on Microfluidic Chips: State-of-the-Art and Future Prospects
Ankur Sood, Anuj Kumar, Vijai Kumar Gupta, Chul Min Kim and Sung Soo Han
ACS Biomater. Sci. Eng., 2023, 9, 62
DOI: 10.1021/acsbiomaterials.2c01080

Biomaterials and Culture Systems for Development of Organoid and Organ-on-a-Chip Models
Katya D’Costa, Milena Kosic, Angus Lam, Azeen Moradipour, Yimu Zhao and Milica Radisic
Ann Biomed Eng, 2020, 48, 2002
DOI: 10.1007/s10439-020-02498-w

Meta-analysis of the make-up and properties of in vitro models of the healthy and diseased blood–brain barrier
James G. Shamul, Zhiyuan Wang, Hyeyeon Gong, Wenquan Ou, Alisa M. White, Diogo P. Moniz-Garcia, Shuo Gu, Alisa Morss Clyne, Alfredo Quiñones-Hinojosa and Xiaoming He
Nat. Biomed. Eng, 2024, 9, 566
DOI: 10.1038/s41551-024-01250-2

Real-Time, Continuous Monitoring of Tissue Chips as an Emerging Opportunity for Biosensing
John S. Cognetti and Benjamin L. Miller
Sensors, 2025, 25, 5153
DOI: 10.3390/s25165153

Eucalyptus Wood Smoke Extract Elicits a Dose-Dependent Effect in Brain Endothelial Cells
Dorothy J. You, Bria M. Gorman, Noah Goshi, Nicholas R. Hum, Aimy Sebastian, Yong Ho Kim, Heather A. Enright and Bruce A. Buchholz
IJMS, 2024, 25, 10288
DOI: 10.3390/ijms251910288

Recent Advances in Body-on-a-Chip Systems
Jong Hwan Sung, Ying I. Wang, Narasimhan Narasimhan Sriram, Max Jackson, Christopher Long, James J. Hickman and Michael L. Shuler
Anal. Chem., 2019, 91, 330
DOI: 10.1021/acs.analchem.8b05293

Advances in nanomedicines for diagnosis of central nervous system disorders
Xun Zhang, Jie Zhou, Zhongwei Gu, Hu Zhang, Qiyong Gong and Kui Luo
Biomaterials, 2021, 269, 120492
DOI: 10.1016/j.biomaterials.2020.120492

In vitro models of the blood-brain barrier: building in physiological complexity
Moriah E Katt and Eric V Shusta
Current Opinion in Chemical Engineering, 2020, 30, 42
DOI: 10.1016/j.coche.2020.07.002

Modeling Neurovascular Disorders and Therapeutic Outcomes with Human-Induced Pluripotent Stem Cells
Allison M. Bosworth, Shannon L. Faley, Leon M. Bellan and Ethan S. Lippmann
Front. Bioeng. Biotechnol., 2018, 5
DOI: 10.3389/fbioe.2017.00087

Litebamine ameliorates cerebral ischemia-induced blood-brain barrier damage by inhibiting pyroptosis
Quanyong Wang, Wenjing Zhou, Lei Liu, Lifang Dong and Linchun Wen
Brain Injury, 2026, 40, 117
DOI: 10.1080/02699052.2025.2591870

Multilayered microcasting of agarose–collagen composites for neurovascular modeling
Hossein Heidari and Hayden Taylor
Bioprinting, 2020, 17, e00069
DOI: 10.1016/j.bprint.2019.e00069

The epigenetic modification of DNA methylation in neurological diseases
Linke Li, Rui Chen, Hui Zhang, Jinsheng Li, Hao Huang, Jie Weng, Huan Tan, Tailin Guo, Mengyuan Wang and Jiang Xie
Front. Immunol., 2024, 15
DOI: 10.3389/fimmu.2024.1401962

Is It Time to Start Transitioning From 2D to 3D Cell Culture?
Caleb Jensen and Yong Teng
Front. Mol. Biosci., 2020, 7
DOI: 10.3389/fmolb.2020.00033

Microfluidics for brain endothelial cell-astrocyte interactions
Jayita Sanapathi, Pravinkumar Vipparthi, Sushmita Mishra, Alejandro Sosnik and Murali Kumarasamy
Organs-on-a-Chip, 2023, 5, 100033
DOI: 10.1016/j.ooc.2023.100033

Tetralol derivative NNC-55-0396 targets hypoxic cells in the glioblastoma microenvironment: an organ-on-chip approach
Clara Bayona, Lía Alza, Teodora Ranđelović, Marta C. Sallán, Anna Visa, Carles Cantí, Ignacio Ochoa, Sara Oliván and Judit Herreros
Cell Death Dis, 2024, 15
DOI: 10.1038/s41419-024-06492-1

Advances of 3D Cell Co-Culture Technology Based on Microfluidic Chips
Can Li, Wei He, Yihua Song, Xia Zhang, Jianfei Sun and Zuojian Zhou
Biosensors, 2024, 14, 336
DOI: 10.3390/bios14070336

Therapeutic roles of plants for 15 hypothesised causal bases of Alzheimer’s disease
Sheena E. B. Tyler and Luke D. K. Tyler
Nat. Prod. Bioprospect., 2022, 12
DOI: 10.1007/s13659-022-00354-z

Role of pyroptosis in the pathogenesis of various neurological diseases
Abiola Oladapo, Thomas Jackson, Jueliet Menolascino and Palsamy Periyasamy
Brain, Behavior, and Immunity, 2024, 117, 428
DOI: 10.1016/j.bbi.2024.02.001

Rapid Prototyping of Multilayer Microphysiological Systems
Sanjin Hosic, Adam J. Bindas, Marissa L. Puzan, Will Lake, Jonathan R. Soucy, Fanny Zhou, Ryan A. Koppes, David T. Breault, Shashi K. Murthy and Abigail N. Koppes
ACS Biomater. Sci. Eng., 2021, 7, 2949
DOI: 10.1021/acsbiomaterials.0c00190

Surface‐enhanced Raman scattering technology based on TiO2/Nb2C coated microfluidic chip for monitoring glioma cells invasion in real time
Jie Zhao, Xiaoyan Liu, Yan Zhou, Tingting Zheng and Yang Tian
Chinese Chemical Letters, 2023, 34, 107895
DOI: 10.1016/j.cclet.2022.107895

A Low Permeability Microfluidic Blood-Brain Barrier Platform with Direct Contact between Perfusable Vascular Network and Astrocytes
Seokyoung Bang, Seung-Ryeol Lee, Jihoon Ko, Kyungmin Son, Dongha Tahk, Jungho Ahn, Changkyun Im and Noo Li Jeon
Sci Rep, 2017, 7
DOI: 10.1038/s41598-017-07416-0

An in vitro bioengineered model of the human arterial neurovascular unit to study neurodegenerative diseases
Jerome Robert, Nicholas L. Weilinger, Li-Ping Cao, Stefano Cataldi, Emily B. Button, Sophie Stukas, Emma M. Martin, Philip Seibler, Megan Gilmour, Tara M. Caffrey, Elyn M. Rowe, Jianjia Fan, Brian MacVicar, Matthew J. Farrer and Cheryl L. Wellington
Mol Neurodegeneration, 2020, 15
DOI: 10.1186/s13024-020-00418-z

Bioengineered tissue models for the development of dynamic immuno-associated tumor models and high-throughput immunotherapy cytotoxicity assays
Amir Seyfoori, Mahdieh Shokrollahi Barough, Meitham Amereh, Bardia Khun Jush, Julian J. Lum and Mohsen Akbari
Drug Discovery Today, 2021, 26, 455
DOI: 10.1016/j.drudis.2020.11.028

Advances in Engineering Human Tissue Models
Chrysanthi-Maria Moysidou, Chiara Barberio and Róisín Meabh Owens
Front. Bioeng. Biotechnol., 2021, 8
DOI: 10.3389/fbioe.2020.620962

Development and Application of Endothelial Cells Derived From Pluripotent Stem Cells in Microphysiological Systems Models
Crystal C. Kennedy, Erin E. Brown, Nadia O. Abutaleb and George A. Truskey
Front. Cardiovasc. Med., 2021, 8
DOI: 10.3389/fcvm.2021.625016

Design criteria and standardization of a microfluidic cell culture system for investigating cellular migration
Young Lee, Gihyun Lee, Minkyung Cho and Je-Kyun Park
J. Micromech. Microeng., 2019, 29, 043003
DOI: 10.1088/1361-6439/ab0796

Recent advances in microfluidic technologies for organ-on-a-chip
Chang Tian, Qin Tu, Wenming Liu and Jinyi Wang
TrAC Trends in Analytical Chemistry, 2019, 117, 146
DOI: 10.1016/j.trac.2019.06.005

Integration of immune cells in organs-on-chips: a tutorial
Lisette Van Os, Britta Engelhardt and Olivier T. Guenat
Front. Bioeng. Biotechnol., 2023, 11
DOI: 10.3389/fbioe.2023.1191104

Microfluidic Tissue Engineering and Bio‐Actuation
Miriam Filippi, Thomas Buchner, Oncay Yasa, Stefan Weirich and Robert K. Katzschmann
Advanced Materials, 2022, 34
DOI: 10.1002/adma.202108427

An overview of in vitro 3D models of the blood-brain barrier as a tool to predict the in vivo permeability of nanomedicines
Alexandre Pérez-López, Ana Isabel Torres-Suárez, Cristina Martín-Sabroso and Juan Aparicio-Blanco
Advanced Drug Delivery Reviews, 2023, 196, 114816
DOI: 10.1016/j.addr.2023.114816

In Situ Surface Modification of Microfluidic Blood–Brain-Barriers for Improved Screening of Small Molecules and Nanoparticles
Bo Peng, Ziqiu Tong, Wing Yin Tong, Paul J. Pasic, Arianna Oddo, Yitian Dai, Meihua Luo, Juliette Frescene, Nicholas G. Welch, Christopher D. Easton, Helmut Thissen and Nicolas H. Voelcker
ACS Appl. Mater. Interfaces, 2020, 12, 56753
DOI: 10.1021/acsami.0c17102

Acoustofluidic Engineering of Functional Vessel-on-a-Chip
Yue Wu, Yuwen Zhao, Khayrul Islam, Yuyuan Zhou, Saeed Omidi, Yevgeny Berdichevsky and Yaling Liu
ACS Biomater. Sci. Eng., 2023, 9, 6273
DOI: 10.1021/acsbiomaterials.3c00925

Micropathological Chip Modeling the Neurovascular Unit Response to Inflammatory Bone Condition
Estrela Neto, Ana Carolina Monteiro, Catarina Leite Pereira, Miguel Simões, João Pedro Conde, Virginia Chu, Bruno Sarmento and Meriem Lamghari
Adv Healthcare Materials, 2022, 11
DOI: 10.1002/adhm.202102305

Organ-on-a-chip: A new tool for in vitro research
Jiasheng Yan, Ziwei Li, Jiuchuan Guo, Shan Liu and Jinhong Guo
Biosensors and Bioelectronics, 2022, 216, 114626
DOI: 10.1016/j.bios.2022.114626

Self-assembled innervated vasculature-on-a-chip to study nociception
Vardhman Kumar, David Kingsley, Sajeeshkumar Madhurakkat Perikamana, Pankaj Mogha, C Rory Goodwin and Shyni Varghese
Biofabrication, 2023, 15, 035008
DOI: 10.1088/1758-5090/acc904

Emerging Roles of Microfluidics in Brain Research: From Cerebral Fluids Manipulation to Brain-on-a-Chip and Neuroelectronic Devices Engineering
Jiandi Wan, Sitong Zhou, Hing Jii Mea, Yaojun Guo, Hansol Ku and Brianna M. Urbina
Chem. Rev., 2022, 122, 7142
DOI: 10.1021/acs.chemrev.1c00480

Abnormal Glu/mGluR2/3/PI3K pathway in the hippocampal neurovascular unit leads to diabetes-related depression
Jian Liu, Yuan-Shan Han, Lin Liu, Lin Tang, Hui Yang, Pan Meng, Hong-Qing Zhao and Yu-Hong Wang
Neural Regen Res, 2021, 16, 727
DOI: 10.4103/1673-5374.296418

Development of a microfluidic system with a bearing micropump for applying fluid shear force in an intervertebral disc degeneration model involving mechanical stimulation
Jae-Won Lee, Seoung Min Back, Tae-Won Kim and Hyuk Choi
Organoid, 2024, 4, e10
DOI: 10.51335/organoid.2024.4.e10

Establishment of an In Vitro Neurovascular Unit Model With Blood and Brain Components and Investigation of Its Blood–Brain Barrier
Gozde E. Kole, Tanil Kocagoz, Vasif Hasirci and Deniz Yucel
J Biomedical Materials Res, 2025, 113
DOI: 10.1002/jbm.a.38013

Methods for in vitro modeling of glioma invasion: Choosing tools to meet the need
Bilge Dundar, Steven M. Markwell, Nitya V. Sharma, Cheryl L. Olson, Subhas Mukherjee and Daniel J. Brat
Glia, 2020, 68, 2173
DOI: 10.1002/glia.23813

Advances in the construction of human organs-on-chips
Yi Zeng and Zhongze Gu
Chin. Sci. Bull., 2023, 68, 4954
DOI: 10.1360/TB-2023-0435

Endothelial cell culture in microfluidic devices for investigating microvascular processes
Robert G. Mannino, Yongzhi Qiu and Wilbur A. Lam
Biomicrofluidics, 2018, 12
DOI: 10.1063/1.5024901

Reconstruction of in vivo-like in vitro model: Enabling technologies of microfluidic systems for dynamic biochemical/mechanical stimuli
Sang Min Park, Seongsu Eom, Hyeonjun Hong, Jaeseung Yoon, Seong Jin Lee, Bum Chang Kim, Hyung Woo Kim and Dong Sung Kim
Microelectronic Engineering, 2019, 203-204, 6
DOI: 10.1016/j.mee.2018.10.010

Thromboinflammation Model-on-A-Chip by Whole Blood Microfluidics on Fixed Human Endothelium
Alexander Dupuy, Lejla Hagimola, Neil S. A. Mgaieth, Callum B. Houlahan, Renee E. Preketes-Tardiani, Paul R. Coleman and Freda H. Passam
Diagnostics, 2021, 11, 203
DOI: 10.3390/diagnostics11020203

Microfluidic biosensors and devices for brain tumor diagnosis and monitoring
Omer Qutaiba B. Allela, Wadhah Hasan Alkhazali, Vimal Arora, Pallavi Prahlad, Biswaranjan Mohanty, Archana Dhyani, Shreeya Uppal, Mansur Aliev, Hayder Naji Sameer, Ahmed Yaseen, Zainab H. Athab and Mohaned Adil
Clinica Chimica Acta, 2026, 582, 120796
DOI: 10.1016/j.cca.2025.120796

Assessment of HBEC-5i endothelial cell line cultivated in astrocyte conditioned medium as a human blood-brain barrier model for ABC drug transport studies
Clémentine Puech, Sophie Hodin, Valérie Forest, Zhiguo He, Patrick Mismetti, Xavier Delavenne and Nathalie Perek
International Journal of Pharmaceutics, 2018, 551, 281
DOI: 10.1016/j.ijpharm.2018.09.040

BBB-on-a-chip with integrated micro-TEER for permeability evaluation of multi-functionalized gold nanorods against Alzheimer’s disease
Sujey Palma-Florez, Adrián López-Canosa, Francisco Moralez-Zavala, Oscar Castaño, Marcelo J. Kogan, Josep Samitier, Anna Lagunas and Mònica Mir
J Nanobiotechnol, 2023, 21
DOI: 10.1186/s12951-023-01798-2

Advancing Blood–Brain Barrier-on-a-Chip Models Through Numerical Simulations
Violeta Carvalho, Raquel O. Rodrigues, Su Ryon Shin, Rui Lima and Senhorinha F. C. F. Teixeira
BioChip J, 2024, 18, 546
DOI: 10.1007/s13206-024-00168-w

Toward three-dimensional in vitro models to study neurovascular unit functions in health and disease
TaraM Caffrey, EmilyB Button and Jerome Robert
Neural Regen Res, 2021, 16, 2132
DOI: 10.4103/1673-5374.310671

Bioprinting and Organ-on-Chip Applications Towards Personalized Medicine for Bone Diseases
Chiara Arrigoni, Mara Gilardi, Simone Bersini, Christian Candrian and Matteo Moretti
Stem Cell Rev and Rep, 2017, 13, 407
DOI: 10.1007/s12015-017-9741-5

Organs-on-a-chip
David Bovard, Anita Iskandar, Karsta Luettich, Julia Hoeng and Manuel C Peitsch
Toxicology Research and Application, 2017, 1
DOI: 10.1177/2397847317726351

Microfluidics for 3D Cell and Tissue Cultures: Microfabricative and Ethical Aspects Updates
Tania Limongi, Francesco Guzzi, Elvira Parrotta, Patrizio Candeloro, Stefania Scalise, Valeria Lucchino, Francesco Gentile, Luca Tirinato, Maria Laura Coluccio, Bruno Torre, Marco Allione, Monica Marini, Francesca Susa, Enzo Di Fabrizio, Giovanni Cuda and Gerardo Perozziello
Cells, 2022, 11, 1699
DOI: 10.3390/cells11101699

Tissue Engineering 3D Neurovascular Units: A Biomaterials and Bioprinting Perspective
Geoffrey Potjewyd, Samuel Moxon, Tao Wang, Marco Domingos and Nigel M. Hooper
Trends in Biotechnology, 2018, 36, 457
DOI: 10.1016/j.tibtech.2018.01.003

Quantify permeability using on-a-chip models in high-throughput applications
Camilla Soragni, Tessa Vergroesen, Nynke Hettema, Gwenaëlle Rabussier, Henriëtte L. Lanz, Sebastian J. Trietsch, Leon J. de Windt and Chee P. Ng
STAR Protocols, 2023, 4, 102051
DOI: 10.1016/j.xpro.2023.102051

Models and approaches to comprehend and address glial inflammation following spinal cord injury
Vaibhav Patil, Raghvendra Bohara, Vijaya Krishna Kanala, Siobhan McMahon and Abhay Pandit
Drug Discovery Today, 2023, 28, 103722
DOI: 10.1016/j.drudis.2023.103722

Glycosylation: A new signaling paradigm for the neurovascular diseases
Dapinder Kaur, Heena Khan, Amarjot Kaur Grewal and Thakur Gurjeet Singh
Life Sciences, 2024, 336, 122303
DOI: 10.1016/j.lfs.2023.122303

Cancer neuroscience: Dissecting autonomic and sensory neural regulation of tumor progression and therapeutic resistance
Jiaxin Sun, Chen Zhang, Jinmiao Zhong and Bing Zhou
Cancer Letters, 2026, 648, 218460
DOI: 10.1016/j.canlet.2026.218460

Advanced 3D biomaterials and bioprinting strategies for in vitro modeling of neurodegenerative diseases
Meenaloshini Gopalakrishnan, Deepshikaa Kannan, Karthikeyan Elumalai, Karthik Karunakar, Sujaritha Jayaraj, Mahalakshmi Devaraji and Nandhini Jayaprakash
Biomedical Technology, 2025, 11, 100089
DOI: 10.1016/j.bmt.2025.100089

Prototyping a Versatile Two-Layer Multi-Channel Microfluidic Device for Direct-Contact Cell-Vessel Co-Culture
Li-Jiun Chen, Bibek Raut, Nobuhiro Nagai, Toshiaki Abe and Hirokazu Kaji
Micromachines, 2020, 11, 79
DOI: 10.3390/mi11010079

Challenges and Future Perspectives in Modeling Neurodegenerative Diseases Using Organ‐on‐a‐Chip Technology
Francesca Michela Pramotton, Sarah Spitz and Roger D. Kamm
Advanced Science, 2024, 11
DOI: 10.1002/advs.202403892

Engineered 3D vascular and neuronal networks in a microfluidic platform
Tatsuya Osaki, Vivek Sivathanu and Roger D. Kamm
Sci Rep, 2018, 8
DOI: 10.1038/s41598-018-23512-1

A novel in vitro co-culture model to examine contact formation between astrocytic processes and cerebral vessels
Shoji Kawauchi, Sayo Horibe, Naoto Sasaki, Ken-ichi Hirata and Yoshiyuki Rikitake
Experimental Cell Research, 2019, 374, 333
DOI: 10.1016/j.yexcr.2018.12.006

Three-dimensional induced pluripotent stem-cell models of human brain angiogenesis
Raleigh M. Linville, Diego Arevalo, Joanna C. Maressa, Nan Zhao and Peter C. Searson
Microvascular Research, 2020, 132, 104042
DOI: 10.1016/j.mvr.2020.104042

Dopamine Neuron Diversity: Recent Advances and Current Challenges in Human Stem Cell Models and Single Cell Sequencing
Alessandro Fiorenzano, Edoardo Sozzi, Malin Parmar and Petter Storm
Cells, 2021, 10, 1366
DOI: 10.3390/cells10061366

Bioprinting Neural Systems to Model Central Nervous System Diseases
Boning Qiu, Nils Bessler, Kianti Figler, Maj‐Britt Buchholz, Anne C. Rios, Jos Malda, Riccardo Levato and Massimiliano Caiazzo
Adv Funct Materials, 2020, 30
DOI: 10.1002/adfm.201910250

Engineering the Human Blood–Brain Barrier at the Capillary Scale using a Double‐Templating Technique
Nan Zhao, Zhaobin Guo, Sarah Kulkarni, Danielle Norman, Sophia Zhang, Tracy D. Chung, Renée F. Nerenberg, Raleigh M. Linville and Peter Searson
Adv Funct Materials, 2022, 32
DOI: 10.1002/adfm.202110289

Advances on fluid shear stress regulating blood-brain barrier
Xiaoli Wang, Bowen Xu, Mengya Xiang, Xinyue Yang, Yi Liu, Xiaoheng Liu and Yang Shen
Microvascular Research, 2020, 128, 103930
DOI: 10.1016/j.mvr.2019.103930

Review of Design Considerations for Brain-on-a-Chip Models
Tiffany Cameron, Tanya Bennet, Elyn Rowe, Mehwish Anwer, Cheryl Wellington and Karen Cheung
Micromachines, 2021, 12, 441
DOI: 10.3390/mi12040441

Advances in organ-on-a-chip engineering
Boyang Zhang, Anastasia Korolj, Benjamin Fook Lun Lai and Milica Radisic
Nat Rev Mater, 2018, 3, 257
DOI: 10.1038/s41578-018-0034-7

A Versatile Platform for Designing and Fabricating Multi-Material Perfusable 3D Microvasculatures
Nathaniel Harris, Charles Miller and Min Zou
Micromachines, 2025, 16, 691
DOI: 10.3390/mi16060691

Targeting pyroptosis as a preventive and therapeutic approach for stroke
Junpeng Long, Yang Sun, Shasha Liu, Songwei Yang, Chen Chen, Zhao Zhang, Shifeng Chu, Yantao Yang, Gang Pei, Meiyu Lin, Qian Yan, Jiao Yao, Yuting Lin, Fan Yi, Lei Meng, Yong Tan, Qidi Ai and Naihong Chen
Cell Death Discov., 2023, 9
DOI: 10.1038/s41420-023-01440-y

Brain‐On‐A‐Chip Based on Human Pluripotent Stem Cell‐Derived Neurons and Astrocytes for Neurotoxicity Testing: Communicative Astrocyte–Neuron DYnamics (CANDY) Chip
Geonho Choi, Han‐Yeol Yang, Sungwoo Cho, Dohyung Kwon, Dong‐Wook Kim and Sungho Ko
Adv Materials Technologies, 2024, 9
DOI: 10.1002/admt.202400107

Chlorpyrifos Disrupts Acetylcholine Metabolism Across Model Blood-Brain Barrier
Dusty R. Miller, Ethan S. McClain, James N. Dodds, Andrzej Balinski, Jody C. May, John A. McLean and David E. Cliffel
Front. Bioeng. Biotechnol., 2021, 9
DOI: 10.3389/fbioe.2021.622175

Bioengineered microfluidic blood-brain barrier models in oncology research
Robin Augustine, Ahmad H. Aqel, Sumama Nuthana Kalva, K.S. Joshy, Ajisha Nayeem and Anwarul Hasan
Translational Oncology, 2021, 14, 101087
DOI: 10.1016/j.tranon.2021.101087

Organoids and organs-on-chips: insights into predicting the efficacy of systemic treatment in colorectal cancer
Jialong Zhu, Linlin Ji, Yitian Chen, Huiyu Li, Mengxi Huang, Zhe Dai, Jing Wang, Dan Xiang, Gongbo Fu, Zengjie Lei and Xiaoyuan Chu
Cell Death Discov., 2023, 9
DOI: 10.1038/s41420-023-01354-9

Advancements in Three Dimensional In‐Vitro Cell Culture Models
Shreemoyee De and Neetu Singh
The Chemical Record, 2022, 22
DOI: 10.1002/tcr.202200058

Unraveling the Mechanobiology Underlying Traumatic Brain Injury with Advanced Technologies and Biomaterials
Xiaowei Shao, Zhongqian Liu, Shijie Mao and Lin Han
Adv Healthcare Materials, 2022, 11
DOI: 10.1002/adhm.202200760

Advanced In Vitro Lung Models for Drug and Toxicity Screening: The Promising Role of Induced Pluripotent Stem Cells
Anabela Moreira, Michelle Müller, Pedro F. Costa and Yvonne Kohl
Advanced Biology, 2022, 6
DOI: 10.1002/adbi.202101139

Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance
Jungeun Lim, Hanna Ching, Jeong-Kee Yoon, Noo Li Jeon and YongTae Kim
Nano Convergence, 2021, 8
DOI: 10.1186/s40580-021-00261-y

A Facile and Scalable Hydrogel Patterning Method for Microfluidic 3D Cell Culture and Spheroid-in-Gel Culture Array
Chengxun Su, Yon Jin Chuah, Hong Boon Ong, Hui Min Tay, Rinkoo Dalan and Han Wei Hou
Biosensors, 2021, 11, 509
DOI: 10.3390/bios11120509

In Vitro Blood–Brain Barrier-Integrated Neurological Disorder Models Using a Microfluidic Device
Jin-Ha Choi, Mallesh Santhosh and Jeong-Woo Choi
Micromachines, 2019, 11, 21
DOI: 10.3390/mi11010021

A Versatile Microfluidic Device System that Lacks a Synthetic Extracellular Matrix Recapitulates the Blood–Brain Barrier and Dynamic Tumor Cell Interaction
Daniel Santillán-Cortez, Andrés Castell-Rodríguez, Aliesha González-Arenas, Juan Suárez-Cuenca, Vadim Pérez-Koldenkova, Denisse Añorve-Bailón, Christian Toledo-Lozano, Silvia García, Mónica Escamilla-Tilch and Paul Mondragón-Terán
Bioengineering, 2024, 11, 1008
DOI: 10.3390/bioengineering11101008

Morphological and functional alterations of astrocytes responding to traumatic brain injury
Xiaoyun Cheng, Jin Wang, Xiao Sun, Lishi Shao, Zeyun Guo and Yang Li
J. Integr. Neurosci., 2019, 18
DOI: 10.31083/j.jin.2019.02.110

Evaluating Nanoparticles in Preclinical Research Using Microfluidic Systems
Derui Zhu, Qifu Long, Yuzhen Xu and Jiangwa Xing
Micromachines, 2019, 10, 414
DOI: 10.3390/mi10060414

Recent Advances in Microfluidic Platforms for Programming Cell‐Based Living Materials
Pengchao Zhang, Ning Shao and Lidong Qin
Advanced Materials, 2021, 33
DOI: 10.1002/adma.202005944

Advances in microfluidic in vitro systems for neurological disease modeling
Paul M. Holloway, Sandrine Willaime‐Morawek, Richard Siow, Melissa Barber, Róisín M. Owens, Anup D. Sharma, Wendy Rowan, Eric Hill and Michele Zagnoni
J of Neuroscience Research, 2021, 99, 1276
DOI: 10.1002/jnr.24794

Degenerative disease‐on‐a‐chip: Developing microfluidic models for rapid availability of newer therapies
Devashree Jahagirdar, Prachi Bangde, Ratnesh Jain and Prajakta Dandekar
Biotechnology Journal, 2021, 16
DOI: 10.1002/biot.202100154

Modeling blood–brain barrier pathology in cerebrovascular disease in vitro: current and future paradigms
Anuska V. Andjelkovic, Svetlana M. Stamatovic, Chelsea M. Phillips, Gabriela Martinez-Revollar and Richard F. Keep
Fluids Barriers CNS, 2020, 17
DOI: 10.1186/s12987-020-00202-7

Neuroregenerative Potential of Stem-Cells-from-Apical-Papilla–Derived Neuronal Cell Spheroids Regulated by Stem Cells from Apical Papillae Under Various Microenvironments in a Pulp-On-Chip System
Haiyun Luo, Mohammed S. Basabrain, Jialin Zhong, Junqing Liu, Yuchen Zhang, Yubingqing Qi, Ting Zou and Chengfei Zhang
Journal of Endodontics, 2022, 48, 1367
DOI: 10.1016/j.joen.2022.09.001

High throughput physiological micro-models for in vitro pre-clinical drug testing: a review of engineering systems approaches
Huagui Zhang, Richard D Whalley, Ana Marina Ferreira and Kenneth Dalgarno
Prog. Biomed. Eng., 2020, 2, 022001
DOI: 10.1088/2516-1091/ab7cc4

Development of Polymeric Nanoparticles for Blood–Brain Barrier Transfer—Strategies and Challenges
Weisen Zhang, Ami Mehta, Ziqiu Tong, Lars Esser and Nicolas H. Voelcker
Advanced Science, 2021, 8
DOI: 10.1002/advs.202003937

Engineering and Characterization of a Biomimetic Microchip for Differentiating Mouse Adipocytes in a 3D Microenvironment
Yu-ting Chen, Latha Ramalingam, Celine R. Garcia, Zhenya Ding, Jiangyu Wu, Naima Moustaid-Moussa and Wei Li
Pharm Res, 2022, 39, 329
DOI: 10.1007/s11095-022-03195-0

Microfluidic Brain-on-a-Chip: Perspectives for Mimicking Neural System Disorders
Mirza Ali Mofazzal Jahromi, Amir Abdoli, Mohammad Rahmanian, Hassan Bardania, Mehrdad Bayandori, Seyed Masoud Moosavi Basri, Alireza Kalbasi, Amir Reza Aref, Mahdi Karimi and Michael R Hamblin
Mol Neurobiol, 2019, 56, 8489
DOI: 10.1007/s12035-019-01653-2

NOTCH3 Mutations in CADASIL: a multicellular perspective on neurodegeneration
Jolene Wei Ling Lee, Adeline Su Lyn Ng, Eng-King Tan and Li Zeng
Cell Commun Signal, 2026
DOI: 10.1186/s12964-026-02764-9

-Omics approaches to study and model cell-cell interactions in engineered tissues
Christine Stark, Sarah E. Jenison and Mai T. Ngo
Front. Chem. Eng., 2025, 7
DOI: 10.3389/fceng.2025.1629455

Angiopep-2-Functionalized Lipid Cubosomes for Blood–Brain Barrier Crossing and Glioblastoma Treatment
Xudong Cai, Ahmed Refaat, Poh-Yi Gan, Bo Fan, Haitao Yu, San H. Thang, Calum J. Drummond, Nicolas H. Voelcker, Nhiem Tran and Jiali Zhai
ACS Appl. Mater. Interfaces, 2024, 16, 12161
DOI: 10.1021/acsami.3c14709

A gelatin hydrogel to study endometrial angiogenesis and trophoblast invasion
Samantha G. Zambuto, Kathryn B. H. Clancy and Brendan A. C. Harley
Interface Focus., 2019, 9, 20190016
DOI: 10.1098/rsfs.2019.0016

Bio‐Mimicking Brain Vasculature to Investigate the Role of Heterogeneous Shear Stress in Regulating Barrier Integrity
Ami Mehta, Anal Desai, David Rudd, Ghizal Siddiqui, Cameron J. Nowell, Ziqiu Tong, Darren J. Creek, Prakriti Tayalia, Prasanna S. Gandhi and Nicolas H. Voelcker
Advanced Biology, 2022, 6
DOI: 10.1002/adbi.202200152

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics
Minju Kim, Kanghoon Choi, Amy Lin and Jungkyu Kim
Advanced Biology, 2025, 9
DOI: 10.1002/adbi.202400571