Biosynthesis of lagopodins in mushroom involves a complex network of oxidation reactions

Takahiro Masuya, Yuta Tsunematsu, Yuichiro Hirayama, Michio Sato, Hiroshi Noguchi, Takehito Nakazawa and Kenji Watanabe

Org. Biomol. Chem., 2019, 17, 234
DOI: 10.1039/C8OB02814A

Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals

Dorothea Tholl, Zarley Rebholz, Alexandre V. Morozov and Paul E. O'Maille

Nat. Prod. Rep., 2023, 40, 766
DOI: 10.1039/D2NP00076H

Fungal volatiles – a survey from edible mushrooms to moulds

Jeroen S. Dickschat

Nat. Prod. Rep., 2017, 34, 310
DOI: 10.1039/C7NP00003K

Mechanistic divergence between (4S,7R)-germacra-(1(10)E,5E)-dien-11-ol synthases from Dictyostelium purpureum and Streptomyces coelicolor

Houchao Xu, Jan Rinkel, Xinlu Chen, Tobias G. Köllner, Feng Chen and Jeroen S. Dickschat

Org. Biomol. Chem., 2021, 19, 370
DOI: 10.1039/D0OB02361B

Characterisation of three terpene synthases for β-barbatene, β-araneosene and nephthenol from social amoebae

Jan Rinkel, Tobias G. Köllner, Feng Chen and Jeroen S. Dickschat

Chem. Commun., 2019, 55, 13255
DOI: 10.1039/C9CC07681F

Current status of secondary metabolite pathways linked to their related biosynthetic gene clusters in Aspergillus section Nigri

Xinhui Wang, Scott A. Jarmusch, Jens C. Frisvad and Thomas O. Larsen

Nat. Prod. Rep., 2023, 40, 237
DOI: 10.1039/D1NP00074H

Biosynthesis, evolution and ecology of microbial terpenoids

Mariana Avalos, Paolina Garbeva, Lisa Vader, Gilles P. van Wezel, Jeroen S. Dickschat and Dana Ulanova

Nat. Prod. Rep., 2022, 39, 249
DOI: 10.1039/D1NP00047K

Engineering fungal terpene biosynthesis

Zhiyong Yin and Jeroen S. Dickschat

Nat. Prod. Rep., 2023, 40, 28
DOI: 10.1039/D2NP00020B

The insect microbiome is a vast source of bioactive small molecules

Carlismari Oliveira Grundmann, Juan Guzman, Andreas Vilcinskas and Mônica Tallarico Pupo

Nat. Prod. Rep., 2024, 41, 935
DOI: 10.1039/D3NP00054K

Discovery of a plant-like tridomain bifunctional syn-abieta-7,13-diene synthase in Streptomyces

Caitlin A. McCadden, Diana P. Łomowska-Keehner, Tracy Qu, Jordan Nafie, Tyler A. Alsup and Jeffrey D. Rudolf

Org. Biomol. Chem., 2025, 23, 9845
DOI: 10.1039/D5OB00724K

Structural-model-based genome mining can efficiently discover novel non-canonical terpene synthases hidden in genomes of diverse species

Tohru Abe, Haruna Shiratori, Kosuke Kashiwazaki, Kazuma Hiasa, Daijiro Ueda, Tohru Taniguchi, Hajime Sato, Takashi Abe and Tsutomu Sato

Chem. Sci., 2024, 15, 10402
DOI: 10.1039/D4SC01381F

Biosynthesis of fungal terpenoids

Pan Luo, Jia-Hua Huang, Jian-Ming Lv, Gao-Qian Wang, Dan Hu and Hao Gao

Nat. Prod. Rep., 2024, 41, 748
DOI: 10.1039/D3NP00052D

Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota

Markus Gressler, Nikolai A. Löhr, Tim Schäfer, Stefanie Lawrinowitz, Paula Sophie Seibold and Dirk Hoffmeister

Nat. Prod. Rep., 2021, 38, 702
DOI: 10.1039/D0NP00077A

Cyclopentane-forming di/sesterterpene synthases: widely distributed enzymes in bacteria, fungi, and plants

Atsushi Minami, Taro Ozaki, Chengwei Liu and Hideaki Oikawa

Nat. Prod. Rep., 2018, 35, 1330
DOI: 10.1039/C8NP00026C

Biosynthesis of bioactive natural products from Basidiomycota

Hsiao-Ching Lin, Ranuka T. Hewage, Yuan-Chun Lu and Yit-Heng Chooi

Org. Biomol. Chem., 2019, 17, 1027
DOI: 10.1039/C8OB02774A

Isoafricanol synthase from Streptomyces malaysiensis

Patrick Rabe, Markiyan Samborskyy, Peter F. Leadlay and Jeroen S. Dickschat

Org. Biomol. Chem., 2017, 15, 2353
DOI: 10.1039/C7OB00234C

Microbial small molecules – weapons of plant subversion

Ioannis A. Stringlis, Hao Zhang, Corné M. J. Pieterse, Melvin D. Bolton and Ronnie de Jonge

Nat. Prod. Rep., 2018, 35, 410
DOI: 10.1039/C7NP00062F

Terpencyclasen aus sozialen Amöben

Patrick Rabe, Jan Rinkel, Britta Nubbemeyer, Tobias G. Köllner, Feng Chen and Jeroen S. Dickschat

Angewandte Chemie, 2016, 128, 15646
DOI: 10.1002/ange.201608971

1,2‐ or 1,3‐Hydride Shifts: What Controls Guaiane Biosynthesis?

Houchao Xu, Bernd Goldfuss and Jeroen S. Dickschat

Chemistry A European J, 2021, 27, 9758
DOI: 10.1002/chem.202101371

Whole Genome Sequence of an Edible Mushroom Oudemansiella raphanipes (Changgengu)

Liping Zhu, Xia Gao, Meihua Zhang, Chunhui Hu, Wujie Yang, Lizhong Guo, Song Yang, Hailong Yu and Hao Yu

JoF, 2023, 9, 266
DOI: 10.3390/jof9020266

Discovery of P450-Modified Sesquiterpenoids Levinoids A–D through Global Genome Mining

Wenchao Liu, Xueying Tian, Xin Huang, Jessie James Limlingan Malit, Chuanhai Wu, Zhihong Guo, Jian-Wei Tang and Pei-Yuan Qian

J. Nat. Prod., 2024, 87, 876
DOI: 10.1021/acs.jnatprod.3c01136

Terpenes in Mushrooms: Natural Products with Diverse Therapeutic Activities

Eda Avcı, Ayşe Kuruüzüm-uz and Didem Şöhretoğlu

HUJPHARM, 2026, 46, 61
DOI: 10.52794/hujpharm.1790368

Biocatalytic portfolio of Basidiomycota

Claudia Schmidt-Dannert

Current Opinion in Chemical Biology, 2016, 31, 40
DOI: 10.1016/j.cbpa.2016.01.002

Norditerpenoids biosynthesized by variediene synthase-associated P450 machinery along with modifications by the host cell Aspergillus oryzae

Lan Jiang, Kangjie Lv, Guoliang Zhu, Zhi Lin, Xue Zhang, Cuiping Xing, Huanting Yang, Weiyan Zhang, Zhixin Wang, Chengwei Liu, Xudong Qu, Tom Hsiang, Lixin Zhang and Xueting Liu

Synthetic and Systems Biotechnology, 2022, 7, 1142
DOI: 10.1016/j.synbio.2022.08.002

Immunosuppressive Isopimarane Diterpenes From Cultures of the Endophytic Fungus Ilyonectria robusta

Ke Ye, Xiao Lv, Xian Zhang, Pan-Pan Wei, Zheng-Hui Li, Hong-Lian Ai, Da-Ke Zhao and Ji-Kai Liu

Front. Pharmacol., 2022, 12
DOI: 10.3389/fphar.2021.766441

Discovery and Characterization of a New Family of Diterpene Cyclases in Bacteria and Fungi

Yan‐long Yang, Shasha Zhang, Ke Ma, Yuxing Xu, Qiaoqiao Tao, Yihua Chen, Juan Chen, Shunxing Guo, Jinwei Ren, Wenzhao Wang, Yong Tao, Wen‐Bing Yin and Hongwei Liu

Angew Chem Int Ed, 2017, 56, 4749
DOI: 10.1002/anie.201700565

Germacrene A–A Central Intermediate in Sesquiterpene Biosynthesis

Houchao Xu and Jeroen S. Dickschat

Chemistry A European J, 2020, 26, 17318
DOI: 10.1002/chem.202002163

Whole genome sequencing of an edible and medicinal mushroom, Russula griseocarnosa, and its association with mycorrhizal characteristics

Yuanchao Liu, Huiping Hu, Manjun Cai, Xiaowei Liang, Xiaoxian Wu, Ao Wang, Xiaoguang Chen, Xiangmin Li, Chun Xiao, Longhua Huang, Yizhen Xie and Qingping wu

Gene, 2022, 808, 145996
DOI: 10.1016/j.gene.2021.145996

Cytotoxic ergosterols from cultures of the basidiomycete Psathyrella candolleana

Ya-Pei Liu, Chao-Jun Pu, Meng Wang, Juan He, Zheng-Hui Li, Tao Feng, Jie Xie and Ji-Kai Liu

Fitoterapia, 2019, 138, 104289
DOI: 10.1016/j.fitote.2019.104289

Biosynthetic investigation of phomopsins reveals a widespread pathway for ribosomal natural products in Ascomycetes

Wei Ding, Wan-Qiu Liu, Youli Jia, Yongzhen Li, Wilfred A. van der Donk and Qi Zhang

Proc. Natl. Acad. Sci. U.S.A., 2016, 113, 3521
DOI: 10.1073/pnas.1522907113

Whole-genome assembly ofGanoderma leucocontextum(Ganodermataceae, Fungi) discovered from the Tibetan Plateau of China

Yuanchao Liu, Longhua Huang, Huiping Hu, Manjun Cai, Xiaowei Liang, Xiangmin Li, Zhi Zhang, Yizhen Xie, Chun Xiao, Shaodan Chen, Diling Chen, Tianqiao Yong, Honghui Pan, Xiong Gao, Qingping Wu and R Dawe

G3 Genes|Genomes|Genetics, 2021, 11
DOI: 10.1093/g3journal/jkab337

Engineering the Prenyltransferase Domain of a Bifunctional Assembly-Line Terpene Synthase

Trey A. Ronnebaum, Samuel A. Eaton, Emily A. E. Brackhahn and David W. Christianson

Biochemistry, 2021, 60, 3162
DOI: 10.1021/acs.biochem.1c00600

Rapid discovery and functional characterization of diterpene synthases from basidiomycete fungi by genome mining

Xin-Lin Li, Yu-Xing Xu, Yuan Li, Rui Zhang, Tian-Yuan Hu, Ping Su, Man Zhou, Ting Tang, Ying Zeng, Yan-Long Yang and Wei Gao

Fungal Genetics and Biology, 2019, 128, 36
DOI: 10.1016/j.fgb.2019.03.007

Terpene biosynthesis in marine sponge animals

Kayla Wilson, Tristan de Rond, Immo Burkhardt, Taylor S. Steele, Rebecca J. B. Schäfer, Sheila Podell, Eric E. Allen and Bradley S. Moore

Proc. Natl. Acad. Sci. U.S.A., 2023, 120
DOI: 10.1073/pnas.2220934120

Fungal biodiversity to biotechnology

Felipe S. Chambergo and Estela Y. Valencia

Appl Microbiol Biotechnol, 2016, 100, 2567
DOI: 10.1007/s00253-016-7305-2

RETRACTED: Set of Cytochrome P450s Cooperatively Catalyzes the Synthesis of a Highly Oxidized and Rearranged Diterpene-Class Sordarinane Architecture

Qibin Chen, Guanyin Yuan, Tao Yuan, Huiting Zeng, Zheng-Rong Zou, Zong-cai Tu, Jie Gao and Yi Zou

J. Am. Chem. Soc., 2022, 144, 3580
DOI: 10.1021/jacs.1c12427

Combinatorial Biosynthesis of Terpenoids through Mixing-and-Matching Sesquiterpene Cyclase and Cytochrome P450 Pairs

Man-Cheng Tang, Cheng Shen, Zixin Deng, Masao Ohashi and Yi Tang

Org. Lett., 2022, 24, 4783
DOI: 10.1021/acs.orglett.2c01785

Transient Prenyltransferase–Cyclase Association in Fusicoccadiene Synthase, an Assembly-Line Terpene Synthase

Jacque L. Faylo, Trevor van Eeuwen, Kushol Gupta, Kenji Murakami and David W. Christianson

Biochemistry, 2022, 61, 2417
DOI: 10.1021/acs.biochem.2c00509

Alkylation-based optimization of antifungal FPPS inhibitors yields a potent, broad-spectrum lipophilic zoledronate derivative

Aidan Kane, Felcia Lai, Joanna G. Rothwell, Thanh Thi Hue Dinh, Leona Campbell, Amy K. Cain, David Hibbs, Jane Hanrahan, Dee Carter and Marvin Whiteley

mBio, 2026, 17
DOI: 10.1128/mbio.03199-25

Biologically Active Secondary Metabolites from the Fungi

Gerald F. Bills, James B. Gloer, Joseph Heitman, Barbara J. Howlett and Eva Holtgrewe Stukenbrock

Microbiol Spectr, 2016, 4
DOI: 10.1128/microbiolspec.FUNK-0009-2016

Sesquiterpenoids Produced by Combining Two Sesquiterpene Cyclases with Promiscuous Myxobacterial CYP260B1

Yujie Yuan, Martin Litzenburger, Shu Cheng, Guangkai Bian, Ben Hu, Pan Yan, Yousheng Cai, Zixin Deng, Rita Bernhardt and Tiangang Liu

ChemBioChem, 2019, 20, 677
DOI: 10.1002/cbic.201800670

Sustainable biosynthesis of valuable diterpenes in microbes

Yanbin Liu, Xixian Chen and Congqiang Zhang

Engineering Microbiology, 2023, 3, 100058
DOI: 10.1016/j.engmic.2022.100058

Characterization of Terpenoids from the Ambrosia Beetle Symbiont and Laurel Wilt Pathogen Harringtonia lauricola

Zhiqiang Zhu, Chenjie Yang, Nemat O. Keyhani, Sen Liu, Huili Pu, Peisong Jia, Dongmei Wu, Philip C. Stevenson, G. Mandela Fernández-Grandon, Jieming Pan, Yuxi Chen, Xiayu Guan and Junzhi Qiu

JoF, 2023, 9, 1175
DOI: 10.3390/jof9121175

Characterization of the Cubamyces Menziesii Terpenome

Létitia Leydet, Julie Couillaud, Agnès Amouric, Elise Courvoisier‐Dezord, Carole Avesque, Thierry Giardina, Mireille Attolini, Pierre Rousselot‐Pailley, Katia Duquesne, Marie‐Noelle Rosso and Gilles Iacazio

ChemBioChem, 2025, 26
DOI: 10.1002/cbic.202401083

Heterologous expression of cytotoxic sesquiterpenoids from the medicinal mushroom Lignosus rhinocerotis in yeast

Hui-Yeng Yeannie Yap, Mariano Jordi Muria-Gonzalez, Boon-Hong Kong, Keith A. Stubbs, Chon-Seng Tan, Szu-Ting Ng, Nget-Hong Tan, Peter S. Solomon, Shin-Yee Fung and Yit-Heng Chooi

Microb Cell Fact, 2017, 16
DOI: 10.1186/s12934-017-0713-x

A madeira como fonte de larvicidas naturais contra Aedes aegypti (Diptera: Culicidae)

Lucia Fernanda Alves Garcia and Mauro Vicentini Correia

Pesq. flor. bras., 2023, 44
DOI: 10.4336/2023.pfb.43e202002174

Novel family of terpene synthases evolved from trans -isoprenyl diphosphate synthases in a flea beetle

Franziska Beran, Peter Rahfeld, Katrin Luck, Raimund Nagel, Heiko Vogel, Natalie Wielsch, Sandra Irmisch, Srinivasan Ramasamy, Jonathan Gershenzon, David G. Heckel and Tobias G. Köllner

Proc. Natl. Acad. Sci. U.S.A., 2016, 113, 2922
DOI: 10.1073/pnas.1523468113

Quantification of Fatty Acid Methyl Esters in Various Biological Matrices by LC-DAD and LC-MS after One-Step Transesterification

Christian Schulze, Simon Merdivan, Lisa Felten and Sabine Mundt

Food Anal. Methods, 2018, 11, 2244
DOI: 10.1007/s12161-018-1184-3

Concise Access to the Skeleton of Protoilludane Sesquiterpenes through a Photochemical Reaction Cascade: Total Synthesis of Atlanticone C

Andreas Zech, Christian Jandl and Thorsten Bach

Angewandte Chemie, 2019, 131, 14771
DOI: 10.1002/ange.201908619

Discovery of fungal onoceroid triterpenoids through domainless enzyme-targeted global genome mining

Jia Tang and Yudai Matsuda

Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-48771-7

Moonlighting Metals: Insights into Regulation of Cyclization Pathways in Fungal Δ6‐Protoilludene Sesquiterpene Synthases

Maureen B. Quin, Stephen N. Michel and Claudia Schmidt‐Dannert

ChemBioChem, 2015, 16, 2191
DOI: 10.1002/cbic.201500308

Identification of a (+)-cubenene synthase from filamentous fungi Acremonium chrysogenum

Chang Chen, Ge Yao, Fuli Wang, Shaoheng Bao, Xiukun Wan, Penggang Han, Kang Wang, Tianyu Song and Hui Jiang

Biochemical and Biophysical Research Communications, 2023, 677, 119
DOI: 10.1016/j.bbrc.2023.08.018

Rapid Assembly of Protoilludane Skeleton through Tandem Catalysis: Total Synthesis of Paesslerin A and Its Structural Revision

Yuzo Mogi, Kazato Inanaga, Hidetoshi Tokuyama, Masataka Ihara, Yousuke Yamaoka, Ken-ichi Yamada and Kiyosei Takasu

Org. Lett., 2019, 21, 3954
DOI: 10.1021/acs.orglett.9b01089

Ascomycete Aspergillus oryzae Is an Efficient Expression Host for Production of Basidiomycete Terpenes by Using Genomic DNA Sequences

Shota Nagamine, Chengwei Liu, Jumpei Nishishita, Takuto Kozaki, Kaho Sogahata, Yoshiro Sato, Atsushi Minami, Taro Ozaki, Claudia Schmidt-Dannert, Jun-ichi Maruyama, Hideaki Oikawa and Emma R. Master

Appl Environ Microbiol, 2019, 85
DOI: 10.1128/AEM.00409-19

Bifunctional Sesquiterpene/Diterpene Synthase Agr2 from Cyclocybe aegerita Gives Rise to the Novel Diterpene Cyclocybene

Nikolas Hoberg, Karen Harms, Frank Surup and Martin Rühl

ACS Chem. Biol., 2024, 19, 2144
DOI: 10.1021/acschembio.4c00178

Accessory Chromosome-Acquired Secondary Metabolism in Plant Pathogenic Fungi: The Evolution of Biotrophs Into Host-Specific Pathogens

Thomas E. Witte, Nicolas Villeneuve, Christopher N. Boddy and David P. Overy

Front. Microbiol., 2021, 12
DOI: 10.3389/fmicb.2021.664276

Biosynthetic Machinery of Diterpene Pleuromutilin Isolated from Basidiomycete Fungi

Momoka Yamane, Atsushi Minami, Chengwei Liu, Taro Ozaki, Ichiro Takeuchi, Tae Tsukagoshi, Tetsuo Tokiwano, Katsuya Gomi and Hideaki Oikawa

ChemBioChem, 2017, 18, 2317
DOI: 10.1002/cbic.201700434

Mechanism of the antifungal activity of the diterpenoid aldehyde traversianal against cucumber anthracnose fungus Colletotrichum orbiculare

Masatoshi Ino, Junichi Kihara, Atsushi Ishihara and Makoto Ueno

J Gen Plant Pathol, 2025, 91, 351
DOI: 10.1007/s10327-025-01249-w

A Review of Fungal Protoilludane Sesquiterpenoid Natural Products

Melissa M. Cadelis, Brent R. Copp and Siouxsie Wiles

Antibiotics, 2020, 9, 928
DOI: 10.3390/antibiotics9120928

Clade III Synthases Add Cyclic and Linear Terpenoids to the Psilocybe Metabolome

Nick Zschoche, Sebastian Schober, Karl Walther, Andrew R. Chadeayne, Markus Gressler, Stefan Bartram, Sarah E. O’Connor and Dirk Hoffmeister

ChemBioChem, 2025, 26
DOI: 10.1002/cbic.202500167

Changes in lighting influence emissions of microbial volatile organic compounds from fungi in house dust

Benjamin Marshall, Amanda Stickney, Karen C. Dannemiller, Atila Novoselac, Juan Pedro Maestre, Kerry Kinney and Pawel K. Misztal

Indoor Environments, 2026, 3, 100145
DOI: 10.1016/j.indenv.2025.100145

Cyclohumulanoid Sesquiterpenes from the Culture Broth of the Basidiomycetous Fungus Daedaleopsis tricolor

Ryuhi Kanehara, Akio Tonouchi, Katsuhiro Konno and Masaru Hashimoto

Molecules, 2021, 26, 4364
DOI: 10.3390/molecules26144364

Selected strains of the Ganoderma lucidum complex from Finnish forests have excellent broadly acting antiviral properties

Dhanik Reshamwala, Sailee Shroff, Jaana Liimatainen, Jenni Tienaho, Ilari Kuukkanen, Mira Laajala, Andrea Civra, Rachele Francese, Pyry Veteli, Marta Cortina-Escribano, Tytti Sarjala, Maarit Karonen, David Lembo, Riikka Linnakoski and Varpu Marjomäki

Sci Rep, 2025, 15
DOI: 10.1038/s41598-025-08377-5

Identification of a novel sesquiterpene biosynthetic machinery involved in astellolide biosynthesis

Yasutomo Shinohara, Shunji Takahashi, Hiroyuki Osada and Yasuji Koyama

Sci Rep, 2016, 6
DOI: 10.1038/srep32865

Fungal natural productsâ€”the mushroom perspective

Marc Stadler and Dirk Hoffmeister

Front. Microbiol., 2015, 6
DOI: 10.3389/fmicb.2015.00127

Hedycaryol – Central Intermediates in Sesquiterpene Biosynthesis, Part II

Houchao Xu and Jeroen S. Dickschat

Chemistry A European J, 2022, 28
DOI: 10.1002/chem.202200405

Modern Aspects of Isotopic Labellings in Terpene Biosynthesis

Jeroen S. Dickschat

Eur J Org Chem, 2017, 2017, 4872
DOI: 10.1002/ejoc.201700482

Acceleration of Mechanistic Investigation of Plant Secondary Metabolism Based on Computational Chemistry

Hajime Sato, Kazuki Saito and Mami Yamazaki

Front. Plant Sci., 2019, 10
DOI: 10.3389/fpls.2019.00802

Subcellular localization of fungal specialized metabolites

Elizabeth Skellam

Fungal Biol Biotechnol, 2022, 9
DOI: 10.1186/s40694-022-00140-z

Some Contributions of Organic Chemistry to the Study of the Biosynthesis of Natural Products

James R. Hanson

Science Progress, 2017, 100, 194
DOI: 10.3184/003685017X14901006155071

Sedimentary diterpane origins—inferences from oils of varying source depositional environment and age

S. D. Killops, A. N. Bishop, E. W. Tegelaar, K. Urdal, M. R. K. Ghammari and J. W. H. Weijers

Front. Geochem., 2023, 1
DOI: 10.3389/fgeoc.2023.1241784

Enfumafungin synthase represents a novel lineage of fungal triterpene cyclases

Eric Kuhnert, Yan Li, Nan Lan, Qun Yue, Li Chen, Russell J. Cox, Zhiqiang An, Kenichi Yokoyama and Gerald F. Bills

Environmental Microbiology, 2018, 20, 3325
DOI: 10.1111/1462-2920.14333

Sesquiterpene Cyclases from the Basidiomycete Cerrena unicolor

Nils Püth, Franziska Ersoy, Ulrich Krings and Ralf G. Berger

Catalysts, 2021, 11, 1361
DOI: 10.3390/catal11111361

Whole-Genome Sequencing and Comparative Genomics Analysis of the Wild Edible Mushroom (Gomphus purpuraceus) Provide Insights into Its Potential Food Application and Artificial Domestication

Yangyang Geng, Shixin Zhang, Ningxian Yang and Likang Qin

Genes, 2022, 13, 1628
DOI: 10.3390/genes13091628

Mechanistic Characterization of Two Chimeric Sesterterpene Synthases from Penicillium

Takaaki Mitsuhashi, Jan Rinkel, Masahiro Okada, Ikuro Abe and Jeroen S. Dickschat

Chemistry A European J, 2017, 23, 10053
DOI: 10.1002/chem.201702766

Lentinulactam, a hirsutane sesquiterpene with an unprecedented lactam modification

Soleiman E. Helaly, Christian Richter, Benjarong Thongbai, Kevin D. Hyde and Marc Stadler

Tetrahedron Letters, 2016, 57, 5911
DOI: 10.1016/j.tetlet.2016.11.075

A Catalytically Competent Terpene Synthase Inferred Using Ancestral Sequence Reconstruction Strategy

Daniele Guzzetti, Aurélien Lebrun, Maeva Subileau, Estelle Grousseau, Eric Dubreucq and Jullien Drone

ACS Catal., 2016, 6, 5345
DOI: 10.1021/acscatal.6b01332

Multi-omics reveals the regulatory effects of Chinese herbal medicine substrates on secondary metabolite biosynthesis in Inonotus glomeratus

Chengbo Peng, Meng Meng, Xiaolong Yuan, Jiaojun Yu, Boyi Wang, Li Zhong, Yi Wang, Lu Li, Tingwen He and Yuan Zheng

Front. Microbiol., 2025, 16
DOI: 10.3389/fmicb.2025.1658730

Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis

Baiying Xing, Jiahui Yu, Changbiao Chi, Xueyang Ma, Qingxia Xu, Annan Li, Yuanjie Ge, Zhengdong Wang, Tan Liu, Hongli Jia, Fuling Yin, Juan Guo, Luqi Huang, Donghui Yang and Ming Ma

Commun Chem, 2021, 4
DOI: 10.1038/s42004-021-00578-z

Lanostane triterpenoids from the fungus Physisporinus vitreus and their inhibitory activity against nitric oxide production

Shu-Han Zhang, Jun Wang, Xin-Yue Dong, Gang-Qiang Wang, Tao Feng, Xiao-Jun Li and Ji-Kai Liu

Phytochemistry, 2023, 206, 113556
DOI: 10.1016/j.phytochem.2022.113556

Corchorus olitorius: A Promising Medicinal Plant in Southern Africa and Effects of Growing Conditions on Its Bioactive Compounds—A Review

Senewa Bobby Pholoma, Gulelat Haki, Goitseone Malambane, Seoleseng Tshwenyane and Joseph Adjetey

JBM, 2024, 12, 255
DOI: 10.4236/jbm.2024.126022

New Acetylenic Acids and Derivatives from the Edible Mushroom Craterellus lutescens (Cantharellaceae)

Ying Huang, Shuai-Bing Zhang, He-Ping Chen, Zhen-Zhu Zhao, Zhong-Yu Zhou, Zheng-Hui Li, Tao Feng and Ji-Kai Liu

J. Agric. Food Chem., 2017, 65, 3835
DOI: 10.1021/acs.jafc.7b00899

Unprecedented [5.5.5.6]Dioxafenestrane Ring Construction in Fungal Insecticidal Sesquiterpene Biosynthesis

Haichun Zeng, Guoping Yin, Qian Wei, Dehai Li, Yi Wang, Youcai Hu, Changhua Hu and Yi Zou

Angewandte Chemie, 2019, 131, 6641
DOI: 10.1002/ange.201813722

A „Magic Mushroom“ Multi‐Product Sesquiterpene Synthase

Eike Schäfer, Paula S. Seibold, Stefan Bartram, Felix Trottmann, Veit G. Haensch, Markus Gressler, Andrew R. Chadeayne, Christian Hertweck, Sarah E. O'Connor and Dirk Hoffmeister

ChemBioChem, 2023, 24
DOI: 10.1002/cbic.202300511

Exploring the Genome of the Endophytic Fungus Botrytis deweyae: Prediction of Novel Secondary Metabolites Gene Clusters: Terpenes and Polyketides

Victor Coca-Ruiz, Josefina Aleu, Carlos Garrido and Isidro G. Collado

Agronomy, 2024, 14, 2747
DOI: 10.3390/agronomy14112747

Identification of sesquiterpene synthases from the Basidiomycota Coniophora puteana for the efficient and highly selective β-copaene and cubebol production in E. coli

Wolfgang Mischko, Max Hirte, Monika Fuchs, Norbert Mehlmer and Thomas B. Brück

Microb Cell Fact, 2018, 17
DOI: 10.1186/s12934-018-1010-z

Impact of Agro-Industrial Side-Streams on Sesquiterpene Production by Submerged Cultured Cerrena unicolor

Nils Püth, Franziska Ersoy, Ralf G. Berger and Ulrich Krings

Foods, 2023, 12, 668
DOI: 10.3390/foods12030668

Discovery of cadinane sesquiterpenoids as GOT1 inhibitors from Penicillium sp. HZ-5

Yeting Zhang, Xinye Huang, Xinming Song, Xuan Li, Jinlong Zhang, Ming Chen, Zhengyi Shi, Binbin Song, Wei Wei, Changxing Qi and Yonghui Zhang

Bioorganic Chemistry, 2025, 157, 108303
DOI: 10.1016/j.bioorg.2025.108303

Compartmentalized biosynthesis of fungal natural products

Lei Du and Shengying Li

Current Opinion in Biotechnology, 2021, 69, 128
DOI: 10.1016/j.copbio.2020.12.006

Screening for improved isoprenoid biosynthesis in microorganisms

Anita Emmerstorfer-Augustin, Sandra Moser and Harald Pichler

Journal of Biotechnology, 2016, 235, 112
DOI: 10.1016/j.jbiotec.2016.03.051

Rhodium‐Catalyzed 1,5‐Sigma Migratory Ring Expansion of gem‐Difluorodienyl Cyclopropanes and Cyclobutanes

Zhiqiang Huang, Sixuan Zhao and Zhi‐Xiang Yu

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202500074

Progress in biological activities and biosynthesis of edible fungi terpenoids

Hai-Ying Chen, Jin-Yu Lei, Shu-Li Li, Li-Qiong Guo, Jun-Fang Lin, Guang-Hong Wu, Jun Lu and Zhi-Wei Ye

Critical Reviews in Food Science and Nutrition, 2023, 63, 7288
DOI: 10.1080/10408398.2022.2045559

Bioactive Sesquiterpenes from the Edible Mushroom Flammulina velutipes and Their Biosynthetic Pathway Confirmed by Genome Analysis and Chemical Evidence

Qiaoqiao Tao, Ke Ma, Yanlong Yang, Kai Wang, Baosong Chen, Ying Huang, Junjie Han, Li Bao, Xiao-Bin Liu, Zhuliang Yang, Wen-Bing Yin and Hongwei Liu

J. Org. Chem., 2016, 81, 9867
DOI: 10.1021/acs.joc.6b01971

Terpenoid Biosynthesis Dominates among Secondary Metabolite Clusters in Mucoromycotina Genomes

Grzegorz Koczyk, Julia Pawłowska and Anna Muszewska

JoF, 2021, 7, 285
DOI: 10.3390/jof7040285

Volatile emission and biosynthesis in endophytic fungi colonizing black poplar leaves

Christin Walther, Pamela Baumann, Katrin Luck, Beate Rothe, Peter H W Biedermann, Jonathan Gershenzon, Tobias G Köllner and Sybille B Unsicker

Beilstein J. Org. Chem., 2021, 17, 1698
DOI: 10.3762/bjoc.17.118

Nerol as a Novel Antifungal Agent: In Vitro Inhibitory Effects on Fusarium oxysporum, Pestalotiopsis neglecta, and Valsa mali and Its Potential Mechanisms against F. oxysporum

Jingyu Ji, Weihu Ma, Jiyuan An, Bowen Zhang, Wenzhuo Sun and Guocai Zhang

JoF, 2024, 10, 699
DOI: 10.3390/jof10100699

Enzymatic Synthesis of Methylated Terpene Analogues Using the Plasticity of Bacterial Terpene Synthases

Anwei Hou, Lukas Lauterbach and Jeroen S. Dickschat

Chemistry A European J, 2020, 26, 2178
DOI: 10.1002/chem.201905827

Diterpene Biosynthesis in Rice Blast Fungus Magnaporthe

Ayousha Shahi, Houlin Yu and Sibongile Mafu

Front. Fungal Biol., 2022, 3
DOI: 10.3389/ffunb.2022.869823

Draft whole genome sequence of groundnut stem rot fungus Athelia rolfsii revealing genetic architect of its pathogenicity and virulence

M. A. Iquebal, Rukam S. Tomar, M. V. Parakhia, Deepak Singla, Sarika Jaiswal, V. M. Rathod, S. M. Padhiyar, Neeraj Kumar, Anil Rai and Dinesh Kumar

Sci Rep, 2017, 7
DOI: 10.1038/s41598-017-05478-8

Genomic and transcriptomic analyses reveal differential regulation of diverse terpenoid and polyketides secondary metabolites in Hericium erinaceus

Juan Chen, Xu Zeng, Yan Long Yang, Yong Mei Xing, Qi Zhang, Jia Mei Li, Ke Ma, Hong Wei Liu and Shun Xing Guo

Sci Rep, 2017, 7
DOI: 10.1038/s41598-017-10376-0

Characterization of the Ergosterol Biosynthesis Pathway in Ceratocystidaceae

Mohammad Sayari, Magrieta A. van der Nest, Emma T. Steenkamp, Saleh Rahimlou, Almuth Hammerbacher and Brenda D. Wingfield

JoF, 2021, 7, 237
DOI: 10.3390/jof7030237

Computational Studies on Biosynthetic Carbocation Rearrangements Leading to Quiannulatene: Initial Conformation Regulates Biosynthetic Route, Stereochemistry, and Skeleton Type

Hajime Sato, Takaaki Mitsuhashi, Mami Yamazaki, Ikuro Abe and Masanobu Uchiyama

Angewandte Chemie, 2018, 130, 14968
DOI: 10.1002/ange.201807139

An Aromatic Cluster in the Active Site of epi-Isozizaene Synthase Is an Electrostatic Toggle for Divergent Terpene Cyclization Pathways

Trey A. Ronnebaum, Sarah M. Gardner and David W. Christianson

Biochemistry, 2020, 59, 4744
DOI: 10.1021/acs.biochem.0c00876

Insight into metabolic diversity of the brown‐rot basidiomycete Postia placenta responsible for sesquiterpene biosynthesis: semi‐comprehensive screening of cytochrome P450 monooxygenase involved in protoilludene metabolism

Hirofumi Ichinose and Takuya Kitaoka

Microbial Biotechnology, 2018, 11, 952
DOI: 10.1111/1751-7915.13304

Mechanistic investigations of hirsutene biosynthesis catalyzed by a chimeric sesquiterpene synthase from Steccherinum ochraceum

Qiwen Wang, Ji-Kai Liu, Qunfei Zhao and Qing-Li He

Fungal Genetics and Biology, 2022, 161, 103700
DOI: 10.1016/j.fgb.2022.103700

Pimarane Diterpenes from Fungi

Ke Ye and Hong-lian Ai

Pharmaceuticals, 2022, 15, 1291
DOI: 10.3390/ph15101291

Genome mining of fungal globin-like enzymes for catalyzing the synthesis of linear terpenes

Li LIU, Xiwei CHEN and Yi ZOU

Chinese Journal of Natural Medicines, 2022, 20, 795
DOI: 10.1016/S1875-5364(22)60192-4

Biosynthesis of Haloterpenoids in Red Algae via Microbial-like Type I Terpene Synthases

Taylor S. Steele, Immo Burkhardt, Malia L. Moore, Tristan de Rond, Hannah K. Bone, Kerrie Barry, Victoria Mae Bunting, Jane Grimwood, Lori H. Handley, Shanmugam Rajasekar, Jayson Talag, Todd P. Michael and Bradley S. Moore

ACS Chem. Biol., 2024, 19, 185
DOI: 10.1021/acschembio.3c00627

Latent potentials of the white-rot basidiomycete Phanerochaete chrysosporium responsible for sesquiterpene metabolism: CYP5158A1 and CYP5144C8 decorate (E)-α-bisabolene

Hirofumi Ichinose, Shota Ukeba and Takuya Kitaoka

Enzyme and Microbial Technology, 2022, 158, 110037
DOI: 10.1016/j.enzmictec.2022.110037

Psathyrins: Antibacterial Diterpenoids from Psathyrella candolleana

Ya-Pei Liu, Quan Dai, Wen-Xuan Wang, Juan He, Zheng-Hui Li, Tao Feng and Ji-Kai Liu

J. Nat. Prod., 2020, 83, 1725
DOI: 10.1021/acs.jnatprod.0c00269

Transcriptome of different fruiting stages in the cultivated mushroom Cyclocybe aegerita suggests a complex regulation of fruiting and reveals enzymes putatively involved in fungal oxylipin biosynthesis

Axel Orban, Annsophie Weber, Robert Herzog, Florian Hennicke and Martin Rühl

BMC Genomics, 2021, 22
DOI: 10.1186/s12864-021-07648-5

Chamilactones A and B, Sesquiterpenes from the Endophytic Fungus Chaetomium nigricolor F5

Yan-Jun Sun, Jin-Zhi Pan, Shuang-Zhi Yuan, Rémy Bertrand Teponno, Xue-Yan Feng, Xiao-Ping Peng, Qian Luo, Hong-Xiang Lou and Gang Li

J. Nat. Prod., 2025, 88, 440
DOI: 10.1021/acs.jnatprod.4c01229

Structural and Chemical Biology of Terpenoid Cyclases

David W. Christianson

Chem. Rev., 2017, 117, 11570
DOI: 10.1021/acs.chemrev.7b00287

Phellibarin D with an unprecedented triterpenoid skeleton isolated from the mushroom Phellinus rhabarbarinus

Tao Feng, Jin-Long Cai, Xue-Mei Li, Zhong-Yu Zhou, Rong Huang, Yong-Sheng Zheng, Zheng-Hui Li and Ji-Kai Liu

Tetrahedron Letters, 2016, 57, 3544
DOI: 10.1016/j.tetlet.2016.06.114

Terpene Synthases as Metabolic Gatekeepers in the Evolution of Plant Terpenoid Chemical Diversity

Prema S. Karunanithi and Philipp Zerbe

Front. Plant Sci., 2019, 10
DOI: 10.3389/fpls.2019.01166

NextGen microbial natural products discovery

Claudia Schmidt‐Dannert

Microbial Biotechnology, 2015, 8, 26
DOI: 10.1111/1751-7915.12184

Genetic Survey of Psilocybe Natural Products

Sebastian Dörner, Kai Rogge, Janis Fricke, Tim Schäfer, Jacob M. Wurlitzer, Markus Gressler, Duyen N. K. Pham, David R. Manke, Andrew R. Chadeayne and Dirk Hoffmeister

ChemBioChem, 2022, 23
DOI: 10.1002/cbic.202200249

Predicting functions of putative fungal sesquiterpene synthase genes based on multiomics data analysis

Tetyana Nosenko, Ina Zimmer, Andrea Ghirardo, Tobias G. Köllner, Baris Weber, Andrea Polle, Maaria Rosenkranz and Jörg-Peter Schnitzler

Fungal Genetics and Biology, 2023, 165, 103779
DOI: 10.1016/j.fgb.2023.103779

Oosporein, an abundant metabolite in Beauveria caledonica, with a feedback induction mechanism and a role in insect virulence

Louise Mc Namara, Stephen K. Dolan, John M.D. Walsh, John C. Stephens, Travis R. Glare, Kevin Kavanagh and Christine T. Griffin

Fungal Biology, 2019, 123, 601
DOI: 10.1016/j.funbio.2019.01.004

Homoterpen‐Biosynthese in Pilzen

Lin Zhou, Tatjana Reuter, Kiara Schumann, Markus Mayer, Dominik Matthias Hanauska and Lena Barra

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202517837

Biocatalyst collection and heterologous expression of sesquiterpene synthases from basidiomycetous fungi: Discovery of a novel sesquiterpene hydrocarbon

Natsuki Masunaga, Takuya Kitaoka and Hirofumi Ichinose

Microbial Biotechnology, 2023, 16, 632
DOI: 10.1111/1751-7915.14204

Synthetic Studies toward the Aphidicolin Family of Diterpenoid Natural Products

Jack Hayward Cooke, Safaa Jamshed and Richmond Sarpong

J. Org. Chem., 2025, 90, 9999
DOI: 10.1021/acs.joc.5c01047

Research Progress on the Regulation and Developmental Utilization of Bioactive Metabolites Synthesis in Floccularia luteovirens

Tongjia Shi, Lihua Tang, Siyuan Gou, Wensheng Li, Chunxiao Xu and Xu Zhao

JoF, 2025, 11, 854
DOI: 10.3390/jof11120854

Chemical Constituents and Their Bioactivities of Mushroom Phellinus rhabarbarinus

Tao Feng, Jin-Long Cai, Xue-Mei Li, Zhong-Yu Zhou, Zheng-Hui Li and Ji-Kai Liu

J. Agric. Food Chem., 2016, 64, 1945
DOI: 10.1021/acs.jafc.6b00176

Combinatorial biosynthesis for the engineering of novel fungal natural products

Elizabeth Skellam, Sanjeevan Rajendran and Lei Li

Commun Chem, 2024, 7
DOI: 10.1038/s42004-024-01172-9

Whole genome sequencing and annotation of Scleroderma yunnanense, the only edible Scleroderma species

Shanshan Zhang, Wenzhong Yang, Jian Chen, Chuanguang Zhang, Siqi Zhang and Lanjing Gao

Genomics, 2023, 115, 110727
DOI: 10.1016/j.ygeno.2023.110727

Genome mining of cryptic bisabolenes that were biosynthesized by intramembrane terpene synthases from Antrodia cinnamomea

Ranuka T. Hewage, Cheng-Chung Tseng, Suh-Yuen Liang, Chen-Yu Lai and Hsiao-Ching Lin

Philosophical Transactions of the Royal Society B, 2023, 378
DOI: 10.1098/rstb.2022.0033

Nigrosporinol Sulfoxides A and B, Sulfur-Bridged Heterocyclic Sesquiterpenoids Produced by Cultures of the Fungus Nigrospora lacticolonia

Apisara Somteds, Thanapat Suebrasri, Sophon Boonlue, Brian O. Patrick, Somdej Kanokmedhakul, Raymond J. Andersen and Kwanjai Kanokmedhakul

Org. Lett., 2025, 27, 288
DOI: 10.1021/acs.orglett.4c04304

Quick guide to secondary metabolites from Apiospora and Arthrinium

Marie L. Overgaard, Trine Aalborg, Emil J. Zeuner, Klaus R. Westphal, Frederik A. Lau, Vibeke S. Nielsen, Kasper B. Carstensen, Emil A. Hundebøll, Tia A. Westermann, Gustav G. Rathsach, Jens L. Sørensen, Jens C. Frisvad, Reinhard Wimmer and Teis E. Sondergaard

Fungal Biology Reviews, 2023, 43, 100288
DOI: 10.1016/j.fbr.2022.10.001

Crystal structure and catalytic mechanism of drimenol synthase, an unusual bifunctional terpene cyclase–phosphatase

Kristin R. Osika, Matthew N. Gaynes and David W. Christianson

Proc. Natl. Acad. Sci. U.S.A., 2025, 122
DOI: 10.1073/pnas.2506584122

Efficient Reconstitution of Basidiomycota Diterpene Erinacine Gene Cluster in Ascomycota Host Aspergillus oryzae Based on Genomic DNA Sequences

Chengwei Liu, Atsushi Minami, Taro Ozaki, Jing Wu, Hirokazu Kawagishi, Jun-ichi Maruyama and Hideaki Oikawa

J. Am. Chem. Soc., 2019, 141, 15519
DOI: 10.1021/jacs.9b08935

Biosynthesis, enzymology, and future of eunicellane diterpenoids

Zining Li and Jeffrey D Rudolf

Journal of Industrial Microbiology and Biotechnology, 2023, 50
DOI: 10.1093/jimb/kuad027

Fungal Metabolomics: A Comprehensive Approach to Understanding Pathogenesis in Humans and Identifying Potential Therapeutics

Vinicius Alves, Daniel Zamith-Miranda, Susana Frases and Joshua D. Nosanchuk

JoF, 2025, 11, 93
DOI: 10.3390/jof11020093

TeroKit: A Database-Driven Web Server for Terpenome Research

Tao Zeng, Zhihong Liu, Jingyuan Zhuang, Yitao Jiang, Wengan He, Hongjuan Diao, Nan Lv, Yongxing Jian, Danhong Liang, Yufan Qiu, Rong Zhang, Fan Zhang, Xiaowen Tang and Ruibo Wu

J. Chem. Inf. Model., 2020, 60, 2082
DOI: 10.1021/acs.jcim.0c00141

Fungal Secondary Metabolism

Javier Avalos and M. Carmen Limón

Encyclopedia, 2021, 2, 1
DOI: 10.3390/encyclopedia2010001

MTPSLs: New Terpene Synthases in Nonseed Plants

Qidong Jia, Tobias G. Köllner, Jonathan Gershenzon and Feng Chen

Trends in Plant Science, 2018, 23, 121
DOI: 10.1016/j.tplants.2017.09.014

Single Point Mutation Abolishes Water Capture in Germacradien‐4‐ol Synthase

Víctor González Requena, Prabhakar L. Srivastava, David J. Miller and Rudolf K. Allemann

ChemBioChem, 2024, 25
DOI: 10.1002/cbic.202400290

Volatilome Profiling of Mycotoxigenic Fungi Aspergillus carbonarius and Penicillium verrucosum in Mono‐ and Coculture With Saccharomyces cerevisiae

Stamatina Panagoulakou, Paschalitsa Tryfinopoulou, Athanasios Mallouchos, Yangtai Liu, Efstathios Z. Panagou and Poulami Jha

International Journal of Food Science, 2026, 2026
DOI: 10.1155/ijfo/5819069

Volatile organic compound patterns predict fungal trophic mode and lifestyle

Yuan Guo, Werner Jud, Fabian Weikl, Andrea Ghirardo, Robert R. Junker, Andrea Polle, J. Philipp Benz, Karin Pritsch, Jörg-Peter Schnitzler and Maaria Rosenkranz

Commun Biol, 2021, 4
DOI: 10.1038/s42003-021-02198-8

Reactivity and mechanism in chemical and synthetic biology

Nigel G. J. Richards, Stephen L. Bearne, Yuki Goto and Emily J. Parker

Philosophical Transactions of the Royal Society B, 2023, 378
DOI: 10.1098/rstb.2022.0023

Unusual (2R,6R)-bicyclo[3.1.1]heptane ring construction in fungal α-trans-bergamotene biosynthesis

Yan-Hua Wen, Tian-Jiao Chen, Long-Yu Jiang, Li Li, Mengbo Guo, Yu Peng, Jing-Jing Chen, Fei Pei, Jin-Ling Yang, Rui-Shan Wang, Ting Gong and Ping Zhu

iScience, 2022, 25, 104030
DOI: 10.1016/j.isci.2022.104030

Biological and chemical diversity go hand in hand: Basidiomycota as source of new pharmaceuticals and agrochemicals

Birthe Sandargo, Clara Chepkirui, Tian Cheng, Lillibeth Chaverra-Muñoz, Benjarong Thongbai, Marc Stadler and Stephan Hüttel

Biotechnology Advances, 2019, 37, 107344
DOI: 10.1016/j.biotechadv.2019.01.011

Characterization of Tremulane Sesquiterpene Synthase from the Basidiomycete Irpex lacteus

Rong Chen, Tao Feng, Min Li, Xinyi Zhang, Juan He, Ben Hu, Zixin Deng, Tiangang Liu, Ji-Kai Liu, Xinghuan Wang and Guangkai Bian

Org. Lett., 2022, 24, 5669
DOI: 10.1021/acs.orglett.2c01975

Cysteine-Derived Pleurotin Congeners from the Nematode-Trapping Basidiomycete Hohenbuehelia grisea

Birthe Sandargo, Benjarong Thongbai, Marc Stadler and Frank Surup

J. Nat. Prod., 2018, 81, 286
DOI: 10.1021/acs.jnatprod.7b00713

Homoterpene Biosynthesis in Fungi

Lin Zhou, Tatjana Reuter, Kiara Schumann, Markus Mayer, Dominik Matthias Hanauska and Lena Barra

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202517837

The Biogenetic Origin of the Biologically Active Naematolin of Hypholoma Species Involves an Unusual Sesquiterpene Synthase

Suhad A. A. Al-Salihi, Trong Tuan Dao, Katherine Williams, Andy M. Bailey and Gary D. Foster

Mol Biotechnol, 2019, 61, 754
DOI: 10.1007/s12033-019-00199-x

Unprecedented [5.5.5.6]Dioxafenestrane Ring Construction in Fungal Insecticidal Sesquiterpene Biosynthesis

Haichun Zeng, Guoping Yin, Qian Wei, Dehai Li, Yi Wang, Youcai Hu, Changhua Hu and Yi Zou

Angew Chem Int Ed, 2019, 58, 6569
DOI: 10.1002/anie.201813722

Engineering of the Filamentous Fungus Penicillium chrysogenum as Cell Factory for Natural Products

Fernando Guzmán-Chávez, Reto D. Zwahlen, Roel A. L. Bovenberg and Arnold J. M. Driessen

Front. Microbiol., 2018, 9
DOI: 10.3389/fmicb.2018.02768

Structure of Sesquisabinene Synthase 1, a Terpenoid Cyclase That Generates a Strained [3.1.0] Bridged-Bicyclic Product

Patrick N. Blank, Stephen A. Shinsky and David W. Christianson

ACS Chem. Biol., 2019, 14, 1011
DOI: 10.1021/acschembio.9b00218

Combined Comparative Genomics and Gene Expression Analyses Provide Insights into the Terpene Synthases Inventory in Trichoderma

Isabel Vicente, Riccardo Baroncelli, María Eugenia Morán-Diez, Rodolfo Bernardi, Grazia Puntoni, Rosa Hermosa, Enrique Monte, Giovanni Vannacci and Sabrina Sarrocco

Microorganisms, 2020, 8, 1603
DOI: 10.3390/microorganisms8101603

Two new bergamotane-type sesquiterpeniods from the plant endophytic fungus Paraconiothyrium brasiliense

Ying Shi and Ling Liu

Journal of Asian Natural Products Research, 2025, 27, 1419
DOI: 10.1080/10286020.2025.2477631

Mechanistic Characterisation of Collinodiene Synthase, a Diterpene Synthase from Streptomyces collinus

Kizerbo A. Taizoumbe, Simon T. Steiner and Jeroen S. Dickschat

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202302469

A detailed view on 1,8-cineol biosynthesis by Streptomyces clavuligerus

Jan Rinkel, Patrick Rabe, Laura zur Horst and Jeroen S Dickschat

Beilstein J. Org. Chem., 2016, 12, 2317
DOI: 10.3762/bjoc.12.225

Discovery of Diverse Sesquiterpenoids from Crossiella cryophila through Genome Mining and NMR Tracking

Shungen Chen, Qian Yang, Xiaowei Zhang, Zengyuan Wang, Hui-Min Xu and Liao-Bin Dong

J. Nat. Prod., 2024, 87, 195
DOI: 10.1021/acs.jnatprod.3c00830

Divergent Biosynthesis of Bridged Polycyclic Sesquiterpenoids by a Minimal Fungal Biosynthetic Gene Cluster

Meng-Meng Zhang, Yi Long, Yuxin Li, Jiao-Jiao Cui, Tinghong Lv, Shangwen Luo, Kun Gao and Shi-Hui Dong

J. Nat. Prod., 2024, 87, 893
DOI: 10.1021/acs.jnatprod.3c01161

Volatilomes of Cyclocybe aegerita during different stages of monokaryotic and dikaryotic fruiting

Axel Orban, Florian Hennicke and Martin Rühl

Biological Chemistry, 2020, 401, 995
DOI: 10.1515/hsz-2019-0392

Cadinane- and drimane-type sesquiterpenoids produced by Paecilomyces sp. TE-540, an endophyte from Nicotiana tabacum L., are acetylcholinesterase inhibitors

Kuo Xu, Qi Zhou, Xiu-Qi Li, Tian Luo, Xiao-Long Yuan, Zhong-Feng Zhang and Peng Zhang

Bioorganic Chemistry, 2020, 104, 104252
DOI: 10.1016/j.bioorg.2020.104252

Diterpenes Specially Produced by Fungi: Structures, Biological Activities, and Biosynthesis (2010–2020)

Fa-Lei Zhang and Tao Feng

JoF, 2022, 8, 244
DOI: 10.3390/jof8030244

Biological activities of Rhizopus sp. Extracts and microemulsions: antimicrobial and antitumor potential

Valéria Maria Sousa Leitão, Kênia Victória Pereira Abdala, Rita de Nazaré Silva Alves, Karina Miyuki Retamiro, João Pedro Pimentel Abreu, Katia Regina Assunção Borges Araújo, Flávia Castello Branco Vidal, Amanda Mara Teles, Geusa Felipa de Barros Bezerra, Celso Vataru Nakamura and Maria do Desterro Soares Brandão Nascimento

Cad. Pedagógico, 2025, 22, e21791
DOI: 10.54033/cadpedv22n13-233

Computational-guided discovery and characterization of a sesquiterpene synthase from Streptomyces clavuligerus

Jeng-Yeong Chow, Bo-Xue Tian, Gurusankar Ramamoorthy, Brandan S. Hillerich, Ronald D. Seidel, Steven C. Almo, Matthew P. Jacobson and C. Dale Poulter

Proc. Natl. Acad. Sci. U.S.A., 2015, 112, 5661
DOI: 10.1073/pnas.1505127112

Molecular and Functional Analyses of Characterized Sesquiterpene Synthases in Mushroom-Forming Fungi

Shengli Wang, Ruiqi Chen, Lin Yuan, Chenyang Zhang, Dongmei Liang and Jianjun Qiao

JoF, 2023, 9, 1017
DOI: 10.3390/jof9101017

Enhancing structural diversity of terpenoids by multisubstrate terpene synthases

Min Li and Hui Tao

Beilstein J. Org. Chem., 2024, 20, 959
DOI: 10.3762/bjoc.20.86

Rhodium‐Catalyzed 1,5‐Sigma Migratory Ring Expansion of gem‐Difluorodienyl Cyclopropanes and Cyclobutanes

Zhiqiang Huang, Sixuan Zhao and Zhi‐Xiang Yu

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202500074

Non-enzymatic reactions in biogenesis of fungal natural products

Shinji Kishimoto

J Nat Med, 2024, 78, 467
DOI: 10.1007/s11418-024-01797-z

Sesterterpene ophiobolin biosynthesis involving multiple gene clusters in Aspergillus ustus

Hangzhen Chai, Ru Yin, Yongfeng Liu, Huiying Meng, Xianqiang Zhou, Guolin Zhou, Xupeng Bi, Xue Yang, Tonghan Zhu, Weiming Zhu, Zixin Deng and Kui Hong

Sci Rep, 2016, 6
DOI: 10.1038/srep27181

Mechanistic Investigations of Two Bacterial Diterpene Cyclases: Spiroviolene Synthase and Tsukubadiene Synthase

Patrick Rabe, Jan Rinkel, Etilia Dolja, Thomas Schmitz, Britta Nubbemeyer, T. Hoang Luu and Jeroen S. Dickschat

Angew Chem Int Ed, 2017, 56, 2776
DOI: 10.1002/anie.201612439

RNA-Seq de Novo Assembly and Differential Transcriptome Analysis of Chaga (Inonotus obliquus) Cultured with Different Betulin Sources and the Regulation of Genes Involved in Terpenoid Biosynthesis

Narimene Fradj, Karen Cristine Gonçalves dos Santos, Nicolas de Montigny, Fatima Awwad, Yacine Boumghar, Hugo Germain and Isabel Desgagné-Penix

IJMS, 2019, 20, 4334
DOI: 10.3390/ijms20184334

Fungal evolution: cellular, genomic and metabolic complexity

Miguel A. Naranjo‐Ortiz and Toni Gabaldón

Biological Reviews, 2020, 95, 1198
DOI: 10.1111/brv.12605

Isolation, (bio)synthetic studies and evaluation of antimicrobial properties of drimenol-type sesquiterpenes of Termitomyces fungi

Nina B. Kreuzenbeck, Seema Dhiman, Dávid Roman, Immo Burkhardt, Benjamin H. Conlon, Janis Fricke, Huijuan Guo, Janis Blume, Helmar Görls, Michael Poulsen, Jeroen S. Dickschat, Tobias G. Köllner, Hans-Dieter Arndt and Christine Beemelmanns

Commun Chem, 2023, 6
DOI: 10.1038/s42004-023-00871-z

Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of δ-cadinol

Marion Ringel, Nicole Dimos, Stephanie Himpich, Martina Haack, Claudia Huber, Wolfgang Eisenreich, Gerhard Schenk, Bernhard Loll and Thomas Brück

Microb Cell Fact, 2022, 21
DOI: 10.1186/s12934-022-01791-8

Fragrant Venezuelaenes A and B with A 5–5–6–7 Tetracyclic Skeleton: Discovery, Biosynthesis, and Mechanisms of Central Catalysts

Zhong Li, Yuanyuan Jiang, Xingwang Zhang, Yimin Chang, Shuai Li, Xiaomin Zhang, Shanmin Zheng, Ce Geng, Ping Men, Li Ma, Ying Yang, Zhengquan Gao, Ya-Jie Tang and Shengying Li

ACS Catal., 2020, 10, 5846
DOI: 10.1021/acscatal.0c01575

Reconstitution of biosynthetic machinery of fungal natural products in heterologous hosts

Hideaki Oikawa

Bioscience, Biotechnology, and Biochemistry, 2020, 84, 433
DOI: 10.1080/09168451.2019.1690976

Genome of Diaporthe sp. provides insights into the potential inter-phylum transfer of a fungal sesquiterpenoid biosynthetic pathway

Jose Guedes de Sena Filho, Maureen B. Quin, Daniel J. Spakowicz, Jeffrey J. Shaw, Kaury Kucera, Brian Dunican, Scott A. Strobel and Claudia Schmidt-Dannert

Fungal Biology, 2016, 120, 1050
DOI: 10.1016/j.funbio.2016.04.001

Residue-Orientation-Dependent Dynamics and Selectivity of Active Pocket in Microbe Class I Terpene Cyclases

Jingyuan Zhuang, Fan Zhang, Jingwei Zhou, Wenbin Deng and Ruibo Wu

J. Chem. Inf. Model., 2020, 60, 4985
DOI: 10.1021/acs.jcim.0c00159

Synthesis of 1,3‐cis‐Fused Tricyclic System through Regio‐ and Stereoselective Epoxidation and Ring‐Rearrangement Metathesis: Access To Basic Core of Presilphiperfolanols

Sambasivarao Kotha, Ramakrishna Reddy Keesari and Ongolu Ravikumar

Eur J Org Chem, 2023, 26
DOI: 10.1002/ejoc.202201448

Characterization and Crystal Structures of a Cubebol-Producing Sesquiterpene Synthase from Antrodia cinnamomea

Sheng-Chia Chen, Bo-Chen Jiang, Yen-Ju Lu, Chia-Hao Chang, Tsung-Han Wu, Sheng-Wei Lin, Hua-Wen Yin, Tzong-Huei Lee and Chun-Hua Hsu

J. Agric. Food Chem., 2023, 71, 13014
DOI: 10.1021/acs.jafc.3c00570

Sesquiterpenoid derivatives isolated from a liquid culture of Hypholoma capnoides 819

Yu-Ting Wang, Hong-Yu Tan, Xue Zhao, Yu Yang, Rui Xu, Shuai-Ming Zhu, Hao Ma, Fu-Yao Luo, Cai-Hong Dong and Chang-Wei Li

Phytochemistry, 2024, 219, 113959
DOI: 10.1016/j.phytochem.2023.113959

Functional analysis of cytochrome P450 monooxygenases from the white-rot basidiomycete Trametes versicolor: CYP502B15 decorates cadinane-type sesquiterpenoids

Hirofumi Ichinose, Megumu Honda, Tsuyoshi Isogai, Chen Chen and Takuya Kitaoka

Enzyme and Microbial Technology, 2025, 189, 110658
DOI: 10.1016/j.enzmictec.2025.110658

Triterpene Glycosides Tricycloiridals A–D with Cytotoxicity Isolated from Fungus Chrysosporium sp. YX1242

Kang Chen, Kainan Song, Xianzhi Jiang and Yuquan Xu

J. Nat. Prod., 2025, 88, 1743
DOI: 10.1021/acs.jnatprod.5c00496

Identification of the sesquiterpene synthase AcTPS1 and high production of (–)-germacrene D in metabolically engineered Saccharomyces cerevisiae

Jiajia Liu, Chang Chen, Xiukun Wan, Ge Yao, Shaoheng Bao, Fuli Wang, Kang Wang, Tianyu Song, Penggang Han and Hui Jiang

Microb Cell Fact, 2022, 21
DOI: 10.1186/s12934-022-01814-4

Total Heterologous Biosynthesis of Fungal Natural Products in Aspergillus nidulans

Yi-Ming Chiang, Tzu-Shyang Lin and Clay C. C. Wang

J. Nat. Prod., 2022, 85, 2484
DOI: 10.1021/acs.jnatprod.2c00487

Probing Labdane-Related Diterpenoid Biosynthesis in the Fungal Genus Aspergillus

Meimei Xu, Matthew L. Hillwig, Mollie S. Tiernan and Reuben J. Peters

J. Nat. Prod., 2017, 80, 328
DOI: 10.1021/acs.jnatprod.6b00764

Ectomycorrhizal Influence on the Dynamics of Sesquiterpene Release by Tricholoma vaccinum

Marycolette Ndidi Ezediokpu, Katrin Krause, Maritta Kunert, Dirk Hoffmeister, Wilhelm Boland and Erika Kothe

JoF, 2022, 8, 555
DOI: 10.3390/jof8060555

Plant specialized metabolism: Diversity of terpene synthases and their products

Matthew E. Bergman and Natalia Dudareva

Current Opinion in Plant Biology, 2024, 81, 102607
DOI: 10.1016/j.pbi.2024.102607

Enhanced triterpenoid biosynthesis in Wolfiporia cocos through combined metabolic pathway engineering and fermentation condition optimization

Tianpeng Chen, Jing Liu, Chenmin Tang, Bin Yu, Huanqing Niu, Yu Sha, Wenjun Sun, Yong Chen and Hanjie Ying

Journal of Industrial and Engineering Chemistry, 2026
DOI: 10.1016/j.jiec.2026.02.045

Metabolism of ganoderic acids by a Ganoderma lucidum cytochrome P450 and the 3-keto sterol reductase ERG27 from yeast

Chengshuai Yang, Weichao Li, Chen Li, Zhihua Zhou, Youli Xiao and Xing Yan

Phytochemistry, 2018, 155, 83
DOI: 10.1016/j.phytochem.2018.07.009

Further Biochemical Profiling of Hypholoma fasciculare Metabolome Reveals Its Chemogenetic Diversity

Suhad A. A. Al-Salihi, Ian D. Bull, Raghad Al-Salhi, Paul J. Gates, Kifah S. M. Salih, Andy M. Bailey and Gary D. Foster

Front. Bioeng. Biotechnol., 2021, 9
DOI: 10.3389/fbioe.2021.567384

Discovery of sesquiterpenoids from an actinomycete Crossiella cryophila through genome mining and heterologous expression

Qian Yang, Jupeng Tian, Shungen Chen, Ziyi Yang, Zengyuan Wang, Hui-Min Xu and Liao-Bin Dong

Bioorganic Chemistry, 2024, 146, 107308
DOI: 10.1016/j.bioorg.2024.107308

Induced production of steroids by co-cultivation of two endophytes from Mahonia fortunei

Zi-Ru Wang, Gang Li, Li-Xia Ji, Hang-Hang Wang, Han Gao, Xiao-Ping Peng and Hong-Xiang Lou

Steroids, 2019, 145, 1
DOI: 10.1016/j.steroids.2019.02.005

Four new sesquiterpenes from the rhizomes of Curcuma wenyujin

Hui Wang, Xiaoye Li, Yahui Li, Huali Wu, Yiming Li and Fujiang Guo

Phytochemistry Letters, 2022, 52, 143
DOI: 10.1016/j.phytol.2022.11.002

A new sesquiterpene with a specialized [4,4] bicyclononane skeleton from the marine-derived fungus Metarhizium sp. P2100

Zhong-Lian Ma, Zhi-Pu Yu, Ling Lv, Zhi-Qing Liu, Chang-Yun Wang and Guang-Shan Yao

Tetrahedron, 2025, 178, 134607
DOI: 10.1016/j.tet.2025.134607

Biochemistry and Chemoinformatics Guided Classification of Hirsutane Sesquiterpenes Isolated from Mushroom

Yaping Liu, Jumpei Nishishita, Chengwei Liu, Hideaki Oikawa and Atsushi Minami

JACS Au, 2025, 5, 740
DOI: 10.1021/jacsau.4c00983

Structure-Based Engineering of a Sesquiterpene Cyclase to Generate an Alcohol Product: Conversion of epi-Isozizaene Synthase into α-Bisabolol Synthase

Samuel A. Eaton and David W. Christianson

Biochemistry, 2024, 63, 797
DOI: 10.1021/acs.biochem.3c00681

Four New Caryophyllene Sesquiterpenoids Isolated From Hypholoma capnoides 819

Yu‐Ting Wang, Yuan Dong, Fang Wang, Shuai‐Ming Zhu, Yang Zhang, Yu Yang, Rui Xu, Cai‐Hong Dong, You‐Zhi Zhang and Chang‐Wei Li

Chemistry & Biodiversity, 2025, 22
DOI: 10.1002/cbdv.202402414

An endophytic Basidiomycete, Grammothele lineata, isolated from Corchorus olitorius, produces paclitaxel that shows cytotoxicity

Avizit Das, Mohammad Imtiazur Rahman, Ahlan Sabah Ferdous, Al- Amin, Mohammad Mahbubur Rahman, Nilufar Nahar, Md. Aftab Uddin, Mohammad Riazul Islam, Haseena Khan and Vijai Gupta

PLoS ONE, 2017, 12, e0178612
DOI: 10.1371/journal.pone.0178612

The regulator of G‐protein signalling Thn1 links pheromone response to volatile production in Schizophyllum commune

Sophia Wirth, Maritta Kunert, Lisa‐Marija Ahrens, Katrin Krause, Selina Broska, Christian Paetz, Olaf Kniemeyer, Elke‐Martina Jung, Wilhelm Boland and Erika Kothe

Environmental Microbiology, 2018, 20, 3684
DOI: 10.1111/1462-2920.14369

Identification of a terpene synthase arsenal using long-read sequencing and genome assembly of Aspergillus wentii

Richard Olumakaiye, Christophe Corre and Fabrizio Alberti

BMC Genomics, 2024, 25
DOI: 10.1186/s12864-024-11064-w

The Ecological Role of Volatile and Soluble Secondary Metabolites Produced by Soil Bacteria

Olaf Tyc,, Chunxu Song, Jeroen S. Dickschat, Michiel Vos and Paolina Garbeva

Trends in Microbiology, 2017, 25, 280
DOI: 10.1016/j.tim.2016.12.002

The evolution and ecology of psilocybin in nature

Matthew Meyer and Jason Slot

Fungal Genetics and Biology, 2023, 167, 103812
DOI: 10.1016/j.fgb.2023.103812

Joint exploration of network pharmacology and metabolomics on the effects of traditional Chinese medicine compounds in weaned yaks

Sijia Lu, Yanbin Zhu, Xiaojuan Zhang, Yangji Cidan, Wangdui Basang and Kun Li

Front. Vet. Sci., 2025, 11
DOI: 10.3389/fvets.2024.1511311

Influence of metal stress on production of volatile inhibitory compounds by endophytes against Ganoderma boninense

Carrie Siew Fang Sim, Chen Son Yue, Yuen Lin Cheow and Adeline Su Yien Ting

Biocontrol Science and Technology, 2019, 29, 860
DOI: 10.1080/09583157.2019.1611735

Artificial neural network-based optimization of medium-polar triterpenoids from the fruiting body of Ganoderma lucidum, kinetic modeling and thermodynamics

Chen Li, Xiaohui Meng, Lingqin Zhu, Junwen Cheng, Yanbin Wang, Liang He, Qi Huang and Guangyao Zheng

Separation and Purification Technology, 2026, 393, 137306
DOI: 10.1016/j.seppur.2026.137306

A Red Algal Bourbonane Sesquiterpene Synthase Defined by Microgram-Scale NMR-Coupled Crystalline Sponge X-ray Diffraction Analysis

Roland D. Kersten, Shoukou Lee, Daishi Fujita, Tomáš Pluskal, Susan Kram, Jennifer E. Smith, Takahiro Iwai, Joseph P. Noel, Makoto Fujita and Jing-Ke Weng

J. Am. Chem. Soc., 2017, 139, 16838
DOI: 10.1021/jacs.7b09452

Integrative Transcriptome and Metabolome Analysis Reveals Candidate Genes Related to Terpenoid Synthesis in Amylostereum areolatum (Russulales: Amylostereaceae)

Lixia Wang, Ningning Fu, Ming Wang, Zhongyi Zhan, Youqing Luo, Jianrong Wu and Lili Ren

JoF, 2025, 11, 383
DOI: 10.3390/jof11050383

CRISPR-Cas system in microbial hosts for terpenoid production

Luan Luong Chu

Critical Reviews in Biotechnology, 2022, 42, 1116
DOI: 10.1080/07388551.2021.1995318

Evolution of isoprenyl diphosphate synthase-like terpene synthases in fungi

Guo Wei, Franziska Eberl, Xinlu Chen, Chi Zhang, Sybille B. Unsicker, Tobias G. Köllner, Jonathan Gershenzon and Feng Chen

Sci Rep, 2020, 10
DOI: 10.1038/s41598-020-71219-z

Root volatiles in plant–plant interactions I: High root sesquiterpene release is associated with increased germination and growth of plant neighbours

Valentin Gfeller, Meret Huber, Christiane Förster, Wei Huang, Tobias G. Köllner and Matthias Erb

Plant Cell & Environment, 2019, 42, 1950
DOI: 10.1111/pce.13532

Overview of fungal terpene synthases and their regulation

Ricardo A. González-Hernández, Norma A. Valdez-Cruz, Martha L. Macías-Rubalcava and Mauricio A. Trujillo-Roldán

World J Microbiol Biotechnol, 2023, 39
DOI: 10.1007/s11274-023-03635-y

Reprogramming the Cyclization Cascade of epi-Isozizaene Synthase to Generate Alternative Terpene Products

Samuel A. Eaton and David W. Christianson

Biochemistry, 2023, 62, 2301
DOI: 10.1021/acs.biochem.3c00247

Fungal metabolites as precursors to renewable transportation fuels

Mark G. Butcher, Pimphan A. Meyer, Richard T. Hallen, Karl O. Albrecht, Christopher K. Clayton, Evgueni Polikarpov, Kenneth G. Rappe, Susanne B. Jones and Jon K. Magnuson

Fuel, 2018, 215, 123
DOI: 10.1016/j.fuel.2017.10.052

Psathyrellanic Acid, a Monocyclic Diterpenoid From the Basidiomycete Psathyrella candolleana

Ya-Pei Liu, Quan Dai, Chao-Jun Pu, Meng Wang, Zheng-Hui Li, Ji-Kai Liu and Tao Feng

Natural Product Communications, 2019, 14
DOI: 10.1177/1934578X19850958

From Genes to Molecules, Secondary Metabolism in Botrytis cinerea: New Insights into Anamorphic and Teleomorphic Stages

Haroldo da Silva Ripardo-Filho, Víctor Coca Ruíz, Ivonne Suárez, Javier Moraga, Josefina Aleu and Isidro G. Collado

Plants, 2023, 12, 553
DOI: 10.3390/plants12030553

Biosynthesis of fusicoccane-type diterpenoids featuring a 5–8–5 tricyclic carbon skeleton

Jing-Yuan Liu, Fu-Long Lin, Jian-Ming Lv, Dan Hu and Hao Gao

Tetrahedron Letters, 2022, 112, 154224
DOI: 10.1016/j.tetlet.2022.154224

Phytohormones and volatile organic compounds, like geosmin, in the ectomycorrhiza of Tricholoma vaccinum and Norway spruce (Picea abies)

Oluwatosin Abdulsalam, Katharina Wagner, Sophia Wirth, Maritta Kunert, Anja David, Mario Kallenbach, Wilhelm Boland, Erika Kothe and Katrin Krause

Mycorrhiza, 2021, 31, 173
DOI: 10.1007/s00572-020-01005-2

Are there conserved biosynthetic genes in lichens? Genome-wide assessment of terpene biosynthetic genes suggests ubiquitous distribution of the squalene synthase cluster

Garima Singh, Anna Pasinato, Alejandra López-Chicheri Yriarte, David Pizarro, Pradeep K. Divakar, Imke Schmitt and Francesco Dal Grande

BMC Genomics, 2024, 25
DOI: 10.1186/s12864-024-10806-0

The genome of Chinese medicinal herb Fuling reveals a key enzyme CYP5035D1C31 involved in pachymic acid biosynthesis

Zhenni Xie, Chuang Liu, Can Zhong, Jing Xie, Ziling Wang, You Qin, Bingbing Shen, Gen Pan, Shuihan Zhang and Jian Jin

Plant Physiology and Biochemistry, 2025, 227, 110173
DOI: 10.1016/j.plaphy.2025.110173

Transcriptome analysis of the brown rot fungus Gloeophyllum trabeum during lignocellulose degradation

Kiwamu Umezawa, Mai Niikura, Yuka Kojima, Barry Goodell, Makoto Yoshida and Monika Schmoll

PLoS ONE, 2020, 15, e0243984
DOI: 10.1371/journal.pone.0243984

Canonical terpene synthases in arthropods: Intraphylum gene transfer

Xinlu Chen, John M. Urban, Jens Wurlitzer, Xiuting Wei, Jin Han, Sarah E. O’Connor, Jeffrey D. Rudolf, Tobias G. Köllner and Feng Chen

Proc. Natl. Acad. Sci. U.S.A., 2024, 121
DOI: 10.1073/pnas.2413007121

Four Undescribed Sesquiterpenes From the Rhizomes of Curcuma wenyujin

Lijia Chen, Hui Wang, Hong Wang, Shuyu Song, Yiming Li, Jingwen Liu and Fujiang Guo

Chemistry & Biodiversity, 2025, 22
DOI: 10.1002/cbdv.202500068

Structural Insights into Three Sesquiterpene Synthases for the Biosynthesis of Tricyclic Sesquiterpenes and Chemical Space Expansion by Structure-Based Mutagenesis

Tingting Lou, Annan Li, Houchao Xu, Jingfeng Pan, Baiying Xing, Ruibo Wu, Jeroen S. Dickschat, Donghui Yang and Ming Ma

J. Am. Chem. Soc., 2023, 145, 8474
DOI: 10.1021/jacs.3c00278

Genomic Comparisons of Two Armillaria Species with Different Ecological Behaviors and Their Associated Soil Microbial Communities

Jorge R. Ibarra Caballero, Bradley M. Lalande, John W. Hanna, Ned B. Klopfenstein, Mee-Sook Kim and Jane E. Stewart

Microb Ecol, 2023, 85, 708
DOI: 10.1007/s00248-022-01989-8

Identifying sesterterpenoids via feature-based molecular networking and small-scale fermentation

Kangjie Lv, Yuyang Duan, Xiaoying Li, Xinye Wang, Cuiping Xing, Keying Lan, Bin Zhu, Guoliang Zhu, Yuyang Qiu, Songwei Li, Tom Hsiang, Lixin Zhang, Lan Jiang and Xueting Liu

Appl Microbiol Biotechnol, 2024, 108
DOI: 10.1007/s00253-024-13299-9

The Evolutionary History and Modern Diversity of Triterpenoid Cyclases

Hanon Solomon McShea, Robb A Viens, Babatunde O Olagunju, José-Luis Giner, Paula V Welander and Fabia Ursula Battistuzzi

Molecular Biology and Evolution, 2025, 42
DOI: 10.1093/molbev/msaf203

Metabolic gene clusters, fungal diversity, and the generation of accessory functions

Jason C Slot and Emile Gluck-Thaler

Current Opinion in Genetics & Development, 2019, 58-59, 17
DOI: 10.1016/j.gde.2019.07.006

5’‐Methoxyarmillane, a Bioactive Sesquiterpenoid Aryl Ester from the Fungus Armillaria ostoyae

Axel M. Orban, Johanna Eichberg, Michael Marner, Sandra Breuer, Maria A. Patras, Ute Mettal, Till F. Schäberle and Martin Rühl

ChemBioChem, 2024, 25
DOI: 10.1002/cbic.202400168

Comparative genomics reveals dynamic genome evolution in host specialist ectomycorrhizal fungi

Lotus A. Lofgren, Nhu H. Nguyen, Rytas Vilgalys, Joske Ruytinx, Hui‐Ling Liao, Sara Branco, Alan Kuo, Kurt LaButti, Anna Lipzen, William Andreopoulos, Jasmyn Pangilinan, Robert Riley, Hope Hundley, Hyunsoo Na, Kerrie Barry, Igor V. Grigoriev, Jason E. Stajich and Peter G. Kennedy

New Phytologist, 2021, 230, 774
DOI: 10.1111/nph.17160

Genetic engineering of yeast, filamentous fungi and bacteria for terpene production and applications in food industry

Zijian Liang, Hang Zhi, Zhongxiang Fang and Pangzhen Zhang

Food Research International, 2021, 147, 110487
DOI: 10.1016/j.foodres.2021.110487

Genome Mining and Biosynthesis of Fungal Africane-Type Sesquiterpenes

Qing-Dong Xu, Guan-Yin Yuan, Feng-Min Li, Qian Yang and Yi Zou

Org. Lett., 2025, 27, 1686
DOI: 10.1021/acs.orglett.5c00062

Transcriptome Analysis of Artificial Cultivated Mushrooms in Qinba Mountains

Zhen Li, Haixia MA, Jie Tan, Yaling Zhao, Jie Huang and Tianli Yue

SSRN Journal, 2022
DOI: 10.2139/ssrn.4131992

Structure-guided product determination of the bacterial type II diterpene synthase Tpn2

Emma A. Stowell, Michelle A. Ehrenberger, Ya-Lin Lin, Chin-Yuan Chang and Jeffrey D. Rudolf

Commun Chem, 2022, 5
DOI: 10.1038/s42004-022-00765-6

Computational Studies on Biosynthetic Carbocation Rearrangements Leading to Quiannulatene: Initial Conformation Regulates Biosynthetic Route, Stereochemistry, and Skeleton Type

Hajime Sato, Takaaki Mitsuhashi, Mami Yamazaki, Ikuro Abe and Masanobu Uchiyama

Angew Chem Int Ed, 2018, 57, 14752
DOI: 10.1002/anie.201807139

Optimization of the production process for the anticancer lead compound illudin M: improving titers in shake-flasks

Lillibeth Chaverra-Muñoz, Theresa Briem and Stephan Hüttel

Microb Cell Fact, 2022, 21
DOI: 10.1186/s12934-022-01827-z

Genome Mining Reveals Pathways for Terpene Production in Aerobic Endospore-Forming Bacteria Isolated from Brazilian Soils

Felipe de Araujo Mesquita, Waldeyr Mendes Cordeiro da Silva, Taina Raiol, Marcelo de Macedo Brigido, Nalvo Franco de Almeida, Bruna Fuga, Danilo de Andrande Cavalcante and Marlene Teixeira De-Souza

Microorganisms, 2025, 13, 2528
DOI: 10.3390/microorganisms13112528

Total Biosynthesis of Melleolides from Basidiomycota Fungi: Mechanistic Analysis of the Multifunctional GMC Oxidase Mld7

Mitsunori Fukaya, Shota Nagamine, Taro Ozaki, Yaping Liu, Miina Ozeki, Taro Matsuyama, Kazunori Miyamoto, Hirokazu Kawagishi, Masanobu Uchiyama, Hideaki Oikawa and Atsushi Minami

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202308881

Mechanistische Studien an zwei bakteriellen Diterpencyclasen: Spiroviolen‐Synthase und Tsukubadien‐Synthase

Patrick Rabe, Jan Rinkel, Etilia Dolja, Thomas Schmitz, Britta Nubbemeyer, T. Hoang Luu and Jeroen S. Dickschat

Angewandte Chemie, 2017, 129, 2820
DOI: 10.1002/ange.201612439

An Isotopic Labelling Strategy to Study Cytochrome P450 Oxidations of Terpenes

Jan Rinkel, Martin Litzenburger, Rita Bernhardt and Jeroen S. Dickschat

ChemBioChem, 2018, 19, 1498
DOI: 10.1002/cbic.201800215

Postharvest Drying Techniques Regulate Secondary Metabolites and Anti-Neuroinflammatory Activities of Ganoderma lucidum

Nooruddin-bin Sadiq, Da-Hye Ryu, Jwa-Yeong Cho, A-Hyeon Lee, Dae-Geun Song, Banzragch Dorjsembe, Jin-Chul Kim, Je-Hyeong Jung, Chu-Won Nho, Muhammad Hamayun, Seung-Hoon Yang and Ho-Youn Kim

Molecules, 2021, 26, 4484
DOI: 10.3390/molecules26154484

Lepistatins A–C, chlorinated sesquiterpenes from the cultured basidiomycete Lepista sordida

Hahk-Soo Kang, So-Ae Ji, So-Hyun Park and Jong-Pyung Kim

Phytochemistry, 2017, 143, 111
DOI: 10.1016/j.phytochem.2017.08.003

Prospective natural anti-inflammatory drimanes attenuating pro-inflammatory 5-lipoxygenase from marine macroalga Gracilaria salicornia

Kajal Chakraborty, Tima Antony and Minju Joy

Algal Research, 2019, 40, 101472
DOI: 10.1016/j.algal.2019.101472

Beneficial bacterial-Auricularia cornea interactions fostering growth enhancement identified from microbiota present in spent mushroom substrate

Chitwadee Phithakrotchanakoon, Sermsiri Mayteeworakoon, Paopit Siriarchawatana, Supattra Kitikhun, Piyanun Harnpicharnchai, Supaporn Wansom, Lily Eurwilaichitr and Supawadee Ingsriswang

Front. Microbiol., 2022, 13
DOI: 10.3389/fmicb.2022.1006446

Chemoenzymatic Total Syntheses of the Enantiomers of the Protoilludanes 8-Deoxydihydrotsugicoline and Radudiol

Ee Ling Chang, Benoit Bolte, Ping Lan, Anthony C. Willis and Martin G. Banwell

J. Org. Chem., 2016, 81, 2078
DOI: 10.1021/acs.joc.6b00043

Engineering Aspergillus nidulans for heterologous ent-kaurene and gamma-terpinene production

Kirsi Bromann, Mervi Toivari, Kaarina Viljanen, Laura Ruohonen and Tiina Nakari-Setälä

Appl Microbiol Biotechnol, 2016, 100, 6345
DOI: 10.1007/s00253-016-7517-5

Paraconiothins A–J: Sesquiterpenoids from the Endophytic Fungus Paraconiothyrium brasiliense ECN258

Ken-ichi Nakashima, Junko Tomida, Takao Hirai, Yoshiaki Kawamura and Makoto Inoue

J. Nat. Prod., 2019, 82, 3347
DOI: 10.1021/acs.jnatprod.9b00638

An Isopentenol Utilization Pathway-Based “Deuterium-Scanning” Method for Mechanistic Investigations of Terpene Cyclases

Shouqi Zhang, Kaibiao Wang, Yuanning Liu, Tao Wang, Yao Kong, Pengcheng Zhang, Bo Zhang, Min Yin, Guohui Pan and Zhengren Xu

ACS Catal., 2024, 14, 17598
DOI: 10.1021/acscatal.4c05811

Sesquiterpenes with new carbon skeletons from the basidiomycete Phlebia tremellosa

Ken-ichi Nakashima, Junko Tomida, Takao Hirai, Yoshiaki Kawamura and Makoto Inoue

J Nat Med, 2019, 73, 480
DOI: 10.1007/s11418-019-01286-8

An HMM approach expands the landscape of sesquiterpene cyclases across the kingdom Fungi

Hayat Hage, Julie Couillaud, Asaf Salamov, Margot Loussouarn-Yvon, Fabien Durbesson, Elena Ormeño, Sacha Grisel, Katia Duquesne, Renaud Vincentelli, Igor Grigoriev, Gilles Iacazio and Marie-Noëlle Rosso

Microbial Genomics, 2023, 9
DOI: 10.1099/mgen.0.000990

Identification and Characterization of a Nerol Synthase in Fungi

Rumeng Li, Bo Yao and Haichun Zeng

J. Agric. Food Chem., 2024, 72, 416
DOI: 10.1021/acs.jafc.3c07573

Biosynthesis and regulation of terpenoids from basidiomycetes: exploration of new research

Qi Wang, Rui Cao, Yuna Zhang, Pengyan Qi, Lizhi Wang and Shiming Fang

AMB Expr, 2021, 11
DOI: 10.1186/s13568-021-01304-7

Effect of fruiting-related genes on the formation of volatile organic compounds in the mushroom Schizophyllum commune

Axel Orban, Lisa Janaina Schwab, Luis G. Lugones, Han A. B. Wösten and Martin Rühl

Mycol Progress, 2023, 22
DOI: 10.1007/s11557-023-01914-4

Deciphering the genome and secondary metabolome of the plant pathogen Fusarium culmorum

Ruth Schmidt, Mikael B Durling, Victor de Jager, Riya C Menezes, Erik Nordkvist, Aleš Svatoš, Mukesh Dubey, Lukas Lauterbach, Jeroen S Dickschat, Magnus Karlsson and Paolina Garbeva

FEMS Microbiology Ecology, 2018, 94
DOI: 10.1093/femsec/fiy078

Phylogenomic Analyses of Non-Dikarya Fungi Supports Horizontal Gene Transfer Driving Diversification of Secondary Metabolism in the Amphibian Gastrointestinal Symbiont, Basidiobolus

Javier F Tabima, Ian A Trautman, Ying Chang, Yan Wang, Stephen Mondo, Alan Kuo, Asaf Salamov, Igor V Grigoriev, Jason E Stajich and Joseph W Spatafora

G3 Genes|Genomes|Genetics, 2020, 10, 3417
DOI: 10.1534/g3.120.401516

Comparative Genomic and Metabolomic Analysis of Termitomyces Species Provides Insights into the Terpenome of the Fungal Cultivar and the Characteristic Odor of the Fungus Garden of Macrotermes natalensis Termites

Nina B. Kreuzenbeck, Elena Seibel, Jan W. Schwitalla, Janis Fricke, Benjamin H. Conlon, Suzanne Schmidt, Almuth Hammerbacher, Tobias G. Köllner, Michael Poulsen, Dirk Hoffmeister, Christine Beemelmanns and Monica T. Pupo

mSystems, 2022, 7
DOI: 10.1128/msystems.01214-21

Expanding the Structural Diversity of Sesquarterpenes through Genome Mining of Noncanonical Class IB Terpene Synthases

Shogo Iwakata, Ikiru Otsuka, Shuya Azuma, Yuka Takaba, Saya Sugisawa, Yumika Suzuki, Yu Shinohara, Yurie Fujii, Daijiro Ueda, Tohru Taniguchi, Masahiro Fujihashi, Tetsuro Shinada and Tsutomu Sato

ACS Chem. Biol., 2026, 21, 74
DOI: 10.1021/acschembio.5c00678

Terpene Synthase Genes Originated from Bacteria through Horizontal Gene Transfer Contribute to Terpenoid Diversity in Fungi

Qidong Jia, Xinlu Chen, Tobias G. Köllner, Jan Rinkel, Jianyu Fu, Jessy Labbé, Wangdan Xiong, Jeroen S. Dickschat, Jonathan Gershenzon and Feng Chen

Sci Rep, 2019, 9
DOI: 10.1038/s41598-019-45532-1

Structural insight on assembly-line catalysis in terpene biosynthesis

Jacque L. Faylo, Trevor van Eeuwen, Hee Jong Kim, Jose J. Gorbea Colón, Benjamin A. Garcia, Kenji Murakami and David W. Christianson

Nat Commun, 2021, 12
DOI: 10.1038/s41467-021-23589-9

Volatile Metabolomic Composition of Vitex Species: Chemodiversity Insights and Acaricidal Activity

José G. de Sena Filho, Ighor C. Barreto, Avaldo O. Soares Filho, Paulo C. L. Nogueira, Adenir V. Teodoro, Ana V. Cruz da Silva, Haroudo S. Xavier, Allívia R. C. Rabbani, Daniel J. Spakowicz and Jennifer M. Duringer

Front. Plant Sci., 2017, 8
DOI: 10.3389/fpls.2017.01931

The Methylerythritol Phosphate Pathway to Isoprenoids

Annika Frank and Michael Groll

Chem. Rev., 2017, 117, 5675
DOI: 10.1021/acs.chemrev.6b00537

Expanding the Diversity of the Terpene Skeleton and Structure through Identification of Noncanonical Class IE and IF Terpene Synthase-Formed Products

Tohru Abe, Tohru Taniguchi, Daijiro Ueda, Takashi Abe and Tsutomu Sato

Org. Lett., 2025, 27, 6211
DOI: 10.1021/acs.orglett.5c01879

Discovery of non-squalene triterpenes

Hui Tao, Lukas Lauterbach, Guangkai Bian, Rong Chen, Anwei Hou, Takahiro Mori, Shu Cheng, Ben Hu, Li Lu, Xin Mu, Min Li, Naruhiko Adachi, Masato Kawasaki, Toshio Moriya, Toshiya Senda, Xinghuan Wang, Zixin Deng, Ikuro Abe, Jeroen S. Dickschat and Tiangang Liu

Nature, 2022, 606, 414
DOI: 10.1038/s41586-022-04773-3

Ancient plant-like terpene biosynthesis in corals

Immo Burkhardt, Tristan de Rond, Percival Yang-Ting Chen and Bradley S. Moore

Nat Chem Biol, 2022, 18, 664
DOI: 10.1038/s41589-022-01026-2

Fungal BGCs for Production of Secondary Metabolites: Main Types, Central Roles in Strain Improvement, and Regulation According to the Piano Principle

Alexander A. Zhgun

IJMS, 2023, 24, 11184
DOI: 10.3390/ijms241311184

Stereoselective AChE/BChE/BACE1 inhibition by enantiomeric norsesquiterpenoids with an unprecedented oxatricyclo[7.2.1.01,9]dodecane scaffold from the soft coral Sclerophytum humesi

Phuong Vu Luu, Cuong-Quoc Nguyen, Huong Lien Ton-Nu, Thuy-Tien Thi Phan, Quoc-Dung Tran Huynh, Ngoc-Thac Pham, Huong-Giang Le, Lo-Yun Chen, Yu-Chia Chang, Jui-Hsin Su, Bo-Rong Peng and Kuei-Hung Lai

Bioorganic Chemistry, 2026, 173, 109652
DOI: 10.1016/j.bioorg.2026.109652

Perspectives for the application of Ustilaginaceae as biotech cell factories

Diethard Mattanovich, Pablo Ivan Nikel, Nick Wierckx, Katharina Miebach, Nina Ihling, Kai P. Hussnaetter, Jochen Büchs and Kerstin Schipper

Essays in Biochemistry, 2021, 65, 365
DOI: 10.1042/EBC20200141

Emerindanols A and B: Two Bipolyhydroindenol Sesterterpenes with 5/6–6/5 Coupled Ring System Discovered by Genome Mining

Shuzhi Liu, Wenjing Wang, Qingpei Liu, Ming Yao, Liangxiu Liao, Shuaibiao Gao, Yi Yu and Xiaolong Yang

Org. Lett., 2024, 26, 4475
DOI: 10.1021/acs.orglett.4c01272

First genome assembly and annotation of Sanghuangporus weigelae uncovers its medicinal functions, metabolic pathways, and evolution

Can Jin, Jin-Xin Ma, Hao Wang, Lu-Xin Tang, Yi-Fan Ye, Xin Li and Jing Si

Front. Cell. Infect. Microbiol., 2024, 13
DOI: 10.3389/fcimb.2023.1325418

Genomic Analysis of Sarcomyxa edulis Reveals the Basis of Its Medicinal Properties and Evolutionary Relationships

Fenghua Tian, Changtian Li and Yu Li

Front. Microbiol., 2021, 12
DOI: 10.3389/fmicb.2021.652324

Terpene Cyclases from Social Amoebae

Patrick Rabe, Jan Rinkel, Britta Nubbemeyer, Tobias G. Köllner, Feng Chen and Jeroen S. Dickschat

Angew Chem Int Ed, 2016, 55, 15420
DOI: 10.1002/anie.201608971

Total Biosynthesis of Melleolides from Basidiomycota Fungi: Mechanistic Analysis of the Multifunctional GMC Oxidase Mld7

Mitsunori Fukaya, Shota Nagamine, Taro Ozaki, Yaping Liu, Miina Ozeki, Taro Matsuyama, Kazunori Miyamoto, Hirokazu Kawagishi, Masanobu Uchiyama, Hideaki Oikawa and Atsushi Minami

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202308881

Chimeric Terpene Synthases Possessing both Terpene Cyclization and Prenyltransfer Activities

Takaaki Mitsuhashi and Ikuro Abe

ChemBioChem, 2018, 19, 1106
DOI: 10.1002/cbic.201800120

Discovery and Characterization of a New Family of Diterpene Cyclases in Bacteria and Fungi

Yan‐long Yang, Shasha Zhang, Ke Ma, Yuxing Xu, Qiaoqiao Tao, Yihua Chen, Juan Chen, Shunxing Guo, Jinwei Ren, Wenzhao Wang, Yong Tao, Wen‐Bing Yin and Hongwei Liu

Angewandte Chemie, 2017, 129, 4827
DOI: 10.1002/ange.201700565

Improved application of natural forest product terpene for discovery of potential botanical fungicide

Yanqing Gao, Yong Wang, Jian Li, Shibin Shang and Zhanqian Song

Industrial Crops and Products, 2018, 126, 103
DOI: 10.1016/j.indcrop.2018.10.008

Terpenoid balance in Aspergillus nidulans unveiled by heterologous squalene synthase expression

Sung Chul Park, Breanne N. Steffan, Fang Yun Lim, Raveena Gupta, Fatma Ayaloglu Butun, Hongyu Chen, Rosa Ye, Timothy Decker, Chengcang C. Wu, Neil L. Kelleher, Jin Woo Bok and Nancy P. Keller

Sci. Adv., 2024, 10
DOI: 10.1126/sciadv.adk7416

Anti-inflammatory diterpenoids from an endophytic fungus Phomopsis sp. S12

Kuang Xu, Xuan Zhang, Jing Wei Chen, Yan Shen, Nan Jiang, Ren Xiang Tan, Rui Hua Jiao and Hui Ming Ge

Tetrahedron Letters, 2019, 60, 151045
DOI: 10.1016/j.tetlet.2019.151045

Four billion years of microbial terpenome evolution

Yosuke Hoshino and Laura Villanueva

FEMS Microbiology Reviews, 2023, 47
DOI: 10.1093/femsre/fuad008

Substitution of Aromatic Residues with Polar Residues in the Active Site Pocket of epi-Isozizaene Synthase Leads to the Generation of New Cyclic Sesquiterpenes

Patrick N. Blank, Golda H. Barrow, Wayne K. W. Chou, Lian Duan, David E. Cane and David W. Christianson

Biochemistry, 2017, 56, 5798
DOI: 10.1021/acs.biochem.7b00895

Whole genome sequence of Auricularia heimuer (Basidiomycota, Fungi), the third most important cultivated mushroom worldwide

Yuan Yuan, Fang Wu, Jing Si, Yi-Fan Zhao and Yu-Cheng Dai

Genomics, 2019, 111, 50
DOI: 10.1016/j.ygeno.2017.12.013

A terpene synthase-cytochrome P450 cluster in Dictyostelium discoideum produces a novel trisnorsesquiterpene

Xinlu Chen, Katrin Luck, Patrick Rabe, Christopher QD Dinh, Gad Shaulsky, David R Nelson, Jonathan Gershenzon, Jeroen S Dickschat, Tobias G Köllner and Feng Chen

eLife, 2019, 8
DOI: 10.7554/eLife.44352

Characterization of γ-Cadinene Enzymes in Ganoderma lucidum and Ganoderma sinensis from Basidiomycetes Provides Insight into the Identification of Terpenoid Synthases

Rui Cao, Xinlong Wu, Qi Wang, Pengyan Qi, Yuna Zhang, Lizhi Wang and Chao Sun

ACS Omega, 2022, 7, 7229
DOI: 10.1021/acsomega.1c06792

Chemical Diversity and Biosynthesis of Drimane‐Type Sesquiterpenes in the Fungal Kingdom

Ying Huang and Vito Valiante

ChemBioChem, 2022, 23
DOI: 10.1002/cbic.202200173

Endophytic Diaporthe sp. LG23 Produces a Potent Antibacterial Tetracyclic Triterpenoid

Gang Li, Souvik Kusari, Parijat Kusari, Oliver Kayser and Michael Spiteller

J. Nat. Prod., 2015, 78, 2128
DOI: 10.1021/acs.jnatprod.5b00170

Volatilized Metabolites Produced by Soilborne Aspergillus flavus Regulate Fungal Conidiation, and Production of Secondary Metabolites

Lina Castano-Duque, Imtiaz Ahmad, Steven W. Lloyd, Matthew D. Lebar, Carol Carter-Wientjes, Nathaniel B. McCartney, Jared G. Ali and Geromy G. Moore

J Chem Ecol, 2026, 52
DOI: 10.1007/s10886-025-01657-4

Genomic comparison between two Inonotus hispidus strains isolated from growing in different tree species

Qingchun Wang, Haiying Bao and Zhijun Li

Front. Genet., 2023, 14
DOI: 10.3389/fgene.2023.1221491

Sesquiterpene Synthase–3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase Fusion Protein Responsible for Hirsutene Biosynthesis in Stereum hirsutum

Christopher M. Flynn, Claudia Schmidt-Dannert and Claire Vieille

Appl Environ Microbiol, 2018, 84
DOI: 10.1128/AEM.00036-18

Plant terpenes that mediate below‐ground interactions: prospects for bioengineering terpenoids for plant protection

Ancheng C Huang and Anne Osbourn

Pest Management Science, 2019, 75, 2368
DOI: 10.1002/ps.5410

Irpexlactones A and B, a pair of ring-rearranged tremulane sesquiterpenoids from the basidiomycete Irpex lacteus and their anti-inflammatory activity

Juan He, Jiao-Xian Du, Meng Wang, Xiao-Dong Luo and Tao Feng

Chinese Chemical Letters, 2025, 36, 110769
DOI: 10.1016/j.cclet.2024.110769

De novo formation of an aggregation pheromone precursor by an isoprenyl diphosphate synthase-related terpene synthase in the harlequin bug

Jason Lancaster, Ashot Khrimian, Sharon Young, Bryan Lehner, Katrin Luck, Anna Wallingford, Saikat Kumar B. Ghosh, Philipp Zerbe, Andrew Muchlinski, Paul E. Marek, Michael E. Sparks, James G. Tokuhisa, Claus Tittiger, Tobias G. Köllner, Donald C. Weber, Dawn E. Gundersen-Rindal, Thomas P. Kuhar and Dorothea Tholl

Proc. Natl. Acad. Sci. U.S.A., 2018, 115
DOI: 10.1073/pnas.1800008115

Identifying and engineering the ideal microbial terpenoid production host

Sandra Moser and Harald Pichler

Appl Microbiol Biotechnol, 2019, 103, 5501
DOI: 10.1007/s00253-019-09892-y

Concise Access to the Skeleton of Protoilludane Sesquiterpenes through a Photochemical Reaction Cascade: Total Synthesis of Atlanticone C

Andreas Zech, Christian Jandl and Thorsten Bach

Angew Chem Int Ed, 2019, 58, 14629
DOI: 10.1002/anie.201908619

Untersuchungen zum Verständnis und zur Kontrolle der Stereoselektivität der Humulen‐Synthase

Carsten Schotte, Peer Lukat, Adrian Deuschmann, Wulf Blankenfeldt and Russell J. Cox

Angewandte Chemie, 2021, 133, 20470
DOI: 10.1002/ange.202106718

Discovery and analysis of a new class of triterpenes derived from hexaprenyl pyrophosphate

Dan Hu

Engineering Microbiology, 2022, 2, 100035
DOI: 10.1016/j.engmic.2022.100035

Cytotoxic Activity of Triterpenoids from Cheiloclinium cognatum Branches against Chronic and Acute Leukemia Cell Lines

Rafael César Gonçalves Pereira, Fernanda Cristina Gontijo Evangelista, Valtair Severino dos Santos Júnior, Adriano de Paula Sabino, Vinícius Gonçalves Maltarollo, Rossimiriam Pereira de Freitas and Lucienir Pains Duarte

Chemistry & Biodiversity, 2020, 17
DOI: 10.1002/cbdv.202000773

Versatile cis-isoprenyl Diphosphate Synthase Superfamily Members in Catalyzing Carbon–Carbon Bond Formation

Chun-Chi Chen, Lilan Zhang, Xuejing Yu, Lixin Ma, Tzu-Ping Ko and Rey-Ting Guo

ACS Catal., 2020, 10, 4717
DOI: 10.1021/acscatal.0c00283

Tandem expression of Ganoderma sinense sesquiterpene synthase and IDI promotes the production of gleenol in E. coli

Qi Wang, Pengyan Qi, Chunsheng Zhao, Yuna Zhang, Lizhi Wang and Heshui Yu

Appl Microbiol Biotechnol, 2022, 106, 7779
DOI: 10.1007/s00253-022-12248-8

Crystal Structure of Cucumene Synthase, a Terpenoid Cyclase That Generates a Linear Triquinane Sesquiterpene

Patrick N. Blank, Travis A. Pemberton, Jeng-Yeong Chow, C. Dale Poulter and David W. Christianson

Biochemistry, 2018, 57, 6326
DOI: 10.1021/acs.biochem.8b00899

Understanding and Engineering the Stereoselectivity of Humulene Synthase

Carsten Schotte, Peer Lukat, Adrian Deuschmann, Wulf Blankenfeldt and Russell J. Cox

Angew Chem Int Ed, 2021, 60, 20308
DOI: 10.1002/anie.202106718