Issue 18, 2025

A copper-catalyzed tandem cyclization reaction of N-acyl enamines and electron-deficient alkynes: direct synthesis of alkynyl substituted pyridines

Abstract

A copper-catalyzed coupling-cyclization reaction of N-acyl enamides with electron-deficient alkynes is developed. This reaction tolerates a wide range of N-acyl enamines and provides a simple and efficient method for the synthesis of 3-alkynyl-substituted pyridines in good to high yields from easily available acyclic starting materials with only water and hydrogen as the by-products in a single step.

Graphical abstract: A copper-catalyzed tandem cyclization reaction of N-acyl enamines and electron-deficient alkynes: direct synthesis of alkynyl substituted pyridines

Supplementary files

Article information

Article type
Paper
Submitted
04 mar. 2025
Accepted
03 apr. 2025
First published
04 apr. 2025

Org. Biomol. Chem., 2025,23, 4441-4445

A copper-catalyzed tandem cyclization reaction of N-acyl enamines and electron-deficient alkynes: direct synthesis of alkynyl substituted pyridines

Y. Gao, J. Peng, Y. Zhang, X. Zhao and Y. Zhao, Org. Biomol. Chem., 2025, 23, 4441 DOI: 10.1039/D5OB00390C

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