Issue 21, 2013
From the journal:

Chemical Communications

Pt(ii) compounds interplay with Cu(ii) and Zn(ii) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease†

Fabrice Collin,*a   Isabelle Sasaki,b   Hélène Eury,b   Peter Fallerb  and  Christelle Hureau*b  

* Corresponding authors

a PHARMA-DEV, UMR 152 IRD-UPS, Université Paul Sabatier, 118 route de Narbonne, 31400 Toulouse, France
E-mail: fabrice.collin@univ-tlse3.fr

b CNRS, LCC (Laboratoire de Chimie de Coordination), 205, route de Narbonne et Université de Toulouse, UPS, INPT, LCC, F-31077 Toulouse, France
E-mail: christelle.hureau@lcc-toulouse.fr
Tel: +33 5 61 33 31 62

Abstract

Five Pt(II) complexes were tested for their ability to interfere in Cu(II) or Zn(II) coordination to the Aβ peptide. Two of them induce modifications of the Cu(II) sphere but not the associated Cu(Aβ) ROS production. In contrast, they do completely preclude Zn induced Aβ aggregation.

Graphical abstract: Pt(ii) compounds interplay with Cu(ii) and Zn(ii) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease

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Article information

DOI
https://doi.org/10.1039/C3CC38537J
Article type
Communication
Submitted
27 Nov 2012
Accepted
23 Jan 2013
First published
23 Jan 2013

Chem. Commun., 2013,49, 2130-2132

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Pt(II) compounds interplay with Cu(II) and Zn(II) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease

F. Collin, I. Sasaki, H. Eury, P. Faller and C. Hureau, Chem. Commun., 2013, 49, 2130 DOI: 10.1039/C3CC38537J

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