Solid-phase submonomer synthesis of sequence-defined oligothioetheramides

Abstract

Sequence-defined polymers have been developed using various orthogonal iterative chemical techniques. Among these, oligothioetheramides (OligoTEAs), which are designed with antimicrobial, cell-penetrating, and other biological properties, are synthesized through iterative solution-phase monomer addition on a soluble fluorous support. To simplify and streamline the iterative process, this work investigates the feasibility of an alternative submonomer solid-phase approach to oligoTEAs.