A concise synthesis of biheteroarenes through Rh(III)-catalyzed cross-dehydrogenative coupling of indoles with thiophenes/furanes is developed, providing access to aza-PAHs.
Herein, a concise protocol for the construction of axially chiral biaryls via Pd-catalysed C–H arylation of 1-arylisoquinoline N-oxides through kinetic resolution using a commercially available chiral mono-protected amino acid has been uncovered.
A straightforward transition-metal-free sustainable methodology for oxidative cyclopropanation of aza-1,6-enynes has been devised, enabling the synthesis of valuable, functionalized azabicyclo[4.1.0]heptane-2,4,5-triones.
The purinyl nitrogen atom is an effective metalation director, which in the presence of Pd(OAc)2, t-BuOOH, and aryl aldehydes, leads to acylation of the aryl ring at the C6 position of the purine.
[β-HIle]2-nodupetide is a nodupetide analogue, in which HMHA residue of nodupetide is replaced with β-HIle and it changes the ester to amide bond in the nodupetide's backbone.