Advances in the bioapplications of ionic pillararenes

Ziyan Shen, Shuang Chao, Luling Wu, Huanyu Liu, Yuxin Pei, Tony D. James and Zhichao Pei

Chem. Soc. Rev., 2025, 54, 8345
DOI: 10.1039/D4CS00458B

A type I and type II chemical biology toolbox to overcome the hypoxic tumour microenvironment for photodynamic therapy

Minzi Ju, Lu Yang, Guowei Wang, Feng Zong, Yu Shen, Shuangshuang Wu, Xuna Tang and Decai Yu

Biomater. Sci., 2024, 12, 2831
DOI: 10.1039/D4BM00319E

Fluorescence-enhanced supra-amphiphiles based on pillar[5]arene: construction, controllable self-assembly and application in cell imaging

Lizhen Fang, Yu Dai, Yiqiao Bai, Yujia Meng, Wenqiang Yu, Yunhan Gao, Ruowen Tang, Yue Zhang, Liang Li, Jin Wang, Yue Ding, Yang Wang, Tingting Chen, Yan Cai and Yong Yao

Chem. Commun., 2024, 60, 7646
DOI: 10.1039/D4CC01987C

Perphenazine modified pillar[5]arene based nano-assemblies for synergistic photothermal and photodynamic cancer therapy

Longtao Ma, Yu Dai, Yujia Meng, Wenqiang Yu, Yiqiao Bai, Yan Cai, Ying Han, Jin Wang, Long Yao and Yong Yao

Chem. Commun., 2024, 60, 8387
DOI: 10.1039/D4CC02528H

Acid/base responsive pseudo[3]rotaxanes from amine naphthotubes and bis-pyridinium/isoquinolinium guests

Li-Shuo Zheng, Hao Nian, Song-Meng Wang, Yan-Fang Wang, Wei Jiang, Li-Li Wang and Liu-Pan Yang

Org. Biomol. Chem., 2024, 22, 7996
DOI: 10.1039/D4OB01268B

Construction of a wavelength tunable supramolecular fluorescent probe for serum albumin-mediated live cell imaging

Wen-Xuan Qin, Kai-Li Chang, Shao-Hu Xu, Jing Zhang and Qing Wang

Journal of Molecular Structure, 2025, 1325, 141001
DOI: 10.1016/j.molstruc.2024.141001

Caged anions in bistren cryptands: Determination of the stability constants by cellmetry method

Mihály Purgel

Journal of Molecular Liquids, 2024, 403, 124863
DOI: 10.1016/j.molliq.2024.124863

Preparation of water-soluble imidazole-functionalized pillar[5]arenes: The activities of antibacterial and antioxidant, catalytic reduction of 4-nitrophenol

Keziban Atacan, Alican Bahadır Semerci, Nuray Güy, Nubar Mammadova, Mustafa Ozmen and Ahmed Nuri Kursunlu

Bioorganic Chemistry, 2025, 161, 108544
DOI: 10.1016/j.bioorg.2025.108544

pH-responsive chiral supramolecular cysteine-Zn2+-indocyanine green assemblies for triple-level chirality-specific anti-tumor efficacy

Qianyun Ye, Yuanyuan Liang, Yuhe Yuan, Xiaohuan Sun, Liqi Zhu, Xuan Wu, Jie Han and Rong Guo

Chinese Chemical Letters, 2025, 36, 110432
DOI: 10.1016/j.cclet.2024.110432

pH-Sensitive Nanodrug Self-Assembled from Aliphatic 5-Fluorouracil Derivative and Doxorubicin for Synergistic Cancer Therapy

Nuo Li, Ludan Zhang, Kaijun Sun, Junheng Liu, Zixuan Wang, Yujing Wang, Huinan Lu, Wenjun Xiang, Hailin Yang, Rupei Tang and Guoqing Yan

ACS Appl. Nano Mater., 2024, 7, 10419
DOI: 10.1021/acsanm.4c00866

Enhancing inter-system crossing efficiency of NIR-II emitting type-I photosensitizers for tumor ferroptosis induction

Fen Liu, Qihang Ding, Jia Jia, Qiang Kang, Jinlin Guo, Yu Liu, Ting Jiang, Chao Li, Jingjing Xiang, Xing Yang, Kun Qian, Chunbai Xiang, Ping Gong, Qinglai Yang and Zhen Cheng

Acta Biomaterialia, 2025, 202, 476
DOI: 10.1016/j.actbio.2025.07.012

Switchable Metal‐Ion Selectivity in Sulfur‐Functionalised Pillar[5]arenes and Their Host‐Guest Complexes

Bunyaporn Todee, Patharaporn Sanae, Araya Ruengsuk, Pattarapapa Janthakit, Vinich Promarak, Jonggol Tantirungrotechai, Mongkol Sukwattanasinitt, Taweetham Limpanuparb, David J. Harding and Thanthapatra Bunchuay

Chemistry An Asian Journal, 2024, 19
DOI: 10.1002/asia.202300913

A supramolecular formulation of icariin@sulfonatoazocalixarene for hypoxia-targeted osteoarthritis therapy

Chao Zhang, Ai-Feng Liu, Shihui Li, Fang-Yuan Chen, Jun-Tao Zhang, Fang-Xing Zeng, Hui-Chuan Feng, Ping Wang, Wen-Chao Geng, Chuan-Rui Ma and Dong-Sheng Guo

Chinese Chemical Letters, 2025, 36, 109752
DOI: 10.1016/j.cclet.2024.109752

Pillar[5]arene stabilized gold nanoparticles for the enhanced light-triggered nitric oxide release with antibacterial and antibiofilm activities

Haixin Zhang, Jinmeng Lv, Xiao Yang, Bo Zheng and Lingyan Gao

Materials Today Chemistry, 2024, 42, 102377
DOI: 10.1016/j.mtchem.2024.102377

Programmable Fe3+-crosslinked alginate grafted β-cyclodextrin derivative/1-adamantaneethyl formate supramolecular microparticles with dual pH- and light-response: A materials chemistry strategy for intelligent drug delivery

Yanan Bu, Jiji Fan, Lei Huang, Xiuqiong Chen, Huiqiong Yan and Qiang Lin

Materials Today Chemistry, 2026, 53, 103496
DOI: 10.1016/j.mtchem.2026.103496

A dual cross-linked pillar[5]arene/porphyrin-based supramolecular polysaccharide hydrogel for promoted wound healing by combating multidrug-resistant bacteria and biofilm eradication

Anan Wang, Wenchen Wang, Wenlong Huang, Zhiwei Tao, Haoran Min, Qu Liu, Weian Zhang and Jia Tian

International Journal of Biological Macromolecules, 2026, 338, 149761
DOI: 10.1016/j.ijbiomac.2025.149761

Pillar[n]arene‐Based Supramolecular Nanodrug Delivery Systems for Cancer Therapy

Shubin Wei, Xinyi Cui, Tingting Li, Xin Ma and Luzhi Liu

ChemMedChem, 2025, 20
DOI: 10.1002/cmdc.202400822

Water-soluble pillar[5]arenes: synthetic strategies, host–guest chemistry, and emerging supramolecular platforms for anticancer drug delivery

Angelina Yuliana Dwi Cahya, Atthar Luqman Ivansyah, Robby Roswanda and Deana Wahyuningrum

J Incl Phenom Macrocycl Chem, 2026
DOI: 10.1007/s10847-026-01338-z

Unraveling planar chirality in pillar[5]arenes

Xiaoyu Hu, Yu Tian and Pangkuan Chen

Tetrahedron, 2024, 162, 134088
DOI: 10.1016/j.tet.2024.134088

A pH-sensitive supermolecular fluorescent probe for albumin-mediated cell imaging

Shao-Hu Xu, Kai-Li Chang, Xian-Ting Yan, Cao-Guo Yan and Qing Wang

Tetrahedron, 2024, 150, 133770
DOI: 10.1016/j.tet.2023.133770

Resveratrol-loaded metal-organic framework for mitochondria-targeted amplified CO gas therapy

Fengqin Wang, Yinfang Jiang and Yang Wang

Front. Chem., 2025, 13
DOI: 10.3389/fchem.2025.1545850

An albumin structure-dependent fluorescent probe for cell imaging and chemo-photodynamic therapy: an in vitro evaluation

Jing-Wen Fan, Shao-Hu Xu, Ying Han, Cao-Guo Yan and Qing Wang

Dyes and Pigments, 2023, 220, 111776
DOI: 10.1016/j.dyepig.2023.111776

A multi-stimuli responsive [3]rotaxane based on hydrogen-bonded aramide azo-macrocycles

Zhiyao Yang, Kuirong Fu, Wentao Yu, Along Jia, Xinnan Chen, Yimin Cai, Xiaowei Li, Wen Feng and Lihua Yuan

Chinese Chemical Letters, 2025, 36, 110842
DOI: 10.1016/j.cclet.2025.110842

Benzopyrylium salt conjugate with 4-diethylamino group enhances D-π-A-D′ to boost type-I/II ROS generation for photodynamic therapy

Yongfei Huang, Junping Liang, Zhefeng Fan and Caixia Yin

Sensors and Actuators B: Chemical, 2025, 427, 137209
DOI: 10.1016/j.snb.2024.137209

Supramolecular Aggregation-Induced Emission Photosensitizer Encapsulated by Cucurbit[8]uril Nanocavity Boosts Hypoxia-Activated Tumor Therapy

Wen Liu, Zeyu Zhang, Qing Huang, Rishi Pai, Lucas Liu, Zufeng Ding, Xing Wang and Zhicheng Jin

ACS Appl. Nano Mater., 2025, 8, 21009
DOI: 10.1021/acsanm.5c03879

Pillar[n]arenes: applications as antibiofilm, antimicrobial, and bioimaging agents

Gangadhara Angajala, Tamar Evan-Salem and Yoram Cohen

Bulletin of the Chemical Society of Japan, 2026, 99
DOI: 10.1093/bulcsj/uoag034

Regulation of Fluorescence and Self‐assembly of a Salicylaldehyde Azine‐Containing Amphiphile by Pillararene

Danyu Xia, Yujie Cheng, Meiru Zhang, Jiaxin Ma, Bicong Liang and Pi Wang

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202304200

Synthesis and evaluation of novel mitochondria-targeted, water-soluble phenoxazine-porphyrins for efficient photodynamic therapy

Lei Dong, Jianhui Zhang, Zhongxing Geng, Shuao Zhang, Yuanqi Wu, Chunxiang Wei, Xiaoli Wang, Hongdian Lu, Wei Yang and San-E Zhu

Dyes and Pigments, 2024, 229, 112279
DOI: 10.1016/j.dyepig.2024.112279

Supramolecular Porphyrin Photosensitizers Based on Host−Guest Recognition for In Situ Bacteria‐Responsive Near‐Infrared Photothermal Therapy

Dan Wu, Xianlong Du, Qiangqiang Xue, Jie Zhou, Kunmin Ping, Yibin Cao, Shuang Liu and Qing Zhu

Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202401662

Editorial: Supramolecular cancer therapeutic biomaterials-volume II

Yong Yao, Guifei Huo and Ruibo Zhao

Front. Chem., 2025, 13
DOI: 10.3389/fchem.2025.1574334

A pillar[5]arene-based supramolecular fluorescent probe for selective GSH detection and GSH-activated mitochondrial targeting cell imaging

Kai-Li Chang, Jing Zhang, Hong-Kai Bian, Xin-Yu Pan, Xiang Ding, Wen-Bo Liu and Qing Wang

Journal of Molecular Structure, 2025, 1337, 142272
DOI: 10.1016/j.molstruc.2025.142272

In Situ NADH-Activated BODIPY-Based Macrocyclic Supramolecular Photosensitizer for Chemo-Photodynamic Synergistic Tumor Therapy

Zhuo Lei, Ya-Hui Song, Yuan-Li Leng, Yi-Jun Gu, Miao Yu, Yong Chen, Qilin Yu and Yu Liu

J. Med. Chem., 2025, 68, 5891
DOI: 10.1021/acs.jmedchem.5c00094

Peptidomimetics based on pillar[5]arene: Charge effect on self-assembly, toxicity, and herbicide binding

Anastasia Nazarova, Olga Mostovaya, Mikhail Bukharov, Anna Nagaeva, George Yusupov, Pavel Zelenikhin, Bin Hua, Feihe Huang, Pavel Padnya and Ivan Stoikov

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2024, 693, 134050
DOI: 10.1016/j.colsurfa.2024.134050

Pillararene‐Based Stimuli‐Responsive Supramolecular Delivery Systems for Cancer Therapy

Xin Li, Meili Shen, Jie Yang, Linlin Liu and Ying‐Wei Yang

Advanced Materials, 2024, 36
DOI: 10.1002/adma.202313317

Synthesis and host-guest chemistry of a thiophene-extended pillar[6]arene: toward applications in nitroaromatics removal and cell imaging

Tingting Chen and Fengqin Wang

Front. Chem., 2026, 14
DOI: 10.3389/fchem.2026.1799183