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Hemin-lipid assembly as an artemisinin oral delivery system for enhanced cancer chemotherapy and immunotherapy

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Porphyrin-based heterojunction photocatalysts: design principles and applications in solar-to-chemical energy conversion

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Microfluidic synthesis of hemin@ZIF-8 nanozyme with applications in cellular reactive oxygen species detection and anticancer drug screening

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Porphyrin-based supramolecular polymers

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In silico prediction of heme binding in proteins

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Journal of Biological Chemistry, 2024, 300, 107250
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Therapy Follows Diagnosis: Old and New Approaches for the Treatment of Acute Porphyrias, What We Know and What We Should Know

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Heme in Cardiovascular Diseases: A Ubiquitous Dangerous Molecule Worthy of Vigilance

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How Does Tuning of the Primary Coordination Sphere Around Ferryl–Oxo Intermediates Affect Structure and Reactivity? Insights into Axial and Equatorial Ligand Field Effects

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Disruption of the dimerization interface of the sensing domain in the dimeric heme-based oxygen sensor AfGcHK abolishes bacterial signal transduction

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Cyanide-free synthesis of aromatic nitriles from aldoximes: Discovery and application of a novel heme-containing aldoxime dehydratase

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Integrated Analysis of Liver Transcriptome, miRNA, and Proteome of Chinese Indigenous Breed Ningxiang Pig in Three Developmental Stages Uncovers Significant miRNA–mRNA–Protein Networks in Lipid Metabolism

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Metal ion coordination sites in ferrochelatase

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Does DNA methylation in the fetal brain leave an epigenetic memory in the blood?

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Delocalization Engineering of Heme‐Mimetic Artificial Enzymes for Augmented Reactive Oxygen Catalysis

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How to Turn an Electron Transfer Protein into a Redox Enzyme for Biosensing

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Molecules, 2021, 26, 4950
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α-Glucosidase isoform G contributes to heme detoxification in Rhodnius prolixus and its knockdown affects Trypanosoma cruzi metacyclogenesis

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Enantioselective induction by G-quadruplex DNA/hemin in intramolecular cyclopropanation

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Binding of a Soluble meso-Tetraarylporphyrin to Human Galectin-7 Induces Oligomerization and Modulates Its Pro-Apoptotic Activity

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Identification of 7-hydroxyindole as an alternative substrate of MauG by in silico and in vitro analysis

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Application of fluorescent probe for labile heme quantification in physiological dynamics

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Catalytic manipulation of reversibility and irreversibility in a supramolecular reaction network to control the self-assembly outcome

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Porphyrin-based nanoporous materials for photocatalytic applications

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Uncovering Porphyrin Accumulation in the Tumor Microenvironment

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Dual-functional fluorescence sensors based on 3D lanthanide metal–organic framework and its mixed matrix membrane

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Sustainable Wacker‐Type Oxidations

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Bioinorganic systems responsive to the diatomic gases O2, NO, and CO: From biological sensors to therapy

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The mrp-3 gene is involved in haem efflux and detoxification in a blood-feeding nematode

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Heme Trafficking and the Importance of Handling Nature’s Most Versatile Cofactor

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Promoting Heme and Phycocyanin Biosynthesis in Synechocystis sp. PCC 6803 by Overexpression of Porphyrin Pathway Genes with Genetic Engineering

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A Chromo-Fluorogenic Naphthoquinolinedione-Based Probe for Dual Detection of Cu2+ and Its Use for Various Water Samples

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Independent somatic distribution of heme and iron in ticks

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Regulation of protein function and degradation by heme, heme responsive motifs, and CO

Angela S. Fleischhacker, Anindita Sarkar, Liu Liu and Stephen W. Ragsdale

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Tyrosine nitration of glucagon impairs its function: Extending the role of heme in T2D pathogenesis

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Unexpected Discovery of Structure‐dependent Aggregation of N‐Oxide Enables Novel Heme‐detecting Probes

Si Ha, Tingyu Guo, Pengfei Lei, Yuting Zhang, Hong Zhang, Feifei Kong, Jing Li, Zhuo Li, Xiang Lv and Chong‐Jing Zhang

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Metabolic engineering and synthetic biology strategies for producing high-value natural pigments in Microalgae

Kai Cao, Yulin Cui, Fengjie Sun, Hao Zhang, Jianhua Fan, Baosheng Ge, Yujiao Cao, Xiaodong Wang, Xiangyu Zhu, Zuoxi Wei, Qingshou Yao, Jinju Ma, Yu Wang, Chunxiao Meng and Zhengquan Gao

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One ring to bring them all and in the darkness bind them: The trafficking of heme without deliverers

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Endogenous molecule-targeted fluorescent probes for ferroptosis visualization: Current progress and future prospects

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Heme Biosynthesis Factors and 5-ALA Induced Fluorescence: Analysis of mRNA and Protein Expression in Fluorescing and Non-fluorescing Gliomas

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Front. Med., 2022, 9
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Mechanisms behind polyphagia in a pest insect: Responses of Spodoptera frugiperda (J.E. Smith) strains to preferential and alternative larval host plants assessed with gene regulatory networks

Natália Faraj Murad, Karina Lucas Silva-Brandão and Marcelo Mendes Brandão

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Complexation of CcmB with CcmACD safeguards heme translocation for cytochrome c maturation

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Hyperoxidized Species of Heme Have a Potent Capacity to Induce Autoreactivity of Human IgG Antibodies

Marie Wiatr, Maya Hadzhieva, Maxime Lecerf, Rémi Noé, Sune Justesen, Sébastien Lacroix-Desmazes, Marie-Agnès Dragon-Durey and Jordan D. Dimitrov

IJMS, 2023, 24, 3416
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Macroheterocyclic μ-Nitrido- and μ-Carbido Dimeric Iron and Ruthenium Complexes as a Molecular Platform for Modeling Oxidative Enzymes (A Review)

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Is ATP the Only Nucleoside Triphosphate among ATP, CTP, GTP, and UTP to Have a Role in Kinase Catalysis of Heme-Regulated Inhibitor toward eIF2α during Lung Cancer Development?

Jakub Vávra, Artur Sergunin, Alžběta Farná, Tomáš Ovad, Toru Shimizu and Markéta Martínková

Catalysts, 2023, 13, 281
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Update on heme biosynthesis, tissue‐specific regulation, heme transport, relation to iron metabolism and cellular energy

Audrey Belot, Herve Puy, Iqbal Hamza and Herbert L. Bonkovsky

Liver International, 2024, 44, 2235
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Heme regulates protein interactions and phosphorylation of BACH2 intrinsically disordered region in humoral response

Miki Watanabe-Matsui, Shun Kadoya, Kei Segawa, Hiroki Shima, Tadashi Nakagawa, Yuko Nagasawa, Shuichiro Hayashi, Mitsuyo Matsumoto, Mariko Ikeda, Akihiko Muto, Kyoko Ochiai, Long C. Nguyen, Katsumi Doh-Ura, Mikako Shirouzu, Keiko Nakayama, Kazutaka Murayama and Kazuhiko Igarashi

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Heme Regulatory Motif of Heme Oxygenase-2 Is Involved in the Interaction with NADPH–Cytochrome P450 Reductase and Regulates Enzymatic Activity

Masakazu Sugishima, Tomoichiro Kusumoto, Hideaki Sato, Hiroshi Sakamoto, Yuichiro Higashimoto, Ken Yamamoto and Junichi Taira

IJMS, 2025, 26, 2318
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Delocalization Engineering of Heme‐Mimetic Artificial Enzymes for Augmented Reactive Oxygen Catalysis

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Cultivation of monoxenous trypanosomatids: A minireview

M. Tannières, D. Breugnot, M.C. Bon and MJ Grodowitz

Journal of Invertebrate Pathology, 2024, 203, 108047
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Unravelling the mechanisms controlling heme supply and demand

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A linear Di-coordinate boron radical cation

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Computational simulation and theoretical comparative study for the complexes of heme-iron and heme-zinc

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Utilizing stimuli-responsive nanoparticles to deliver and enhance the anti-tumor effects of bilirubin

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Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel

Mark J. Burton, Joel Cresser-Brown, Morgan Thomas, Nicola Portolano, Jaswir Basran, Samuel L. Freeman, Hanna Kwon, Andrew R. Bottrill, Manuel J. Llansola-Portoles, Andrew A. Pascal, Rebekah Jukes-Jones, Tatyana Chernova, Ralf Schmid, Noel W. Davies, Nina M. Storey, Pierre Dorlet, Peter C.E. Moody, John S. Mitcheson and Emma L. Raven

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Influence of the Interdomain Interface on Structural and Redox Properties of Multiheme Proteins

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Recent Advances in the Elucidation of Frataxin Biochemical Function Open Novel Perspectives for the Treatment of Friedreich’s Ataxia

Beata Monfort, Kristian Want, Sylvain Gervason and Benoit D’Autréaux

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Recent advances in microbial production of high-value compounds in the tetrapyrrole biosynthesis pathway

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Severe homocysteinemia in two givosiran-treated porphyria patients: is free heme deficiency the culprit?

Petro E. Petrides, Michael Klein, Elfriede Schuhmann, Heike Torkler, Brigitte Molitor, Christian Loehr, Zahra Obermeier and Maria K. Beykirch

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Comparing Properties of Common Bioinorganic Ligands with Switchable Variants of Cytochromec

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Anemia warrants treatment to improve survival in patients with heart failure receiving sacubitril–valsartan

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Characterization of the interaction of metal-protoporphyrins photosensitizers with β- lactoglobulin

Omar Castillo, James Mancillas, William Hughes and Lorenzo Brancaleon

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Liberation of host heme by Clostridioides difficile- mediated damage enhances Enterococcus faecalis fitness during infection

Alexander B. Smith, Jonathan T. Specker, Katharine K. Hewlett, Troy R. Scoggins, Montana Knight, Abigail M. Lustig, Yanhong Li, Kirsten M. Evans, Yingchan Guo, Qianxuan She, Michael W. Christopher, Timothy J. Garrett, Ahmed M. Moustafa, Daria Van Tyne, Boone M. Prentice, Joseph P. Zackular and Kimberly A. Kline

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A Chemical Proteomic Map of Heme–Protein Interactions

Rick A. Homan, Appaso M. Jadhav, Louis P. Conway and Christopher G. Parker

J. Am. Chem. Soc., 2022, 144, 15013
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Retention of Intrinsic Photophysical Properties of Porphyrin Building Blocks in 3D Organic Frameworks through Magic Angle Alignment

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Heme Interactions as Regulators of the Alternative Pathway Complement Responses and Implications for Heme-Associated Pathologies

Stefanos A. Tsiftsoglou

CIMB, 2023, 45, 5198
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Supramolecular Modulation for Selective Mechanochemical Iron‐Catalyzed Olefin Oxidation

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Bacterial TANGO2 homologs are heme-trafficking proteins that facilitate biosynthesis of cytochromes c

Sirui Han, Kailun Guo, Wei Wang, Yizhi J. Tao, Haichun Gao, Matthew R. Chapman and Neal D. Hammer

mBio, 2023
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The Worst Things in Life are Free: The Role of Free Heme in Sickle Cell Disease

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Front. Immunol., 2021, 11
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The role of bHLH-PAS transcription factors in endoplasmic reticulum stress

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N-Heterocyclic carbene-derived second-period main-group radicals: Synthesis, fundamentals, and applications

Solhye Choe, Chaerin Lim, Sunghoon Kang and Eunsung Lee

Chem, 2025, 11, 102714
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Linking Labile Heme with Thrombosis

Marie-Thérèse Hopp and Diana Imhof

JCM, 2021, 10, 427
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Exploiting Differences in Heme Biosynthesis between Bacterial Species to Screen for Novel Antimicrobials

Laurie K. Jackson, Tammy A. Dailey, Brenden Anderle, Martin J. Warren, Hector A. Bergonia, Harry A. Dailey and John D. Phillips

Biomolecules, 2023, 13, 1485
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Haem transporter HRG-1 is essential in the barber’s pole worm and an intervention target candidate

Yi Yang, Jingru Zhou, Fei Wu, Danni Tong, Xueqiu Chen, Shengjun Jiang, Yu Duan, Chaoqun Yao, Tao Wang, Aifang Du, Robin B. Gasser, Guangxu Ma and Edward Mitre

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Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival

Megumi Nishinaga, Hiroshi Sugimoto, Yudai Nishitani, Seina Nagai, Satoru Nagatoishi, Norifumi Muraki, Takehiko Tosha, Kouhei Tsumoto, Shigetoshi Aono, Yoshitsugu Shiro and Hitomi Sawai

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Ferruginous hemeprotein HhuH facilitates the cadmium adsorption and chromium reduction in Stenotrophomonas sp. SY1

Zijie Zhou, Hongbo Yu, Jiahui Liu, Lin Zhu, Gejiao Wang, Kaixiang Shi and Jennifer B. Glass

Appl Environ Microbiol, 2025, 91
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Heme-Based Gas Sensors in Nature and Their Chemical and Biotechnological Applications

Ana Claudia Silva Gondim, Wellinson Gadelha Guimarães and Eduardo Henrique Silva Sousa

BioChem, 2022, 2, 43
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External Hemin as an Inhibitor of Mitochondrial Large-Conductance Calcium-Activated Potassium Channel Activity

Agnieszka Walewska, Adam Szewczyk and Piotr Koprowski

IJMS, 2022, 23, 13391
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Heme inhibits the activity of a c-di-GMP phosphodiesterase in Vibrio cholerae

Ilana Heckler, Sajjad Hossain and Elizabeth M. Boon

Biochemical and Biophysical Research Communications, 2020, 529, 1112
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Rational Design of Daunorubicin C-14 Hydroxylase Based on the Understanding of Its Substrate-Binding Mechanism

Jing Zhang, Ling-Xiao Gao, Wei Chen, Jian-Jiang Zhong, Chao Qian and Wen-Wen Zhou

IJMS, 2023, 24, 8337
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The Cys‐Pro motifs in the intrinsically disordered regions of the transcription factor BACH1 mediate distinct and overlapping functions upon heme binding

Kei Segawa, Kazuhiko Igarashi and Kazutaka Murayama

FEBS Letters, 2022, 596, 1576
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Exacerbation of Neonatal Hemolysis and Impaired Renal Iron Handling in Heme Oxygenase 1-Deficient Mice

Aleksandra Bednarz, Paweł Lipiński, Rafał R. Starzyński, Mateusz Tomczyk, Izabela Kraszewska, Sylwia Herman, Kacper Kowalski, Ewelina Gruca, Aneta Jończy, Rafał Mazgaj, Mateusz Szudzik, Zenon Rajfur, Zbigniew Baster, Alicja Józkowicz and Małgorzata Lenartowicz

IJMS, 2020, 21, 7754
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Metatranscriptomics sheds light on electron transfer in anammox bacteria enhanced by the redox mediator neutral red

Xingcheng Zhao, Fangxu Jia, Bo Wang, ZhiFeng Hu, Baohong Han, Ning Mei, Feirui Jia, Yawen Liu and Hong Yao

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Characterization of the interaction between the tumour suppressor p53 and heme and its role in the protein conformational dynamics studied by various spectroscopic techniques and hydrogen/deuterium exchange coupled with mass spectrometry

Jakub Vávra, Artur Sergunin, Petr Pompach, Dariya Savchenko, Jakub Hraníček, Ivana Šloufová, Toru Shimizu and Markéta Martínková

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Role of indoleamine 2,3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process

Antero Salminen

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