Issue 1, 2023

Visible light metallaphotoredox catalysis in the late-stage functionalization of pharmaceutically potent compounds

Abstract

The late stage functionalization (LSF) of complex biorelevant chemicals is a valuable approach for accelerating the discovery of structure–activity relationships (SARs) and optimising ADME (absorption, distribution, metabolism, and excretion) profiles. To this end, visible-light metallaphotocatalysis provides a unique opportunity to develop smooth and clean drug functionalization by realising site-specific reactivities under very mild reaction conditions. This study provides a comprehensive evaluation of the current research, highlighting recent advances in the discipline while emphasising predicted future advancements and prospective applications along with visible-light metallaphotocatalytic synthesis methods for the LSF of medicines and pharmaceutically potent compounds that are now accessible.

Graphical abstract: Visible light metallaphotoredox catalysis in the late-stage functionalization of pharmaceutically potent compounds

Article information

Article type
Review Article
Submitted
07 out 2022
Accepted
04 nov 2022
First published
08 nov 2022

Org. Chem. Front., 2023,10, 216-236

Visible light metallaphotoredox catalysis in the late-stage functionalization of pharmaceutically potent compounds

P. P. Singh, P. K. Singh and V. Srivastava, Org. Chem. Front., 2023, 10, 216 DOI: 10.1039/D2QO01582J

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