Issue 33, 2023

Understanding the role of metal–organic frameworks in cancer treatment

Abstract

Since cancer is regarded as a nonnegligible health problem, many researchers have paid much attention to establishing all-around cancer treatment methods. Compared with chemotherapy, the most typical cancer treatment methods, photodynamical therapy (PDT) and sonodynamical therapy (SDT), have gradually been proven to be efficient in cancer treatment through different reaction mechanisms. Metal–organic frameworks (MOFs) are a series of star materials owing to their designable structure, high surface area, and porosity. Hence, an in-depth understanding of MOFs will allow us to improve patient health and maximize safety in clinical cancer therapy, which has the potential to treat various difficult cancers. Herein, we focus on the roles of MOF-based cancer treatment systems in chemotherapy, PDT, and SDT and try to clarify the design direction of MOF structures. Some perspectives are also proposed. We hope our perspective can provide insights into the roles of MOFs in cancer therapy.

Graphical abstract: Understanding the role of metal–organic frameworks in cancer treatment

Article information

Article type
Perspective
Submitted
02 jul 2023
Accepted
23 jul 2023
First published
26 jul 2023

New J. Chem., 2023,47, 15407-15421

Understanding the role of metal–organic frameworks in cancer treatment

Y. Zhang, X. Wang, R. Wang, Y. Chen, L. Wang, Y. Shi, Z. Wang, W. Niu and W. Shi, New J. Chem., 2023, 47, 15407 DOI: 10.1039/D3NJ03073C

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