Issue 11, 2021

Stereoselective synthetic strategies of stereogenic carbon centers featuring a difluoromethyl group

Abstract

Difluoromethyl groups possess specific steric and electronic properties due to their slightly acidic C–H bonds and the natural characteristics of fluorine atoms, which allow them to act as chemically inert hydrogen-bond donors and then as surrogates in a wide assortment of important molecular recognition processes. As a result, the construction of chiral carbon centres bearing difluoromethyl groups is not only valuable for the synthesis of various fluorine-containing compounds, but also useful for the modulation of the properties of organic compounds in drug design. The scope of this review is to summarize routine asymmetric synthetic methods which enable the effective and selective introduction of difluoromethyl groups into the desired compounds.

Graphical abstract: Stereoselective synthetic strategies of stereogenic carbon centers featuring a difluoromethyl group

Article information

Article type
Review Article
Submitted
14 jan 2021
Accepted
13 mar 2021
First published
15 mar 2021

Org. Chem. Front., 2021,8, 2799-2819

Stereoselective synthetic strategies of stereogenic carbon centers featuring a difluoromethyl group

F. Gao, B. Li, Y. Wang, Q. Chen, Y. Li, K. Wang and W. Yan, Org. Chem. Front., 2021, 8, 2799 DOI: 10.1039/D1QO00032B

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