Issue 40, 2021

Transition metal-free C-3 functionalization of quinoxalin-2(1H)-ones: recent advances and sanguine future

Abstract

Transition metal-free C-3 functionalization of quinoxalin-2(1H)-ones has recently emerged as a modern sustainable protocol, as C-3 functionalized quinoxalin-2(1H)-ones offer robust applications in the medicinal, pharmaceutical and agriculture industry. In recent times, various sustainable protocols for the construction of C–C, C–N, C–P, C–S, and C–O bonds via the C–H functionalization of quinoxalin-2(1H)-ones were developed. A gradual shift from metal-catalyzed to metal-free methodologies has been observed in last few years, as the latter provide an environmentally benign synthetic route in organic chemistry. The present review offers an extensive discussion on recent advances in transition metal-free C–H functionalization of quinoxalin-2(1H)-ones. The review has been decoratively categorized based on C–C, C–O/C–S and C–N/C–P bond formation using metal-free, visible light and electrochemically catalyzed strategies. In addition, mechanistic features of chemical transformation of quinoxalin-2(1H)-ones have been highlighted.

Graphical abstract: Transition metal-free C-3 functionalization of quinoxalin-2(1H)-ones: recent advances and sanguine future

Article information

Article type
Perspective
Submitted
16 jul 2021
Accepted
03 set 2021
First published
04 set 2021

New J. Chem., 2021,45, 18722-18763

Transition metal-free C-3 functionalization of quinoxalin-2(1H)-ones: recent advances and sanguine future

Kiran, P. Rani, S. Chahal, J. Sindhu, S. Kumar, R. S. Varma and R. Singh, New J. Chem., 2021, 45, 18722 DOI: 10.1039/D1NJ03445F

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