Issue 41, 2021

Efficient and reproducible synthesis of an Fmoc-protected Tn antigen

Abstract

This concise total synthesis of the Thomsen-Nouveau (Tn) glycoconjugate was accomplished using a palladium-catalyzed coupling between the glycosyl donor and Fmoc-protected serine acceptor. This is, to the best of our knowledge, the shortest synthesis reported from galactose for preparing this essential building block for large-scale solid phase peptide synthesis.

Graphical abstract: Efficient and reproducible synthesis of an Fmoc-protected Tn antigen

Supplementary files

Article information

Article type
Communication
Submitted
11 mar 2021
Accepted
10 set 2021
First published
13 set 2021

New J. Chem., 2021,45, 19224-19227

Efficient and reproducible synthesis of an Fmoc-protected Tn antigen

S. M. Piazza, M. R. Reynolds, J. Chiaramonte, P. Xu, F. A. Chapa-Villarreal and J. F. Trant, New J. Chem., 2021, 45, 19224 DOI: 10.1039/D1NJ01173A

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