Issue 41, 2019

Spiropyrans for light-controlled drug delivery

Abstract

The supramolecular assembly of acetylsalicylic acid to a merocyanine–Zn complex translates into a photo-controllable drug delivery system. Herein, we present the synthesis and spectroscopic analysis of a three-component assembly combining a spiropyran derivative, a zinc(II) cation, and acetylsalicylic acid. The ON/OFF system can be modulated by safe and easily affordable stimuli, for the specific delivery of more than one active compound. Our results confirm the formation of a ternary system in solution, where the behaviour is dominated by photo-induced responses, and pave the way for the use of such smart platforms for medicinal chemistry purposes.

Graphical abstract: Spiropyrans for light-controlled drug delivery

Supplementary files

Article information

Article type
Paper
Submitted
17 mai 2019
Accepted
09 jul 2019
First published
10 jul 2019

Dalton Trans., 2019,48, 15537-15544

Spiropyrans for light-controlled drug delivery

F. Cardano, E. Del Canto and S. Giordani, Dalton Trans., 2019, 48, 15537 DOI: 10.1039/C9DT02092F

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