Issue 9, 2018

Catalytic enantioselective synthesis of α-chiral azides

Abstract

α-Chiral azides represent a special subclass of chiral amines, which not only widely exist in bioactive compounds but also play a significant role as a building block in a variety of value-added chiral products. The catalytic asymmetric synthesis of α-chiral azides is of current interest and three synthetic strategies have been developed. This review summarizes the recent progress in this research area, discusses the advantages and limitations of each strategy, and outlines synthetic opportunities for future research.

Graphical abstract: Catalytic enantioselective synthesis of α-chiral azides

Article information

Article type
Review Article
Submitted
27 fev 2018
Accepted
26 mar 2018
First published
27 mar 2018

Org. Chem. Front., 2018,5, 1542-1559

Catalytic enantioselective synthesis of α-chiral azides

P. Ding, X. Hu, F. Zhou and J. Zhou, Org. Chem. Front., 2018, 5, 1542 DOI: 10.1039/C8QO00138C

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