Issue 35, 2016

Graphene oxide nanohybrid that photoreleases nitric oxide

Abstract

We report herein a photoresponsive nanoplatform that delivers nitric oxide (NO) on demand, achieved by the covalent functionalization of graphene oxide (GO) with an amino-terminated nitric oxide (NO) photodonor (NOP1). The resulting GO–NOP1 hybrid nanomaterial is dispersible in water, is very stable in the dark and has been thoroughly characterized by SEM, TEM, AFM, XRD, FTIR and UV-Vis absorption spectroscopy. Photolysis experiments demonstrate that the photodecomposition of the NO photoreleaser integrated into the GO scaffold occurs with an efficiency similar to that observed for a free model compound, ruling out any significant quenching effect (i.e. photoinduced energy/electron transfer) and accounting for the excellent preservation of its photochemical properties upon grafting. A combination of direct amperometric detection and indirect measurements based on a fluorometric assay prove that the remote-controlled release of NO from the GO–NOP1 nanoplatform is exclusively regulated by visible light stimuli.

Graphical abstract: Graphene oxide nanohybrid that photoreleases nitric oxide

Supplementary files

Article information

Article type
Paper
Submitted
28 jun 2016
Accepted
04 ago 2016
First published
04 ago 2016

J. Mater. Chem. B, 2016,4, 5825-5830

Graphene oxide nanohybrid that photoreleases nitric oxide

N. Marino, S. Petralia, M. Perez-Lloret, J. Mosinger, S. Conoci and S. Sortino, J. Mater. Chem. B, 2016, 4, 5825 DOI: 10.1039/C6TB01599A

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