Issue 5, 2015

Formal base-free homolytic aromatic substitutions via photoredox catalysis

Abstract

We developed a simple and convenient method to assemble biaryls exploiting a photoredox catalyst and visible light. Diazonium salts generate aryl radicals that could then add on unactivated (hetero)arenes and the sequence eventually delivers products via formal homolytic aromatic substitutions. The direct C–H arylation of these usually unreactive substrates is achieved at room temperature using low catalyst loadings and shows broad functional group tolerance.

Graphical abstract: Formal base-free homolytic aromatic substitutions via photoredox catalysis

Supplementary files

Article information

Article type
Research Article
Submitted
27 jan 2015
Accepted
25 mar 2015
First published
26 mar 2015

Org. Chem. Front., 2015,2, 464-469

Author version available

Formal base-free homolytic aromatic substitutions via photoredox catalysis

F. Gomes, V. Narbonne, F. Blanchard, G. Maestri and M. Malacria, Org. Chem. Front., 2015, 2, 464 DOI: 10.1039/C5QO00031A

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