Issue 4, 2024

A multimodal therapy for infected diabetic wounds based on glucose-responsive nanocomposite-integrated microneedles

Abstract

Diabetic wounds in a state of high glucose are refractory to treatment and healing, especially if they are infected with bacteria. Herein, a novel nanocomposite (CIP/GOx@ZIF-8) was synthesized by loading ciprofloxacin hydrochloride (CIP) and glucose oxidase (GOx) into zeolitic imidazole framework-8 (ZIF-8) that exhibited good glucose sensitivity and catalytic activity. The high glucose in diabetic wounds could be decomposed into hydrogen peroxide (H2O2) and gluconic acid via the catalysis of GOx, which further destroyed CIP/GOx@ZIF-8 to release Zn2+ and cargos. The combination of glucose starvation, Zn2+, H2O2 and CIP could elevate the antibacterial effect and reduce bacterial resistance. Subsequently, the nanocomposite was fabricated into dissolving microneedles (CIP/GOx@ZIF-8 MNs) using polyvinylpyrrolidone (PVP). The microneedles exhibited good mechanical strength, puncture performance, dissolving performance, glucose responsiveness, antibacterial performance and biocompatibility. For in vivo wound healing, CIP/GOx@ZIF-8 MNs with good biosafety facilitated neovascularization and collagen deposition as well as reduced inflammation, and the wounds were almost healed after treatment. This multimodal therapeutic strategy is created to provide a unique treatment for infected diabetic wounds.

Graphical abstract: A multimodal therapy for infected diabetic wounds based on glucose-responsive nanocomposite-integrated microneedles

Article information

Article type
Paper
Submitted
03 nov 2023
Accepted
28 dez 2023
First published
16 jan 2024

J. Mater. Chem. B, 2024,12, 1007-1021

A multimodal therapy for infected diabetic wounds based on glucose-responsive nanocomposite-integrated microneedles

Q. Zhou, X. Li, N. Gao, G. Ling and P. Zhang, J. Mater. Chem. B, 2024, 12, 1007 DOI: 10.1039/D3TB02609D

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